Top Banner
N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I ,= OTIC Larry I. Sanders . JpdL 1," I LaserSurge, Inc. i I 1991 I I * Office of Naval Research Department of the Navy I *1 1 .!, 1
420

Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

Apr 27, 2019

Download

Documents

vankhue
Welcome message from author
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
Page 1: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

N-FIN-1990

IAD-A230 971

Towards Wound Closure Optimization: Final Report

I,= OTIC

Larry I. Sanders .JpdL 1,"I

LaserSurge, Inc.

iI

1991II* Office of Naval Research

Department of the Navy

I *1 1 .!, 1

Page 2: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DISCLAIMER NOTICE

THIS DOCUMENT IS BEST

QUALITY AVAILABLE. THE COPY

FURNISHED TO DTIC CONTAINED

A SIGNIFICANT NUMBER OF

PAGES WHICH DO NOT

REPRODUCE LEGIBLY.

Page 3: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IEPORT DOCUMENTATION 1. RPORT NO. I R" cint s Aceono

PAGE N-FIN-1990 A

Title and S& itle S. Report 10

15 JAN 1991

Towards Wound Closure Optimization: Final Report

SAuthor'e) L Performilng Organizaion Rept. No.

Larry I. SandersPerforming Oraniuation Memo and Addres MO PreoletftsklWork Unit He.

LaserSurge, Inc.2144 Brighton-Henrietta Town Line Road 11. Contr€l or Crnl(G) No.

Rochester, NY 14623 1e) N00014-89-C-0263

I- Sponsoring Orgenization Nem* end Address 13. Type of Report & Period oro*.

Office of Naval Research

I Department of the Navy Contractor Report (Final

800 N. Quincy Street 14.

Arlington, VA 22217

Supeetr Note$

Abitr-t (Limit: 200 *ordsl

U.Extensive experimentation with many combinations of lasers and chromophores was conducted to dete(mine

the optimal parameters for laser tissue welding. New Zealand White rabbit small bowel was used as an in viLrmodel for this study. The analysis indicates that particular chromophores can be utilized to enhance theeffectiveness of certain lasers. For example, India ink is an effective chromophore for the 1.06 micron Nd:YAGlaser, while blood is most effective for the 0.514 micron Ar laser. The 2.1 micron Ho:YAG laser producedstrong chromophore-free welds, and also produced strong welds in the presence of India ink and blood. Thelaser welding literature indicates that Indocyanine Green is an adjuvant to laser welding with the 0.808 micronGa:AI:As diode laser. The diode lasers that were examined in this study did not provide sufficient energy toweld tissue and evaluate these statements. Indocyanine Green did prove to be an effective chromophore forthe 0.532 micron KTP laser. The apparatus designed and developed for this study provides an unique methodto determine the laser tissue welding parameters which will produce the strongest welds.i

I Document Anaiysis a. Deeeriptora

Ib. idant1fer/Op*n.ed Terms

I,COSA~iTI aled/0.oup

II~vallablilty Stalernent It. Security Ciose (This Report) 21. Ne. of Pae*.

20. Sacutity Class (This Page) 22. Price

I

Page 4: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

UI

CONTENTSUSummary ..................................................................................................... 1

Introduction ......................................................................................................... 1

I Methods, Assumptio=is, and Proceaures ................................................... 2

Results and Discussion .............................................................................. 4

Conclusions ............................................................................................... 10

Recommendations .................................................................................... 11

I Appendix A- Included Data

IAppendix B- Excluded Data

I Appendix C- Supplemental Figures and Illustrations

UIIU

I!

Page 5: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

II

I Summary

IExtensive experimentation with many combinations of lasers and chromophores was conducted to determinethe optimal parameters for laser tissue welding. Nzw Zealand White rabbit small bowel was used as an inviromodel for this study. The analysis indicates that particular chromophores can be utilized to enhance theeffectiveness of certain lasers. For example, India ink is an effective chromophore for the 1.06 micron NdYAGlaser, while blrx'd is most effective for the 0.514 micron Ar" laser. The 2.1 micron Ho:YAG laser producedstrong chromo,,.ore-free welds, and also produced strong welds in the presence of India ink and blood. Thelaser welding literature indicates that Indocyanine Green is an adjuvant to laser welding with the 0.808 nicronGa:AI:As diode laser. The diode lasers that were examined in this study did not provide sufficient energy toweld tissue and evaluate these statements. Indocyanine Green did prove to be an effective chromophore forthe 0.532 micron KTP laser. The apparatus designed and developed for this study provides an unique methodto determine the laser tissue welding parameters which will produce the strongest welds.I

Introduction

LaserSurge, Inc, of Rochester, NY was established to develop, demonstrate, and facilitate the clinical use ofautomated surgical laser delivery systems. The speed, effectiveness, and reliability of using laser energy toconnect or weld living tissue makes laser tissue welding one of the most promising areas of medical researchtoday. The controlled application of laser energy thermally induces intrinsic tissue changes which lead to bothimmediately strong bonds between tissue and rapAd restoration of tissue function. Conventional surgicaltechniques typically require sutures and staples to close tissue wounds or to construct anastomoses (i.e., surgicalconnections that provide functional communication between hollow organs such as bowel). A surgeon'sbonding of tissue using laser tissue welding can be compared to a metal worker's handling of steel. Whereasthe conventional suturing or stapling is like the use of screws or rivets in steel, laser tissue welding, like weldingsteel, uses an outside energy source to cause intrinsic material changes which alone provide for the strong bond.A fundamental requirement to weld either material is that the surfaces to be welded be in intimate contact witheach other. To fully realize the enormous potential of this revolutionary wound closure modality, an enhancedtheoretical understanding of laser tissue welding is essential. In an effort to better recognize and evaluate themany factors that determine a successful laser tissue weld, LaserSurge has developed a laser tissue weldingequation which describes laser tissue welding as a function of its component parameters; lasing parameters,chromophores, and tissue parameters. Using this structured approach, an investigator can readily dissect and .....compare the effects of changes in individual or multiple variables. This study was designed to identify the most - ,-favorable laser tissue welding conditions. To accomplish this goal, an integrated laser tissue welding andtensiometry (weld strength measurement) system was designed, constructed, and tested. This system permitsthe user to selectively vary several parameters of interest including welding temperature, welding time, aperturesize, laser type, power, and chromophores. Experimental trials using different combinations of theaforementioned parameters were performed in this study.

Statement "A" per telecon Beth Morgan.Naval Medical Research & DevelopmentCommand/code 40D. Bethesda, MD 20889-5044.

VIG 1/17/91

Page 6: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

I Methods, Assumptions, and Procedures

I Methods

Device Refinement and EvaluationIIn order to examine the effects of multiple combinations of lasers and chromophores, a new device wasdeveloped to quantify the strength of laser welds. The laser welding/tensiometry apparatus permits any laserwhich can be transmitted through an optical fiber to be coupled to the beam alignment system. The beamalignment system configured the beam so that it slightly overfilled the aperture. The beam passed through ahigh-speed shutte. hich opened and closed in response to the thermocouple temperature readln-. Theaperture size was ftix.' at either 0.5 x4.0 mm or 2.0 x 4.0 i, and the aperture was placed just above the surfaceof the tissue strips to be welded. The beam impinged perpendicularly upon the tissue strips at the site ofapposition. A thermocouple was placed between the strips so that it was positioned 1 mm beneath the surfaceof the weld. The strips were then brought into contact by a piezoelectric motor under computer control. Thelaser welding temperature control program allowed the operator to designate the parameters of interest,including the welding control temperature. Following welding, the welded tissue was pulled apart and the loadrequired to rupture the weld was measured as a function of the distance moved. Graphs of lead versus distancewere generated to determine maximum weld strength.

3 The tensiometry software was seamlessly integrated into the laser welding control program by Mr. WilliarKraft. This new program eliminated the need to reboot the computer between experimental trials. This majorimprovement permitted more rapid data acquisition and reduced the average time between trials toapproximately five minutes.

3 The thermocouple placement system has also been modified to provide more reproducible and accuratetemperature measurements. A single thermocouple was mounted on a specially-designed plexiglas holder.This thermocouple was placed 1 m below the surface of the apposed tissue at the site of welding, as depictedin Figure 1 in Appendix C. The temperature recorded from the thermocouple controlled the opening andclosing of the shutter mechanism, thereby maintaining the designated tissue welding temperature. The newthermocouple holder permits easier, faster, and more reliable thermocouple placement.IA new problem surfaced during the experimentation. The stages began to stall and resist free movementbecause of dried bowel and saline which had entered the stage. The stages were removed, cleaned, andremounted. Periodic cleaning and maintenance have rectified this problem.

II Assumptions

An implicit assumption in the original design of this experimental protocol is that the freshly harvested inbowel very closely resembles native in 3jW bowel. The time from resection to welding was minimized bysequentially harvesting small sections of bowel from intravenously anesthetized rabbits. The resected bowelwas placed in physiological saline to maintain its integrity, while the remaining intact bowel was returned to the

3 2

Page 7: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

I abdomen for later use. Tissue processing and handling were minimized to the extent possible. Tissue traumawa s minimizd by handling and manipulating the bowel gently. We have assumed that the in 3jia tissue wouldnot be significantly altered by th- removal and processing steps. The veracity of this assumption is importantsince the intent of this study is to generate data which will be readily transferrable to clinical applications.

3 One set of experiments suggests that the in k*ro bowel model may not be wholly representative of the in k=state. When more than one hour elapsed between bowel resection and welding, the welds produced were clearlyinferior to welds produced using freshly harvested bowel under the same conditions. This lack of success maybe attributable to changes in tissue turgidity and perhaps also to other biological effects (platelet aggregationand adhesion, etc.). The bowel turgidity appears to change as a result of storage in physiological saline. It isunclear whether this change might influence the laser welding of bowel. Ischemia and oxygen deprivation mayj also cause changes which are responsible for the difference seen between welding in vitr and in Amo.

As a consequence of the invitro alterations to bowel, the weld strengths obtained in this study were much lowerthan anticipated based upon our earlier in vivo data. In order to obtain recognizable welds, the highest laserpower and temperature settings were employed. Several of the lasers, namely the diode and Argon", wereunable to provide the high power output required to weld tissue. Thus, the results for the diode and Argonlasers are inconclusive, and few or no welds were performed using these lasers.

I Experimental Procedure

I The experimental protocol required the resection of small bowel from New Zealand White rabbits. Asdiscussed in the third quarter 1990 report, weld strength appears to diminish as the length of time betweenbowel harvesting and welding increases. In order to more closely emulate the clinical setting, fresh bowel wassequentially resected from an intravenously anesthetized rabbit (see Figure 2 in Appendix C for a completedescription of the experimental protocol). The harvested tissue was cut into strips measuring 4 mm x 20 mm.The strips were carefully positioned on the laser welding/tensiometry apparatus. The thermocouple waspositioned 1 mm deep at the site to be welded and the tissue strips were brought into apposition. Next, thelaser was fired and, following the laser exposure, a welded tissue seam was created where the tissue strips werein contact. Thus, the thermocouple was imbedded in the welded tissue. The laser welding temperature controlsoftware directed the opening and closing of the shutter to maintain the designated welding temperature.Immediately following laser welding, the tissue was pulled apart and the load required to break the bond (ingrams) was measured as a function of the distance (in millimeters) moved. Load versus distance plots were3 generated to assess the strength of each weld. Maximum strength was determined for each weld.

The 0.808 micron diode lasers used in this study were not powerful enough to use for laser welding using theapparatus as designed. Both LaserSurge's Spectra Diode Laboratory 3 W laser diode array andColumbia-Presbyterian's 1.5 W IRIS Medical OcuLight SL diode were coupled to the laser welding/tensiometryapparatus. The power delivered to the weld site, as measured by a power meter, was insufficient to weld tissue,since less than 0.15 W was transmitted through the optical delivery system. No appreciable temperature risewas observed, even with the Indocyanine Green chromophore. Thus, further studies of the diode laser and itsinteraction with chromophores were not performed.

III!

Page 8: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

U Another laser which was initially included in this study was the 1.32 micron Nd:YAG. Rochester GeneralHospital has one 1.32 micron laser, and it had not been used in more than one year. When the laser was turnedon, the ias.-' power setting mechanism did not function. This laser was unable to be repaired prior to theconclusion of this study. Thus, the 1.32 micron Nd:YAG laser was not studied further.

I The Rochester General Hospital 0.514 micron Ar laser was studied. This laser, a 7.5 W Lexel Aurora Model150 Pump Laser and a Model 600 Dye Laser, is a tremendously large research unit. The delivered power wasquite low, approximately 0.7 W, and this precluded testing of some chromophore and temperaturecombinations.

3 The 100 W, CW, Sharplan 2100 1.06 micron Nd:YAG laser was examined using all chromophores and bothaperture sizes. The maximum pcwer of 5.0 W (delivered to the site of welding) was selected for use throughoutsince, at the lower temperatures even with this high power, weld strength was low. Thus, the lower powersettings were not examined.

U The Columbia-Presbyterian Medical Center in New York, NY has a Coherent Two Point One Holmium laser,with a maximum output power of 15 W operating in pulsed mode. The 2.1 micron Ho:YAG was examined atapproximately 1 and 5 W with the small and large apertures.

The 20 W, CW, LaserScope 0532 KTP laser was also examined in this study. Both aperture sizes were examinedat the highest obtainable delivered power of 4 W.

3The power delivered to the weld site through the optical system was occasionally not sufficient to attain someof the higher temperatures. These results are indicated in the data section that follows.

Results and DiscussionIUResults

The data collected and included in the subsequent analysis are limited in number. Most of the early datacollected using the ASYSTANT data acquisition program has been excluded due to problems with thetensiometry apparatus, as will be explained in the Discussion (see Appendix B for these force versus distanceplots). A great deal of time was devoted to software development and testing, and therefore, the resultsreported herein generally come from one or two samples. A thorough statistical analysis was not performed;rather, averages were obtained for each laser and chromophore combination. These averages were assessedto determine the most promising combinations. The averages are presented in Table 1.

*4

Page 9: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

TABLE 1- MAXIMUM WELD STRENGTH (g)

0.514 Micron Argon (Small Aperture, 0.7-0.8W delivered)TEMP BIQOC INDIA INK

UNWELDED 0.9 0.6 0.2500 C 1.2 0.7 1.1

600 C 1.4 1.0 0.9700 C - 0.7 1.3

80 0 C 3.8 - -

SO0OC -

0.532 Micron KTP (Small Aperture, 4.0 W delivered)TEMP BLOOD ICG INDIA INK

UNWELDED 0.7 0.1 0.5500 C 1.7 1.0 0.4

600 C 1.1 2.2 0.5

70 0 C 1.7 2.7 0.9

80 0 C 1.3 1.3 1.0

100o c 2.1 3.4 0.6

N .532 Micron KTP (Large Aperture, 4.0 W delivered)TEMP BLOOD ICGINDIA INK

IJNWELDED - 0.1500 C - 0.7

600 C 0.8 -

700 C 1.0 -

800 C 1.0 -

3100o C 3.7 -

1.06 Micron Nd:YAG (Small Aperture, 5.0 W delivered)TEMP BLOOD ICGINDIA INK

UNWELDED 0.2 0.1 0.5

500 C 0.9 0.9 1.060 0 C 1.5 1.1 0.7

70 0 C 1.6 1.2 2.8

800 C 1.9 !.O 2.0

100oc 1.8 1.1 18.6

I 5

Page 10: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

II

I 1.06 Micron Nd:YAG (Large Aperture, 5.0 W delivered)TEMP BLOOD MG INDIA INK

UNI"WELDED - 1.0

50 0 C - - 1.0

600 C - - 1.0

I 70 0 C -1.0

80 0 C - 1.25

1000 C - 2.0

2.1 Micron Ho:YAG (Small Aperture, 5.0 W delivered)TEMP BLOOD QGINDIA INK NO CHROMO

UNWELDED 0.6 1.7 0.6 0.7

500 1.8 3.4 5.6 4.0600 3.7 2.9 9.4 5.8

700 4.8 9.6 7.0 7.9

I 800 13.6 5.9 21.0 8.9

100o 29.4 10.9 21.0 20.8

2.1 Micron Ho: YAG (Large Aperture, 5.0 W delivered)TEMP BLOOD ICG INDIA INK NO CHROMO

U WE ,.DD 0.6 0.9 1.0 0.8500 C 0.6 4.0 5.4 13.9

S60 C 1.5 11.4 2.4 1.1

700 C 2.8 2., 16.3 2.8

800 C 31.3 45.0 14.2 34.0

10oouC 36.5 50.8 2.1 39.0

2.1 Micron Ho:YAG (Small Aperture, 1.0 W delivered)TEMP BLOOD IC INDIA INK NO CHROMO

UNWELDED 1.3 0.8 1.6 1.2

500 c 2.1 2.1 1.7 1.7

600 C 2.8 0.4 2.4 1.4

S700C 2.4 4.8 3.4 1.5

800 C 1.5 3.6 7.0 2.1

m 1000 C 9.5 5.9 17.9 2.9

I

Page 11: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

I 2.1 Micron Ho:YAG (Large Aperture, 1.0 W delivered)TEMP BLOOD ICG INDIA INK NO CHROMO

UNWELDED 1.0 0.3 0.2 0.2

500 C 6.7 2.7 1.3 1.5

60 0 C 6.1 6.8 0.9

700 C 5.5 24.5 2.0 4.4

800 C 4.9 4.1 0.8 1.4

100 oc 11.3 5.3 3.1 4.1

I NOTES:BLOOD = fresh whole blood collected in a Vacutainer blood collection tube with heparin.ICG =prepared as a 2X solution (25 mg Indocyanine Green per 10 ml aqueous solvent).

I - = unable to perform.

IIIIIIIIIII

I7

Page 12: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

Discussion

Thermocouple Placement

The earlier observation that thermocouple placement is crucial continued to be supported by exptrimentation.If the thermocouple is placed above the weld site, the recorded temperature is an artefact which Lirrespondsto the heating of the thermocouple and not to the heating of the tissue at the weld site. If the thermocouple isplaced too deeply, it again fails to accurately represent the temperature increase at the site of welding since therecor"Cd temperatures are lower than those at the weld. Since the laser welding temperature control programcontrols the temperature at the weld site based upon the thermocouple measurements, proper thermocoupieplacement is imperative. The final thermocouple holder design provides adequate reproducibility. Whenthermocouple placement was incorrect, as evidenced by either an abnormally short or a protracted time toattain the stipulated control temperature, the traia was repeated with fresh tissue strips.

I Prior to the design and construction of the new thermocouple holder, there were major problems withthermocouple placement. The thermocouple was difficult to position reproducibly, and thus, much of the earlydata is erroneous. Since the temperature control program utilizes feedback from the thermocouple, and sincethe thermocouple was incorrectly positioned, the time of laser exposure as well as the actual temperature atthe weld site were incorrect as well.IChromophore Delivery and PlacementIPrecise chromophore placement was another important factor in this study. Each of the chromophores testedwas a liquid. Attempts were made to deposit the chromophore at the weld site using a micropipettor. Thisallowed a fixed amount of chromophore to be deposited, but the application was not evenly distributed alongthe weld seam. A cotton-tipped applicator was used to apply a barely visible coat of chromophore to both tissue

strips prior to bringing the strips into apposition. The strips were then brought into contact by thecomputer-controlled piezoelectric motor. When the requisite apposition was obtained, the top surface of theweld site was gently wiped with a clean cotton-tipped applicator to remove any chromophore which oozedupwards when the tissue was compressed. When too much chromophore was placed at the top of the weld site,excessive energy was absorbed at the surface, rather than in the deeper areas of the weld site, and smoking,charring, and diminished weld strength were noted. Chromophore placement in the deeper half of the weldsite resulted in stronger, more homogeneous welds.UMaintenance of equipment, software package, and Its effect on data.IMaintenance of the laser welding/tensiometry apparatus was crucial. The stages upon which the tissue isclamped are highly susceptible to stalling if they become contaminated with dried bowel and saline. Stalling ofthe motor due to a contaminated stage was readily apparent on the first control run of the day, as the tensiometryplots of force versus distance indicated the resistance of the stage to movement. Periodic removal of the stagesfor cleaning and maintenance was a necessity. The outside surfaces of the laser welding/tensiometry apparatusI wre carefully cleaned after each use. These steps prevented corrosion of the apparatus.

3 8

Page 13: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

U

I initially, however, the problem of stalling was not so readily apparent. Using the original ASYSTANT dataacquisition software package, we were unable to obtain plots of the data in either real time or immediately afterthe completion of the trial. To plot data in ASYSTANT required a lengthy process of file conversion andcomputer rebooting. Thus, data was not analyzed until after the animal had been sacrificed. This softwareproblem resulted in the generation of tremendous amounts of erroneous data (see Appendix B), since it wasimpossible to interpret the effect of stage resistance on the measured weld strengths.

Since there were substantial problems with the software, several different software programs were utilizedduring this study. ASYSTANT was utilized for the earliest data acquisition, but it was cumbersome andinefficient. The time between welding and tensiometry was often more than five minutes. The final version ofthe temperature control and tensiometry program is written in BASIC and can switch from the weldingtemperature control program to tensiometry in a matter of seconds. The data acquired using the BASICprograms was imported into either Lotus 1-2-3 version 2.1 or Lotus Symphony release 2.0 for subsequentanalysis and graphing.IAll data were collected at the laboratory and were stored on 3.5 inch high density floppy disks to permit dataanalysis at the office. Additional backup copies of the data have been made for the LaserSurge software archivesin case of loss or damage to the working disks. These disks are stored off site.

I Overall results- difference in aperture size and its effect, power delivered and

its effect, chromophores and their effect, time of welding and Its effectIAperture size was one parameter examined in this study. 'wo aperture size. vere utilized, 0.5 x 4.0 mm and2.0 x 4.0 mm. The small aperture, with its attendant higher power density, generally produced stronger welds.This was true for all lasers examined, except for the Ho:YAG. For the 5.0 W Ho:YAG trials, the large apertureproduced better welds with either Indocyanine Green or in the absence of chromophore. For the 1.5 W trials,the large aperture again produced stronger welds with Indocyanine Green, blood, and without a chromophore.

Power densities can also be calculated for the two aperture sizes used. The power densities, in W/cm2, were:

I o Small Aperture, 1 W- 50o Small Aperture, 5 W- 250o Large Aperture, 1 W- 12.5o Large Aperture, 5 W- 62.5.

Since the large aperture appeared to weld better than the small aperture for the Ho:YAG lasei, perhaps theincreased surface area of welding was responsible for the strong welds seen.

I High and low power settings were also examined. The higher power of 5 W produced welds of superior strengthwhen compared to the lower power welds. This is true for equal welding temperatures, and seems surprisingsince the lower power setting often required a longer total laser exposure to reach the desired weldingtemperature.

I9

Page 14: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

U

I The effect of the length of exposure to laser energy on weld strength was not assessed in this study. Most ofthe temperature settings used required between 15 and 30 seconds to reach the designated control temperature.

* When the control temperature was attained, feedback from the thermocouple to the shutter control maintainedthe desired temperature for 10 s. Since there was significant variation in the amount of time requir d to reachthe predetermined welding temperature, the differences due to the variation of controlled exposure would bevery difficult to interpret. Thus, a single, fixed 10 s exposure was consistently uE d throughout the study.

The relationship between maximum temperature and weld strength is also unclear. The highest temperatureexamined, 100 degrees C, usually elicited smoking as well as tissue blanching and desiccation. Occasionalcharring was noted in some samples. As mentioned above, the time required to reach the desired temperaturevaried from sample to sample. Thus, the conclusion that weld strength appears to increase with increasingtemperature must be tempered with caution. This is particularly true because the 100 degree welds were oftenslightly weaker than the 80 degree welds. We speculate that this might be due to increased thermal injury atthe higher temperature. Many samples that were welded at 100 degrees became charred or carbonized, andthe tissue was dry and brittle. This type of extreme thermal injury may compromise the strength of the weld,and may explain why the 100 degree welds were weaker than the 80 degree welds. Many of the 100 degreewelds that were mildly desiccated and blanched seemed to be strongly welded. The overall pattern seemed to

indicate that weld strength did increase with increasing temperature.

I Conclusions

3 Laser tissue welding is successful when the correct combinations of laser wavelength, chromophore, andaperture size are utilized. Based upon the in 3i= results obtained in this study, the followinglaser/chromophore combinations appear to show promise for laser tissue welding:

* 0.514 micron Ar +- blood or ICG chromophore9 0.532 micron KTP- blood or ICG chromophore* 1.06 micron Nd:YAG- India ink chromophore* 2.1 micron Ho:YAG- blood, India ink, or no chromophore.I

In comparing the weld strength produced by each of these lasers, the Ho:YAG laser clearly produced thestrongest welds. Many of the Ho:YAG welds appeared to be full thickness welds. The optimal weldingtemperature for any of the tested laser and chromophore combinations appeared to be between 80 and 100degrees C. The higher power levels seemed to produce stronger welds, at least in the range of 1 to 5 W Acertain minimum power is required to increase the tissue temperature to the desired range (80 to 100 degreesC). Whether additional power above this threshold actually improves the strength of the welds cannot beasserted from the data collected.

1II3 10

Page 15: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

U

I Recommendations

UThe laser welding/tensiometry apparatus developed for this study provides an unique and ideal method toanalyze the effects of various parameters on weld strength. The in yitM model has some limitations, and an inZ= corroboration of these results is needed. An in y model would permit an assessment of the effects ofthermal injury and healing, two clinically relevant issues.ILaser tissue welding continues to show great promise for clinical application, and the data generated in thisstudy provide a solid foundation for future pre-clinical and clinical investigations of this new modality.

IUIIIIIIIIII ,

Page 16: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

U

Appendix A- Included DataIIIIIIIIIIIIIIIII

Page 17: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

* 10

160

60

-20 -

-40

Page 18: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

-3

* -45

* -41

-44

-45

Page 19: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

-V~ STkN SEP a4C,'z

-40

I 5*6 -4fIII111111

.. ........2

1

Page 20: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

M L o .K-TP- I bA ( K, C t x L ) /i j °.

-35

!I -40 , ,

-45

i* -50

I-55

iI _ flll~llllllll -fllll Ii111111 I,,,l,, ilf fmmtIfllflllmeIllfmef ef,, mm,.,,, .me,,,,, em,,,,,, mm,,,, me,,,, mef I II IIff fflllf ff l fl Ifmmfm, II,,,,, em, I lltfll fllfn, ff mm,,,, .mmm m I f m. f in ,,, l f mm fcmlf ,, .I me,,,,f I mll , mmml~~llf

me,1,,, .me,,,,,,i I iiIi m ii iii ii i ii 11 Ii miim im,,,i 11 I iiitii eii $m1IIIIiiimmiii mim,,,i, eiiI~iiig.,,,ii I imiiiI ,,II ,, I IIImmII Il,, I mm,,,,,, em,,,,,II me,,,,., III emI .,,, it II II mm$1I m I! Ie IllI ImI Itm III m$lI,,,.,II

UIIIIIIII

Page 21: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

aI -38

1 -39

* -48

1 -41

-42

1 -43

Page 22: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

-3

-39

-45

-46

Page 23: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

II -34

S-39 -

* -40

-41

*-42

* -43

* -44

-45

I.

IIIIIII

iIm Il iI l

Page 24: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

1 -37.2

1 31.3

1 -37.3

-31.6-

I -37.1-

5 -37.96

I38I8.

Page 25: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

30

20

10

n __ ___ ___

5 -20

* -30 ttt~ II I l I I I lllll!lIIl~lIlll IIIfllllfllllflllf ~l!llil lllllJ lt l

5 -: :tI l 6 Ii t |ItII}I III tt€1II It€l t itsiIiIII II J ir l | ltI III li tt|€

II

IU

Page 26: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

o.Cok :ib C-cb f - s cPL9

I-4.

I -41

S-41.5* -4?5

l 4 2

-42.5

-43

I -4.5

I 441

IIIIII

14I...............IIll.. ....... ......

..I

Page 27: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I-37I-J

* -39

* -40

* -4'

* -42

* -43

3 44

IUIIIIIIU

Page 28: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

* -32

* -34

*-36

-38

-40

-42

* -44

5 -46

3-48----

Page 29: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

ATQ~ to-60

I-38.5

I -39 -

1 -39.5-*-40

-40.5

1 41

I|~ ~ I~ t|

1 II III

I I1 $ 1 1 1l l l O I l l l l ~10 1 1 1 1 1 IIIII IIII1111|I|I|I1 011

I

IIUIIIII

Page 30: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

~ S~z~bCc~ ~L C f~t7I(

-31

-35

-36

I -38

I -39

3 -40

* -41

3 -42

Page 31: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

-U4s

-42

-42.5

I -45

I -44.5

Page 32: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

i(-Yo J ,, w ,\P _ ONG- ST KIP P

I

I 50

1 40

S30

20

101 0-

1 -10

* -20

1 -30 - _ _ _ _ _ _ _ _ _ _ _ _ _ _

II

II!

IIIUI

Page 33: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

* ~~~~~90- _ _ _ _ _ _ _ _ _ _

80

70

* 60

50

* 40

30

* 20

* 10

0-

* -10

-20

I3

Page 34: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

I -26

* -27

-28

I -29

-30

I -31

I -32

-33

* -34

* -35

-36

I

IIIIIIII

Page 35: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

cij~.-ThAju ST~keS JCG-- UYN\PtEL-UEi ('Ot\JTRUL

*-29

I-30*-31

3-32*-33

I -34

Page 36: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

~ -26

-27 rn

|II

* -28

* -29

I -30

* -31

* -32

I

IIIIIII

Page 37: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

ji~A QytL Ci CS C T R L L) D 93 (o oD0c

I ~ ~~~~-26 -__ _ _ _ _ _ _ __ _

I-27-28B

* -29

I -30

-31

I -32

I -33

-

34

I -36

Page 38: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

* -29

1 -30

-31

-32

I-33*3 11111m2 111im u

Page 39: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

3 -25 -

* -26

* -27

-28

-29

-30

1-31I-32

Page 40: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

1 -28 4

I- 28.5

-28 6

1 -28 7

1 -28.8

I -28.9

1 -29

-29 1

1 -29.2

1-29 3 8i IIIIHII11Ifu fnR I n01111i ifm i loo

Page 41: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

-28.5I

I-29

1-29.5 -UL =AW L'L--n

1 -30

-30.5

-31

-31.5

3" -32

-32.5

-33

-33.3 -- 3 .5 - *INmINiUlmu ll lI2E ulmuhu mmIuIuu ~mnllIIIIIUUl~mUI.EU PIUIEEUlIIEIIUEIIUUUUIII UUll

iI

I

I

I | / 11 1III I J EII

Page 42: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I " I& 5Q2i

I

i -29.6

-29.8

1 -30

-30.2

-30.4

-30.6

U -30.8

-31

I -31.2

-31.4

1 -31.6

-31.8

* -32

-32.2

1 -32.4AI

IIIIIUU

Page 43: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

* 40

* 30

* 20

3 10

*0-

* -10

* -20

U3

Page 44: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

vvv3 HI\ -

J

Page 45: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

OCT9A

I 60-

1 40

1 30

20

-10

-20

-20

Page 46: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I OCT98

* -37

I -38

* -39

1 -40

-41

1 -42

* -43

1-44jo-4

Page 47: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I-4 OCT9C

-46.4

1 -45.6

-48.8

-46

* -46.2

-46.4

1 -46.6

-46.8

* -47

-47.2

7-47.4

-47.6

-47.8

1 -48 - IlUnllnI Etli Il I rn uw ININ N NIINI I N IEiu I

II

*~75 VUP Am ~

I

I

II

Page 48: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

OCT9D* -34.3

-34.4

S-34.5--34.6

* -34.7-34.8

* -34.9

-35

-36.1

-35.2

-36.3

-36.4

-36.6

* -35.7

-36.8

-.M.9U -36-X

I

I

III

I

Page 49: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I-4 OCT9E

-41 -

S-41 -

IS-42

-

I-43

II-44

I

I____________________I GtA~~

Page 50: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

* OCT9F

* -41.1

-41.2 -

-41.3

1 -41.4 -

-4.6 --41.6 -

-41.7 -

-41.A8

-42 -

-42.1 -

-42.2

-42.3

1 -42.4

-42.6-42.61 -42.7-42.81-4249

-43

-43.1I ~~~-40.2-_ _ _ _ _ _ _ _ _ _ _

IvI

I1

II

Page 51: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

II OCT9G

* -46.3-46.24 C

I - 46 .7-

-46.9-

I -47-

1 -47.1

-47.2

I -47.3

-47.4

1 -47.6

I

I T) S .,V< ,Qk&

I

III

Page 52: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I ,OCT9HI -3,9.6-

-40.2

I -40.3-40

* -40.1

-40.2I -_0.

-40.9-41-

-41.1

I

I

INII

Page 53: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

- OCT91

-- 45.8 -9 o

1 -46

-46.2

*- -46.4

-46.6

* -46.8

-47

1 -47.2

-47.4

1 -47.6

-47.8

-- -48

-48.2

* -48,4

-48.6

* -48.8

-49

I -49.2 II

II

I

UIII

Page 54: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I,14 .OCT9J

-48.7

I -48.8

-48.9

I -49

-49.1

I -49.2

-49.3I -49.4-

-49.65

I -49.6-

-49.7

1 -49.8

-49.9

I -6-60.1

* -60.2 ..

I

II

I

Page 55: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I OCTQR

70

*60

40

I30*20

10

1 -10

-20

* --30

Page 56: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

II

OCT9S

I -36.4

-36.6

-36.8

-37

-37.2

-37.4

-37.6

-37.8

-38

-38.2

-38.4

-38.6

-38.8

I

Page 57: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I OCT9T

* -37.8

I -38.

* -38.1

I -38.4

-38.6

-38.9

Page 58: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

II OCT9U

-4.9 -

I -41.1

I -41.3

-41.4

i -41,A

-41.6

-41.9II -,2-41.9

* -42-42.1

-42.2

1 -42.3-42.4

-42.5-42.4

-42.7

1 -42.8-42.9

1 -43 .

I \(l II

I

II

Page 59: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I* OCT9V1

i-40.6 - _____________________________

-40.7 0

* -40.8

-40.9

-41

-41.1

-41.2

-41.3

S-41.4

-41.5 -

-41.6r-41.7

1 -4f.8

-41.9

3 -42-42.1

-422

_

I

IIIII

Page 60: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

II OCT9W

-41.7-41.7

-41.0 -

-42

-42.1-42.2

-42.3-42.4

-42.5

-42.6

-42.7I -42.8

-42.9

* -43-43.1-43.2

* -43.3-43.4

-43.6

* -43.6-43.7

I -43.8

I

IIIII

Page 61: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

II _ _ _ _ _ _ _ _ _ _ _ _ _

-42.4 - C-) CA__ _ _ __ _ _ _ _ __ _ _ _ __ _ _ _ __ _ _ _ _

-42.5 -

-42.6-

-42.7 -

I -42. -

-42.9 -

-43 --43.1

I -43.2

-43.3-

I -43.4

-43.6

-43.6I -43.7-43.8I -43.9

-44I -44.1-44.2I -4431

I

IIII

Page 62: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

I OCT9Y

I -42.6 --42.7 -

I -42.A

-42.9-43

-43.1-43.2

-43.3-

-43.4

-43.6-43.6

-43.7

* -43.8-43.9

-44

I l-44.1-44.2

* -4.3-44.4-44.6

* -44.6-".7M

v

III

Ii

Page 63: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

OCT10A

* 30

Ii20-

* 10 -

I 0II -10

* -20

-30-

I

*! ~A~

III

Page 64: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

mI

-41.4 OCT10B

-41.7 - ____ __ _

I -41.8-I -41.9

I -42

mm -41 .,* -42

I -42.2

I -42.2

II

,II

Page 65: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

OCTi1OC

* -48-

* -49

* -61

-62

* -63

* -64

-66

-b 1

* -68

* -69

-60

* -61

-62 nnh~~nhiunnnngnInnnnInnvunn~nnhuunnnnnnwnnr

-I -A

Page 66: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

OCT10OD

I -32.15 C

I -33

I -33.5

I -34

* -34.5

I -35

1 -36

I -35

I -0

CICII- Gc CVtUWW_

Page 67: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I OCTiQOE6

I -9

-13

I+-

Page 68: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

II* OCTIOF11 -18- '5

-19

1 -20

I -21

* -22

* -23

-25-26

1 -27

* -27

II 4 T9- C - _

I c4

III

Page 69: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

III OCTIOG

1 -24 0 j

* -26

I -26

* -27

£ -28

I -29

* -30

* -31

I ~ ~~~~~-32- _ _ _ _ _ _ _ __ _II - 2 I III +-II

Page 70: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

iUi OCT10H

-21

I -22

-23

* -24

I -26

-26

I -27

i -28

-29

* -30

-31

* --32

-343I -34- _ _ _ _ _ _ _ _ _ _ _

-3

I

Page 71: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

U OCTiO01

* 15-

-10

I -

* -6

IJ"NP&, -10,Vl

Page 72: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IIi OCTIOJ

-41-

* -42

-43

I -44

-465

* -46

-47 -

* -49 -

-60

I -61

-62

-63

-64

* -66-66 u

I

I

IIII

IU

Page 73: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I.

I OCT 1 5A

ONE STRIP UNWELDED CONTROL

* 90

80

I 70

60

50

* 40

30

* 20

* 10

0

* -10

-20-

I

I f v Lo.s Q

I

Page 74: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

OCT1 5BI - TWO STRIP UNWELDED CONTROL

I -10V

I -11

-12

-13

U -14

I -15

* -16

I1 i il 111 I 1111111111 11111111 11 I 11I M 1 M l i

Page 75: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

SOCT15CTWO STRIP INDIA INK UNWELDED,

3 -10

I -11

1 -12

I-13I

14

3 - 15 - m m ~ ~ mm mmmmmmmmm11mm~l 111lTl1111 IIIIIITII IT111111 111

IIII

IIII

Page 76: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I OCTI 5DI -1 - NLAA NR -50 DEGREES

-16,5

1 -17

* -1 7.5 M

1-18.51 -19

1 -19.5

-20

1 -20.5

-2 1I1T TT M I i l l if ll i f l l 1 1 1 1 1 1 1H I I t1 1 1 1 1 1 1

Page 77: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

II .

OCT I 5E-9-INDIA INK- 60 DEGREES-9

*-9.5

I -10

U -10.5

* -11

1 -11.5

* -12

I

III

IUI

Page 78: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

INDIA INK.- 70DGES(7DEGREES)

-92

U -942

-9.6

-9.8

* -10

-10.2

5 -10 4

-10 6

-10.8

-11

- 1 1 2 -1 1 I H( I I I I f1 1 1 1 1 1 1l l ]l l 1 1 i f i l1 1 1 1 1 1 1 1 I I

Page 79: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

UI

OCT 1 5C II INDIA INb:- 70 DEGREES (64 DEGREES)

-8

i -8.5

-9

-9,5

-10--

I -11

I -11.5

-12

-12.5

- 13 - l ii i fffhfhhhhh;hhhhlh I JhhIujiIii i ii i

IUIIIIIII

Page 80: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

II OCTISHI

- IMDIA iN[ - 80 DEGREES (66 DEGREES)

* -8

-8 5

i -9

* -10

1 -10.5

-11

I -11.5

I -~~~~~~- 2 -II r | ' m mm ~ H HI r H

IIIIII1I

Page 81: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I ST~iP OCT 151TWO SRPUNWELLED BLOOD CONTROL

-9

* -9.1

-9.23 -9 3-9 4

-9 5

* -9 6

-9.7

* -9 8

-9,9

-10I -10.1-10,23 ~ ~~~~-10.3 -II 11li )

Page 82: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IOCT 1 5J 1

i 8LC'CD- T00 DEQPE[7 (77 D£0( Fc)

I - 5.54

-7.5-

I -8

Ii9

IiIi

II

Page 83: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

FII L ~ TF E 1

-884

-9 2

-9 4I-9 6

-102 -

--101 -108

-T4

Ir

Page 84: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DIT 5M1

I -17 L' - 70 DEGEES (62 DEGREES)

T2

-17 4

-1768-178

I8-184

-186

-188

i ' -19

-192

I-19 4

_ -196

1-198--20

-2 2 -F Fi T i mI 11 1 1 1 1 1fll T i llT IIII Fr I ' ll 1111

IIII

I m

Page 85: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

3 OCT I 5P 13 - -BLOOD- 100O nrPFF (56 [DEOREES)

-73

-7.6

-7 7

* -7.8

-7 g

-8 II

* -8 1

-8 2

* -83

-8 4

-8 6

-8 7

* -88

Page 86: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

1 OCT 1 6A

ONE STRIr UINIWELDED CO(tJTROL1 ~150 - -

1401 1~30 -

120

1101 100-

90

so70

* 60-

50

40

3020

* 10

0 -

1-10

I

IV! V?

!AtXI!~\<'

)f

Page 87: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

II OCT I 6B

-8 -- TWO STRIP UNWELDED CONTROL

-8

S-82

I -86

-94

-9,4 -

-9 6

-98

-10 -I -tO2 -

-104

-108

I m

II

l

Ii

I II I

Page 88: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

OCT 1 6C3 ___ ___IWO riplr 2X IrC LNWELPED CONTROL

* -

I -95-

-10

I -10,5-

I -115 -

- 1 2 -MII"M"ITM"ilTPTUIITlmritmrIMmmnm mmilijm mmimml

Page 89: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

OCI10I310 2X ICG- 50 DEGREES (44 DEGREES)

I-11.2-1 12

-1? 1A

1215 -12-1231

- 1242

--125 3

-126 5

-127 65 - 1 2 7

U1 M~ijlilTTMIITT~Mnti~tTmimynmmimm~mmr~r~

Page 90: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

OCT I 6F

I ~862Y IC(7- 60 DEGREES (53 DEGREES)

3 -9

-9 2

I -964

I- 2-10

-104-

I -10~ f

U -I~~~~~rr-l - V TTTT7 TI-TTTTvrTT-Trl-TTrTTTT-rTT-jTTrTTTTTTr-TTiiiIIiii

Page 91: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

1 1 -21 Ir- 70 D C .P U -___46_DECREES)

- 0I

t A2

24

2A

'21 1 1,11 1 1 i l t l t t t ll l l1 T T I T IF T I 1

* No

Page 92: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

SOC T 1 9A

3 ONE STRIP UNWELDED COrTROL

70I 7o /

60I/

50 /

* 40

* 30

20

10

U-10 .... ... .... ...

ce

I

I

I

Page 93: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

OCT1 9B

-35 TWO SIPlF LINWELDED CONITROL

N ~-45

-5I-5.5

1 -7I -6.5

S-7

9 5 6I iil i' 1 iii T I I I I 11 ! i1 TIlT IIT I i III I 11 -

IIIIIUl

II

Page 94: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

OCT 19C

-O tw STRIP INWELDED BLOOD COrIPOL,4I -4 I/

-46

* -4.8

-5

-5.2

* -5 4

-56I -58

-6

-6.2

* -6 4

-66

-6 8 1 1 1TT 111111 iii IT l r T IT TIlT III 111 1liii IT Fi ltlI I I 1 1 1 1 1T

I- -- -. -. .. m .- '

mImmmIIII

Page 95: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I OCT1 9D1I - BLOOD- 50 DECREES (44 DEGRPEE-)

-3

-3 1

* -2

-3.3

-3.4

-3 6I -3 7-3 8

-4

-4.1I -4.2-4.3I -4.4-4 5

-4.6

-4 7 - 1 tI It l I I T I i lM t l 1H ft l

Page 96: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IT

OrIE STPjr IrW LOEU COIJTPIL

* 40-

I 30

* 20

1 10

* 0 - _ _ _ _ _ _ _ _ _ _ _ __mr iln1111111 m lpi11HM~fff

Ua

Page 97: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

0)CT24E3TWO STRIP UNWELDED CONTROL

-3 2 - _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _

-3 4

* -3.6

-3.8

1 -4-4.2

I -4 4-4,6

-52

-5.4

-

Page 98: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

HOCT24CTWO STRIP BLOOD UNWELDED CONTROL

* ~~~~~~~-4.2 _ _ _ _ _ _ _ _ _ _ _ _ _

-4.3

-44

-4.5

-4.6

-4.8

-5l-5 1 i~-5.2

-5.3

-5.5

-5 6

-5.7

-58

-5.9 -7TT ij) j ji III IJ i111111 11111 111II--TTIIII l III I l III II III1 l III~ 11111 lIi

3

IIII

IIi

ItIlI

Page 99: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

TWO STRIP LINWELDED BLOOD CONTROL-2 8

*-3,2

*-3.4

-3.6

I -4

*-4.8

-5

1 -5.2

I0

Page 100: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

OCT24E 1BLOOD- 50 DECREES (42 DEA EES)

-5

*-5 4

-5. 6

*-5.8

-6

* -6.2

-6,4

* -6.6

-6.8

-7 - --.I -7.2-7,4I -7.6-7.8

1 - 8 1 1 1 1 I I T 1 1 1 1 1 1 1 1 1 1 , I ~ l l , 1 1 ~ 1 1 I I I 1 1 I I 1 1 I

Page 101: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

NOVBA- ON E 'STRIP CONTROL1 06 rl4 ACA,, SMALL APERTURE. 5W

110

80

*70

60

*50

40

I3020

I1 1)

0-

1 -10

-20-

Page 102: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IIOVBC- ILJDIA Nkv UfJWELDED COHTPOL1 06 Nd A(,,WL APEPT P.E

-12

* -12

* -124-

-12.63-12.8-13I-13 2

-1.34-

-13.6I -1 3.8

-1423 42-II ii 111 T 11111 IIlii111111111111111 1111111111111111111

Page 103: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

N OV80- WlDA INK CONTROLLED AT 50

16I 1C 06Nd iAC SMALL AF'PHIP-E

-17

-18.

I -195

3 ~ ~~~ ~~ ~~~-20 - 111111 11TI II 1 it 17 MI III 1 Miill 11111111111111111i I1111111111 ii11111 1111111111111 It111 1 1111111111

no

Page 104: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

III

HO,'E- ;rjD:A ,Nt<, CONTROLLL0 AT 60

- 6_ -1 06 Nd iAC. SMALL APERTURE

-198

-20 2 A3 -20 4 \

-20.6

-20.8

-21

-21.2

-21.4

-21 6

-218

-22

-22 2

-22 4

-22 61-22 8 i li ii 111 i 11 11 1I 1 11111 1 1 ITIIIif I 1 I III I IT FTITII I I 111111

-I -- - _. .. .. ..... i ...IIIII!II

Page 105: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

[NC)VVF-ILIDIA fI CO,'TRQLl-ED AT 70

I~~ 0?1C6 rij- t MALL APERTT'RE

1 31

3 29

* 28

3 27

* 26

255

GUSENU2

Page 106: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

27

I 25

I 24 1 AVA/AfAt ~/v<I

* 23

2 1 1 11 11 Fir Ti I I I 1 III111 ffI I I I i Ii I I I II II I 1 1 11i1111i 11 11 1111 1 11

Page 107: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I~~ rJ, A,-~A-~j: N I'.rT LL A T

c K.

* 20

'II.IIIITIIII ~ ~ ~ ~ ~ ~ ~ .. .1T!1TTTT~tir .u .i .i .i .i . n .r . .... .n ri m run m lmm iT

Page 108: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I.I I-I!1[i!~5 (~rJ1F~L~F[ 'J

* ~: 7V

* 74 .1'I 11~

* 10

* 8V

/ >1 \~At~~

1V\ /'1.

I 5

3 - I 1111 III Ill FF111 111FF 1111FF 111FF IF F F F F 1111FF F F F 1FF 11FF F F Fill

IIIIIIIII

Page 109: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC17A-ONE STRIP UNWELDED CONTROL2.1 Hm:YAG, 1.0 W, SMALL APERTURE

3 60

* 50

* 40

* 30

120

-0 01767241 -4.78319 -9.543535 -14.30086

Page 110: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

1 DEC 1783-TWO STRIP UNWELDED CONTROL2.1 Hm:YAG. 1.0 W SMALL APERTURE

I 5.9

I 4.8

5 .6

5.5

4.4 -

-0034 -047090.774-1444-1931-2191

5.I5.

I54.4.I4.I4.I4.I4.I.. ..

Page 111: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC17C-TWO STRIP INDIA INK UNWELDED2 1 Hm:YAC, 1.0 W, SMALL APERTUREI 6~f

* 5

I 4

* 3

2

-0.009913793-0.487069 -0.9637931 -1.44181 -1.920259 -2.398707 -2.878879

Page 112: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I.

DEC17E-INDIA INK CONTROLLED AT 100

2.1 Hm:YAG, 1.0 W SMALL APERTURE

1354

3 12.5

* 12

11.5

I 11-

I

10.5

II

10

!9.5

I9

8.5 -

8 -0.01465517 -0.9806034 -1.944828 -2.911638 --. 880603 -4.849569

IIIII

Page 113: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

DEC17F- NO CHROMO SET=100, TC MAX=70

2.1 Hm:YAG, 1.0 W, SMALL APERTURES16- _16

15

14

* 13

* 12

11

1 10

* 9

* 8-

7 .. .... ...

-0.00991 379":.981 0344- 1.949138-2.918104-3.888793-4.861207 -5.83319 -6.805173

IIIIIIIII

Page 114: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

DECI7G-INDIA INK CONTROLLED AT 50, lOs2.1 Hm:YAG, 1.0 W, SMALL APERTURE

7-

6.9

6.8

* 6.7

6.6

6.5

* 6.4

6.3 -

6.2

6.1

5.9 f

* 5.6

5.5

5.4

5 .2 ............. . . . ........ ........ . . . . . . . . . . . . .

-0.01422414 -0.7448276 -1.472845 -2.200862 -2.931035

UIII

I

I

I

Page 115: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DEC 1 7H-INDIA INK CONTROLLED AT 60, 10 s2.1 Hm:YAG, 1.0 W, SMALL APERTURE

U 6.5

* 5.5

U 5

* 4.5

I 4

* 3.5

3 ......... .......... ...............3-0.01422414 -0.9879311 -1.958621 -2,932759 -3.90819 -4.882759

Page 116: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DEC171-INDIA INK CONTROLLED AT 70, 10 s2.1 Hm:YAG. 1.0 W, SAMLL APERTURE

* ~~ ~ ~~9 _ _ _ _ _ _ _ _ __

8.5

I8* 7.5

7

I 6.5

* 6

5.5

* 5

* 4.5

4-

-0,01 0344830.4952587--0.9806034-1 .467241 -1.953448 -2.440517 -2.92931

Page 117: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DEC17J-INDIA INK CONTROLLED AT 80, 10 s2.1 Hrm:YAC, 1.0 W. SM4ALL APERTUREU 13

12

1 10

1 9

* 7

1 65A

1 -0.00991 379-40.981 8966-1.956034 -2.932328 -3.910345 -4.889224 -5.868104

Page 118: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DEC17K-INDIA INK CONTROLLED AT 100, 10s2.1 Hm:YAG, 1.0 W, SMALL APERTURE1 ~~~~55 -__ _ _ _ _ _ _ _ _ _

50

*45

*40

35

*30

*25

20

*15

50 -

-0,01 034483 -1.471552 -2.937069 -4.406035 -5.87543 1 -7.345258

Page 119: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I3 DEC17L-INDIA INK CONTROLLED AT 100, lOs

2 1 Hm:YAG, 1.0 W, SMALL APERTURE

I 9

8.5

1 8

* 7.5

, 7

* 6.5

* 6

5 .5 . i ......... ......

-0.01034483 -0.9857758 -1.963793 -2.943966 -3.924138 -4.905173

IIIIIIIII

Page 120: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

UDEC17M-NO CHROMO, CONTROLLED AT 50, los

2.1 Hm:YAG, 1.0 W, SMALL APERTURE7.6

74

7.3

I 7.2

7.1

7

6.9

6.8

6.7

6.6

6.5

6.4

6.3

6.2

6.1

6

I 5.9 /

5.7 -

5.55 4 ............

-0.01422414 -0997844B -1.978448 -2.960245

IIIIIIIII

Page 121: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

DEC17N-NO CHROMO CONTROLLED AT 60, 10s2 1 Im:YAO, 1.0 W, SMALL APERTURE

7.2 '

7

6.4 46.2A

5 6 -

5

* 5.

44 14 4

....... . . . . . ... . . . . . . .[ .......... . . . . . . . . . . . . . . . . . . . . . .1 -0 C1034483 -0.9913794 -1.971983 -2.954741 -3.937931 -4921983

IIIIIIIII

Page 122: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DEC<70-NO 1HOM ?2~r7 47S'L?LE? 4T 70, 1 Os I*6 4

*6 k-01078 -0443 -1744 -2072 -986 -3603

I65.

I5.I5,I5.I5I5I5.

Page 123: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

m DEC17P-NO CHROMO CONTROLLED AT 80, 10 s2 1 Hm:YAG, I0 W, SMALL APERTURE

II

i 85

7.5

6.5

1 65 . . . . . . .. . . . 1 . . . . . . . . . . . I . . . . . . . . . . . 1 . . . . . . . . . . . . .7 -'

-0 01034483 -0.7357758 -1.461638 -2.189655 -2.918104

IIIIIIIII

I • • ,

Page 124: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DEC170-NO CHROMO CONTROLLED AT 100, 10s

2.1 Hm:YAG, 1.0 W, SMALL APERTUREU ~~~~~95- _ _ _ _ _ _ _ _ _ _

9

8.5

* 8

* 7.5

* 7

* 6

5.5 .............3-0.01034483 -0.7323276 -1.4560I34 -2.180604 -2.906466 -3.631897

Page 125: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IDEC17R-2X ICG CONTROLLED AT 50, 10s

2 1 Hm:YAO, 1.0 W, SMALL APERTURE

* 7.5

* 7

* 6.5

6

I 5.5

* 5

* 4.5

4 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . I . . . . . . . . . . . . . . . . . . . . .-0.01422414 -0.7Z92241 -1.460776 -2.184052 -2.90819 -3.632759

IIIIUIIIU

Page 126: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

DEC17S- 2X ICc CONTROLLED AT 60, lOs

2.1 Hm:YAG, 1.0 W. SMALL APERTUREI87

I

4I3

I2

S. ...... ...................... 1 .............. I .......................

-0009913793-0.7318965 -1.455172 -2.17931 -2.905604 -3.631897

IIIIIIII1

Page 127: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DEC17T-2X ICC CONTROLLED AT 70, 10s

2.1 HM:TAG. 1.0 W, SMALL APERTURE121

* 7

* 6

5

* 4

* 3

2 ......... .. . . . . . . . . . .

-0.009913793-0.7301724 -1.451724 -2.174138 -2.897845 -3.622845

Page 128: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

DEC17U-2X ICG CONTROLLED AT 80, lOs2.1 Hm:YAG, 1.0 W, SMALL APERTURE

II

10

II

6

I 5

4

I

3-0.009913793-0.9698276 -1.930172 -2.893103 -3.856035 -4.820259 -5.784914

IIIIIIIII

Page 129: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DEC17V-2X ICG SET AT 100, TC MAX=90,2.1 Hm:YAC. 1.0 W ,SMALL APERTURE

10

I 9

* 8

I 7

* 6

-0.009913793 -0.487931 -0.9663794 -1.44569 -1.925 -2.405604

Page 130: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DEC17W- 2X ICG UNWELDED CONTROL2.1 Hm:YAG, 1.0 W, SMALL APERTURE

4.7

4.4

4.3

5 .24.1

4 .93.8

3.7

4.5 -

-. 0104807871.444-.614-.824 -3620-.2795564

4.I4.4.

I43.

I.3.3.3.I.. ... ........ ...............

Page 131: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DEC17X-BLOOD UNWELDED CONTROL

2.1 HrnXAG, 1.0 W, SMALL APERTURE

* 4.5

I 43.5

1 3

3 2.5

I21 .5 .. . . . .. . . . . . . . .3 ~-0.00991 3709-D.7306035-1.452586 -2.174138-2.896983-3.621121 -4.344828 -5.069828

Page 132: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DEC 17Y- BLOOD CONTROLLED AT 50, 10 s2.1 Hm:YAG, 1.0 W. SMALL APERTURE

8-

7.5

* 7

* 6.5

6

1 5.5

I 54.5

1 4

* 3.5

3. . . . . .. . .. .3-0.01034483 -0.7293103 -1.448707 -2.170259 -2.892672 -3.614655

Page 133: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IDEC17Z-BLOOD CONTROLLED AT 60, lOs

2.1 Hm:YAG, 10 W, SMALL APERTUREI 7.5

7

* 6.5

6

1 5.5

5

* 4.5

£4I 3.5

3 -............... I ... .......1 -0.01034483-0.7280172-1.446983 -2.165949 -2.8875 -3.60819 -4.329311

IIUIIIIII

Page 134: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

DEC17AA- BLOOD CONTROLLED AT 70, 10s2.1 Hm:YAO, 1.0 W, SMALL APERTUREI S ,8

7.5

,7

* 6.5

6

* 5.5

* 5

4,5

* 4

* 3.5

3 . . . ... ......... ...... .......... ............... .......

-0.00991379-0.9672414-1.926724 -2.888362 -3.850862 -4.813793 -5.777156

I,IIIIIIII

Page 135: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

DEC17AB- BLOOD CONTROLLED AT 80, 10 s

21 Hm:YAG, 1.0 W, SMALL APERTURE, -64

6

* 5.8

5.6

544

5.2

5

4

4.6 ,

4.4 -

* 384

3.6

* 7.4

3.2

3 . . . . . .... . . . . . . . . . . .... . 1 1 . . . . . . . . . . .. . . .. . . . .... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

-0.009913793 -0.9655172 -1.922845 -2.881897 -3 842672 -4 804311

IIIIIII

Page 136: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

IEC17AC--BLOOD CONT ,OLLED AT 100, 10 s

2 1 HimYAG. 1.2 W, SMiAtL APERTURE

15 -

I 4 -

13 -

I 12-

3 10

6IV4 I ..... ...... . .I ... . . . . . . . .... ... ..... ..... ........... .... ' ........ ....... ...

' .....10 4 8 - .9 7 9 1 - . 'f 5 5 - 2 7 2 9- 3 8 6 2- 4 9 6 23-0.01034483 -0.9637931 -1.18535 --2.B76293 -3.8'362 1 -4.792672

II,UIIUIIU

Page 137: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

3 DEC18A- ONE STRIP UNWELDED CONTROL2.1 Hm:YAG, 5.0 W, SMALL APERTURE

100 - _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _

90

17060

*50

*40

30

I200-

3-0.01637931 -4.898707 -9-771982 -14.62802 -19A47241

Page 138: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I OEC18B-TWO STRIP UNWELDED CONTROL

10 ~2 -21 Hm:YAG, 5.0 W. SMALL APERTURE

U 9

8

I 7

* 6

* 5

4

* 3

* 2

I-0.009051723 -1.2'29741 -2.453448 -3.679742 -4.907759

Page 139: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC18C- INDIA INK UNWELDED CONTROL2.1 Hm:YAG, 5.0 W. SMALL APERTUREI9

U76

5

* 4

3

* 2

0

I -1

-2-I-0.009051723 -0.7431035 -1.477155 -2.212931 -2.949569 -3.686638

Page 140: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DEC18D-INDIA INK CONTROLLED AT 50, 10 s2.1 Hm:YAG, 5.0 W, SMALL APERTURE

13

312I 1

10

I 9

* 8

7

1 6

* 5

4 .. .. . .. . . . .3-0.009051723 -0.9844828 -1.960776 -2.939224 -3.918535 -4.898276

Page 141: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

3 DEIC18E1-INDIA INK CONTROLLED AT 60, 10s2.1 Hm:YAG, 5.0 W, SMALL APERTURE

* 18 -

17

*16

15

*14

*13

12

I 11

I 10

9

I8-0.01810345 -0.7530173 -1.484914 -2.218966 -2.953879 -3.689224

Page 142: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DEC18F-INDIA INK CONTROLLED AT 70, 10s2.1 Hm:YAG, 5.0 W. SMALL APERTURE

15

14

13

I 121 1

* 10

9

* 8

7

I 6

I 43

* 2

-0.008620689 -0.986206&o -1.965086 -2.946121 -3.928018

Page 143: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC18G- INDIA INK CONTROLLED AT 80, 10s2.1 Hm:YAG, 5.0 W. SMALL APERTURE

* ~~~~30 - _ _ _ _ _ _ _ _ __ _

28

*26

24

*22

20

*18

14

*12

10

* 8

6

-0.008620689 -1.475862 -2.945259 -4.417672 -5.891811

Page 144: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

DEC18H-INDIA INK CONTROLLED AT 100, lOs

2.1 Hm:YAG. 5.0 W, SMALL APERTUREI 30 -

28

*26

24

*22

20I 1818 -

*16

14

*12

10

* 8

6

-0.009051723-1.231035 -2.456035 -3.684052 -4.913362 -6.143966 -7.373276

IIIIIIIII

Page 145: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DECiBI- NO CHROM CONTROLLED AT 50, 10s2.1 Hm:YAG, 5.0 W, SMALL APERTURE

* 12-

I 1

I 10

* 9

I8I 7

* 6

5-I-0.009482758 -1.482759 -2.958621 -4.4375 -5.918535

Page 146: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC18J-NO CHROMO CONTROLLED AT 60. 10s2.1 Hm:YAG. 5.0 W, SMALL APERTURE

* 15 -

14

*12

I 1

I 10

9

I 7

6 .. ...... . .. .I-0.009482758 -1.48319 -2.959483 -4.438362 -5.918966

Page 147: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

3 DECIBK- NO CHROMO CONTROLLED AT 60, 10s2.1 Hm:YAC. 5.0 W, SMALL APERTURE

* ~~~~~13 - _ _ _ _ _ _ _ _ __ _

12

* 10

I 98

7

1 6

* 5

4-

-0.009482758 -1.239224 -2.473707 -3.711638 -4.95

Page 148: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

3 DEC18L-NO CHROMO CONTROLLED AT 70, 10 s2.1 Hrn:YAG, 5.0 W. SMALL APERTURE

17

* 16

15

I 141.3

* 12

I 109

* 8

7

* 6

I 433-0.009913793 -1.485345 -2.965517 -4.448276 -5.932328

Page 149: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC18N-NO CHROMO -CONTROLLED AT 80, 10s2.1 Hm:YAC, 5.0 W, SM'ALL APERTUREI 1~~~ ~~7 _ _ _ _ _ _ _ _ __

16

15I 1413

* 12

11

9

I7

5

* 4

3

2-

-0009913793 -1.493535 -2.983621 -4.476293 -5.970259 -7.464656

Page 150: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

I DEC 80- NO CHROMO CONTROLLED AT 100,lOs

2E 6 2 1 Hrn YAG, 5.0 W, SMALL APr rI'RE

I 25-243 23 p22

21

20 -

* 18

17 6V15

4-I 1313

12

I I1

9 .. ............ ... ............... .................. .............. ...........

I -0.009913793 -1.49569 -2.985776 -4 477587 -5.97069

IIIIIIIII

Page 151: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

i

I DEC18P-NO CHROMO CONTROLLED AT 100, lOs

2.1 Hm:YAG. 5.0 W, SMALL APERTUREI 4038 -

34 -

32 -

30

28

I 26

24

22

?0

18

16

14

12

10 --0.009482758 -2.191379 -4.384483 -6.580173 -8.769827

IIIIIIIII

Page 152: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DECiBO- 2X ICC UNWELDED CONTROL2.1 Hm:YAG. 5.0 W, SMALL APERTURE

* ~~~~15 - _ _ _ _ _ _ _ _ _

* 14

*13

*12

I 11

5 10

1 9

8 .. . . .I . . . .5-0.009482758 -0.9702586 -1.932328 -2.89569 -3.860776

Page 153: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC 18R- 2X ICG CONTROLLED AT 50, 10 s2.1 Hm:YAC, 5.0 W. SMALL APERTURE

* ~~~~16 - _ _ _ _ _ _ _ _ _ _

15

14

I 12

I 10

8-

-0-009913793 -1.450862 -2.893966 -4.340518 -5.7875

Page 154: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

U DECiBS- 2X ICG CONTROLLED AT 60, 10 s2 1 Hm:YAG. 5.0 W. SMALL APERTURE

* ~~~15 - _ _ _ _ _ _ _ _ _

14

*13

12

I 1

10

8

* 7

6

I 54

* 3

2 .. . . .. . ..-.. . .

-0.009482758 -1.209483 -2.410345 -3.614655 -4.819397

Page 155: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

3 DEC18T- 2X ICG CONTROLLED AT 70, 10 s2.1 Hm:YAG, 5.0 W, SMALL APERTURE

22 -

*21

20

1931817

16I 1514

13

12

I 109

8I 76

5

3-0.009482758 -1.929311 -3.855173 -5.78319 -7.709914

Page 156: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC18U- 2X ICC CONTROLLED AT 80, 10s

S2.1 Hmn:YAG, 5.0 W, SMALL APERTURE

12

12

10

* 9

I 8

* 7

* 6

5 . ... .....1 . .............. .. . . .I-0.009482758 -1.209483 -2.410776 -3.616379

Page 157: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC18V- 2X CIC CONTROLLED AT 100, 10s2.1 Hm:YAG. 5.0 W. SMALL APERTURE

25I2423I2221

*20

19

I1817

* 16

15

* 14

13

* 12

-0.009482758 -1.932328 -3.862069 -5.794397 -7.725431

Page 158: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IDEC 1BW 1- 2X ICG CONTROLLED AT 80, 1 Os2.1 Hm:YAG, 5.0 W, SMALL APERTURE

21 -

20

19

*18

17

*16

15

1431312

31109I 87

* 6

5

-0.009482758 -1.213362 -2.427586 -3.637069 -4.848707

Page 159: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC18X- BLOOD UNWELDED CONTROL2.1 Hm-YAC, 5.0 W, SMALL APERTURE

*12

- l

I 11

U10

7 7

3,-0.009482758 -0.7344828 -1.458621 -2.184914 -2.912069

Page 160: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC 18Y- BLOOD CONTROLLED AT 50, 10 s2.1 Hm:YAG, 5.0 W, SMALL APERTURE

* ~~~~~13 - _ _ _ _ _ _ _ _ __ _

12

1 1

10

3 9

* 8

* 7

* 6

3-0,009482758 -1.456897 -2.908721 -4.362932

Page 161: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IDEC18Z- BLOOD CONTROLLED AT 50, 10 s

2.1 Hm:YAG, 5.0 W, SMALL APERTURE14 -

13

* 12 -

11

10

*9

8

*7

1 6

5

* 4

-0.009482758 -1.214655 -2.421552 -3.631897

I

I

II!III

Page 162: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IDEC 18AA- BLOOD CONTROLLED AT 60, lOs

2.1 Hm:YAG. 5.0 W. SMALL APERTURE15I14

* 13

* 12

*1 1

1 109 To

U -0.009482758 -1.212931 -2.419397 -3.629741 -4.839656

IIIUIIIII

Page 163: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

3 DECiBAB- BLOOD GON77ROLLED AT 70, 10 s2.1 [Am:YAO, !I.0 W, SMALL APERTURE

* 16

15

14

13

1 12

* 1

* 10

1 9

8 .. . . . . . . . . . . .3-0.009482758 -1.211638 -2.423707 -3.631466 -4 840948

Page 164: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

3 DEC18AC- BLOOD CONTROLLED AT 80, 10

I25 - 24 - 2 1 HrnYAG, 5 C' W. SMALL APERTUE

2332221

I2019

1 8

* 17

163 1514

3

* 12

to

I-0 ,009051723 -1.453448 -2. 9 -4.348707 -5 -799138 -7.248707

Page 165: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC18AD- BLOOD CONTROLLED AT 100, 10 s

40 - 2.1 Hm YAG. 5.0 W, SMALL APERTURE

I3836

13432

j3028I 2624

22

20

18

1 16

4

12

10-

-0.009482758 -1.212069 -2.417673 -3.625862 -4.836207

Page 166: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC19A- ONE STRIP UNWELDED CONTROL808 DIODE, 0.15 W. SMALL APERTURE

70 - _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _

60

50

I 40

I 30

1 20

1 10

1 0

- 1 0 ..................

-0.02025862 -1.953448 -3.884052 -5.810776 -7.729311 -9,642672

Page 167: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC19Ei- TWO STRIP UNWELDED CONTROL808 DIODE. 0.15 W. SMALL APERTURE

I - 1.3

-1.4

1 -1.5-1.6

-1.7I 1 .8

-2

-2.1

-2.21-2.3-2.4

-2.5I-2.6-2.71 -2.8-2.9

-3-I -O.0I89F5552 -1.438362 -2.871552 -4.314224 -5.760345

Page 168: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC19C-TWO STRIP 2X ICC UNWELDED CONTRO808 DIODE. 0. 15 W, SMALL APERT URE

-. 7

£ -1.8

-2

-2.2

-2.3

-2.4

-2.5

* -2.6

-2.7

* -2.8

-2.9

-33

-3.2

3-0.009051723 -0.7155173 -1.426293 -2.141811 -2.860345 -3.581897

Page 169: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IDEC19D-2X ICG SET=50, CMX 2808 DIODE. 0.15 W. SMALL APERTUREI 8

7.5

1 7I 6.5

6

I 5.5

I 54.5

I 43.5

I 3

1-0.009051723 -1.193535 -2.388362 -3.590087

Page 170: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DEC19D-2X ICG SET=50, TC MAX=208- 808 DIODE, 0.15 W. SMALL APERTURE

7.5

6.5

4.5

I 43.5

1 3

1-0.009051723 -1.193535 -2.388362 -3.590087

VAL

Page 171: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC19E-2X ICC SET:=100, TIC MAX=20

808 DIODE, 0. 15 W. SMALL APERTURE

6.5

6

5

I4.5I 3.5

* 3

2.5 . .......... .. ......... .. . .

-0.009051723 -1.193535 -2.388362 -3.590087 -4.794828

Page 172: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

3 DEC 19F-ONE STRIP UNWELDED CONTROL2.1 Hm:YAG, 5.0 W, LARGE APERTURE

80

I 70

60

* 20

3K 10

0 - ---- - - - - - 1- - - - T3.-0.009482758 -3.602586 -7.219827 -10,81509 -14.38578

Page 173: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

N DEC19G-TWO STRIP UNWELDED CONTROL2.1 Him:YiAG, 5.0 W, LARGE APERTURE

3.4 - _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _

3.2

3

M.!. 2.8

2.63 2.4

2.2

Nfl 218

1.6

1.431.20.8*0.60.4 -.....-0.009051723 -0.9461206 -1.890517 -2.843104 -3.803448

t

Page 174: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DEC19H-NO CHROMO CONTROLLED AT 50, 10 s2.1 Hm:YAC, 5.0 W, LARGE APERTURE3$' ~~~~~~28- _ _ _ _ _ _ _ _ _ _

26

24122* 20

* fl~1816

Ii 1412

10 10

83. 64

* 2

-2 -. . .**.1-0.00905 172.3 -2.365086 -4.769397 -7.192242 -9.61638 -12.02457

Page 175: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC191-NO CHROtAO CONTROLLED AT 60, 10s2.1 Hm:YAG. 5.0 W. LARGE APERTURE3. 17-

16

* 14

13

12

I -0.009482758 -1.190517 -2.384052 -3.590087 -4.805604

jI

Page 176: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DEC19J-NO CHROMO CONTROLLED AT 70, 10 s

2.1 Hm:YAG. 5.0 W. LARGE APERTURE

21-

20 -

I 19

18

17

i 0,14

16

I:~. 15

14

13

12

-0,009051723 -1.901724 -3.826724 -5.772414 -7.718965

III

IIII)

'Iir,

Page 177: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

1 DEC 19K- NO CHROMO CONTROLLED AT 802.1 Hm:YAG. 5.0 W. LARGE APERTURE

* 50-

35

30

U 25

20

1 15

10

-0.009051723 -2.3875 -4.811207 -7.251724 -9.688362

I

Page 178: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DEC19L-NO CHROMO CONTROLID AT 100, 10s~ 2 1 Hm-YA6, 5.0 W, LARGE APERTURE

I 50

45

40

35

* 30

25

20

* 15

I0... .......... ..... .....-0.009051723 -2.398276 -4 836638 -7.280173 -9.718534

Page 179: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DEC19M- NO CHROMO CONTROLLED AT 50, 10s

I ~ -2 1 Hm:YAG. 5.0 W, LARGE APERTURE

I 12

10

I 7

I 6

5I -0 009482 758 -2 387069 -4.8 10345 -7.253449 -9.691379

Page 180: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DEC19N- INDIA INK UNWELDED CONTROL

I - 2.1 Hm:YAG. 5-0 W, LARGE APERTURE

1 14

13

If 12

I 11

I 10

I 9

.. .. . .. .I-0.00905 1723 -0.9 534 --1.904311 -2.863362 -3.829741

Page 181: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

ID[C190-INDIA INK CONTROLLE D AT 50, 1lOs

19- 2.1 Vim:YAG, 5.0 W, LARGE APERTURE

46 . 17

16

15

j 14

13

12

1 1110

1 9

-0-009051723 -1.428448 -2.865086 -4.318535 -5.780604

Page 182: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DEC 19P 1-INDIA INK CONTROLLED AT 50, 'Os

2.1 Hm:YAG. 5.0 W, LARGE APERTUREI 13 -

12

10

j$ 9

I 8

1 7

1 6

-0.00905 1723 -1.196121 -2.396121 -3.608621 -4.830604 -6.056035

Page 183: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC19Q-INDIA INK CONTROLLED AT 60, l0s

I 11 -2.1 Hm:YAG, 5.0 W, LARGE APERTURE

10

I98

7

j 6

5

I43

I 2

1 10-

I .- 0.009482758 -2.407328 -4.848276 -7.303018

Page 184: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC19R- INDIA INK CONTROLLED AT 70, 10s

I 2. 1 HmYAG, 5.0 W, LARGE APERTURE

23

I2221

2019 19

18

171 1615

1 4j 1312

1 1

109

7

6

I5 .........-0.009051723 -1.446121 -2.901724 -4.371121 -5.848707

Il

Page 185: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

i DEC19S- INDIA INK CONTROLLED AT 80, !Os

2.1 Hm:YAG, 5.0 W, LARGE APERTURE25

24

23

22

21

20I1918

171' 1615

14

* 13

12

11

* 10

9

8

i 7

6

1 -0.009482758 -1.947414 -3.911638 -5.892242 -7.1I72845 -9.852156

i

Ui

UU1

II

Page 186: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DEC19T-INDIA INK CONTROLLED AT 100, 10s

2.1 HmiYAG. 5.0 W, LARGE APERTURE* ~~~~13 - _ _ _ _ _ _ _ _ _

12

10

* 7

* 6

-0.009482758 -1.942672 -3.905604 -5.885776 -7.868104

Page 187: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC19U-2X iCG UNWELDED CONTROL2.1 Hm:YAG. 5.0 W. LARGE APERTURE

12

9

8

I 7

* 6

5

* 4

3-0.009051723 -0.975 -1.949569 -2.930173 -3.91681

Page 188: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

U

I DEC19V- 2X ICG CONTROLLED AT 50, 1OsI17 2.1 Hm:YAG, 5.0 W. LARGE APERTURE

16

* 15

14

* 13

12

1 1

10I8

* 7

* 6

5

4 ........... ...... ..... .......

-0.009482758 -0.9775861 -1.953017 -2.934483 -3.922845 -4.915948

IIIUIIIUI

Page 189: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

U DEC19W-2X ICO CONTROLLED AT 60, 10s

8- 2.1 Hm:YAG. 5.0 W, LARGE APERTURE

6

* 4

2

10--2

3 -4

-6

* -8

-10

-121 -144

1-0.014655 17 -2.463793 -4.951293 -7.450862

Page 190: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

DEC19X-2X ICG CONTROLLED AT 70. 1Os

-2.1 Hrm:YAG. 5.0 W, LARGE APERTURE

| -31

-3.23

-3.

-34

4-3.

-3.5

U -3.7

-3.8

1 -3.9-4

-4.2

-4,3-4 4

-4 5

-4,7

I -48

-49 - 63.962069 _5.96681

I 01465517 -1.976293

III,

IUII

Page 191: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

U DEC 19Y- 2X ICC CONTROLLED AT 80, 10sU - 2.1 Hm YAG, 5.0 W. LARGE APERTURE

* -4

1 -5

-7

-8

1-0.009482 758 -1 47931 -2.965086 -4.464225 -5.971552

Page 192: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

1 DEC19Z-2X ICC CONTROLLED AT 100, lOs2 1 HmTYAG, 5.0 W. LARGE APERTURE

~~~~44. _ _ _ _ _ _ _ _ _ _

42 -

5 40 -

38

U 3°34 '12P

12624

22

20.- ..

-0.009482758 -2.49181 -5.000862 -7.510345 -10.025 -12.52543

IIIIIII3I

Page 193: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC19AA-BLOOD UNWELDED CONTROL2.1 Hm:YAC, 5.0 W. LARGE APERTURE

* ~~~~~51.1~ _ _ _ _ _ _ _ _ _

51

I 50 9

50.8

1 50.7

350.650.5

*50.4

*50.3

50.2

150.150 -5-0.02025862 -1,249138 -2.485345 -3.731897 -4.987069

Page 194: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

U

I DEC19AB-BLOOD CONTROLLED AT 50, 1Os

2.1 Hm:YAG, 5.0 W. LARGE APERTURE339 -

33.8 -

3? 7

33.6 -

33.5 -

33.4 -

1 33.3 -

33.2 -

5 331 -

33

32.9 -

32.8 -

332.73 2 .6 .... ..... . ......

-0.009482758 -1.237069 -2475862 -3.724138

IIII

I

III

Page 195: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DEC21A-ONE STRIP UNWELDED CONTROL2.1 Hm:YAG. 4.8 W. LAiRGE APERTURE

* 90-

80

* 70

* 60

1 50

40

30

*20

* 10

101-0.02025862 -3.728879 -7.453017 -11. 15474 -14.83276

Page 196: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

DEC21A1l-NO CHROMO CONTROLLED AT 70,10s2.1 Hm:YAG. 1.5 W, LARGE APERTURE

18

17

15

14

13

I 1213-0 01939655 -1.47069 -2.931897 -- 4,405173

Page 197: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

*I DEC21AB-NO CHROMO CONTROLLED AT 80, 10s

2.1 Hm:YAG, 1.5 W. LARGE APERTURE* ~~~~17 - _ _ _ _ _ _ _ _ __ _

168

15

13

I 11

1 10

9

3 8

-0.009913793 -1.951293 -3.913793 -5.8875 -7.863363

IIIIIUIII

Page 198: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

i DEC21AC-NO CHROMO CONTROLLED AT 100,10s2.1 Hm:YAG. 1.5 W. LARGE APERTURE

19-

18

* 17

* 16

15

14

13

* 12

* 11

10

8 .

-0.009913793 -2.438362 -4.9 -7.371983 -9.841379

,IIIIIIUII

Page 199: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC21AD-INDiA INIK UNWELDED CONTROL2.1 Hm:YAG, 1.5 W, LARGE APERTURE3 ~~~~~~16-_ _ _ _ _ _ _ _ __

* 14

I 12

*1

10

I 98

I 76

5

4 .. . .. .. . . . .I-0.009913793 -1.468535 -2.941379 -4.425

Page 200: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC21AE-INDIA INK CONTROLLED AT 50,10s2.1 Hm:YAG, 1 5 W, LARGE APERTURE

* ~~~~~16- _ _ _ _ _ _ _ _ _ _

* 15

14

13

I 12

I 1

* 10

* 9

-0.0099 13793 -0.9780172 -1.953448 -2.94181 -3.928018 -4.918103

Page 201: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC21AF-INDIA INK CONTROLLED AT 60. 10s2.1 Hr,2'YAG. 1.5 W, LARGE AP7E -:UPE

* ~~~~~15- _ _ _ _ _ _ _ _ __

* 14

*13

I12

10

-0.009913793 -0.9775861 -1.951293 -2.931035

Page 202: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC21AG-INDIA INK CONTROLLED AT 70, 1os

i 2 1 Hm YAG, 1 5 W, LARGE APERILIRE

* 16

* 15

* 14

* 13

* 12

*~ ii

10 fI-0.0099 13793 -1.456466 -2.917241 -4.389655 -5.867673

II

I

IIUIII

Page 203: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

I DEC21AH-INDIA INK CONTROLLED AT 80, los

2 1 Hm YAG. 1 5 V LARGE APERTURE

I 19

I 13

I11I

I 10

9 .. .. ...-0009913793 -1 214224 -2 428017 -3 651293 -4 880604

II

I

IIIIII

Page 204: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC21E-TWO STRIP UNWELDED CONTP'_L

24 2 1 Hm YAG, 4 8 W, LARGE APERTURE

23 -

21

20

19

II17

* 16

15

14

13

12

10

93 87

6 . . . . . .. . . . . . . . . . . . . . . . . .

-0 009913793 -1.234052 -2.467672 -3 709483

IIII

IIi

Page 205: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC21C-TWO STRIP 2Y ICG UNWELDED (CONTRO2 1 Hm:YAG. 4.8 W. LARGE APERTURE

* ~~~~~~~24 __ _ _ _ _ _ _ _ _ _ _ _ _ _ _

22

*20

18

16I 1412

* 10

8

* 6

4

* 2

* -2

-4

1-0.009913793 -1.236207 -2.47069 -3.713362

Page 206: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

U D[C21D-2X ICC CONTROLLED AT 50, 10s

18 2.1 Hm:YAG, 4.8 W. LARr~E APERTURE

16

* 1 4

12

* 10

8

6

* 4

2

I0-2

I -4-6

* -8

-10

I-0.01077586 -2.478017 -4.975431 -7.477587 -9.971552

Page 207: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC21AI-INDIA INK CONTROLLED AT 100,10s2.1 Hm:YAG, 1 5 W. LARGE APERTURE

17

*15

14

*13

11211

-0.009913793 -1.216379 -2.432328 -3.656035 -4.887069

Page 208: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC21E-2X ICG CONTROLLED AT 60, 10s2.1 Hrn:YAG, 4.8 W, LARGE APERTURE

10.5

10

1 9.5

* 9

1 8.5

* 8

3-0.009482758 -1.2375 -2.475862 -3.721983 -4.974569

Page 209: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC21F-2X ICC CONTROLLED AT 70, 10s2.1 Hm:YAG, 4.8 W, LARGE APERTURE

165 -

14

13I12* 10

9

8

7

65

* 43

2

* 1

-1

-3

-0.009913793 -2.480173 -4.981035 -7.488363

Page 210: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

I DEC21G-2X ICG CONTROLLED AT 80, lOs

2.1 Hm:YAG. 4.8 W, LARGE APERTURE28 -

26 -

24 -

22 -

* 20 -

18 -

* 16 -

14 -

* 12 -

10

* 8

6

4

2

0 -

-0.009913793 -1.489655 -2.981035 -4.481897 -5.985776 -7.489225

III1IIIII

Page 211: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC21H-2X ICC CONTROLLED AT 100, los

110 -2.1 Hm:YAG, 4.8 W. LARGE APERTURE

100

190*80

70

60

1 50

* 40

30

* 20

10 JI-0 009482758 -3.725862 -7.471552 -11.17759 -14.86595 -18.54095

Page 212: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

I DEC21H-BLOOD UNWELDED CONTROL2.1 Hm:'YAG, 4.8 W. LARGE APERTURE

,717 -

15 -

14

I

13

* 12

* 10

9

I7

I65

4 .. . . . . .. . . . .

I

II

Page 213: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC21J-BLODOD CONTROLLED AT 50, 10s2.1 Hm:YAG, 4.8 W, LARGE APERTUREI1

15

* 14

13

* 12

I 98

I 76

* 5

-0.01422414 -1.505603 -3.005603 -4.516811 -6.032328

Page 214: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC2H<-BLOOD CONTROLLED AT 60, 10s2.1 Hm:YAG, 4.8 W. LARGE APERTURE

141 1312

11

1 10

9

8

7

* 5

4

3

* 2

0-I -1-2U-

-0.009913793 -1.750431 -3.5 -5 263362

Page 215: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC21 L- BLOOD CONTROLLED AT 70, 1 Os2.1 Hm:YAC, 4.8 W. LARGE APERTURE

* 1~~~~~~8 _ _ _ _ _ _ _ _ _ _ _ _ _ _

17

* 15

14

13I 12

* 10

9

8

* 7

6

5

43

* 2

-0.0099 13793 -1.496983 -2.995259 -4.505604

Page 216: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC21M- BLOOD CONTROLLED AT 80, 10s2 1 lirn:yAG 4.8 W. LARGE APERTURE

* 60

3 50

*40

*30

20

I010

I-0.009482 758 -1.498707 -3000862 -4.512931 -6,028448

Page 217: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC21N-BLOOD CONTROLLED AT 100, 10s2,1 Hm-YAG, 4,8 W. LARGE APERTURE

* ~~~~60 - _ _ _ _ _ _ _ _ _

* 50

I40U30

20

I 101

0 ... .......1' I ...' ... ..I-0 0099 13793 -1247414 -2,494397 -3.75 -5 013362

Page 218: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IDEC2 101 -BLOOD CONTROLLED A F 50, 1lOs2.1 Hm-YAG, 1.5 W. LARGE APERTURE

* ~~~~23 - _ _ _ _ _ _ _ _ _

22

21

20

I19I 18

* 17

* 16

--0.02025862 -2.487931 -4.982759 -7.487069 -9 983189

Page 219: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC21P-BLOOD CONTROLLED AT 60, 10s

21 2.1 Hm:YAC. 1.5 W. LARGE APERTURE

20 19 118

* 17

16

* 15

1 4

* 13

12

* 98

7 .. ..

-0.009482758 -0.988362 -1.972845 -2.962931 -3.95819

Page 220: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC210-BLOOD CONTROLLED AT 70, 10s2.1 Hrn:YAC. 1.5 W. LARGE APERTURE

* ~~~20 - _ _ _ _ _ _ _ _ _

19

U 18

17

* 16

15

*14

13

I12

* 8

7 .. . . . . . .I-0.009913793 -0.9879311 -1.972414 -2.961638

Page 221: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC21R-BLOOD CONTROLLED AT 80, 10s2.1 Hm:YAG, 1.5 W, LARGE APERTURE1 20 -

19

18

1 17

1 16

15

14

*12

5-0.009482758 -1.96681 1 -3.944828 -5.934052 -7.922414 -9.904741

Page 222: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC21T-2X ICG CONTROLL[D AT 50, 10s

2.1 Hm:YAG, 1.5 W, LARGE APERTURE3 20 -

19

3 18

1 17

16

15

1 14

* 13

12

10 ...-..I 0.0094-8275-8 " .. 462069 -2.927155 -4.405604 -5.888362 -7.371121

Page 223: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC21S-BLOOD CONTROLLED AT 100, 10s

27I 2.1 Hm:yAG. 1.5 W, LARGE APERTURE

26

25

24

23

22

*21

20

19

18

17

16

15

14

* 13

12

1 15 109

1-0.009913793 -1.467673 -2.938362 -4.421121 -5.910776

Page 224: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

I DEC21U-2X ICC CONTROLLED AT 60, lOs

2.1 Hm:YAG. 1.5 W, LARGE APERTUREI 2

21 -

20 -

* 19

18

* 17

16

15 -

14

13 -

* 12 -

11 -

10

I 98 -

* 7

6 -

I1... . .... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

-0.009482758 -1.951293 -3.914224 -5.890086 -7.868104

IIIIIIIII

Page 225: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

I DEC21V-2X ICC CONTROLLED AT 70, lOs

* 23 - 2.1 Hm:YAG. 1.5 W, LARGE APERTURE

22

32120

* 19

* 17

16

* 15

14

13

i 12

11 -

3 -0.008620689 -1.218535 -2.4375 -3.665086 -4.899569 -6.136207

IIIIIIII

Page 226: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

U DEC21W-2X ICC CONTROLLED AT 80, 10s2.1 Hm:YAG. 1.5 W, LARGE APERTURE1 20 -

19

*18

17

U 6 -v 'V11514

*3 13

12

1 1 -

10

* 9

8 -

-0.009051723 -2.435776 -4.89569 -7.365518

Page 227: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC21X-2X ICC CONTROLLED AT 100, 10s2.1 H:A,1.5 W. LARGE APERTURE

21 -

20 rfA

*19

18

* 17

-16

* 15

14

* 13

1 12

11

* 10

9

8 .-.......I-0.008620689 -1.943103 -3.899569 -5.871121 -7.843535

Page 228: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I DEC21Y-NO CHROMO CONTROLLED AT 50, 10s2.1 Hm:YAG, 1.5 W, LARGE APERTUREI ~ ~~~~~15.5 __ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _

15

314,5*14

313.513

12.5

*12

*11.5

-0.009051723 -1.211638 -2.423707 -3.645259

Page 229: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IU Appendix B- Excluded Data

UIIIIIUIIIIIIUIII

Page 230: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

.............

. . .... . ... .. . . . ... . .....

.. ..... .... ... .. .. ..... .. ...... ..I

K Lo

co Irm a c

Page 231: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

.. ..... . . ........

............ .... . .. .... * ........ .. .. .....

.. .. .... .. .. .. .. .. .. .. .. .. ..ILO

InI

-Ise

. ..... . -.. .

..... .... .... ... U........... ) ....... ..................

........... ..... .......... ...........wL

CQ 0OD kDI

Page 232: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

* ... ....... .. . . . . . . . . . . . . . . . . . .. . .. . . . . .

.. .. .. .. .. .. .. ..* .. .. * .. .. .. .. .. .. .. .. U... .... .... .. ... .. ... ..

ODI... ... .. ... ... ... ... ... .:... ... A

ODI

.. . . . . .. . ... . . .. . . ... ... .. . . ... . . . . . .. .. .

I j i I. ......... . . .. ..... . .....

....., . .. ..... .... . .... .. ... .. . ...

OD OIODI

0~~ in) I IcmI-L

Page 233: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

* . .. . .. .. .. . . ... .. . ... . . .. .. .. .. . .. .. .

. ...... ....... ...... . . . ........ I

.. . . .. . . .. . . .. . . .. .. .. .. .. . . . . . . . . ... ....... I

.. . . .. .. . .. . ... . . .. . .. . .. . . . . . .. . . . . . .. .. . ID

. . . .. . . . .. . .. . . . . . .. . . . . . . . .. . . . . .. . . .

.. . . . . . . I I

* a

Page 234: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

............ ....... .............. . .. ..

.. .. .. .. .. .. .. .. ... ... .. .. .. .. .. ... .. .. .. .. .. .. .. .

koW

... .. .. .. .. ... .... .. ... .. .. .. .. .. .. . .. ..

.. .. .. .. .. .. .. .. .. .. .. .. ... .. .. . .... .. .. .. .. ..d

... .. .. .. .... .. .. .. .. ...... ... .. .. ... ..

... .. ... ... ... ..... .. I

... .. .. .. .. .. ... .. .. .. . .. ... .. .. .. ... ..

... .. .. ... ... .. ... ... .. .. .. .. .. ... .. .. ..

ODI

OD 4D D OD OQ dD D ODI

CV) CI'-I'-wI

Page 235: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

* ... . . . . . . .. . . . ... . . .. . . . . ... ....... . 0

... * .. .. ... ... . .. . . . ..... .I

... . -..... . .. . . .. . . . ... . ... .. . .. . .. .. .I. d

. . .. . .. . . ... .. .. .. .. .. .. .. .. U..... .... ....

Page 236: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

..... . . . . .. . . .. . . .

.. . . .. .. . .. . ... .. . .. . .. . . . ... . . . . . . . .

.. . . .. .. . .. . . .... ... . .. . . .

.................. _ .. . . .. .. . OD

K .............I . ....... .. ... .. .. .

,,v

Page 237: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IOI.. .. . .. . ._ ....... -

. . ....... .. ..... ...... .. ... .... .......

. . . . . .

..........

.............

.........

coI

ODUON ccI

Page 238: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IS)..... ... Im

wIOI

. . ..... I..toI

.. ............. ...... .....I.... .. .....

OD 00 Ico rI

Page 239: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

* . .. . . . .. . . . . ... . . .. * . . . . ... . . . . ... .I

.. .. .. .. ... .. .. .. .. ... .. O

... .. .. ... .. .. ... .. .. .. ... .... ... .... ..

. ......

_ r?

Page 240: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

.. . . . . . . .. ..*. . .. . . . .. . . . . . .. .. . . .. . . J S

- . .. . .. .. .. . . . . . . . . . .I . .. I .. . . .. . . . . . .

4

ID (DC C

qC c CC

Page 241: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

... . . . ..

................ .. . .........

4

. ... . . . . . . . .. . . ... . . . . . .

... .. . ... .. . . .

OD 0ID - D -D OD

I .OD

co I i I I I

ODN

Page 242: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

.. .. .. . ... .. ..

... .. . . . ... ..

_IS)

.. .I.. ..... ..

m. m

I! W

Page 243: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

. . .. . .. .. . .. . .. . . . . ..

* .. .co

.. . . .. . . .. .. ... . . . . .. . . .

.. ........ ..... .. ........ . .. ..... ..

... ... ......... ... . .

.. .. ... ..... .. ........ .. ....I

. . . .. ....

.. . . . . . . .. . . --- - - - . . . . . . . .

............. .....

Page 244: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

I

°I

-* U

. .. ...... . ..... .

.. . ...... .. ... :. ... .. . ....... ...

. ................ ....... ....... .... .. .. .. . .. .. .

... .I.. ... ... ..

II

I 0

oI

-- 7 1 I0 "

Page 245: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

. .. .. . . ... . ... ... .. ....

. . . . . . .. .. .. . .. .. . ... . . . . . . . . .. ..

I. .. ... .. . . . . . . . . .. . . . . . ... . . .. . ... ..

.. .. .. . .. . . .. . .. ..,

.. . ... .. .. ... ..

* ..............

aDI

* . . I I

fi__ __ __l

Page 246: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

.. . . . . . . . .. .. . .. .

... ... .. ....... ....... .

-- -- -- --- -- -- -

~~-(& I __ ___ ~-____

Page 247: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

........................................... ..

.. .. .. .. ..... .. ... .. .. .. ..... .. ... .. .. .. ... ... .VtA- I

................ ..

.... ... .... ... ... ... .. ....

.... ... ... .... ... ... I

... .. .... ... ... .. . .... .... .. .. .. .OLrI

1: jr*. .~fj:.... ... ... ...

* ID... ... ... ... .. ... ... ... ........ ...

CVI... .. .. .. .. .. .. .. ..... .. .. . .. .. .. .. .. .. .I

.. .. .. . ... .. ... .. .. ...... ..3s

coU14dDd

ID ODCD O

Page 248: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

.. .. .. .. .. .. ... .. .. .. .. .... ... .. .. .. .. ... .

INI

.... .. .. . . ........ 1

or . ........ AD

Ln UlU

Page 249: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

II

I

* .... . ....... I

.......... ......... ... . ...... . .. .. .. ..... .. ..- _.. ..... .. .... .

•............ d

...

........ ...

.. . .. .. ... * " . .. - -- . ......

co

Io I I I n I I I

Page 250: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

....... ......... ..... ..............I... .. .. .. .. .. ... .. .. ... .. ... .. .. .. .I

.... .... .... ... ... .... .... .. I

... .... ....... ............ ........V)U

.... ...... .. ... .... ... .. ... .. U

... ... ... ... ... .. ... ... ..

CM

4DUwI

Page 251: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

.... .... .... ... .... ... .. I

................. .................I

.. .. .... .. ... .. .. .. .... ... .. .. .... .. ... .. .. .I.

... .... ... .. .. ... .. .. .... .. .. ... ... .U

.. .. . . . . .. . . . . . . % I.. . .. . .. .....

.. .. .. .. . ... ... ... .. .. . . . .. . . . .. I.. . . . .

......................

....... ...... ...... .... INrU

OD OD

*~O OD - . .cla.

ODI

Page 252: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

II

.. .. . .. . ........................ ................ ............... ........

. . .. . . . .......................... ........................... ...... . i

-.... . ....... •....... •........ ....... a....... ........ .... . ....... ...... .

* *-* l

I-I

.. . . . .. . . . .. . ... .. . . . . . . .. . . ...... C.

I

.. . .. ... . .. . . .. . .

.... .... .... .... .............. ... .................. ... .. . . . . . U U

c cI

C C C CI-% a N I U

I

Page 253: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

II

I

*. .. . . . . . . ... . . .. . ... . . . .. . . .. . ... .. G oI

. . ... . . ... . . .. .. . .. . . -. . . . . . . . . . . .. .. .

.. . . . . . . .. . . . . . . .. . . . ... . . .. . ... ......... C

~I

* ................ . .................. ......... ........................

*. .. . .. . .. . ... . . . . . .. . . .. . ... ....... I

OD

................ . . .................. .... ... ...... ...... . ...... ..

~I

IS . . ....... . . ......

S I i i i I

I I I

Ir --

Page 254: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

* *.. ..... ......

* .. ... .. . . . . . ... . . . . . . .

. . . . . .. . . . . . . ... . . . . . . . . .... ... .. ... .

IDI

ID ODOD I I I I

w

Page 255: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

.... . . . . . .. . . . . ... . . . . .... I

- . .. . .. .. . . . . . . . .. . . . ... ...

.................... ...............

dD ODOD O*~ a . i

9-Y V

Page 256: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

* . ... ..... .. .. . . . . .. ..

*.

..... .....

* . .. . *. . .. ...

if) InLr) 1IIn NrCl) I

Page 257: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

.... ........ ... ... .... --- ---.. .. .... .. .. .. .. .. .. .. .... .. .. .. .. .. .... .. .. .. .. .

CVI.. . . . . . . .. . ... .. . .. . . .. . ... . .. ... . .

.. . . .. .. . . . . . ............

.. .. .. .. .. ... .. .. .. ... .. .. .. .. .. .. .. ..

... .. ... .. ... .. .. .. ... .. ... .. ... . ... .. I

... ... .. ... .. ... ..... ..... .. .. ...... ..

. . . . . . . . . . ........ .....

CP r-LO cI

Page 258: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

* ... . . . . . .. . . . ... . ... . .. . ... . C C

..... ..... ... . ....

I U.... .... ... .... .... ... ... .... .A

. . . . ... ...

OhDI..... ... ..... .... .. WA

WO II) II

Page 259: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

*. ........... ......... ... ..........

.. . .. . . . . . . . . . . . .. . .. . . ... . . . . . . .. . . . . . . .

* ... . . . . . . . . . . . . . . . . . . ... . .. . ... .. *I.. . . . . .I

.. . .~ . .

* . .. . .. . .. . ... .. . . . . . .. . . . . . . . .

.. .. .. .. .. .. .. ... .. ..... .. .. .. .... .. .. .. I

.... ... .... ... .... ... .... ...

co__ 0 10

9--L-l-YliI

Page 260: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IMM MM MMMMtIMPIPIIiMPlfrIN~l l pIrlr File Input/Uu tput I' /ri'i'u'iijjpjp/i,,'n,,,; 'un a I ", ii,, ii, ii,

I -File Name: <B:AUG28V.USR> Quit/Continue: *

8 Comments Subfiles (otal #: 7

:1> FERRONYL, 100 DEGREES CONTROLLED Start# Shape #Repts2> SOME BLANCHING 2x 256 73> ONE OF THE BEST WELDS TODAY

0 3 II I I i I I i i I i

.. .. . ... ... .. .. ..... .... ...... ....

... .......... ... ..... "... .I - . $

... .... ... .. . ... ... ... ....... ......... .............. .

'_.. _, .. - I

-I ......i ....... ..." " ..... .. .......................... . .-...... .

0

... - mr " ....:... .. .. ..". " .............. ....... ......

0

II 10I

IC f

I ...

Page 261: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

1MM~~rI1'iri~rippirutru~File InpLut / Uu t put PNIrN~1NW7r~('rrfl'rrlulllrrr

-File Name: <B:AUG28W.USR> Quit/Continue:*

8 Comments Subf iles (Total #: 9

> FERRONYL, 50 DEGREES CONTROLLED Start# Shape #Repts)> NO VISUAL CHANGES 2. x 256 9> NOT A VERY GOOD WELD> BURLEIGH STAGE DID NOT MOVE AT THE BEGINN~:

~Y1u

coo ........ ... ...... . .... ...

.1P

................ ...... ...... .............

_ _7 .. I . . . . . . . .% . . . .. . . . . . . . . . .

. .. . . 77 3 0 W . . . . . . . . .

Page 262: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

F ie In put /Output tr1PPP1PN7Pfi11,7M:PI7PllnFil e Name: <B:A~UG28X.USR> Quit/Continue:*

B Comments Subf iles (Total #: 6

1> FERRONYL-60 DEGREES CONTROLLED Star-t# Shape #Repts2> NO VISUA~L CHANGES 1 2x 256 63> ONE OF THE BETTER WELDS

- ___ __-- .--- - -M

kD~ co

_ _ _.. . .. . . . . ... ..

.. ....0. .... .. ... ...CD

__.. ... 7 7. . ... . . .

u1... .....0. .. ..7 ... ....

I... .....

Page 263: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

L ~MM~MPt7NN,'1NIM~tltlFile InpUt/OutPUt lI'r'lrirrrlIIui"''i ii ii i

r~ile Name: eB:AUG2E3Y.USR> Quit/Continue:

3 Comments Subf iles (Total #: 4

1> INDIA INK, TEMP CONTROLLED AT 60 Star-t# Shape #ReptsI2> SLIGHT DESSICATION 2 2"56 43> GOOD WELD

4> LOOKS BETTER THAN FERRONYL

._ . .. ..I .. .. ...

.........

. . . . . . . . . .. ..-.

Page 264: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IM ~''Q1~?. MIMPMPPIPIMMM(MMFile I nP Lt /OutQ~ut

File Name: <B:AUG28AB.USR> Quit/Continue:*

8 Comments Subf iles (Total #: 7

t>INDIA INK, 60 DEGREES, LARGE APERTURE, SL: Start# Shape #ReptsP2> WELDED. ONE OF THE BETTER WELDS 12x256 7

3>

(S ........ .. ...

.. .. ... ..... .. ... . ...

... .. ... ..

.. .......... .....................

I Io

.. ........I. ..... ... ...........

......... ....................IC

.. .........IV

........I. ...................

M ...........Ip C

Page 265: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

File Input /Out put

File Name: <B:AUG28AA.USR> Qulit/Continue:

1> LA~RGE APERTURE, INDIA INK, 5ob np-REEcS Shape #Repts2> WELDED 2 2x256 5

wIla

. .. .. .. .. .. .. .. .. .. .. .. . .. ......

.. .. ... .. .. ... .. .... ...

13

Page 266: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IP1MPMMM fliiii fM*PI~fPIJI1tIM File Input /Out pu t 17I~11P(WIMf(i ~irir.t

E.-File Name: <B:AtJG28Q.USR> Quit/Continue:

I B Comments Subfiles (Total #: 7)jj~jjjjjj I'7NitiilNP1mf'1 'VlitMM~pWlll1PIfrIrW1M~tM'9

1> FERRONYL, TEMP SET = 0 DEGREES, TC MALX =:Start# Shape #Repts2>TODEEP. 12 x 256 7

3NOT A GREAT" WELD

B - __

cINC3 M !.3

_ _ _ _ _ _ _ _ _ _... _ _. _ _......._ __.

.. ... ..... .... ..... .. ... .

w ii

........... ~ ~ ~ ~ ~ ~ . ...... ..........

I '* .......... .

IW ........... 7 ........

.. ..... .. . .. .. . .. ....CIC........... ..... . . ....

Page 267: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

ltlMMlirlN~lrrl~~uIM'llrP~lMFile Input/UUtPL Li~~t/iUt.:Pl'''aaai a,

File Name: <8:AUG26R.ISF> Quit/Continue:*

6 Comments Subfiles (Total #: 7~9

1.> REPEAT FERRONYL-TEMP 80 Start# Shape #ReotS2> BETTER TC PLACEMENT 2 2x 2563> SOME BLANCHING4> WELDED

00

...... .... ...... .... ...... IA

_ -

C2J

................... ..........

Q _________________

Page 268: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

(Al

011

.. ......

CI M

i l Inu / Lt~

I File Name: <8:AUG2E3S.USR2 OlJJt/Continue:*

* 8 Comments Subf iles (Total #:

FERRONYL TEMPERATURE AT 100 DEGREES Start# Shape #R8epts

2SOME BLANCHING AND DESSICATION 2 2x256~

: 3> WELD WAS NOT VERY STRONG -

Page 269: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

1 ~ F le lnPL t /ULI t put N1110111'/fr'Nrruiu vvIll , l/ i / ./W/I iid l UJ

lr--'ile Name: <B:AUG28T.USR, Quit/Continue:*

I 8 Comments SUbf iles (Total #: 5

1> FERRONYL, 70 DEGREES, TC MAX=55. TC TOO D: Start# Shape #Repts2WE HAVE A WELL) 2 x256 5

I: 2>

.... ...... ......

Ic. ..... ... .. . . ..... .. . .... ....

.. ........ ...... . ..............I Ip

I . .. ... ...... ..:. ...

.. .........I. .....07I... ...

UM.. ........ ...I. ...I. ........ .......

IL.. .. .. .. .... .

7 7...

.. ........ ....I. .... .. ......... .......

I ...................coI

.. ..............I. .. ................

Page 270: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

File Iflput/ULtPUL ..u'n~, ..u .. ..

'Vile Name: <B:gAUG28U.-JSR> Quit/Continue:

1> FERRONYL, TEMP SET Ar\D COINUL-LED A-f' 8u 0:; 'tart# Shape #Repts2> GES 2 253LOOKED STRON\GER THAN THE 70 DEGREE AND S-14> WELDS FROM THIS MORNING.

I - - - - _

Ax.-< b

.....I. ... . .. . .. ... . .. .... .... .. .. . .

........____. ..__

Ic

**el

CD,

* -

Page 271: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

tMPIM P~tI1NNWMNWIFile Input/Out put

File Name: (8:AUG28K.USR> Quit/Continue:*

E38 Comments Subfiles (Total #:7

1> INDIA INK, 70 DEGREES (NOT REACHED) SOME Star-t# Shape #Repts:I WELDED, BROKE APART AT SEROS(AL SURFACE. 1 2 x 256 7

3> WELD SEEMED TO EXiEND THROUGHOUT TISSUE

Im 1 3 Da3

....... ... . t.......1 .... .. .... . ...... ... .........

....... ........ .... ....... .. II

... ................

Page 272: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

MI MMM / I- lie inputleu t put I

V File Name: <B:AUG28L.USR> Quit/Continue: *

I : 8 Comments Subfiles (Total #: 6LtfMMMMMMMMMMMMMMMMMMMMMMNMf71PM1r7rNrrif'MpMMMIM K MMMMMMMMMMMMMMM MMMMMMf1

: 1> INDIA INK, TEMP = 80 DEGREES. TC MAX = 38: Start# Shape #Repts: 2> TISSUE BLANCHING AND SLIGHT SMOKEE 1 2 x 256 6:3> OK WELD

I .. --- 0 P0 0IO '0 Ca3 COf -0

I I I I I I I I I I I

.. .. .. .. .. .... . ... .. ... .. . ... . * . .... ...

I - -. . ...

I....... ............ .Ji . .... ...... ...... ........ .. ... .............. ........

II

II

C.1-- . .... .CD .

........ .

I

-I -.,. -. .I _ _ _ _ _ __ _ _ _ _

IJ

Page 273: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IMMMMMlltflltlrnfiitPMtplMtltMitp, File Input/U Lt put r::77'(Mtf1MP7wIrMrnr,1n,,

T File Name: <B:AUG28M.USR> Quit/Continue:*

6 Comments Subf iles (Total #*: 7I91> INDIA INK, TEMPERATURE SET AT 100 AND CON: Start# Shape #Repts2> LOOKED LIKE A GOOD WELD 1 2 x 256 7

I-' _ G

ri N (A)I M

.~~ .........

. . . . . . .. .. - .. . . . . . . . . . . . . . . . . . . . . . . . ... .. .

.......... .....

......... ..........

..................... .................... ............ .... .......

Page 274: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

PI F ile Input / UL toput riIfIll7 rrrIrrr/I 1*I'

3 File Name: (B3:AUG283N.USP> j/Cft"~*

B CmmetsSubf iles (Total 1* 7

TEMP 50 CONTROLLEHD MMMT 41 DE(3RE: Start# Shape #Repts

2'> SOME BLANCHING LOOKS LIKE A WELD 2' 5

----U tD

...... .......... ...

.. . ... ..

.. ............ ..... .... .... .... .....

............... .... ...... ...

.... ...I3

I -~....... . ....

.~~ . ... .. .

Page 275: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IMMMMMMMMMM1-If'NNP1,-1r MMr MMfIPMpPlM1,? F ii e I npu t/ UuI t JuLit N/IIM PPI'I,/pII/''I/'I''.u 1 .'..' ii a l a1 i, i,, ii .. ,

File Name: <QAUG2e0.USR> Quit/Continue: *

,Comments SUbf iles (Tctal1 #: 8

1> FERRONYL, TEMP CONTROLLED AT 60 DEGREES Start# Shape #Repts

2> BURLEIGH STAGE MAY NOT AHVE MOVED AT PIRS: 1 2 x 256 E

3> WELD DID NOT LOOK VERY STRONG4>

II N'-

- * ... ........... ...... 1

NIC-

I _

.I-

... ...........

-- MWA* .. .. . .. .. .

. . .. .._....

. ... .. . .. .. . . .

ItLin

Page 276: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I F-U Name: <R3:AUG2E3PUSR> Quit/Continue:*

8 Comments~ Subf iles (Total #: E3

1>) FERRONYL 70 DEGREES LITTLE DESSICgATION AN: Start#* Shape #Repts2) A WELD, STRONG3ER THAN 610 DEGRES, B~L- NUT 7 x 256 83

3 > FERRONYL BARELYVIBL

IM-

* - 4

.............. .......... .. ................ ... ..

rC

-U-

............ ......

Page 277: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

1,t'fMMMMMMM IPt'IfMMMMM f1PMMMMMMMMMMM'~1 F i ! e I n[ pt t / ULu t pu Lt i'lfirff'Ip7PlfiP/Plll~l'/I'l'lt/"II "/u "11 "/j1 "11/WI"1""/i "i Ull UIIt

[--Te Name: (B:AUG28E.USR> U uit/Continue: -

8 Comments Subfiles (Total #: 5

1> FERRONYL COMPOUND Start# Shape #Repts

2> 1 SECONDS L 2 x256 5

3> SMOKED4> WELDED OR STUCK TOGETHER

'Q rj A

. . .... ......... ... I............ . .... . ... . ... . . ............ ......

_ I-

.t . % . ......7 143l. . .. .. . . . . . .. . . . . .

............ I___ _ ...... ...... ... ...... ....

Page 278: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

U IMMMMMMM NM7MNPI'7MM PIPIM F il e Inptt/Out pu t L/L

[ le Name: <B-AUG28F.USR> Quit/Continue: *

E3 Comments Subfiles (Total #:4

1> LIGHT INDIA INK. DRIED TISSUE, CONTROLLED: Start# Shape #Repts

> NOT MUCH OF A WELDL 2 x 256 4

MI

.... ..... ..... ....... ....... ......... .. ... ........ ... ....... ........ .. .

I .. . .. .. .. . . . .... . ... ..." .... .. .. .. . .. . . .. . . . . . . ... . .. .. . ... . . . . . . . .. .. ..

II_

............I. .. ....

' 3 .~ .. . . . . . . .. . . . . . . .

.I........ I ..... ... . ..... ...... .. ......

.' ..... ... ...........

M-IIp c

Page 279: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

__ I MMMMMMMMMMMMMMMMMMMM File Input / U t put rrirlrrll1,WI(, 1(l.(lri.i/./'I/JI'f'idI/Ii.IIIIIIIoiIl "

"n:" File Name: <B:AUG28G.USR> Quit/Continue: *

: Comnts Subfiles (Total #: 6

> LIGHT INDIA INK, DRIED WITH 0 TIP, NEW 80: Start# Shape #Repts

I I I i I I Ii 1 1 I

_I _ __.---_ -

.... .... ...". .. ........ .........I 0 I.- -

.. ......... .........

I|

I ...................

........ . .. : ..... ........- ' .. ... ... ..... ...

I

.............. ..... ....... .......... ...... . ...... '

II

I I Iu I, , , ,

Page 280: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

It ,, MMMM MMMMMMM MMtMIM II F ile I rput/Out put rI'I rlP l MPIrlI'7rlfIPMrMMMM MMMMMMMM;

[File Name: <B:AUG28H.USR> Ouit/Continue"

8 Comments Subfiles (Total #: 5IMtNMMMN1irtI PY plMM7 ryryMrrMMMM rrrMMM tlMMMPMMMMMMMMMMM 9

1> NEW BOWEL WITH CLAMPS, LIGHT INDIA INK, D: Start# Shape #Repts

2> THERMOCOUPLE PLACEMENT NOT CORRECI-ALIUNE: 1 2 x 256 53> CLAMPS ARE INTERFERING WIIH EXPI. :

N N

.. ... ...... .. ........ ......; ........ ... ... .. .... ..... . .... ... .. .

-)4_|_.

................ .. .. ....... ........

-, . ....... ... ....... ... ..... ................. .............. . . .

J r _. , " ..... ..i .. .. .. : .... i... .# .... ....i.... ... ...... i...... .i ...

_!~C ....,.

Page 281: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I It It1 ii II It /I to It /I It I/ I/ I/It OVI II'II 1,1 i t'IIII II lJ 'l i'lol' t- .Ile-

11 )p_ L L, U LU LPJ.'_, L I'll'll I/ W10l'i'l 11 W11 I II 11 1/ l'it I/ ll 'll l 11wII II II ii 01/

[ ~ File Name: <B:AUG281.USR> Quit/Continue: *

8 Comments Subfiles (Total #: 8

1> TEMP AT 50 DEGREES, LIGHT INDIA INK, NO C: Start# Shape #Repts.2> WELDED 2x 256 8

.. .. ---.... "7w-

II I I i I

' ' . ............ ....... i " : ....... .. . . ........ ...... . ........ . .... ....... .I-

I. . ...I .... .

. - -S. .-

• 1 . .. . .. .. . .. . . . . .. . .. . .. ..." . .. . .. . .. .. . .. .. ..

! , '" " ...... .... .... ........... .. .

iu .. I

............k .-...........

...... ..... ...............I -

.............. ....... ..4. .. .

Page 282: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

e .1 IflPLI L / ULJ LQUL t lif ilJ'J /' I ,i/ II ' .' ' " ''

File Name: <B:CAUG28J.USR> QLuit/Continue:

B1 Comments Sbf iles (lotal #: 6

1i> INDIA INK. TEMP =60 DEGREES, SLIGHT DE5S: Start# Shape #Repts

2> LOOKS LIKE A WELD, TORE AT SEROSAL SLJRFCE: 12 x256 6

L~3LA

Ilk ...........

.. ... .......... .. ..... . . . .

.. .... ....... ........

. . . . ........... .......

Page 283: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

~NM~pypr~p,,.py,~,NFile I nQLI t /Out pUt

File Name: <B:AUG28B.USR,~ QUt/Continue:

8 Cments Sb f le (Ttl#5

> TWO STRIP CONTROL Start# Shape #Repts

2 2x25 6 5

............. . ..........

. . .. . .. . . . .. . . . . .. . . . . . .. . . . . . . . . . .

Page 284: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

MMMMMMMM1P M MMMMr MMf 1 P~nirIM I- ile I lnpL t/ Uu tPLI t 1 nuI' PI1*l' 'tl , I /l u ii i, idi g 0 ,

Fe Name: cB:AUG28C.USR.*. Quit/Continue:-

8 Comments Subfiles (Total #: 4

ILASER CONTROL Start# Shape #Repts

2> DID NOT LOOK LIKE MUCH OF A WELD 1 2 x 256 4

iJ r J

I i I I I i j

I . . . .. . . . .

I ' . . .* ............ .. .. . ..

.- ............... ...... ........... ........................ ......... ....

I . . . . ... . . . . .... .. . . ......

I . . . . .............. ...... ....... .......................... ...... ........

I .

I

I I II I I I

.. .........I. ....... ..... ...........

Page 285: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

MMMM MMM MMM MMMM MMM MMM F il e I npu t/ULIt p~it 'II'/II'II'P'I''I'#I'IH J... "... ... ...

[FiJ Name: <B:AUG28D.USR> Quit/Continue:

B Commnent s Subfiles (Total #: 4

INDIA INK LIGHT Start# Shape #Repts

NOT A GOOD WELD 1 2 x 256 4

......... I ...........

I .

?-~IA

.... ............ ..... ........

CI.... ....... . ... .... . . ...........

.... .. .......... ......... . .... .... . . . . . . *

Ir r I.. ........ .. .... . ...... . .....

. .. .

!.

Page 286: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

5-10 1

II.

Ir

- I1±

K II

L4:~ I-4~

K I

K I-V. U

I

2~ -~ - U-~ . -:--. -F-- I

..~ ~,

rU .. *,, - I

IUI

Page 287: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I- -. IJEI

LAJ U

I

IIIII

I-'

I- I

IL

II

-II

Page 288: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IF

UL -

U- I

III

=1.-'--- I-- I I

I[

~4W! I IU

_ A IIIU

I

II

Page 289: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IIII

F IUI

.1 IF

2

II-( ~u~: I

I

If I

IU

I UU

)

-- *1*I.,. I

I,

- I

II

______________]

Page 290: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

flh~--

I I2 IL-.1*I IK I[

.IL ILiI.

K III

A -

IIIU

-N.

"C* I I

IP I

IU

Page 291: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

II

ii-- I41

I*1 I

i-f: -

J9~ I-.- it

-4;., WV U'C',

9eC4.> II I

I-- - I

-~ -~--- I -.

-~ I I4fl. 3

I -

I II

I. Ir - - U

C '-Ct- a'

- - C -, - 11CC

* - -=~ I_______ I

II

Page 292: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

Si II.

I- I

IU"'

4' F I-- is-

~~1 h

It

I

I I- I

I II

Si ISi

* K* - -~ if' - U-K I

* C-"

III

Page 293: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

II

I ri

..- I• . . -

' " - '" ' a'

., -r ...

- I -[S

N-a -

'iI

. In -A- I

II I

Page 294: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

7. II

I- NI

K.K I

I*27

I*t-.

-t t-. II I

.1 II

-S2-I

2' I I'F

-t K I,,1

- A IA'. .~.

* rr I. II

.4 I4-

II

Page 295: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

- IF

I* 'N I* II..,

a-_ Ia

4--*db~

-~ K IC

I----c I'

In I-~ I I

II -

U3

I- III

* cv* -*~ *- 'Si

,-t ! * - -~ I- 4

Ir I *

'1~ III

Page 296: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

II

* NH I

1-

- II

k 34)j I

ISF

trtI, U

ibi Is, I

Sj

AC. IN Kp

- -- ~

r SI. S Ia

Un

II

C

II

Page 297: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

II- I

II

I4

I-~ F

I I- I

1. II

I I

'7 11

Ak

I-~ U

i I Ir.

II

Page 298: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

SI II

A. - I-s I

II

I.--4 V UI-~ I

-- I

II

-r v - - I

'p K I-i I

P I -

'-A IIIII

Page 299: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

F II

- d

* II

C, I- I

I_ I

II

*1~~

I~2

-uF.t~J-4? 1F

-~ I~~-P*~.- I I

- II'

- . II I

- IIU

Page 300: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

bU

ULI

* r~..

I~1

It I

S~nr In II

rrra

i~Gtts.

U2* I I

- I

UI

K IU

K A-,

-4* - -. -- * '1 UUUII

Page 301: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

II

La II

-J

I- -- -- -- I I

I-. I-V -~ I

.1III

-i U- - - -: -~ U

ii IUIU

Page 302: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

* ... .. ... . .. . . . . . .. . . . . . .. . .3.. .. . . . . . .

.. . . . . . . . . . . . . . . . . . .. . ..* . . . . . . .... ..

* ... . . . . . . . . . . . . . . ... . . . ... . .. . ... . . .. .. .

* ... . . . . . . . . . . ... .. . . .. . ... . .. .. .. . .

* . .. . .. .. .. . . . . .. . . . . . ... .. . . .. . .. .. .

... ... ... .......~ ~ .... .

cm N I I I IN 0I

ON N

1) -4 4

Page 303: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

.. . . . . . . .. . .. . . . . . . . . . . . .. .. . . . . . . . ..

.* . . . .. . . . .. . ... ... .. . ... 4

.. . ... . . .. . . ... ... . . . . . . .. .. .. ..I

.. .. ..... ....... .

* .'.CD

1 * 10 *IIn LO CQIODII

pi UInI

Page 304: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

......... .. . .. . .. .

. . .. . . . . . . .

................ .....

.. . . . .. . . . .. . ... . . . .. . ... . ... ... .. .....

* ... . . . . . . . .. . .. . . . . . . . . . . . .

cla (Vw U

LP.) I

Page 305: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

.. .. . . .. . . . .. . . . . . . .. . .. . . .. . .I.. .

CDI......: 1...... ..... ....:. .... ... .......l

... .. .. .. .. .. .. ... .. .. .. .. .. .. .. .. .. .. .. ..

.. ...... .. .. .. .. ... .. ....... I I .. ..I .. .... ...

Lo m5

Page 306: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

I

.....- * _ ....... _........

............................... ............................. . ,

.................................... ................ * .............I

. io I

4C.

...... "............ . ...... ..... I..

........ ..... . ..... .... .

I I

II

JMUcl m V

Page 307: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

*. .. . ..* . . .. . .. . .. . .

.. . . . ... . .. .. . ... . . . .. . . .. . . . . ... .. . .. I

.. . ... . ... . .. .... .. . . . .:. . . . .. . . .. .. . .I

... .. .. .. ... .. .. .. ... .. .. .. .... .. .. . . . . . . . . .

.......j1..... ... ........ ............. .. .. .. .. .. .. .. .. ..... .. ... .. .. .. .. .. ..

OD OD1.n mI4W

Page 308: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

.. .... .... ... . . . . . ..i

.. . .. .... .. . . . . .... . ... ...

_.. ...

I

.... .... ... .. ... ... .. ....... ... ... .... ... ... .... ... ...

.... ... ... ... ... ...... ... ...

cl ItoI

wI

Page 309: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

.. . . .. . .. ... .. ... . ... .:' .. . . .. . . .

.. . .. .... . . . .. .... .. . .. ... . . .. C

. ... . . . . . .. . . . ... .. . . . .. . . .

.. ...... ................... ....

. .. . . . . . . ... . .. . . . . .. .. .. .

ID. ID

_ _ _ _ _ _ w~ I I ' '. I I IODI

Page 310: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

. . ... ... . . . . . . . . . . .. .. . .. . . ... . . . . .. . . . .

.. ...... .. ... .. ............ . . . ...I .

........... . . . .....

.. . .. . . . .. .. .. . . . . . . .. . .I . . .

. . .i . . . . .. . . . . . . . ......... . . . . . . .

CA.I

Page 311: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

....... .. ..

.. . . . . . . ... .. . . . . . . . . . .

... .. .. ... ... .. ... .. .. .... .... ... .. .. ..

.. ........ .. ........... .I.. .

...... . _ ... ......... .. .......... ...... ..... .....

.. .. ... .. ..... .. . .. . . ................

El lE

Page 312: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

MnMMPMMMMt,^MMl~P1P1NNNMP7('~lltll7MPlt F ile Ir1DU tIOU t PiitI 4File Name: <C:SEP7U.LJSR QlUit/Curti hue:

S Comments Sub f IeS (10tal44

: I INDIA INY Start# r': 2>' CONTROLLED AT 61.1: :' SLIGHT DESSICAIHON: 4> NOT VERY Ir1PRES51IYF

1 /O Variable CR - Z 1: 14 R~EAL

*Subfile: (1 2 256 (Ma:: Lenath:. .76V*Row (0-all): ()0*Start Column: I

# 44 f1 Columns: < 256

*Re ad/Write/Append/ Scrol/Plot /Edit /List/ New f3de/Ouit:*

U M

M ;h M

a vLfl .% .-..

0% .............. ... .. .. ...*.... ...........I.... ...................

.. ... . .. ..._... .. ...... .._ ...

* CR

I........... ... ....... ... ..I ........... .... ....

I,7Ia

I. .. .

Page 313: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

Fil Name: CSF'7.LF, ~ ~ /oltrfe

8 ComentsSuofidesE ki ltel

: ,IDAINK. CONTROLLED A( ;eIepts

7.

: Subtile: 1 2 2 ('1- Lvnciti: !i1:2:Row (O1 all): -0

:Start Column: < II # of Columns: < F5

Read/Write/Append/Scrol I/riot /Edit/L i-t /New file/Qui1t:*

INp&

v(

*i a

.....................I q.. ... . ..... ............ .

Page 314: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IFile Name: C:SEF7W.t'j R t1'SitiFu ti .u: k

8 Comments Subi Jl (1otal #:

1 INDIA IN CONTROLLEI' AT 8i : Start4, .t #Rept-2' SLIGHT DESSTCATIOIJ 1 2

DID NOT LO0M vFFI ITR(I UHEIJ I I ArIr (16 0::4*5

I/0 Variable P P - Z ): 51r REAL

I : Subfile: I 2 256 (a;: Lencith: 76EI ) Row (O=all): C)Star

* Column: < II : # of Columns: " 256

Read/Write/Append/Scroll/Plot/Edit/List/New file/Ouit:

HflIflIftIIMMPI MIM/IilI

I'"

I W

. .. . ...... . . . ........ ..... :.... .... ............ ...

~~. ... . . ...... .... ........ ......... .......

I

w

. ....... ....... . ..................... ........... .......

Eqq

. .I ' i"UIIPI II

Page 315: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I M/MMfl MMMMMfl MIM17tI("' A£ I 'L ' rlut /Output MIMM'?rit Ii# h~~1)lpI ~~yIpM I 'IrMMrW1 lWiMM1:

4 : File Name: 'C:SEF'7X.USR Ouit/CortLnue

E 8 Comments Subfiles (lotal #: 2

: 1' INDIA INK LONGIIUDINAL SECTION Start# 0hape #FP7-

: 2- CONTROLLED AT 7:C : 3> NO VISUAL CHANGES

: 4' PROE OUICILY-DIL I Ij!,13tE A WEt I

I6I/O Variable ( P - Z 1: 76H rEA[-I: Subfile: 1 2 5 (Ma' Lenth: 52,

: Row (all): 0Start Column: I

. of Columns: 56

* Read/Write/ADpend/Scroll/F lot/Edit,'List/New file/Ouit: *

Ht MMllMMMMMMMMMr~lMmlt~l'lfillilrfl~~lrlmmmll~r!MMMlMMIPIMMt~lll~l~tll~lMI IM M P IM M M M M M I

lll . M M M M M M M M M M M M

illlr ml r

lll"lllffIM I M M

M

r

I;: CA IM - - %D

==,, = i...................... .. .

........= ....... ....... ...... ........

. .. ............ .. .. ........... ......................... . ... . ......... . .. . ..

! ...... ! . .................. .. ... ..... .. ... ................... .. . .. .... .

•a

I g

IM

.

Page 316: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IfllMMMNMM~?lMMt~tf~fflfNNN~7F iIe Input / Otu llffQlMMLPfPPf1~N7~1t1:~

F ile Name: 'S.SEF12A.USR Ouit/Continue:

* 8 Comments Subfies (lotal #: 2

I> TWO STRIP CONTROL Start# Shape #et2>SMALL AERTURE 1 126- -'SWA

56>7>

1/0 Variable (R - Z ):1024 REAL

Subfile: 1 > 2x256 (Ma: Lernath: 5121:Row (0all). < 0>:Start Column: < 1: of Columns: ,' 256

Re ad/Write/Append/Scroal 1 't /Edit/Lis t /New fYi1e,'00it:

01 M M

........................ ................

* .. .... .... ..........

7-....

Page 317: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I ZMM1M flfMfMMMMMMMMMMMMMMftf File Input/Output Mt MMIMMMIn MMMrlMrIrnmn MMMrrMnMn rlnMMM

File Name: <B:SEP12E.USR> Quit/Continue:

: 8 Comments Subfiles (Total #: 4 )I . flflflflflflflfl MMM MMMMMMMMIMMMfMMMlMMfMKflMfMMffMfMMM lMffnlMMiMrIMMlMfMA9: 1> ONE STRIP CONTROL : Start# Shape #Repts

2> NO SLIPPAGE 1 2 256 4

: 4> svJ

: 6>* 7>8>LM fMM flfMM flM M MMlPnlItflP NPlP ft I t IPIf I frItlf'hPIIM I IM IIIIIIIIIIM IPM IIIM IM

IIM IMq

:1/0 Variable ( R - Z ): 512 REAL :

: Subfile: < 1 2 256 (Max Length: 1024

: Row (0 al1: Start Column: < 1 >

* of Columnst C 256 >

:Read/Wrte/Append/Sr oll /F'lot /Edit /Lis t/New file/uit:

I HMMMMMMMMMMMMMMMPMMMMMMMMMMPP MMMP MP£P PMMMMMMMM MMMP

MMMM 1MMMMMMMM

IWIL

I ' U

!S

i _ ... .. ... ...... ....... ... ......... ............. .......:

C. 7.........

C... ....... ................

...... ........ ...... ....... .......... ..... .......... ...... ......... ........

S....................... .............................. ...............................i. ......?. ............ ....................... .......... l ...... .......... ..... ......... .... .......... ...... ....... ..........

i . . . .. . ....................... ........ ........................ ...... ....... .. .... . . ....... ..... .... ....

I

Page 318: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

M M M M M M MpMM M M M M M M M M F i l e I n p t t / O t p LntMM :

: File Name: <:SE12C.USF / Quit/Continue: :

: 8 Comments Subfiles (Tota! l: 1

1> INDIA INK UNWELDED CONTROL Start# Shane #Rents

Sutie <15> 5 (a: eah 5: Ro" (O: :

: 7> Cu:

: of Columns: < 256:

SRead/Write/Append/SlrloPlot/Edit/List/New file/Quit:

M

IV I I I . . I . II I I

... ...... ! ....... ........ i ....... !....... * ....... * ....... ........

i ....... i....... ......... ....... !...... ....... .......tC

ICI

CC

........ .. .......... ... ............

... . . . . . . . . . . . . . . . . . . . . ... .. . .

... .S ... ..... ....... ...........

.............................L. ......to

I. ........................

Page 319: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

iMlfMMMMMMMMMMMMMMMMMMr7N File Ilput/OLtput IMMMM nMIiMMMtMMMMFMMMIMMMIMMM.3"C File Name: <B:SEF12D.USR; Ouit/Continue: * *

8 Comments Subfilea. (Iotal #: 2

: 1> INDIA INK CONTROLLED AT 5o StArt# Shape #hept:: 2> LOOKS LI.E A WELD . 2'6: 7 NO SMOKE::

: 4> NO BLANCHING: 5" WEAK WELD:6:: 0 - _:.S7 " S IJ

I Subfile: I 2 256 (Ma:: Length: 512* Row (O=all): < 0* Start Column. 1| :# of Columns: :i256

:Read/Write/ADpend/Srr)ll/Flot/Edit/List/New file/Quit: 2

M3 C RMMMMMM

... .. ... ..... o ....... •...... ... .. ... ,.......

,'-~ ~ ~ ~ ~ ~ ~ ~ ~....... .............ii iiiii~iiiiii!iiii. .. ...... . .... ...... ...... ..................... .. ........3c

I , ~ ~ ~... .. ....... . . ........ ....... ....... ..., ...... ,....... , ......., ...... ....... ....... i....... ....... ...... ....... i........I .......... .. ..

I

. ......... .. . . . . . . . . . .. . . . ............. .......... ...........

*L

3 (AI o r) . . . .;. . . .. . . . . .. . .. . . ..* . . . . . . .. . ... . . . .

.. . . .. . . . .. .. . ... . . . . . . . . . .. . . . .

Page 320: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

3i !MMMMMMMMMMMMMlMNMMM/IMMMMM File InuLIt/Out)t PMM

File Name: <B:SP12EUSR Ouit/Continu-: *:

8 Comments SubfiLe (r~t&I t: _MLMtMMM MM M MM rMMMM M l MMMMffrMMMMMfMMfMnn7P r f I PI~ M PrII S PMMhM M~ f;MlIII M

I INDIA INK SMALL APERTURE : Startt 4haP:I 2:" CONTROLLED AT e. : .7' -. ' NO VISUAL CHANCES:

I 4 WEAV WELD::

I. : 6-7'8

I/0 Variable ( R - Z ): 51 ' R'EI

: Subfile: < 1 > 2 x; 256 (Max Length: /6H

Row (0Oall), < 0: Start Column: < I

: of Columns: 256

Read/Write/Appnd/Scroll/Flot/Edit/List/New file/Uuit: *

(i (A -4

-J -J -4 J -

..... . ... .. . ..., I, I I I I I I I F

i .................... ....... ....................... ... ..I S

. . ....... .

...... . . ...... . ....................... ........

f.. . .

S.. .. .... . . .

Page 321: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

06 MM MMM MMIMMMMMMMi File input/Output MMMMMMMMP;MMrlMMMMlmM MMMIl:

File Name: <EB:SEFI2F.USR' Quit/ContMIu I: :

* 8 Comments Subfjl' (l-tk t#: I1.MMMMMMMMMMMM1,MMN(PMPNM1N7PYMMM1'rMMI'IPMM MMMMMIIM IIMrlrIIpMIMMI

1> INDIA INK CONTROLLED AT Start# 3hkre #he.nts: 2' SLIGHT DESSICATION 1 -. 6

3> TORE APART FROM SE;WUS4 MEDIUM STRONG WELL:

I/O Variable ( R - Z ): : 762 -EAL

Subfile: <1 2 256 (1a Lerith: 7cHRow (O=all):SatClm: < 10i

:# of Columns: < 256,

:Read/Write/Append/Scrol1)/1'toL/'Fdit/tList/P Jkw f iein-it:

I .

ICI

... ..................

I . ........ ...-....... ...

I ...... ...... ................ ...... ....... .......

S........................................ ....... ................ ....... ...... .

IL .EQ

Page 322: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IJMMMMMMfMMMMMMMMMMMMMMlMMMt'1flf: il e Input/Out put MI'IlMlMIfMMMflrlI'' IP'lrlr~rlrI'I:

Fi1e Name: <B:SEFI2G.USP' Ouit/CorltfnUl:

8 Comments Subfii,'- Ct i *: -I INDIA INK CONTROLLED (41 91 ' Start# ttke, ., ffe nts:2> SLIGHT DESSICATION 13; SMALL AF'ERTUFRE4' WEAV WELD

: 8

I/0 Variable ( R - Z 1: 7b I---L

: Subfile: 1 2 256 (Ma:: Length: 760I Row (0-all): 0 f/Qt.

IStart Column:of Columns: < 256

:Read/Write/Append/Scroll/Pllot/Edit/List/New fil/Quit:

.. .. ... ... . .. . .

S• . .. .. . . . .

i 0. "

i..... .. . .

S....... ............................ .....-- I. p

I. : . ....

ICD

I

Page 323: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

File Name: <E:SEF12H.USR' Quit/Continue:4

J! 8 Comments SUbLtn'E I tl Al .

I> INDIA INK CONTROLLED (AT It" 5jtjrt# 91p2'VERY MINIMAL DESSICAr1rlN

SMALL APERTURFE4> DID NOT AF'FEAK- 11) H ELU :5.. S'tw7.>

1 /0 Variable (R -Z I:768 [FAL

* :Subfile: 12 :t258 (Ma:: Leniath: 512-Row~ WC~al):Start Column: II# of Columns: 25e,

:Read/Wr ite/Append/Sroil /F ot/iEdit/ListNE-w file/Quit: It

I tto

0 S a0

a ......

.. .. .. .... . .0. ... ... ......0 .

..............

I i .. .... ... . ... .

.. ... ... ..... .. ..._. .. ......

.... . .. . . . . . . . . . . . . . . .

*................. ................C. ... . .. . .. .. .. . .. ... . . . . ... . .. . .

Page 324: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

3 ! JfMMMMMMp~fMMMMMM~ql~~MMMM pMP~r1,1N F il Input / ut p Lt M~fMMMM llMlMM iPMMMMM, IM PIMMMMPMMtMM:

File Name: <B:SEF'121.USVk Oiuit/Continue: *

8 Comments SUi , 1 nC I Otal 4*:

1> INDIA INK CONTROLLED AT lio : St, trtl Shouti2> TC PLACED DEEFER THAN FREVIOUS RUN 256

: ' DESSICATION. SMELLS CU3I1 n4.> STILL LOOKS WEA

:6.> ~K7.':81

I/O Variable ( R - Z : 1,' REOL

1: Subfle: 1 2 :256 (Ma:: Lenoth: ;',:: Row (()=all): C,.: tart Column:. I.

• : # of Columns: 2 6 "

Read/Write/ApperndlScr ol I ifHJt/Edit/L it/New tlimp,1it: *

W b

. .

* '9i i • : i i"

. . . . . .

I " . . . ... . ........ ........ . ....... ........

I0!o

C'

U

Page 325: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

. File Namez r.F:SEFJ.USR CkIt/CoI1tj1Ue:*

.8 Comments SUtf1V (I ot&1 #: 7

I > INDIA INK CONTROLLED 01 10t, Start# hap* '> DESSICATION A~ND EBL3NLCHJN(i 2

7.> TORE AT SEROSAL SIJF7.rACr

1 /0 Variable 8 Z ) 6 ~

*Subfile: 1 2 -256 (Ma:: Length: 76E4:Row (O~all): ()0

* Start Column: < 1*# of Columns- 256

IedWieApn/SrolF'o./dt t /N- l[,L~t

00 0,

U. U.......................................... ................................ .......

..................... .................................

.. . . .. . . . . .. . . . . . . . .. . . .. . . . ... .. .. .

*S. ... . . . . . .. . . ... . .... ... . . . . . . . . . ..

C.

Page 326: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I. JMflMflMIMMMflMMMMM,~I/A~A~fWINtI/7,1I r ilv ,'Uit' '.t ..t

File Name: <B:SEP12 .USr LuitlContijLt:

8 Comments ,utb I I.A>U

1> INDIA INK CONIROLLEV AT IA".) !4 .trt OF -its

2, SMALL APERTURE : ,BURNING. DESSICATIUNJ. F;Lwr(i4iIJ H

4 TC MOVED TOWARFI'S -I : 5 WEAK WELD

I/O Variable ( F - 7 I:

• : Subfile. - 1 " : !i. Le t /1: '1P I: Raow (O=all): 0 O: Start Column: < 1: # of Columns: < 256

* Read/Write/Append/Srroll/F'lot/Edit/List/New file/Luit: *

to'

I I I I I I I I I I

or ............. ...... .... ....... ..

i ........................ .. ......

I "i I 1 .............. .. ...... v3 .. ... .. ... . . ... ........ .......

Iiip

i0

i . .. .. ... .. .

to .. . .. . . .. . . .. . . . . . . . .. . .

-4I IS 5..........................

Page 327: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I MMMF i r I np' 't / (i -+ r "t /1p rINNIfItM'II'I. ,r,,,, JP U7,Y/'lr". P ( J:1,, lr ),^Nt1' :

File Name: <':SEFl2L.U5R OuLt/Contit e: :

B Comments1M 0M MM M M M M pI'M^IMI~;MIM M /,MIM M i1,IfMMl',NfrN,'iIr rak')lrMi,,1/1''Ir',1,fh~, ' /ift/P,- 0

: I" INDIA INK CONTROLLED Al 9- 7-_,-t# "hp t=

: 2' NOT MUCH OF A VI;ch'1 (11 II.•

- SMALL AFERTURE:

:4 WEAV WELD :

• L MfMP.,'IMMM MM MMMMtll tMIt 'tt ' lrllilliltlflllliliillillilfllrl/'IMM/IMMMMI'II'IMMMI Ir MM l,;I'I PIIIII/ ,,'' *!

,1

'1;;11

,1ll

,'M I I.

I I I r~ ," ll "!!r:"

y i' l l

: 1/0 Vari ble ( R - Z )" 76P FPU. AL

Sublile: < 1 2 : 56 )1:: Lenoth: 769) . SRow (Oall): < Q

: Start Column: 1of (.alumns: < 256

I : Read/Write/Append,'ScrollF'Iot /-.dit,;List/New lile.'l,."t: *

• c I i . ... .. . . . ... ..

....................... .....

I®'S 0

cp1

.. .. ... ... .. ... ....

.0p

". I ...

~~~~~........ ...... ...... ........ ........ ...... i ... ...... i..... ........

* S

• / .. .. .. .. .... .. ............... ....... ............................... ... ... .

0 ... ..... .. ........

i _• •

Page 328: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

ItMfMMMMMMMMMflMMM, IMMMM F u." In U ti u t Eu t f1I/IMMtql P tllrP7lr 'P1/,'f/lff'M/(~f'7f-77pIM:

I , * File Name- eB:SEF1I2M.USR, Quit/I(cnt1J)1,: :

8 Comments ELUbFil, JTel :C 4

: I CNE STRIP CONTROL L 'NWEL EP ft.rt# . , ,: 21 LARGE APERTURE 4i-: 7 ERO4'E AT CLAMF" :: 4" NO SLIPPAGE

.7

I/O Variable ( R - Z ): h-

Subfile: K 1 2 256 (Ma;: Lenath: 1)2 1 •

Start Column: <I: of Columns:

<"256:

S ReadWritelApperd/Scroll/ lnt,-'EiT:t/New filpL: It: X

I HMMtPI MrMMPIMMPMI MM M Mrh',MflPIP-I r NNPIr1M llhPrfrIr;, r "I r "i r:P7"' ?Th 7 ,/ ';,!r:M f . IP , MM hlIrtMP

v w

• ! ! i~i i l].. ....................... ..... ... ......... .

N I I I

I. _

O .... ~. ....... ... .......... .. . .................................. . . . .

.• . . ..... ......... .. .. ... . ....... ....... ...... ........ ...... .

I/

i ..... . . ......... ..............., ...................... ......... .......

.. .......... .. .... ....... ..

Page 329: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

* ~File Name: ~s r14Uffit/lstnr'

8 Comments I3b tc- 1 c.' 4: I

: 'TWO STRIP CONTROL UNt.ELDED Start#t Th-p-IIe;ts

1 /0 Variable (R -Z ):1024 F47CAL

Subfile: 251~ ~6 (Man: Leriath: tiS

IStart Column: I# of Columns: 26

Read/Write/Append/.'crcill] FIr't/Edit.'Ljst/New tile/ElUIt:

MS

. . .. . . . . . .... .....

... . . . . . .. . .. . . ... .. . . ... .. . .. .

.. ... .. ... ..... . . ......

....... ..........................

Page 330: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

8 Comments SUb~I Jt-oi.t t

TWO STRIF INVIA IN U.NHLDV 1:01-.!) rA~l ts ~rU

*4'

XL'O Variable (R -- Z 51

* Subfile: 1 I 2 (Mv, Leri'jtt: 51-: Raw (O=all): 0: Start Column:I # of Columns: 25A

* Read/Write/Append. ;crciil/,F'lo!-/Edit/List.'Ne-w file/ODuIt: V

IMM

....... ....... .. ... ..... ...

....... ..... ... .

... ... ... ... .... ...... ... ... .... ... ..: 1.. .I S77

~ .. ......................

....... ...... ........... . ...... ...

.. ........ ......... .... ............. ..* E. ....... ....... ...............

Page 331: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

* JflPMMMMMMMMMMMMMfl1MIi/MMNM F ile Triptit/L1utOLt MuMt/Cont'r:• File Name: <ELEI2.S Uit/Contit1,,( :: )k O

8 Comments bLUbti_ (I otal V:

I> INDIA INV CONTRFJLLED A1 5 1

LARGE APERTURE I "7' NO VISUAL CH¢%NCF -4" DID NUT LULI WSEI M-11':

I/0 Variable ( R Z : 51' HL:E-L

: Subfile: 1 2 25. (MA: Lnath: 7 ! ): Row (C=all): 0 "

Start Column: I: # of Columns: 7 56:

K : Read/WritelAppejd,':crolI/F'l.tlEdit.iLi t/N . fic!/kit:

I?

.. ... ...........I ..... ...

S S

.. . ............

. .. . .I ,

i ~~....... ....... .... ....... :....... .......... ..... ................ .......•

• ,............... ....... ....... .................. ........................

I • ... ...................................................... ... ... .......

I .. .

I.

Page 332: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

*File Name: <E':SEP1--U.1-'SP OLUjt/C'nnt~flUe.

8 Comet Subfie (ot j:4

: * > IDAIt.CNRLEDI rt

: Row (0a1) MA EAL1

: Stat olm: <-5 (MxIrnh .2

: * of Columns:' 2,6'

IedWie/ped Sc olI/lt/dt/istNwf*/u

-3 S S S

ap I I I I

.. .. ... . ....

..... ... .......

.. . . .. . . .. . . . . . . . .. .. .. . . . . . . . . .... ..

.. .. . .. .. .. .. . ... . . . . . . .. . ... ..

.. .... ..... .. ........ .... .... . .. . ... ..

M ............ ....

..... ... . .. .* . . .. ... .. ..

..... . . .

Page 333: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

* File Names <E6:SEF12R<.tSF QUit/LCint JiiW:

.8 Comments SUbfJILeS l(1cIt~i 4

1,1 INDIA INK SET=7tO TC M ' Start#t2>LARGE APERTURE -

3SLIGHT DESSICAlIONI WA WELD

1 /0 Variable CP -Z104. NL--4,

:obfil::r , 2 -- i (t11LncItin -704 1

Ro S0al~

... ... ..

I. .S..................

- -- 4

I ... ............ ...........,...

.. . . . . . . . .. .. .. . .. . .. . . .. .

Sih S -

Page 334: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

File Name: <EP:SEPl-_.SFZ, 1lut/Cort mu.':

71MINIMAL DESSICOTICIN4.' NOT IMP'RESSIVE .- wriw

1/0 Variable (R -- Z ! 6~I-~

U .fie I t6(aSLegm etRow Oall)

............ I ..... I ....

7 ... ......

... . . . . . . . .. . . . . .. . .. . . . .. . . . . .. .

.. .. .... ..... .. .... .. .. ... .... ..

I........ ..... .............

.. .. . . . . . . 7 . .. . . ... . . . . . . . ... ... .

* ........... . . .........

S. ... .. ... . . ... . . .. . .

.. ........ .......

.. ... .*b S -

Page 335: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

L ' INDIA INP. CONTROLLED Al1 'S~tartii ShI-jc tLARGE APERTURE. 1

: 7 SLIGHT DESSICATI01.: 4 WELDED. BUT NO1 11M17,1

:5WE(A) WELD

1 /0 Variable f F

Row a-)a l -' 1:

Str Coun I

Iw w

a a

.. .. ..... . . . . . . .... ... . ... ..

.. . . . ..*. . . . . .... .. . . .. . . .

t ,. .. . .. . .. . ... . . . . . . . .

.. ... .. ..... - .. . .. ... .... ...... . ...

I I _ __ _ _ __ _ _ _

Iw

Page 336: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

~~~ i I ~Lr I ut I ff! t , ? ' It.:;I * File Name: <B:SEP2U.USf I 'mi 1t :1i* )

: 8 Comments :uO. 4k7 hf.t,.' pltfrp: .'

1> INDIA IN ' SET=u.(..T IqO'-'

2> LARGE APERTURE I ".7 SOME BLANCHING ,ir '' .IJi :0

:4. WEA WELD ::5 -SWI

: 7. -

I/O Variable P Z

• : Subfile: 1 2 -lS 2i ,r: th: /-,:

: Row (CK=all): 0: Start Column: .

# of Columns: 256

: Read/Write/Appendr1ro]'E1t/di /Li-_t/Nw 1iu. uit: 4

I ~ ~~~~HMMMMMMMMMMNMMMM NNP I !M MMM r ,I h"' I i/ MM IM M '",I !r' " MiM/' I,^ "r ,fl~~l~.lfPPW~lfMl'llIMP", MPIMMrI !rIt ,,r MI MM

I "0I. •

I .I I I I

7 . . . . ....

I. .. . ...... ......... . . . . . .. . . . . . .. . . ...... ..... . ... . .I -

$ ~~~ ....... !....... ....... ....... ....... . ""....... .......i ....... !....... •I.

*.. .. .. .. .... .. . ... ... .. .... ...

.. ... .. .... ...

"II * "

I .I

Page 337: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

~ i E I r t - Lit t Ih 'h-". -. ;*' . " "~f' , ,. I... ,.;

: File Name: <B:SEF'12V.ISF LTL4it/I~ort:;t,'? 0

8 Comments 5Lub:- I-t I

: 1 INDIA INK SETI- (.,-. IL Mt. 'tart#t .n--2, LARGE APERTURE : " 2 4

SLIGHT DESSITCTTIlN.rI. !':4 A WELD :: 5' PD MOVED AP AofI l!,:IV '!. ; ilI6

I/O Variable ( R - Z )t7 -,4L:

Subfile: < 1 2 2 (Ma!: Lenath: 1.-Row (O=all): ( .... eStart Column: I

of Columns. < 256

• ReadlWritelAppend/Scroll/F'ILt/Edit/List/Ne fi~e;'tuit,

HMt*MMMMMMf MMMM ;MMtll lt,;Ill h l~l.MMM MM MM Ml11!ll!llltlllmMMMMMMMMllltllllrli"lfl,"II Mr : : r, / r; "Ili,'.;-,,"ilfr"IM flMMMIM

I .

I, . .... .

• .. .... .... .... .......................... .... .......................

S S

...... . .... ...... ....... :....... : . ... ..... ......................

c:,

., .............. ........................ ..... ...................... ........

3 . . . ........

.. .... .. ... .. .. . .. S. . . .. .. .. .....

.. ........ ......... ..... .. ... ...

I. a.. . . . . .. . . . . ......._ _ w0.. . . . . . . . . . . . .

Z _____

dh = ________

Page 338: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I. SI I~~.MMftMM M tM t1MMMfit*7NMIi'II'lPi/r'I,.h'Irm t I Ii r1 l 1 t j't P;P1/,7/ rl/i'lt,,,;r'.'1, , 'r'rJI',/'. hi;,'" 'L 'r."".

-- File Name: B:SEFP'r WUS1I iF.t' -i. j,

8 Comments SU, IjL, il t:LfMnMMnMMMfMMMMMM~~l~fP flfPriflrr,!qpwhr 1f'7NNV r.1fir.r~f// N! /~; ,: ,,:,'.'',),i;,PM,llhPI,p,,l,P.,,.. lhit=

O<

1> INDIA INK CONTROLLED Al f: St t#':2' TOOK A FEW SECONDS TO RF(CH J

-- CONTROL TEMP S4' SOME DESSICArI () IJo l' I'L r;' ', IIJC;5. WEAK WELD

:7" S 'JS7

I/O Variable Z - 1K' 1 Fk -

• : SL~bfile: I (M "'" ' , r i ,'vt : '. ,

Row ((=all): < 0I : Start Column: "1 "

: # of Columns: 256:

Read/WritelAppendiScrolliF lot .'Edit /List./Plp fil"'Uult: .

I * S I I I I t1

S .i~I-i "00 ? "..................... ................w q

• :........... ....... ....... ;....... -....... "...... ;....... ;....... ...

• , • .... ,;....... ....... :

r v! 0

i .. . ..

... .. . . . ... .... . . .:. ........ .. . .. . .....

Page 339: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I tiMMMMMMMtMMMMtMMIN'/IMM r I fl nt /Lu trut M MMMMM #bI/.IfePPiM'IMMMMM/'i1:

File Name: <C:SEF14A.USR- Ouit/Cont i u: :

8 Comments Subf i lc 1 otal it: C

1, ONE STRIP UNWELDEL L-NrrJL : rt# T hpoe2' OBROKE AT THE CLI" "

: 4 NO SLIF'FAGE ,

I/O Variablp ( R - Z : 7.6UEj .1

* Sl~bfile: 1 .; . l Ii l 1h: 768

: Row (O=all): : .: Start Column: I: # of Columns: 768

* Fe-j!Write/Aopend/Srr{illd-'r-'dih-/L~t,.*Nw f iln.(T,,t= *i

I I I I I I I I I I

iiS, 7 i i7 i ~ ilC..... .... .... ...... ...... ...... ....... ...... .

i/ ......................... ......................

* . .

l x

Page 340: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

i ~ ~IMMMlMMMfMMMMMMMMMPMfItlMrMM F EJ I [nI)LI t / UuI t ti.t t MIIIIIMPrIII MM*MIIhIM'PPP~PI'M

FiJ 1: File~tkFile Name: ,C:SEF'14E.USFc OLuit/Contuw.e: *

8 Comments SUbI ilvs I Ital #:I LMMMMMMMMLPnIfMMMMfMPpI'pp~I,/yIIM,"1NNN'PrPPMftMnfMfI l.PIPPI NphlrlMII,'NpIPPPPINNNI:'1wpIpIr1.1T.'q.P,7'

V" TWO STRIP UNWELDED CONTRFjL : ta, to Shape

.4

6.

S/0 Variable ( R-- "V:~ fie 7" 2', : Leiih

: Row (O=all): • I

# Str O l~m'f Columns: "2f

: Read/Write/ApDeridScr,'ll/Flc't/FditI.ist/Nw fi)e,flitit: :

I I I . I I I I I

.-cp

...... . ................... ..... ......

.... ..... ................ ......

... .. .. ... .. .

. . . . .. .

I _1.

. . . ..... . .. .... ... .................................. .OF , -- .

. . . . . .

.. .... ....... ....... ........ ;..... .. ............................ . . . ..

I ...... . .

IIII

I

Page 341: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

F ile Name: <C:S'F1I.Ij,' OLlt.Cont,riue;

* 6 Comments 1UL,1 0 a

I-INDIA INV UNWELDEDM 4 4

.4*61 /0 Variable (R - 7 F;1 ~6 i-U .~ SUbfile: I~M ~'th

. # Of COlUmns: _5

* Read/Wr 1ts/Append- , I 1.'. h)t f- (iil i- I tq I~ lit-

.. .~ .. . .

Iot

a

I I...... . .........Ic

Page 342: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

F ile Name: C:9EF I t .1ic I-rw w

Ei Comments e -~ ;.4I 1 INDIA IN1I CONITROL LUL P~-~-k UP r' t:2 NO VISUAL CH4P(3H3

- NO SMM E4 NO OEIV1U(FE3 W-!-Af5 E4OWEL LUJ 9 GCIFI"

I SUbfile:

2Start Colum:I 2 # of Columns:

FRe~d/Write/Arcie-1 ,cr -11, r lu' 'F-,Jji ti;,N-w fiI'lc '

A o N CD

N OR

wI a

AI7 ...........w

IM wI 'w

.. ... . .. ....y ......... .... .....

.............. ...........................

Page 343: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

J pt'I1lffInIMpIM 1MNM/I~pIr,'7.I~pl,:irh,/I I F_, I r If z.l I N,' ?IhJll'I?trf 1/I,. :,'",''lr7l/.'; I 7r',",rP7rJ. ,'"/'P!'M !PJr.

I : File Name: 'C:FEF'I 4FLI'3r (iuI,.) ,

8 Comments FuI ii, tt r~v~a :

I INDIA INK CONiF<OL.IjI' (4; .1 .o" tIr-tl , I " (.,':2 NO VISUAL CHANU E. _ " b

NO E

'.)CWAI WELD

cHNL: .E t F F l/OI I

| IMPM M M ^ MqPiM. P FM MM M h~ M !iPUTPI II'JpfpMI7 p;/p/'p;. ';,il' ,"l' . I,"!'/',' '/,'. '" ", '. .;ll7:1 P?.

1/0 Variable I P -Z ,'- H I'

Subfile: 1 1 2 : 256 (Ma;t: Length: 768 1Row 1O=all): 0 (•

: Start Column: 1: of Column_- 256

rr

:Read/Wrlte/Appe'rd/ S7:rr'1

I F lot; Ecdt/List/New f1Je/1lL*'t: S

- - w

.. . .. . .. . .. . .. . .

E l I I I I I I I I I

.. ..... . . . . ., ................ ...... ... ..... ....... : ...... .

I-

. . . .. .

...... .. ....... .... ............... ....................... ........ . . .

" . a............. . .. . .

.. ...... . . .

... ... . . .

a

Page 344: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I ~ IIMNNMMMMMMMMMMIVMPP/FPImi' r ie II1pu+ ici t r' ,'rMlA~,,qr, .'., *.,. fPH'I~lmi"'7.' fI vPfr ."~m

I File Name: C:SFF*IJ- , ut ii-' "ic, :

9 Comments *' 4:

I INDIA INK CONiIdil IE' r W ' r c!a t j -h .r,: -,. t - :

2 SLIGHT )ESSICA(I[UI.'-7 MIN['IAL BLANCHIN''

:4L OM ED LIIE A IF! f"I c: 1 NU SMOKE

:1/0 Variable ( R - Z I: 768 NEsIL

: Subfile: ( 1 2 256 (1.:: Lenoth: 7641: Row (0=all):

: Start Column:- I

# of Columns: 256

* Read/Write/Append/ScrrIliPlot/EditLit/Ne . I .U']/(uit: *

I 1.S

,- t,, I- I-

W 0 -4II- I-

I I-.I I-.

I I I I I I I I I I

or ...

...... . .. .... . ... .....

.... ...i.. ... ....... -........: ....... -....... ........... ....... .....

.. .. .. .. .. .. ................. .. .................... ......... .. ..,

'. .. . .. .

.. ... .... .. .. .

... . ........:: ... ... ........S..... .......... .... .. .. . . ....... ,

IM •

II

Page 345: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I ~File Name. ,.C:SEF'14U,.1JF7, 't.(3,.*fIE:*

B Comments cIr±1#:I :I~~L INDIA INV' CDNTI:-OLL FT) (41 * ~ ~ sSOME E.LANCHIrJ -.

43 Srluk ILI1 TLE DESSICA 'I"I ~ N'J WELD SEENJ

UU' Variable CR -~-1: 7~ ~

if SUbfile: I 2 ' ,,,1 . 1I i,t h:

Str Column: -# ofClms65

I I ~ C 'I allI I I

Re;d/rie/Iped .., Ot - a i-e- it

. . .. . . ... . . . .. . . .. . . . .. . . . . . . . .

6... . . . .. . . . . . . . .

. .6 . .. . . .. . . . . . .. . .. . .. . .. .. .

(. . .. . .. . . . . . . ... . . . . .

I . . .....

.. .. .. . .. . . ... . .. . ..I. .... ......

.. .. . ..... . . . .. . . .. .. .. . . . . . . .

IenIp

.. ............I. ...............

Page 346: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

si' I If I It." Ou t u tFile Name: <C:SER14H.X -F, Lni _ ::

8 Comments Sub f il I nt~ l : I

:I INDIA INK SET=B( TV I' Ix = - :oq'v i. - :

: SLIGHT DESSICATIOrI4 .NO CARBONIZATIUN 3

: SLIGHT BLANCHIN:NU SMOKE

: P D LEANED ON 'TAPFl.

:? NO EVIDENCE OF A 'ILLU

: I.'0 Variable R -- 7 1: , ': ,

| : Stub~ile: (M- 1.' :"Y. " 1-,. I rK:tth: 'f :|

Sta t Column: "| # of Columns: 2 -5t, "

i eakd/Write/Append/9crol,'FiF" ti/Edil/L.IF.-tzN ,w tile,,14,,it: I

II:®

V.-

~... ....... ...... I ....... ........ ........ !.......

. .. ............. ................Sw

(w

1 ..........I !-

I........................ ... ....................... ............ :............

q q2

1 w .. . . . . . . . . . . . . . . .... . . .. . .

IM

|S!S

Page 347: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

6 : File Name: -IC:SErFll4.JSF - ,"_r ., ,

8 Comments Subi is5 (Total 4: 4n . IrMMM, nMMnMMMMMM P lI-nM Ph III M t 'IM MMfIP 7 MrM , Ir I IrrPI, MMwP I r I,

•IPrt t Mr MP f l' flM ~l PIr . I 'I:1 INDIA INK SET=l('. TC MAX-.q4 : 'art# 9. , v

2' TOTAL TIME=25S . ,., DESSICAT10N AND EL.,141 11 0', :

4 NO SMO'.E

STRONGEST A\T Ili[E''B " EST WELD SCI Ucf " l)lIm

: 8

' D'0 V jri. )le ( R - 7 1: y:, _

6. : Subfile: 2.' . (Mai L.rit .jl: .. 4' :

P ow (O)=Zll): I

Start Column: I. :# of Columns: 256

* r .ad/Write/Apperd/ScrollF 'H!tiEd.t/Lirt/Nk. file/Ouit:I 6

all 0w w. ;

I . . ____.

.............................. . .

i .. ..... ~............... ......... .- _- ...-...................... .......

.. ...... .... .. ..I:. .... ..

6: 3

. . .

......

............................ .. ........... : .............. .....

Page 348: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I'. I: : File N,,me: C':S' 14-!.~ 11:4*-.-

: Uomment SIzt f!: 1 lr t j*: -

:1 INDIA INO SET=IQ'i .! I!p '4 : _ rt;I _4h1av c.

2 TIME = 15 S. 2. t -1 ' ,,%- '. (3NFr!EL' ' .. PLANCHING ANI ! ' 7. I

I IEA, WELD I ',:-' lS . : 6 ir.F.EARI; 1 t0l: l JEIA'Es H.. IH- 1 ! V'tL!.

: I/O Variable ( R - Z 1: 1I '- k

So'bfile: I E '> c& jI*-,, I. on'cth: h...':Row (O-all).-:

Start CoIlumn:

Of Columns: 5!

SRead/Write/Append/i'.,, c',"l/ ,t/Fdt,'s.l t'j-,'(Iuit: I

G1

.. . .. .. . . . .. . . .. . . ... . . .. . . . . .. .

! •IS 1

I S

C ,E............ ... 3... ... ...

......................... ..............-.......v.......................

S :.

iw

i ... .. . .

........ .. ....... ............ . . ....

....... ....... ... ......ILR

Page 349: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

SFile Name; f:& 1iiL'V'I A

:2SMA~LL AF'LRTUFL

7 EROOE BY 1HE "'LI,

'1 (AT THE M9OVING i ii

3t of£~ Columns: 251

H* PofM olms:~prmIIIf py/ 111

* F~d~'riteApprid~--u1,i :t dII'tAt , ~j ~'.J-~t

U ..............

.. ....... .... ..........U * I

I. S * I * mS w

.. ......

.. .... . ... ... ... .... . ... ....

I.. ,*- S

Ia m.............. ....... ......... ....1OD wq

S 5 wIa3w

..................-.. .. .. .

Page 350: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I I *uf J L8 Comments 't I., s .f H:

I TWO STRIF' CoN : 1 .111., -" 1 , "1 z t 2 0

INN ...... ..

'., V.ra l R ,

Sub.ile: t ' Z , (i i .r : .... . .

I Str .Colu I

3 * i I l

RE- d /Write/ Aovendt3'tt 1, f' F~ .is, t - ile/(AliL: I

..... 4X .

i .. ... : ...... ...... .... - . : ....... .............................

I I • =~ ~ ~~~~~ ...... ....... ...... !......... ....... !..... .. ..... .. . ..... •

* *l

I * i S

1 , ..... ............. 0......

• .. .. ... ... ...... .... .. ....... ........ ...... ....... .. ...

............ ..

,. S

.~ ...... i . ..... ....... i..... ............. ....... ...........k ,,: ,

3; .,- -"•..',.* ."% 0. 4.:

1i

Page 351: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

* f~~ ..Ue Name: :Er' I. j .

8 Comments zoi~ 'L t-IT3 . 1 TJ- STFIF iNDU ) 'P1 1! iv 'L 7I .-.I F1,JP~f'I1f't';T1NI -rr~

Z .

1 /0 Variable (R -Z'. I-7

S* yb f il e: .I. . I : ..

*Ster-t Column: IS Sof CoL'inns: ".9,I FCfl/Write/Appprd,. c-cr 11- F tf A; V r;,~~:

3... ..... 1...II

I .......... .. . .

.................U... ... ..... ...* w

.. . . . .. . . . . . . . ...

-. .....

.. .. .. . .... . ..... . .......... . .. . .... ..

*. .. . . .. . . . . . ... .

Page 352: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

• ~ l l qp N mc:. :: i I. .' ?u it, " ,." .

Comments a

V INDIA I10 . O I I ., rtr ' =>.II .- .I: A

: SMALL APFRTFLV:*NCO YISU. UH-V!--,'-

NO WELD SEEH

B

3 , I.' ','riabce ( F, -- . :D

*S : Subfime: 1 ..2 ' 2 . ..,t .: Row (O=all): 0: StArt r-olumn: t

Oof Cojlumns

* 0

S. ... ... - ..... .

.. .. . .. .

• " .... .. ... .. "" i....... i....... ......... ...... ....... •

n • ....... ... ... ...... ................. - S

t .... . ! : . ! ..... .i .. ..... ........ ... .......

: ................ ............... .............. ................. ....... O

. , i , ... .............. ......... ............. . ... ..... ...........

0 0-

* 0

I.

Page 353: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

1 0 : ~File Name .C:S' yi ...I

6 Comments '' l'. *.-. ~

INDIA INK: C0NT,-MLI 71' Ci I ;t tar I '-l-'.

* E~LIGIIT ELN:I~*4 NO I)ESSICAT'f Il

* .- ~.W~ll)WELL)0TORE AlT SER05A

10- Vaibl

Sta t Cou--tA of 5-Ams

0w ......

U . ..........

I.CC

.. .. ... ... ..... . .... 4

I . .*ff ....... .......... ..... ..............*~ ~4 p

..... .. .. ....w .. ...... ... .........

Page 354: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

: £- mmert i :. : . 'h . , ' -:"

I INDIA INt: CFFF'.ITLF. F , : - ..

SMA.LL .FE 'F.. , , '

- 'I tr Col n

# of Columns: 256 . S

: Re-ad/Write/Append/ "' c, i . F . , " . . 'iF," .,t"-

- - -

I * I I I I 0

" C

a

.. .... ... ..... ... ..

JFS -

- ;~~ ~ .......... ... ... ....... ...... ....... ....... :.. ......

I , : Si..I.. ............ ...... ......

Page 355: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I * r~~ile Name: !4,' *. *iW ;'

fI Comen tt . ,0.0

,0 Vii*be r, 1

St'r Criol'~ Ci\

# fCOILIMTIS:

Y:. 7

LA m

I.-

Im .. .. .. ... ..... ....

........

u 'r~

cp0

. .. .. .. .. .. ... .. ... .. .. .. .. .. .. ... .

* 10

Page 356: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

1 'LB'f ? .f '

I . ~ d 0~-,(j~ ,

-If-

m a

~a

U. ~z7

* S ~aI.r.............. . ........

* o?,

Page 357: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

~~~1 0 r..-,. J

.. . .. . . .. .. . . . . . . . . . .

10

* __-.- . ij.1

Page 358: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IE

f c

IlW tEO P

*~~~l 1*Ln ~j~IL LMcbfk L K

* :.'~C 1

I ICD

CDL J L W ~

I ~CD

I4

.......caA

Page 359: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

-' % Naime. :F ! 1

'N")J 13MIP UNWF'''L

# o f Colunin' : 75'.

co . .. .. ... .. ... ...

C__

CDI:IL

ep

co

Page 360: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

1

II

..... .. . .. ... .. *

CD,3I I I I

CD CD-

Page 361: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

II

I N (7 NC NI j

v I I I

S u I :,I

Ii ... ..

CD 1~

........I *~ CDIC

. .....

CD .....I CU.I. ....

Io .....

Page 362: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I1 'I7~'I, I'fPI/ fl IItIP IfI'7 //IIDIT',,''' /, , , ,J, ,,j Ji ,. .. i," .1' -" ',., I '. 't , ,,fI.' .' I ., r, .1I ,.

_ Ccimmentc ,*r

: 1 FERRO'YL+ L IlL' ? "4,L' ! ' - ., -. ..MU. C. ,. h2,Y4.L'MAL EL4II tW:. ,' , r;,;. ! '

!ILI7[ SPICIP F

: , 'ELLDED, Efli! , Ir.

: F, oj,.i('=a11): I.

: Start Column: I# of Columns: T"e

It

I_ I I I I ! I I

I..-.. ..-.. .... . ..

7 .. . .. .... ..-

I'U

I

I,l~

ii

Page 363: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

' ~ ~ ~ F L f- e N_ mo,: :: :,, ,;,, 1

- " I'l V, P-r. I I

5 I,,J .riab - "

S ,bfil: 1 1

I' t0 f E lcnI ':,''

t'

i ' (........./M, .7,..... .

I.- I

,* CA ..I| LL i J. L.CD

w.,

. . . . . . .................. .....

4~.. .. . .

I

Page 364: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I40.

U~... .. ..... -''*

5 :. I

7 ~ ,- L * .

IC

UrN

Page 365: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

•. * • .mr: C

•- I

* . S . . .

3. 5

U I

3. S

i Q I

I.

Page 366: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

i!I V • ""~ ~ ~P', 'i "7'l!, l !.l' I t'," . >"//'! '. ""7 . . ;' ', . "', '. '" ."

II

* : : V,, flI:! 77

I -Q

.2, l ?,' :,l, N/7; ,^; f jjU' P pv.l! i .2,'.hk . ' I h, :" ', ,; , ., , e, ,, ,: *p,,* . *, m .'/,': ,. ,' , ,, .,,S '

: -, ," ,. ,*. .. ."*

4f: t of t 71'l~I7r77,: '-

* n~;rt~~p'V l; ' . "' L

tv,

I •

I ...... ..... ... . .

.. .... ....... ..........

...... ... . ~~.. ........ . . ... ... .. ...... . . . . . . . . . .

ILi

I

Page 367: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

- P.

B"-~ 2 HI .:- A,

• "~~~. 0..J; !

Ro

Ln Ll u

I I ! y _f ! I FI I

S. ..... ... ... ...... ..

I '0

if L

* ,* iCD

I ** D

Page 368: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

1 I ki. 'I 'r; pIM'r,/;; l','f!r'/1( '7/P1f '!. / /!p/, " ' . ~ I I( , ' . . . :/; 4 +, r= . . 4 " ":'; '. . . ,=

r =

• -ly , : ,~

i :' AL E[_I LJ' ' SF2 F

0 : 'p-' S1

-I. -- I

4M

__- S I !.[

M II

n~... .. .i ... . .I....,. ....... .. .

: -. . . . . . . .. . . . . . . . . . . . . . . :. . . . . .. . . . . . . . . . . . . . . . . . . . . . ...

- t • . ...~ .... i....... . . .... .. ...... ...!....:....

. I ..C•

I o

I;

! D----

Page 369: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

....... .... ...

.. ... .. .... .. ..... ..

OR C

Page 370: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

9 ~ 1*~0

* :7;,,.~..,.. 0

Ia. ~. 0

I, 0~ 0

m ~ ,, 0mU - - -~ ~.- 0

I 4- g- N* 4- I S

a,,£ ~ - I

I I 'I

I * 0~

*

I. ~1T~I * I-.

-- I3.ID -,=.---- I

* ~ .

I * 0

9 __ 0* .4 -'3m M .

* S

lie 0

is1 S

1 4

I

Page 371: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

0 S *

*Iti, C ItCS

wJir~. yr.ri rr~p CM ).il . .. ,

I*

I * .'~<i: 9- - I:

'~,i.r'. 9U * ~I. - S

I .~ . .. ~ S

* SI * - -

S

L.LW ~L- ± i i.~J

I.* - S

I-....-1~ 1 -I S

*

I.* 1I*

ID -- I,

ii. A - SII.S

-'3

lie 03%

I ___

Page 372: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

*

1*. 0

* 0

I * . 0

1*< 0* '"f''P"''td'7X'y .',' . 9

I * . . I-

10.. 9

'7 t'r~7rIN,'h.':~

I. .-. _ 90 31

I 3 3 3 3 I 93

6 ~ L~ I- - 9

0 3 1 1 919 3 .1 I9

1I 9* 1 ... I 9

31. 3.7 .

*** I9 33. 3

4) ,1-I. *1.....

3

I ~* 0

Ij~ -~ . -~

I. .11* 9

I

Page 373: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I, 0

I S

I. S

I.I

I. . S

I . A__ . 1 !. IS

I S

I . t

0• f

I

Page 374: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

*

I. S

* 0

0* 0

I 0

I. .,, 0* 0I * -.-.---.----- ~- -- - 0

Ill

* 0

B-C -~ 0

* - r

I. -.-. 0

- 0 .] - I 0U * -~ L4'--~- I 9

U * I

* 0 I 0

I. ~1 -t S0 jaIl '{j S

1k-3 0 I 9-9-K

9 1 S

* I*1 9

I. .1 A S

I 0

3 0 0I. 0

I

Page 375: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

0

* 0

0

I.. 0

0* 0

I * 0

* 0

'C

05,

I I- 0

I - - -- -----.--------- 9* 9

1. 9

I 0

9

1* 9__ 0

L'I.~i -~

1 -~ 9I. 9I.,*

1. 0* 0

-4

0 0

0

I - - --- J

II

Page 376: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

It

I *

S

9

5

I. S

I

S

I **

S

0

I.I.

I S

I.*

-

-

S

1

SS

9

S

9

S

14+0

9

1 ~

U 9 S

S 1.-

0*

S -I.

I i

S

0.

S0

I

00

I -~

Page 377: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

fpfrI1P~01f~flMP1MMP7MMMINH Fle InPLut/OUtpUt MfMMNMMM~IMMMMMMrM

File Nai CtSEP16AE.USR> Quit/Continue:*

:1> BLOOD SET-8O TC MAX=40 Start# Shape *FRepts

r2.T(ITAL EXPOSURE -30S 2 25i >N"IIL CHANGES4>NO SM1OKE~

6> NO WELD

1 /0 Variable (R - Z 1024 REAL

*Subtiles < I > 2 x 2156 (Ma: Length: 76BRow (0-411) <> fl Out '

z tr oun* fClms 5

t Red/Wite/pped/ScallF'Io/Edt/Lit/Nw fie,'uit

Ur*c.. ..U. ......... ..... ........

03......,........ ..............I .... ... ............

L,

3V ....i ..M... .,............ ....S *

UU

Page 378: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

~3 Corn~ntsbff1f'ff1ptrfflff/~7p7(7flf'7p,/q(f.'rjp7':,Thfi';,' ff11 7':k'gf,'f~W '1111' V P.1 .:u,.. I.;. V5 :~ E3LC1OD ~~i-1~'

YE~ F. H

* .1

5 '~.h

p-+ r~',-,3 ~. rif CPL!.sp.

I~ri. >J~ :t~i' Pr5 .. i.~,;Il1Ii1M'~YiN, 1,.. ~ ~ ..*'; '.*V-. . . .TPP Pt . .>~/f7~t

3

I3 I I LJLJ~JLb

T __I 3

*33

F.,, -- a-p

3

Th&,~II-*

j;;

M

* 33,

*IU

Page 379: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

.- . _ .

arL at] pI 'N -T° ~"

3I T I I J ILWJ _

I

II

I

N".4

I

I CD

I :NI _ _ ---CD

IC

UA

Page 380: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

V Eor i',--r m r 'E ; ' '- - -

I,

I ..II

II

* . . . . . . . .. . . . .. . . .

IT if,-°! 4

I

I

ICIA

Page 381: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

* If Colu ris .

U a f Cougnr~,:

I NCo

(L LI

Page 382: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

Pre ~I It-,

*q 44 kK

1 '' ;'1~f N'7NPP7Nth't1P co

I/O V~r~ibICD

.:Ln

* I :D-

2 CD

Page 383: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

A-p

Ir ,LM co'P~f

- oltn

Page 384: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

1 p lie ,X;d'uINIU,'. .,",;.-, . -, - .

N'~n~ F-~'-.. -1' 2

.~ -

~ _

VAt-* F -.

4 ~

I.4 / ,,.',. -*'t,,AIP"1,.- -

)- - Lit; ~<~:3 6 ~t Th1tnr~: 7

4.

*1ri

IN N N Li

* -~ Li

I Ii~ ----- I

I 4.

I.U ~

*

I,U '~1I * ~

I,,3I M

t.

I'ii

I

Page 385: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

lNprtitiP;/7p7r.. '1* ' : ~ ~ ~

I .iz

* p

I *~p*.~'q~fi:

icLc~Iumrv~:

~ - WV ~- Ii [p

1tt-tptNtrt1~VNfl.'~7pTrftpI(if':,'-t'?~W ~r' "/~VI~, '~;P "-"~ '~PI' P ~.; Y~T.,'I p

I.P

I V I I

V

I ~V

-

I3 ~1 WIIt. H

V

It~ .1

I' ~d :~

I t

UI

Page 386: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

TC :y 4E f . .

1-

.. .. .. .. .

9 .* '*. 1

....... ..

* *'?>7~.W. i' */i'~~~COD

Page 387: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I .S. ,'~,;, ! '7/" ~~I7Nfr1/r~, V

*

. ,,~.r ,,..

.7

~ ''J

P .. i'~~ (fl

* V

* .... ,-.

** F~" </p-''

'N,' '/N/'l/'7Pt/P7/'PW~/.?,~ .''V. . F

** *1

N) N) N) N)

* L'~ -4N) N) N) N)

____________ - IPa ~ - . .1

p St

p 5*

I-.

p Ii

p 1'

p SI

I 5'

aS

5 -4M

* . . . .. ..

-l

4, 9

Page 388: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

II,

IIII

CD-

Page 389: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

fj3le 'NM" *:

£ub~1~ ..................................................... ......

- t~ ~ n~V.S.'

Page 390: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

3 Commnrtsi

1 UIELED P

rU .

CD.

to CD

Page 391: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

File Name: -LF~21 P-

6 Corments

I' BLOOD CON IRCL -

2'NO VISIBLE UlVN SM1O E

110J WELD

B ~I/0) Variable(

S~bfile M 4 1

I "*o C fkl'mn -

P-d/W'ite/Ac'. I -

Ii (I- N N N N

. .. .. .. . . . . . . . . . . . ... .

.I. .. ............. .. .

I I.. iq

Page 392: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

3t .e )".am e: . . / ,I1-

R Comments

1 E UQTo rIAI .N: 7 ELANCH! :JG C/fV

: rCHGFT PE A W['

35 0 WEA WELP

. ' Variab!, ( ri

Subfile: ", iRow (V=all):CI rt Column:

# of Columri,:

P e -P d/ Write -/A r) v i i

. .. . ... .......... ..... . . . - ... . ..

- ,, . .. . .. . . ... . . . . ....

| ... .. ....... ....... i ....... .. .. ......

".. . .

Page 393: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

File Niffle:.

B Comment s

I E'LOOD CONJF I'LAW;NUN

- NO SMFIflF23 LOO 5Li

- ORE )I~'

1/0 Variable

: SLubfile:..-.: Row (O~all):: Start Colun:!

o f columnF:

3 r!IMNMfNP~l~t~N'. p - 'p

I i7

.. ... ... ....... .. .......

Page 394: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

* Comment-

I~9 UI' I I;D U

4 LL'UJS LIIE

M~ODERATE WELI'

7 1EJRE AT SE~f-

I 1/EJ Variable .

* £ubfile:

I E~st*~rt Column:

* Fead/Write/App!'r.1! --i f.--t I~

I IV

. . .. . .

Page 395: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

) r Aa ,JMne : -

* ~ commen -

IJ

RaF~w (0-al1):t rt COLIM-1:I S~Of Columns:

*F-'id/Write/Lpa .

NLI LM -4

cpw

IC

Page 396: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

*~70 C ~JfTVC r U

IIleI I L J'

Ch C

UC

*C

I C

Page 397: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I Ii-le Namp:

FILOOD COIJT''. 1

2ELANCHNL3 .,r"- NOJ CHARFINC-*4NU SMOIKE

5 OOV5 WELDEPI ~ FLOTTED S'Eiv,!ELCKIDI

I ~ ~ 1 0* I.(3arip blp

S ubfilc'' OW (')= ll):c L~rt Colun:

*# of Columns~:

II

LDL L.-.LiL

1nq... ..I. .

Page 398: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

* File' W4 mQ:

' 3 ComnIul-I

CIF Variabl

' L P1 ?N ~ 7 P! ?1 1P . P;'. ....... .. . ... . . . ..... ,.

* 10 Vr-i ~ CD

.. ..I. ......... ... ........* f;'j (0= ' II o

Page 399: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

* l

9 c ommc-riti

7WC ' 5,1 S FIV I'! J

: cw (f=all):Start Column:

# of Column:.3

Read#Write/AcpEuv. K i

i X

Ip-Ma

I I I l !

Il

j .. - .. ..-..... , .. . ... . .

.7 •

I .. .. ... . ....

I ,

N)- a ..

M

Page 400: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

83 Comrint-

*Row ff-all):

* ifcolumniw

I H N,8~MffM~lrflt~.",,~~.., . - .. ....... - .... ....... *~.

tv'

....................

I. ......... ... . . .. .. .

Page 401: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IIII

.1 I

I II

u-i

* II II

2 I* I

I* k I

.-- ~-- . I* Ij

-I.4 Ui#~- -b. .~i 3

-~

AC I

I

Page 402: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

•I ' ,K. , rl lll, ;, 7

I

flt.

.. .. .. . .. J .. . . .. . . .

.... ........

I *

I"

I!

Page 403: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

IfM~tpf1~tMrM I~i~I'7,', q'Irjh; I 1; I I I, P irl . pi ,.,I rpin; a'1IFile Name: 1'F I

- CON I!-L* 40 VISIEILE

N .rO SML1IE

L V.

Ii- aral

It_

Iu

CD

Page 404: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

L<CsSEPMD.USRW

OLLED hT 7ol' vE CHANGESt

1 /0 Variatie ~T

Subtile: .:'

# fColumns: 25in

II

.- .. . . . . . .

Cit * w

Im- a

.. ... .....I ..... .........Ip

I- a

Page 405: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

File Name: !' '•

8Comments ,1 :ILM,1Nflf IMM MM 'f'n/,t .,r , • ,: • .-r,','r ,,p,. ' .... ", :'.~ ,,,,-'a' " ' a" m r,.-

Y-' ICG CONT ROI2 NO VISIDLF'

i. No SMrIU F

: 5 r-l!) W, F-L!

:7 8 '

LMMMllfMMMM ltMMNMMMIIM,'Pl'ir,1,I, ,.. '<h '<ff1 , Fl."' ,. . , , , . ,,,, ;;• , /'!r ;, ... 1. F'llrl ,, 'fl ' ',;." ' ,a "I':ji"

F'7

I/O Variable F

: SUbfil_:

Row (O-all):

Start Column: II o nf Column-i

: R-eadlWrite.'App•

. '' 3,! .: L ,..., . .

7, .. ......

HMPI MMPIM TM I tIPh,'1, !;";." ' ". ": JT 'a a " .'l' '- . : ., ,'r -... , ' ,' . , r , '* . ,',. :r; f... Tl'! " *;/° ,', .- '!. l'

I °

I ± -

.... .. ...... ...... ....II

. . . . . .~ ~.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . .

W

I "

I

IIlM

Page 406: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

93 CommentF,

* :L(NCH14Ci Al.

* NO CHRPN4 NO qMOIF

V1 ~r . t,1

: E5ubfile:: Powj (C-allp:3 : Start C~olumn:

Sof Columnis:

*Read/Write/Apric..r -11' ' i '/A '. h

to IQ

.. ..... ...II-.

.. ... .... .... .. .... ...

I -m

Page 407: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

1 INDIA INK. UNLI -1F I'

I'5 Lb fil e:

Str Co..w (OI4 of Coltfins:*.

*Read/Writ/Aenwrl "I"U~'.'

3 t.i' I I..~ ~* F. ~ -... .. I 1.~Q'

IM.. .. .....

.. ... .. ..... ... .

Page 408: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

F 1 i m c~t:I L'C Comimenits

S LIGHT HLAN,'-

N"C WELL)

SLbfile:.Row (0=all):

StR-t ColUmn:

RL-E-d/Write fr-'-

t- N

cp

I ,* .

I "

* 1Q

coCD

Page 409: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

Z NO V'Mf 14

Ro~cw M~al)-.

Start Column:

#Of COILumns:

R* dWrt/ rpeU

I H~flff'fNMMM/P!1IMJI C.

Page 410: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

h, N" WFLD

*r l

tif -£ e :C~r

ti f

I _ _ _ _

IV0I

IC

CD*CICILIC

Page 411: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

File Nime:

8 Comment:,II INDIA INI, 1,:0

s Lbfile;Row (()=all):Sta t ColUMn: I

# of Columns:

In

I ID

Page 412: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

* F ile r4~ac:

I '-)PC E ' JT :I

N4'J CHAP'. !N-

:~J~WEL'.

* !.O ''arjitI

R Fow (f)=S1 IL

of~' Cchtil'

rvi

to C , C C

IPi

. 12)

. . ... . M

u.

co

Page 413: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

U Appendix C- Supplemental Figures and IllustrationsIIIIIIIIIIIIIIIII

Page 414: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

Figure 1- T[hermocouple Placement

Loser ILaser ILaser

IFiber Fiber Fiber

I Inverted Bowe\ Inverted Bowel WlSie Inverted Bowel Weld Site

I Stafionary End Puh Stationary End L RStationary En

Thermocou~1e Thermocouple Pu ll/Tes

PulTs

Page 415: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

Figure 2- Experimental Protocols

LASER TISSUE WELDING OPTIMIZATION PROTOCOL

Time s) Aperture Size (mm) Power (W) Chromophore2 0.5 x 4.0 0.05 None10 0.5 x 4.0 0.05 None2 2.0 x 4.0 0.05 None10 2.0 x 4.0 0.05 None2 0.5 x 4.0 2.0 None10 0.5 x 4.0 2.0 None2 2.0 x 4.0 2.0 None10 2.0 x 4.0 2.0 None2 0.5 x 4.0 5.0 None10 0.5 x 4.0 5.0 None2 2.0 x 4.0 5.0 None10 2.0 x 4.0 5.0 None2 0.5 x 4.0 0.05 India Ink10 0.5 x 4.0 0.05 India Ink2 2.0 x 4.0 0.05 India Ink10 2.0 x 4.0 0.05 India Ink2 0.5 x 4.0 2.0 India Ink10 0.5 x 4.0 2.0 India Ink2 2.0 x 4.0 2.0 India Ink10 2.0 x 4.0 2.0 India Ink2 0.5 x 4.0 5.0 India Ink10 0.5 x 4.0 5.0 India Ink2 2.0 x 4.0 5.0 India Ink10 2.0 x 4.0 5.0 India Ink2 0.5 x 4.0 0.05 ICG10 0.5 x 4.0 0.05 IcG2 2.0 x 4.0 0.05 ICG10 2.0 x 4.0 0.05 ICG2 0.5 x 4.0 2.0 ICG10 0.5 x 4.0 2.0 ICGI 2 2.0 x 4.0 2.0 ICG10 2.0 x 4.0 2.0 ICG2 0.5 x 4.0 5.0 ICG10 0.5 x 4.0 5.0 ICG2 2.0 x 4.0 5.0 ICG10 2.0 x 4.0 5.0 ICG2 0.5 x 4.0 0.05 Blood10 0.5 x 4.0 0.05 Blood2 2.0 x 4.0 0.05 Blood10 2.0 x 4.0 0.05 Blood2 0.5 x 4.0 2.0 Blood10 0.5 x 4.0 2.0 Blood2 2.0 x 4.0 2.0 Blood10 2.0 x 4.0 2.0 Blood2 0.5 x 4.0 5.0 Blood_ 0 0.5 x 4.0 5.0 Blood2 2.0 x 4.0 5.0 Blood10 2.0 x 4.0 5.0 Blood

Page 416: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

I

I Rabbit Animal Prep Protocol

ISupplies Needed:

Alcohol Preps

I 1ml Tuberculin Syringe

3 ml Syringe

#18 Needle

I #22 Needle

Gemini Xylazine (Rompun)

IKetaset (Ketamine)100 ml. bag of 0.9% NaCl or 5% Dextrose in Water for intravenous use

Microdrip (60 drops per ml) dispenser and tubing

I Animal Clippers

Manual (non-electric) Razor

IArtificial Tears Ointment

#22 JELCO IV Catheter Placement Unit

Paper Tape

Beuthanasia (sodium pentobarbital or formerly known as Sleepaway)

IIIII

Page 417: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

II

Procedure:1. One day prior to desired surgery, remove food container from rabbit's cage.Leave water bottle.

2. Prepare tray of surgical instruments for autoclaving. Place blue cloth drapeunder and over instruments. Add hemoclips, needle holders, atraumatic clamps,and other specialized instruments as needed. Autocjave instruments.

3. Collect all supplies listed above. Place in rabbit room.

4. Close door to rabbit room.

5. Determine amount of Rompun injection. A chart which indicates theappropriate amount to inject is appended to this document.

6. Prepare Rompun injection. Wipe the septum of the Rompun bottle with analcohol prep. Remove tuberculin syringe from packaging. Insert syringe intobottle and carefully dispense correct amount.

1 7. With syringe in hand, gently and quietly open door to selected rabbit's cage. Petrabbit gently to reassure. After calming rabbit, obtain control over the animal bygrasping firmly at the neck. Hold down rabbit and inject Rompun into the musclein the hind quarter.

8. Close rabbit cage. Wait approximately 10 minutes for rabbit to become sedated.Rabbit may slouch or turn head to side.

9. Remove rabbit from cage, supporting head and neck carefully.

1 10. Transfer rabbit to sink.

11. Using chart in appended to this document and the actual weight of the rabbit,determine the appropriate amount of Ketaset to inject.

12. Prepare injection of Ketaset. Remove the 3 ml. syringe from its packaging andplace the #18 needle on the end of the syringe. Wipe the septum of the Ketasetbottle with an alcohol prep, and insert syringe. Remove desired amount of Ketasetand then carefully change needles from the #18 to the #22. Grasp the rabbitfirmly and inject Ketaset, using the #22 needle, into the hind quarter.

13. Wait approximately 10 minutes for the rabbit to become completelyanesthetized. The rabbit is completely anesthetized when it can be picked up andplaced on its back and does not attempt to turn itself over.

14. While waiting, prepare intravenous anesthetic cocktail. To the 100 ml. 0.9%NaCI bag add 4.0 ml. Rompun and 8.0 ml. Ketaset. Invert bag to mix. Hang bag onIV pole. Insert microdrip and tubing into bag and then remove plastic cover from

distal end of tubing. Place three or four strips of paper tape on the IV pole for1later use.

15. Place three or four paper towels on the countertop next to the sink and twopaper towels inside the sink. Place rabbit, belly up, on the countertop.

I

Page 418: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

16. Apply Artificial Tears to the rabbit's eyes to prevent painful drying.

17. Using a marker, number the rabbit by writing its identification number fromthe experimental protocol inside its ear

18. Use electric clippers to shave appropriate area of rabbit, usually abdomen andgroin. Push excess fur onto the Daper towels. Quickly remove paper towels andfur as soon as clipping is completed.

19. With non-electric razor, gently remove hair from the ears, particularly along theexternal vein. This vein will be used for the intravenous anesthetic.

20. Transfer the rabbit to the surgical site.

21. Wipe the external ear vein region with an alcohol prep. This should improvevisualization of the vein.

22. Remove JELCO catheter from its packaging. Insert catheter into the externalvein. Use needle to enter vein and then pull back on the needle so that thecatheter slides along the inside of the vein. Watch catheter slide inside the vein.Look for a backflow of blood into the top part of the catheter placement unit.Remove the needle completely when the catheter has been correctly positioned.

23. Attach the tubing from the IV bag to the top part of the catheter placementunit. "lest catheter placement by slowly opening the anesthetic flow regulator andwatching for anesthesia flow. Alternatively, open the saline regulator if one hasbeen piggy-backed, and watch its flow. When adequate placement is verified,carefully tape the tubing and the catheter placement unit to the rabbit's ear. Tapeexcess tubing to the table.

24. Adjust the anesthetic flow rate to 1 drop every 4 seconds. Watch the rabbit'schest rise and pupil size to monitor anesthesia. If rabbit begins to come out of theanesthesia, increase rate to I drop every 2 seconds for about 1 minute. Return to 1drop every 4 seconds, and wait until rabbit is sedated (1-2 minutes).

25. If rabbit is to be euthanized, inject 4.0 ml. of 1:1 diluted Beuthanasia into theseptum of the IV line. The bottle will indicate if it has already been diluted. If ithas not been diluted, mix equal parts of concentrated Beuthanasia and 0.9% NaCl,and inject this solution into the IV line. Do not inject concentrated Beuthanasiainto the IV line because it is very viscous, and therefore, it is difficult to force itout of the tubing and into the rabbit.

26. After rabbit has died, remove IV line and place rabbit remains into a largebrown plastic bag.

27. C*.efully wash instruments. Alconox or similar detergent should be used.Never ,-.ave instruments soaking in water. Rinse instruments and place them on atowel to dry.

I

Page 419: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

II

I RABBIT ANESTHESIA

I INITIAL INTRAMUSCULAR DOSE OF XYLAZINE GIVEN, FOLLOWED

10 MINUTES LATER BY AN INTRAMUSCULAR DOSE OF KETAMINE.

DOSAGE BASED ON WEIGHT OF RABBIT.

WEIGHT(LBS.) XYLAZINE 20 MG/ML KETAMINE 100 MG/MLML ML

4 0.5 0.72

I 4.25 0.53 0.77

I 4.5 0.56 0.81

4.75 0.59 0.86

I 5 0.63 0.9

5.25 0.66 0.95

5.5 0.69 0.99

I 5.75 0.72 1.04

6 0.75 1.08

6.25 0.78 1.13

6.5 0.81 1.17

6.75 0.84 1.22

7 0.88 1.26

INTRAOPERATIVE ANESTHESIA CONSISTS OF 4 MG KETAMINE +

2 MG XYLAZINE IN 50 ML DILUENT, INFUSED AT 1 DROP EVERY

I 4-6 SECONDS FOR A 6-8 LB. RABBIT.

III

Page 420: Towards Wound Closure Optimization: Final Report I ,= OTIC · N-FIN-1990 I AD-A230 971 Towards Wound Closure Optimization: Final Report I,= OTIC I Larry I. Sanders .JpdL 1," i LaserSurge,

Tissue Preparation for Weld Strength Optimization Study

1. Make a midline incision with a #15 scalpel.

2. Identify and isolate the small bowel.

3. Place an atraumatic clamp across the mesentery at the section to be resected.

4. Place a hemoclip at the site of the nearest vessles to occlude blood flow.

5. Resect a small segment of bowel measuring approximately 5 cm.

6. Return the remaining in situ bowel to the abdomen.

7. Make a longitudinal cut in the bowel segment, and open it up. Carefully rinsethe bowel segment in physiological saline to remove succus entericus.

8. Using the specialized cutters, cut two strips measuring 4.0 x 20.0 mm. Place thetwo strips into the clamps, making sure that the strips are aligned relative to themarks on the clamps.

9. Apply a barely visible amount of chromophore with a cotton-tipped applicator.The chromophore should be applied to both tissue strips.

10. Position the thermocouple between the two tissue strips.

1 11. Slowly bring the two tissue strips into apposition using the computer-controlledpiezoelectric motor.

I 12. Verify appropriate thermocouple placement (1 mm below surface of weld).

13. Set laser welding parameters in laser welding control program. Weld tissue.

14. Switch to the tensiometry data acquisition program. Pull tissue apart andmeasure the load required to rupture the weld.

1 15. Repeat steps 5-14 to prepare additional tissue strips.

U 16. Import data into Lotus or Symphony to generate load versus distance plots.

1

III

I