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4th International Conference
for IPT Practitioners
Innovations in Cancer Care
Chicago 2008
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Topical and SystemicTreatments of(people with)
Skin Cancer
Bradford S. Weeks, M.D.Corrective Medicine and Psychiatry
360-341-230 www.weeksmd.com
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"When an animal dies, it leaves
behind his skin.
When a man dies, all he leavesbehind is his reputation."
Korean Proverb
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Which box are you thinking outside of?
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"A physician once told me that nothing arouses so much
bitter enmity and heated arguments among his
colleagues, as the subject of cancer. This may be due tothe guilty recollections of cancer victims expiring who
might have been saved; or of the memories of patients
pronounced hopelessly ill who recovered under the
treatment of a 'quack,' or who miraculously livedwithout further treatment. Possibly these guilt reactions
and the remorse over exhausting the money of patients
and their relatives in futile cancer treatments, account
for some of these psychological manifestations whichare expressed in hostility and attack."
Nat Morris (written in 1958)
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Even Bill Gates took some risks in life
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"The universities do not teach all
things ... so a doctor must seek out
old wives, gypsies, sorcerers,
wandering tribes, old robbers, and
such outlaws and take lessons fromthem. A doctor must be a traveller.
Knowledge is experience."
Paracelsus
(1493-1541)
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Brief Pictorial Review
of
Human Skin Cancers
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Actinic keratoses may itch or burn.
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Squamous cell cancer effects
men more than women
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Bowens is the earliest form
of squamous cell cancer
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Basal Cell Cancer
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Melanomasoccur anywhere on body
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"ABCDE"
A stands for Asymmetry,B stands for Border,
C for Color,
D for DiameterE for Evolving
~
4 types of melanoma
3 in situ
1 invasive at start
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Antioxidant supplementation and risk of incident
melanomas: results of a large prospective cohort study.
Asgari MM
OBJECTIVE: To examine whether antioxidant supplement use is
associated with melanoma risk in light of recently published data
from the Supplementation in Vitamins and Mineral Antioxidants(SUVIMAX) study, which reported a 4-fold higher melanoma risk in
women randomized to receive a supplement with nutritionally
appropriate doses of antioxidants.
Conclusion: Antioxidants taken in nutritional doses
do not seem to increase melanoma risk.
Arch Dermatol. 2009 Aug;145(8):879-82.
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Centers for Disease Control and Prevention.Sunburn Prevalence Among AdultsUnited
States, 1999, 2003, and 2004.Morbidity and
Mortality Weekly Report2007; 56(21):524-528.
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Blacks are more than three times as
likely as whites to be diagnosed with
melanoma after it has reached a late
stage, and Hispanics are nearly twice
as likely, according to a University of
Miami study released Monday.
http://www.msnbc.msn.com/id/13441328
Bob Marleymalignant melanoma RIP
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Non-sunscreen photoprotection: antioxidants addvalue to a sunscreen.
Matsui MS, et al
Non-sunscreen protective strategies have been developed.
These include topically applied botanical extracts and other
antioxidants as well as topical DNA repair enzymes.
Standard terms of photoprotection such as sun protection
factor (SPF) do not accurately reflect the photoprotection
benefits of these materials.
J Investig Dermatol Symp Proc. 2009 Aug;14(1):56-9.
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Matsui%20MS%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstracthttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Matsui%20MS%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract8/3/2019 Topical and Systemic Treatments of (People With) Skin Cancer
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Tea extract containing polyphenols via ability to reduce
oxidative stress and inhibit NF-kB.
Botanical antioxidants and vitamins C and E to a broad-
spectrum sunscreen may further decrease UV-induced
damage compared with sunscreen alone.
Conclusion:
Non-sunscreen materials such as botanical extracts,
antioxidants, and DNA repair enzymes can contribute
value when applied topically to human skin in vivo.
J Investig Dermatol Symp Proc. 2009 Aug;14(1):56-9.
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Cancer is not the problem.
Cancer is an adaptive response
to the problem.
Toxic blood and tissue is the
ProblemEvery town has a garbage dump.
Solution: make less trash, recycle.
To avoid cancer: eat non-toxic foods and eat less!
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Removing the tumor is the least
important step in curing cancer.
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Whidbey Island mushroom - Cancer Metaphor
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Basal, squamous cell carcinomasand melanomas and their pre-
cancerous keratotic cousinsrepresent better than 50% of the
average dermatologists work.
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Insulin PotentiationTherapy
Hard on the cancer,
Easy on the patient.
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Threefold approach to treating(people with)
skin cancer
1) get rid of the tumor (least important)
2) take down the cancer welcome sign
3) enhance immune vitality
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Oxygen breathing may be a cheaper and safer alternative to
exogenous erythropoietin (EPO)
Recently discovered normobaric oxygen paradox demonstrates that
renal tissue can be stimulated to increase EPO production via a simple
pattern of oxygen breathing at normal atmospheric pressures. This
leads directly to the hypothesis that oxygen breathing may provide
chemotherapy patients with a convenient and inexpensive alternative to
ESAs. Stimulating endogenous EPO production eliminates the small
risk of immune system reaction associated with ESAs. Further, the
endogenous physiological EPO doses provided by this method may be
safer, in terms of cancer mortality, than the exogenous pharmacological
doses inherent in ESA administration.
Author: R. Burk Medical Hypothesis published on line 5/ 11/ 07
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Change Diet
Change LifestyleChange Level of Enjoyment
Change Beliefs and Attitude.
The Challenge:
People want to be cured with
their sins, not from their sins.
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SUN WORSHIP
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Mom smearing
sunscreen
to avoid.Sunburn
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Does sun exposure increase the
risk of skin cancer?
Poison is a matter of dosage.
Toxicity depends on degree of insult
(dose/time)
and degree of resistance
(nutrient status, immune enthusiasm)
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UVA vs. UVB
sunscreens vs. tanning salons
Goethes dying words:
Mehr Licht!
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Systemic Interventions
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The
Four Bodies
The
Violin Concert
http://../8/3/2019 Topical and Systemic Treatments of (People With) Skin Cancer
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Protective effect of pomegranate-derived
products on UVB-mediated damage inhuman reconstituted skin.
Afaq F, et al
Solar ultraviolet (UV) radiation, particularly its UVB
(290-320 nm) component, is the primary cause of
many adverse biological effects including
photoageing and skin cancer.
UVB radiation causes DNA damage, protein
oxidation and induces matrix metalloproteinases
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Pomegranate, from the tree Punica granatum,
contains anthocyanins and hydrolysable tanninsand possesses strong antioxidant and anti-tumor-
promoting properties.
Conclusion:
pomegranate-derived products may be useful
against UVB-induced damage to human skin.
Exp Dermatol. 2009 Jun;18(6):553-61. Epub 2009 Mar 6.
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5-Methyltetrahydrofolate can be photodegraded
by endogenous photosensitizers.
Free Radic Biol Med. 2009 Oct 15;47(8):1199-204.
Epub 2009 Aug 6.
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed&LinkReadableName=Related%20Articles&IdsFromResult=19647791&ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstracthttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed&LinkReadableName=Related%20Articles&IdsFromResult=19647791&ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract8/3/2019 Topical and Systemic Treatments of (People With) Skin Cancer
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Beta-carotene prevents ozone-
induced proinflammatorymarkers in murine skin.
Toxicol Ind Health. 2009 May-
Jun;25(4-5):241-7.
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed&LinkReadableName=Related%20Articles&IdsFromResult=19651793&ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstracthttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed&LinkReadableName=Related%20Articles&IdsFromResult=19651793&ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract8/3/2019 Topical and Systemic Treatments of (People With) Skin Cancer
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Prevention of the ultraviolet effects on clinical
and histopathological changes, as well as the
heat shock protein-70 expression in mouseskin by topical application of algal UV-
absorbing compounds.
(the red alga Porphyra rosengurttii)
De la Coba, F.
J Dermatol Sci. 2009 Sep;55(3):161-9. Epub
2009 Jul 7.
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Chemoprevention of human actinic keratoses by
topical DL-alpha-tocopherol.
Foote JA et al
Prior research shows that topical application of free,
nonfatty acid-conjugated vitamin E (DL-alpha-
tocopherol) prevents skin cancer in mice, as well as
immunosuppression induced by UVB radiation.
This study investigated the chemopreventivepotential of DL-alpha-tocopherol in humans through
monitoring surrogate end point biomarkers in sun-
damaged skin.
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Conclusion: DL-alpha-tocopherol-inducedreductions in polyamine metabolism are
consistent with the inhibition of skin
squamous cell carcinogenesis as seen in
previous human trials and animal models.
Cancer Prev Res (Phila Pa). 2009Apr;2(4):394-400. Epub 2009 Mar 31.
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A preponderance of evidence from the best
observational studies... has led to the conclusion that
public health action is needed.
Primary prevention of these cancers has been largely
neglected, but we now have proof that the incidence
of colon, breast and ovarian cancer can be reduced
dramatically by increasing the public's intake of
vitamin D."
Professor Cedric Garland the University of San Diego, California
after reviewing 63 recent studies on vitamin D and cancer.
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A daily dose of vitamin D3 could cut the
risk of cancers of the breast, colon and
ovary by up to a half, a 40-year review
of research has found.
The evidence for the protective effect of
the "sunshine vitamin" is so
overwhelming that urgent action must
be taken by public health authorities to
boost blood levels, say cancer specialists.
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Topical Interventions
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Cancerlytic Herbs-
a history of suppression
http://www.altcancer.com/lysis.htm
http://www.meditopia.org/index_ing.htm
Escharotic agents, Fred Mohs, and
Harry HoxseyJD. Elston J. AmericanAcademy of Dermatology, Vol 53, I 3, P 522-524
T i l A t
http://www.altcancer.com/lysis.htmhttp://www.meditopia.org/index_ing.htmhttp://www.meditopia.org/index_ing.htmhttp://www.altcancer.com/lysis.htm8/3/2019 Topical and Systemic Treatments of (People With) Skin Cancer
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Topical Agents
iodine (Lugols / SSKI)vitamin A, E, C
selenium
zinccesium
enzymes
raw honey
all can be potentiated with DMSO
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Escharotics (caustic compounds)- botanical ingredients
- metal salt, often a halogen metal (halide),
- potassium iodine
-"butter of antimony" (antimony trichloride)
Many dermatologists are aware that along with
zinc chloride, butter of antimony was one of theingredients in a number of early escharotics of
the 1900's. But its use goes back even to
Paracelsus in the 1500's --
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Curcumin, the yellow pigment found in
the spice turmeric and a key ingredient
in yellow curry inhibits melanoma cell
growth and stimulates tumor cell death
via apoptosis
potent antioxidant, anti-inflammatory
and cancer terminating effects
CANCER August 15, 2005
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Zinc chloride was one of just three
ingredients in the initial Mohs surgicalpaste that is now central to a standard
dermatological procedure approved
through the West. The three ingredientsthat Mohs used in his formula and
taught were: zinc chloride, bloodroot,
and stibnite (antimony sulfide, another
Paracelsus favorite)
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Standard of Care:
Mohs micrographic surgery is the
best procedure to preserve skin
tissue surrounding the cancer. Butit requires special training and
equipment, and it is time-
consuming and expensive.
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Harry S. Hoxsey's formula was almost
identical to Mohs. The difference?Mohs called the topical a "fixative," and he
artificially and unnecessarily inserted the
act of surgery as a necessary part of theprocess. Yet the AMA, FDA and other
pillars of orthodox medicine exerted
enormous effort to put Harry S. Hoxseyout of business
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Zinc chloride has no
capacity to discriminate
healthy from malignant
tissues. the healthy tissue
is definitely not impervious
to this product.
"Zinc chloride is made bypouring hydrochloric acid
over zinc. It is extremely
caustic and may damage
skin."
www.cancersalves.com/
Ingrid Naimen
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Dr. Jonathan Hartwell, one of the
founders of the National Cancer
Institute, spent most of his adult life
categorizing cancer herbs and
eschoterotics, leaving behind a reference
that would become a classic in the field
of phytopharmacology and ethnobotany.
Jonathan L. Hartwell, Plants Used Against Cancer,Quarterman Publications, Inc., Lawrence, Mass., 1982.
(Out of print).
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Bloodroot
ointment wasmade and used
by Indians of
the LakeSuperior region
to treat cancer,even uterine.
S i i d i
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Sanguinaria canadensis
The Doctrine of Signatures
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The Doctrine of Signatures
(bloodroot)
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THE LEG
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THE SHOULDER
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THE CHEST
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THE CHEEK
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THE BACK
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Temporary
fever
from a
hot shower
Hypotheramia
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HOMEOSTASIS
Hypotheramia
Hypoglycemia
Hypertheramia
Hyperglycemia
Gi th
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Give me the power
to create a feverand I will cure
all illnesses.
Parmenides (540-480 b.c.)
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Topical, localized Fever
duration ~ 24 hours
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Anti-Cancereffects of
topicalhoneybee venom
(BVT)
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Bee venom induces apoptosis and
inhibits expression ofcyclooxygenase-2 mRNA in human
lung cancer cell line NCI-H1299.
J Pharmacol Sci. 2003 Feb;91(2):95-104. Jang
MH,
Bee venom induces apoptosis andinhibits expression of cyclooxygenase-
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inhibits expression of cyclooxygenase
2 mRNA in human lung cancer cell
line NCI-H1299.
J Pharmacol Sci. 2003 Feb;91(2):95-104.
Jang MH, Shin MC, Seoul, Korea.
Cytotoxic properties of
http://www.ncbi.nlm.nih.gov.offcampus.lib.washington.edu/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Jang+MH%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov.offcampus.lib.washington.edu/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Shin+MC%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov.offcampus.lib.washington.edu/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Shin+MC%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov.offcampus.lib.washington.edu/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Jang+MH%22%5BAuthor%5D8/3/2019 Topical and Systemic Treatments of (People With) Skin Cancer
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immunoconjugates containingmelittin-like peptide 101 againstprostate cancer: in vitro and invivo studies.Russell PJ, Hewish D, Carter T et al.
The induced apoptosis of
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recombinant adenoviruscarrying melittin gene forhepatocellular carcinomacell.[Article in Chinese]Li B, Ling CQ, Zhang C Li SX
Inhibitory effect of
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.
recombinant adenoviruscarrying melittin gene onhepatocellular carcinoma.Ling CQ, Li B, Zhang CAnn Oncol. 2005 Jan;16(1):109-15
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[Effect of melittin onapoptosis and necrosis ofOsteosarcoma cells]Chen YQ, Zhu ZA, Zhang C
CONCLUSION: Melittin inhibits theproliferation of osterosarcoma cell linethrough up-regulating Fas expressionand inducing apoptsis.
Dear Dr. Weeks,
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Dear Dr. Weeks,
In our studies we successfully
destroyed prostate and breast cancer
tumors and metastases withmembrane disrupting peptides;
examples for these are naturally
occurring peptides like mellitin.
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These peptides destroy the outer
cell membrane and cause rapid
cell death in vitro and in vivo.
Carola Leuschner, PhD
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Anti Skin Cancereffects of
topicalhoneybee venom
(BVT)
Effect of honey bee venom on
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Effect of honey bee venom on
proliferation of K1735M2 mousemelanoma cells in-vitro and growth
of murine B16 melanomas in-vivo.
J Pharm Pharmacol. 2002
Aug;54(8):1083-9.
Liu X, China.
http://www.ncbi.nlm.nih.gov.offcampus.lib.washington.edu/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Liu+X%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov.offcampus.lib.washington.edu/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Liu+X%22%5BAuthor%5D8/3/2019 Topical and Systemic Treatments of (People With) Skin Cancer
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Bee venom has been reported to
exhibit antitumour activity in-vitro
and in-vivo.
Apoptosis, necrosis and lysis of
tumour cells were suggested as
possible mechanisms by which beevenom inhibited tumour growth.
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The in-vivo experimentindicated that bee venom
could be used as achemotherapeutic agent
against malignant tumors.
A matrix metalloproteinase 2
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cleavable melittin/avidin
conjugate specifically targets
tumor cells in vitro and in vivo.
Int J Oncol. 2003 Jan;22(1):93-8.
Holle L, Song W,
Melittin alone is extremely toxic
http://www.ncbi.nlm.nih.gov.offcampus.lib.washington.edu/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Holle+L%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov.offcampus.lib.washington.edu/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Song+W%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov.offcampus.lib.washington.edu/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Song+W%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov.offcampus.lib.washington.edu/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Holle+L%22%5BAuthor%5D8/3/2019 Topical and Systemic Treatments of (People With) Skin Cancer
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Melittin alone is extremely toxic
to cells and induces immediate celllysis, but becomes inactive when
coupled with avidin.
The incorporation of the MMP2
target sequence into the peptide
was used as a means for targetingtumor cells.
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Considerationof
Risks and Benefits
One of the Arts of Medicine
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SUMMARY
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SUMMARY:
The Standard of Care
is sub-therapeutic.
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"I die by the help oftoo many physicians."
Alexander the Greaton his deathbed, 323 B.C.
SUMMARY (cont.):
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Non-standard of Caretreatment modalities
both Topical and Systemic
exist and are well supported by
scientific literature
as well as clinical practice.
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"Caustics should be triedbefore knife or cautery."
Aulus Cornelius Celsus, the first centuryRoman physician and medical writer in his book
"De medicina," 1478
The Role of Hope
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The Role of Hopeand
The Role ofHaving a
Reason to Live
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Why we offer beyond the standard
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y y
of care therapies?
1) more effective treatment
2) more grateful patients
3) more personal and professional
satisfaction
Dear Dr Weeks
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Dear Dr. Weeks,
After my amazing treatments atyour wonderful clinic, I feel
so fantastic that I thinkI can walk on water.
But I know that you can!
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We all can walk on water.
It is only a matter of motivation.
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Welcome to Come and Visit Us in Seattle!WELCOME TO VISIT US IN SEATTLE !
THE END
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I thank my esteemed friends
and colleaguesfor your kind attention
andinvite any questions