TOPIC-9: METABOLISM OF LIPIDS - Centurion Universitycourseware.cutm.ac.in/.../2020/06/9-Metabolism-of-Lipid.pdf2020/06/09  · de novo Synthesis of Fatty Acids Glyoxylate Cycle β-Oxidation

TOPIC-9:METABOLISMOFLIPIDS

v Fatty acid synthesis starts with thecarboxylation of acetyl CoA to malonylCoA by acetyl CoA carboxylase, with theconsumption of ATP.

v In a subsequent reaction, CoA is exchangedfor acyl carrier protein (ACP). ACPcontains a serine residue to which apantetheine residue is linked via aphosphate group. Since the pantetheineresidue is also a functional constituent ofCoA, ACP can be regarded as a CoA, whichis covalently bound to a protein.

denovoSynthesisofFattyAcids

GlyoxylateCycle

β-OxidationofFattyAcids

…Stage 3β-oxidationproperinMitochondrialMatrix

β-OxidationofFattyAcids