5/3/2010 1 Page 1 Welcome to NEW “Chromatography Tips & Trick” India Seminar tour Low Thermal Mass and Capillary Flow Technology for Faster Cycle Times Abhijit Pal Marketing Program Manager , India Chemical Analysis Solution Life Sciences and Chemical Analysis Agilent Technologies , India Goa 4 th May , 2010 Group/Presentation Title Agilent Restricted Month ##, 200X Agenda Significantly Reduce Analysis Times: • Avoiding Bake-Out of Heavy Components Beyond Your Peaks of Interest • Rapid Heating and Cooling GC, GC/MS News … Using Agilent’s Technologies: “Backflush” via Capillary Flow Devices L ow T hermal M ass (LTM) System Both sold with new 7890 GC, GC/MS… but existing 7890/6890 systems can also be upgraded to utilize these “productivity” technologies Agilent’s Newest Technologies: • Blos bead for GC/NPD • Triple-axis detector for GC/MSD • Agilent 7010 GC/MS/MS
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5/3/2010
1
Page 1
Welcome toNEW “Chromatography Tips & Trick” India Seminar tour
Low Thermal Mass and Capillary Flow Technology for Faster Cycle Times
Abhijit PalMarketing Program Manager , India Chemical Analysis Solution
Life Sciences and Chemical Analysis Agilent Technologies , India
Goa 4 th May , 2010
Group/Presentation TitleAgilent Restricted
Month ##, 200X
AgendaSignificantly Reduce Analysis Times:
• Avoiding Bake-Out of HeavyComponents Beyond Your Peaks of Interest
• Rapid Heating and Cooling
GC, GC/MS News
… Using Agilent’s Technologies:
“Backflush” via Capillary Flow Devices
Low Thermal Mass (LTM) System
Both sold with new 7890 GC, GC/MS…but existing 7890/6890 systems canalso be upgraded to utilize these “productivity” technologies
Agilent’s Newest Technologies:
• Blos bead for GC/NPD
• Triple-axis detector for GC/MSD
• Agilent 7010 GC/MS/MS
5/3/2010
2
Defining Productivity
• More analyses per unit time . . .
– Faster and more efficient separations– Shorter analysis cycle time (time from injection to injection) – Reduced requirement for sample preparation
EnvironmentalNeed for high through-put, especially for low margin samples (eg. Total Petroleum Hydrocarbon (TPH)), where analytical cycle times are a critical element in making a profit
Hydrocarbon ProcessingCertain process control analyses (eg. Simulated Distillation) lend themselves to batch analysis. Shorter analytical cycle times get data back to operations faster, or allow more samples/shift
5/3/2010
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Group/Presentation TitleAgilent Restricted
Month ##, 200XAgilent Restricted
Developing Faster GC Run Times for TPH Analysis(C10�C44 Standard Shown)
2x Faster,7890
min5 10 15 20 25 30 35
pApApApA
020
40
60
80
100n-
C10
n-C
12
n-C
14
n-C
16
n-C
18
n-C
20
n-C
22n-
C23
n-C
24
n-C
26
n-C
28
n-C
30
n-C
32
n-C
36
n-C
40
n-C
44
min2 4 6 8 10 12 14 16 18 20
pApApApA
20
40
60
80
100
120
n-C
10
n-C
12
n-C
14
n-C
16
n-C
18
n-C
20
n-C
22n-
C23
n-C
24
n-C
26
n-C
28
n-C
30
n-C
32
n-C
36
n-C
40
n-C
44
min0.5 1 1.5 2 2.5 3
pApApApA
0
200
400
600
800
1000
n-C
10
n-C
12
n-C
14n-
C16
n-C
18
n-C
20n-
C22
n-C
23n-
C24
n-C
26n-
C28
n-C
30n-
C32
n-C
36
n-C
40 n-C
44
10oC/min30m Column - 7890
20oC/min15m Column - 7890
200oC/min5m Column –LTM/7890 10x Faster,
LTM/7890
StandardGC RunTime
Group/Presentation TitleAgilent Restricted
Month ##, 200X
LTM Also Greatly Reduces Cool-Down Times,� 9x Faster Heating/Cooling Cycle Times
Agilent Restricted
40 min + 5.4 min
20 min + 5.4 min
3 min + 2 min
GC Run Time Cool Down
9x Faster Cycle Time LTM/7890
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Group/Presentation TitleAgilent Restricted
Month ##, 200X
Soil Sample by TPH Analysis using LTM/7890Reliable Calculated Results, <3 minute run time
Agilent Restricted
Concentration*
Original Method (30 m) 1097 µg/mL
2X Method (15 m) 920 µg/mL
LTM Method (5 m) 909 µg/mL
*Calculated by Area Sum and Peak Grouping
Group/Presentation TitleAgilent Restricted
Month ##, 200X
pA
0
1000
2000
3000
4000
5000
6000
min0.25 0.5 0.75 1 1.25 1.5 1.75 2 2.25
C5
C6 C
7
C8 C 9
C10
C11
C12
C14
C15
C16
C17
C18
C20
C24
C28 C
32
C36
C40
pA
min0.25 0.5 0.75 1 1.25 1.5 1.75 20
500
1000
1500
2000
Fast Simulated Distillation Under 3 Minutes by Use of Low Thermal Mass (LTM) Technologies… 6x faster compared to conventional ASTM D2887 proc edure
ASTM D2887 Reference Oil
LTM Module : 45ºC to 350ºC at 150ºC/min
Calibration sample C5-C44
LTM Module : 45ºC to 350ºC at 150ºC/min
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Group/Presentation TitleAgilent Restricted
Month ##, 200X
LTM System Technology - Summary
• High efficiency temperature programmingfast heatingfast cooling (< 1 min in some configurations)high throughputfast method development
• High performance chromatographyutilize commercially available columns (up to 30m length)very good retention time repeatability