Structure of the mammalian heart
1. idea that there are four chambers ; 2. correct reference to
relative position of atria and ventricles ; 3. idea of left and
right sides separate / septum ; 4. reference to muscular nature of
walls ; 5. reference to cardiac muscle ; 6. idea of relative
thickness of ventricle (walls) ; 7. correct reference to position
of {atrioventricular valves / eq} ; 8. correct reference to
position of semilunar valves ; 9. reference to position of {tendons
/ tendinous cords / papillary muscles / eq} ; 10. correct reference
to position of {aorta / pulmonary artery} ; 11. correct reference
to position of {vena cava / pulmonary vein} ; 12. correct reference
to coronary arteries ; 13. reference to {SAN / Sino Atrial Node /
pacemaker/ AVN /Atrioventricular Node / Purkinje fibres /Purkyne
fibres / Bundle of His/eq } ;
Why many animals have a circulatory system
1. idea that {it overcomes limitations of diffusion / it is
involved in transport / heat transfer} ;
Animals need a heart and a circulatory system.
1. idea that the heart has to pump blood a long way around the
body of the animal ; 2. (therefore) blood needs to be (pumped) at
high pressure / eq; 3. blood vessels are needed to contain the
blood / reference to closed circulation / eq ; 4. idea of double
circulatory system ; 5. capillaries needed to ensure that all parts
of animal are close to blood supply/ eq ; 6. idea of need for a
circulation to {provide oxygen / remove carbon dioxide / other
correct named substance} ; 7. idea of {oxygen / glucose} needed as
{high metabolic rate / high rate of respiration; eq} 8. idea that a
circulatory system is needed to overcome limitations of diffusion /
eq ;9. reference to low surface area to volume ratio ; 10. idea
that circulatory system helps regulation of body temperature ;
Circulatory system and efficient gas exchange
1. idea that one side (of heart) transports blood to the lungs
other to the body ; 2. comment on blood pressures e.g. lower to
lungs, higher to body3. separation of oxygenated and deoxygenated
blood / eq ; 4. idea that moving blood helps to maintain a
concentration gradient ;5. idea that a { steep / eq } concentration
gradient gives a { fast / eq } rate of diffusion ;6. idea of {
network / lots / eq } of capillaries ;7. large surface area of
capillaries / eq ;8. idea that large surface area increases the
rate of diffusion ;9. idea that capillaries have very thin walls
;10. idea that diffusion is fastest over small distances ;11. idea
that no {organs / cells / tissues } are far away from blood /
capillaries cover alveoli / eq ;12. Reference to mass flow
generated by heart / supply of O2 to body cells maximised ; 13.
idea of need for a good supply of oxygen as (mammals are) {very
active / high rate of metabolism / warm blooded / eq} ;14. idea
that efficiency is related to double circulation ;
The heart requires oxygen and glucose to function
Oxygen supply to the cardiac muscle
1. Correct reference to the coronary circulation; 2. Via the
coronary artery; 3. From the aorta; 4. Reference to capillaries
(within) cardiac muscles; 5. Reference to {red blood cells /
haemoglobin} {carrying / releasing} oxygen;
Glucose and its purpose in the heart
1. Glucose is {a monosaccharide / soluble / doesnt need to be
digested} / eq; 2. Glucose can be quickly absorbed into the blood
stream; 3. Can pass into muscle (cells); 4. Can be used for
respiration; 5. To provide energy; 6. For (muscle) contraction;
Mammals have a heart and circulatory system whereas a single
cell organism (e.g. flatworm) does not.
1. Flatworm has a large surface area : volume ratio / converse;
2. Diffusion {sufficient / effective} for flatworms {needs / eq} /
converse;3. Mammal {has higher metabolic rate / is warm blooded /
eq} / converse;
Double circulatory system advantage to mammals1. Separation of
deoxygenated and oxygenated blood ; 2. (Therefore) better
{oxygenation of blood / oxygen supply to tissues} ; 3. Maintains
different pressure to lungs and rest of body / eq ; 4. Mammals have
a high (er) demand for oxygen ; 5. Idea of repressurisation ;
Double circulation is important in maintaining high pressure of
oxygenated blood in the arteries1. Reference to blood in the lungs
/ reference to oxygenation of blood; 2. Reference to {narrow /
extremely long} capillaries;3. Results in {low pressure / loss of
pressure} of blood (when it emerges from the lungs); 4. Not enough
pressure to get through rest of {capillary network / the body}; 5.
Pumping the blood again {raises / restores} lost pressure OR
provides extra boost of pressure / reference to second pump; 6.
Higher pressure in system
Advantages of human circulatory system over single
1. blood flows {faster /at higher pressure / eq} (to the body)
;2. blood flows {slower /at lower pressure / eq}to the lung ;3.
idea that this reduces risk of damage to lungs;4. correct ref to
more efficient {exchange /transport} of gases / eq ;
Mammalian heart is divided into a right side and a left side
1. idea that it keeps oxygenated and deoxygenated blood separate
; 2. idea that this results in as much oxygen as possible being
carried to the {tissues / cells } ; 3. reference to different
pressures in each side / need for different pressures explained
;
Insects do not need blood vessels to transport its blood around
the body (open circulatory system)
1. correct ref to large surface area to volume ratios ; 2. idea
that (all) {cells / eq} are very close to the {blood / heart} ; 3.
idea that diffusion is fast enough for exchange of {nutrients /
gases / waste} ; 4. idea of low metabolism ;5. idea that movement
of blood back into the heart is fast enough (to return blood back
into the heart) ;
Daphnias heart and gas exchange 1. Idea that blood carries
{oxygen / carbon dioxide} ; 2. Idea that blood moving maintains
concentration gradient ; 3. Reference to mass flow ; 4. Idea that
organs have large surface area to volume ratio
Closed circulatory system and open circulatory system
1. closed circulatory system = blood vessels2. to generate high
blood pressure3. open circulatory system = no blood vessels 4. all
cells are close to heart so diffusion is fast enough for exchange
of nutrients
Mass flow
1. mass transport of liquids
Cardiac cycle 1. sequence of events from one beat to the next
beat / eq; 2. reference to {contraction / systole} and {relaxation
/ diastole}; 3. correct detail of sequence e.g. atrial systole
ventricular systole diastole / approx 30% of time spent in systole
and 70% in diastole; 4. correct detail of electrical regulation of
cardiac cycle/eq;
Coronary circulation1. From aorta ; 2. Coronary artery ; 3.
Supplies {blood / oxygen / glucose / nutrients / named nutrient} to
heart {muscle / tissue / myocardium} / correct reference to removal
of {waste products / named waste product} by (cardiac vein)
coronary circulation ; 4. Returns to right atrium;
Atrial systole
1. Ventricles relaxed;2. Atria contract;3. Volume of chamber
decreases and pressure increases;4. (pressure) opens
atrioventricular valve; 5. Blood is pushed into ventricles;6.
Ventricular pressure / chamber volume increases; 7. as the
ventricles receive the ejected blood from the contracting
atria;
Ventricle systole
1. ventricle (muscle) contracts; 2. higher pressure in
ventricles relative to atria; 3. (pressure) closes atrioventricular
valve; 4. higher pressure in ventricles relative to the {aorta /
pulmonary artery / arteries}; 5. (pressure) opens the semilunar
valve; 6. blood forced into the {aorta / pulmonary artery /
arteries};
Ventricular diastole / Atrial diastole:
1. Ventricles and atria relax;2. Higher pressure in pulmonary
artery and aorta force SL valves shut to prevent backflow into
ventricles; 3. Blood returns to the heart and atria fill again;4.
due to higher pressure in the vena cava and pulmonary vein;5.
atrial pressure increases;6. ventricles continue to relax, so
pressure falls below the pressure of the atria;7. (so) AV valves
open;8. Blood flows passively (not pushed by atrial contraction)
into ventricles from the atria;9. Atrial contraction occurs and
process is repeated
Ventricles diastole and systole blood pressure
1. pressure increases as blood forced into ventricle during
atrial systole; 2. pressure increases during (initial) ventricular
systole/eq; 3. (due to) reducing volume of ventricle (causing
pressure increase); 4. pressure starts to decrease due to blood
into artery / loss of blood from ventricle; 5. decreases during
diastole / eq; 6. (due to) increasing volume (of chamber);
Difference in pressure between right ventricle and left
ventricle
1. Right ventricle pumps blood to lungs ; 2. Left ventricle
pumps blood all around the body ; 3. Correct reference to relative
thickness of ventricular walls ; 4. Correct reference to pressure
in relation to lungs / body / e.g. more pressure needed to pump
blood round body / converse OR less resistance to blood flow in
lungs / converse; 5. blood from (left ventricle) has to divide
between more capillaries / eq;
Difference in pressure between left ventricle and aorta1.
Reference to closure of semilunar valve ; 2. Elasticity / eq of
aorta wall ; 3. Recoil (in aorta) maintains pressure ;4. Reference
to refilling / relaxation of ventricle ;
Explanation When the ventricles relax/refill the semilunar valve
will close causing the pressure to drop The elasticity of the aorta
walls and recoil in the aorta will maintain the same pressure
throughoutLeft ventricle structure and valves aid in its
function
1. {Valves} close; 2. (To) prevent backflow (of blood); 3.
Reference to {contraction / systole} of ventricle; 4. Thick
(muscular) wall / more muscle; 5. Provides high {pressure / force /
eq}; 6. To pump blood through {systemic circulation / round body /
eq}; 7. Reference to elasticity of {aorta} (to accommodate blood
expelled from ventricle) / eq;
Roles of the atrioventricular (bicuspid and tricuspid) valves
during the cardiac cycle
1. valves {separate / eq} atria from ventricles ; 2. open during
atrial {systole / contraction } / eq ; 3. so that blood can pass
through to ventricles / eq ; 4. closed during ventricular {systole
/ contraction} eq ; 5. to prevent {blood being forced back /
backflow / eq} (up into atria) / to maintain pressure in ventricles
; 6. open during diastole / eq ; 7. so that ventricles can start to
fill up (as atria are filling) ;
Role and location of Semilunar valve
1. {base / eq} (of aorta) ; 2. prevents backflow (of blood into
heart / ventricles) / eq ; 3. during { diastole / atrial systole }
/ eq ;
Importance of valves in preventing wrong directional flow of
blood
1. Valves only open one way;2. Dependant on the relative
pressure of the heart chambers;3. if pressure > behind valve,
its forced open;4. once bloods flown through the valve, pressure is
greater in the front of the valve;5. (which) forces it shut,
preventing blood from flowing back into the chamber/backflow
A. Artery B. VeinC. Capillary Artery
Tunica media or middle coat containssmooth muscle fibrescollagen
Elastic fibres.
Adaptation structure
1. thick {wall / layer} of (smooth) muscle / thick elastic
{layer / wall}; allows artery to expand (elastic recoil) /
withstand pressure from the pulse of blood / eq; 2. collagen
(fibres); Provide {strength / support } / prevents bursting ; Idea
that they enable artery to withstand high blood pressure / eq ;3.
smooth lining; prevent resistance to blood flow / eq; 4. small
lumen / eq; to maintain high pressure / eq;
Structure of arteries relating to function
1. Muscular walls;2. Contain elastic tissue;3. Endothelium/inner
lining is folded and can expand;4. These features enable effective
control and regulation of high blood pressure
Aorta, major artery has elastic fibres
1. {middle layer of wall of vessel / eq } / tunica media / in
the muscle layer ; 2. reference to allows { stretching / recoil /
description} ; 3. to prevent damage (of the aorta) / eq / {to
maintain the pressure of the blood / eq } ;
Advantages of coronary artery branching from aorta
1. Blood at high pressure; 2. High concentration of oxygen / eq;
3. High concentration of glucose / eq;
Consequences of narrow lumen in artery
1. narrowing leads to higher blood pressure; 2. increases risk
of {further damage to the artery wall/ aneurysm} 3. platelets stick
to damaged wall; 4. correct reference to mast / foam cells /
inflammatory response;5. triggers blood clotting process / eq;
Vein
Describe how blood is moved through veins
1. (skeletal) muscle contracts / eq; 2. squeezes vein / named
vein; 3. blood forced in both directions (away from squeezed area)
/ eq; 4. (one way) valves present (in veins); 5. one way flow /
prevent backflow / eq; 6. reference to role of thorax e.g. pressure
changes during inspiration / expiration / breathing; 7. lower
pressure in {heart / atria} during {diastole / eq};
Capillary
Adaptation1. {squamous / pavement / flattened /thin / eq } cell
/ endothelium; 2. Wall (only) one cell thick; 3. small lumen
present /(capillary) small diameter; 4. pores present / gaps
present / eq;
Function Force fluid out to form tissue fluid at arterial end1.
High {hydrostatic / blood} pressure; 2. Which is higher than
{solute potential gradient / eq} / correct osmotic effect
described; 3. (Plasma forced out) through {pores / gaps} in
capillary wall; 4. The fluid is forced out of the capillary into
the intercellular space;
Function of tissue fluid1. For transport / eq of, solutes/
nutrients / molecules, to / from, cells / tissues ; 2. Movement of
waste products
Accumulation of tissue fluid and swelling 1. Blocked lymph
vessels / high blood pressure / {low solute potential / high water
potential} in blood / loss of plasma proteins / damage to tissue /
histamine / eq;
What is this swelling called?1. Oedema
Factors that could cause oedema1. Increased blood pressure /
hydrostatic pressure / hypertension / increased capillary
permeability / decrease in plasma protein / colloidal osmotic
pressure / protein / amino acid deficient diet / blocked lymphatic
vessels / faulty valves in lymphatic vessels ;
NOTE:1. proteins are large (molecules); 2. cannot pass through
capillary wall / eq;
Structural differences between arteries and veins
Insects not needing blood vessels
1. Larger surface area to volume ratio;2. Diffusion efficient;3.
(because) cells are very close to blood/heart;4. idea of low
metabolism ;5. idea that movement of blood back into the heart is
fast enough (to return blood back into the heart) ;
Why is Daphnia a suitable organism?
1. Heart is visible / transparent organism / reference to
ethical issues / eq;Daphnia needs a heart and circulatory
system
1. Very active / high metabolic rate; 2. Supplies oxygen /
removes CO2; 3. Slow diffusion 4. Low SA/V ratio / eq;
Sequence of blood clot1. platelets stick to damaged wall of
artery / eq; 2. thromboplastin released (from damaged
tissue/platelets); 3. correct reference to Ca2+ / Vit. K; 4.
prothrombin (plasma protein) converted to thrombin (enzyme); 5.
fibrinogen (soluble plasma protein) converted to fibrin (insoluble
strands of protein); 6. fibrin mesh traps blood cells forming a
clot;
Blood clot and coronary artery1. Lack of blood to {cardiac /
heart} muscle; 2. So lack of {oxygen / glucose} / ischaemic /
anaerobic / eq; 3. Muscle stops working / damaged / cells die; 4.
Pain / angina / lactic acid build up; 5. insufficient energy
release for contraction/ damage to heart muscle/Myocardial
infarction / heart attack;
Explained: Blood contains oxygen/glucose which is required for
the muscles to stay functioning. A blood clot, at the coronary
artery, stops the flow of blood to the heart. This causes the
muscle to stop working/die which leads to lactic acid build up
(from anaerobic respiration) and eventually a heart attack.Blood
clot and stroke1. idea of {reduced blood flow / bleeding} ; 2.
{less/no} {oxygen /glucose} (reaches brain) ; 3. idea of {less/no}
(aerobic) respiration ; 4. idea of {less / no} ATP produced ; 5.
idea that brain needs lots of {energy / ATP} to function ; 6.
lactic acid produced (from anaerobic respiration); 7. lactic acid
{inhibits enzymes / toxic / eq };
Atherosclerosis/Atheroma
1. damage to {endothelial cells / epithelial cells /cells lining
artery (wall)} ; 2. reference to inflammatory response ; 3.
reference to (accumulation of) white blood cells in (damaged area)
; 4. {build up / eq} of cholesterol (in damaged area) ; 5.
reference to build up of {calcium salts / fibrous tissue / fibrin /
platelets} ; 6. reference to formation of {atheroma / plaque} ; 7.
reference to {loss of elasticity (of artery) / narrowing of lumen}
/ eq ;
Thrombosis
1. (Blocks) coronary artery / artery supplying heart muscle /
tissue / cells; 2. Reduces blood supply3. Reduces oxygen / glucose
supply (to heart muscle / tissues / cells); 4. less oxygen;
anaerobic respiration; 5. build up of {lactic acid / lactate}
(causes pain);
Factors making atherosclerosis develop CHD1. narrowing of the
arteries ; 2. thrombosis / blood clot ;Arteries and atherosclerosis
1. Higher (blood) pressure / more chance of damage to
endothelium;Plaque1. Consists of fatty deposits2. Plaque forms due
to damage to the endothelial cells
Factors effecting CVD1. gender 2. smoking 3. genes / inheritance
/ eq4. stress 5. high LDL level / LDL to HDL ratio / high blood
cholesterol 6. reference to inappropriate diet such as high {salt /
fat / cholesterol / calorie} intake / eq7. high alcohol intake 8.
obesity 9. lack of exercise / eq Dietary factors that increase
CHD1) high {salt / sodium} 2) high cholesterol 3) high saturated
fat / high trans-fat 4) high calories 5) high alcohol 6) low fibre
/ low NSP 7) low antioxidants / low vitamin C / low vitamin E ;
High Blood Cholesterol High Blood PressureSmoking
1. Fatty deposition in artery walls / plaque formation;2.
Atheroma formed; 3. Increased blood pressure; 4. Lumen of
(coronary) arteries narrowed / reduced elasticity of artery wall /
eq; 5. Correct reference to LDLs;1. Damage to (lining of) arteries;
2. Risk of aneurysm / damaged lining (of arteries) rupturing; 3.
Increased risk of blood clot blocking coronary arteries; 4. Correct
reference to inflammatory response;1. Increases blood pressure; 2.
Increases risk of aneurysm; 3. Less antioxidants / more free
radicals; 4. Increases {number / activation} of platelets; 5.
(Leading to) increased risk of blood clot blocking coronary
arteries;
Age 1. older increases risk, {arteries {become less elastic /
more easily damaged / blood pressure increases} with (increase in)
age ; Gender 1. {women less likely to develop CVD than men /
oestrogen offers some protection to women against CVD } (pre
menopause) / eq ;
HDLS
1. Mainly protein;2. Activate more cholesterol receptors on the
liver, so more is brought in (where cholesterol is recycled);3.
Reduces total blood cholesterol when level is too high4. Opposite
for LDLs - with LDLs being mostly lipid
Diet and CHD1. High intake of {saturated fat / animal fat /
example of fat / cholesterol}; 2. Atherosclerosis / description of
deposition inside arteries; (smaller lumen/damaged arteries)3.
(Which leads to) reduced {blood flow / oxygen / eq) to heart muscle
/ increased blood pressure (in coronary circulation) / reference to
thrombosis; 4. High {salt / Na+} intake; 5. High blood pressure /
hypertension; 6. (Which leads to increased) {risk / eq} of {heart
attack / heart failure / myocardial infarction};
High fat diet and inactivity
1. idea of energy imbalance ;2. idea of individual becoming
{overweight /obese / eq } ;3. idea of increased blood pressure ;4.
idea of obesity leads to diabetes (a CVD risk factor) ;5. idea of
increased (blood) {cholesterol / LDL levels / LDL to HDL ratio} ;6.
idea of {damage to endothelium / overloading of receptors} ;7.
formation of { atheroma / plaque / atherosclerosis } / eq ;8. idea
of {loss of elasticity of artery / narrowing of lumen / eq } ; (NOT
NARROWING OF ARTERIES)
Genetic - inheriting a greater risk of developing cardiovascular
disease.
1. has gene(s) which increase chance of developing CVD / eq; 2.
named example of gene (e.g. SRY, APOE4, AZE, MTHFR); 3. genes do
not necessarily mean you will develop the disease /eq; 4. {other
risk factor / named risk factor}also contributes to chance of
developing CHD;
Obesity and coronary heart1. Higher cholesterol levels; 2. Fatty
deposits in arteries / atheroma / plaques / reference to
atherosclerosis; 3. Higher blood pressure; 4. Risk of damage to
(coronary) arteries; 5. Risk of blood clot blocking coronary
artery6. Risk of type II diabetes;
Alternative mark scheme - Smoking on increasing risk of CVD
1. Carbon monoxide;2. Joins with haemoglobin to form
carboxyhaemoglobin;3. Reduces amount of oxygen transported;4.
Reduces oxygen available to tissues;5. {Heart muscle / tissues /
cells} unable to respire;
6. Less antioxidants / more free radicals; 7. Antioxidants
protect cells from damage;8. (so) the artery walls are more likely
to become damaged;9. Increases {number / activation} of
platelets;
10. Nicotine;11. Increases stickiness of platelets;
12. (Leading to) increased risk of blood clot blocking coronary
arteries;13. (leading to) atheroma formation14. Increases blood
pressure; 15. Increases risk of aneurysm; Allow description of
atheromas for two for marks MAX.
Suggest how ACE inhibitor could prevent the conversion of
angiotensin I to angiotensin II.Angiotensin II causes blood vessels
to constrict.
1. inhibits the enzyme (that catalyses the conversion); 2. by
active site-directed inhibition / eq; 3. inhibitor {is a similar
shape to the substrate } / blocks active site; 4. by non active
site-directed inhibition; 5. inhibitor attaches to enzyme at point
other than active site / eq; 6. (and) causes active site to change
shape;
Drugs in treating CVD
ANTIHYPERSENITIVES:1. Reduces blood pressure;2. Decreases risk
of {atheromas / blood clots} forming;3. Diuretics;4. Increases
urine production so decreases amount of blood5. Beta-blockers;6.
Reduces strength of heart beat; 7. Vasodilators;8. Widens blood
vessels; BENEFITS: Work in different ways so can be given in
combination; Blood pressure can be monitored, so efficiency can be
checked; RISKS: Palpitations / Fainting / Headaches / Drowsiness /
Allergic reaction
PLANT STATINS:1. Stanols / Sterols;2. Reduce blood
cholesterol;3. Reduces amount absorbed by the gut; BENEFITS:
Reduces risk of CVD; RISKS: Reduces risk of absorption of
vitamins;
ANTICOAGULANTS:1. Reduces blood clotting;2. Artery walls less
likely to get damaged; BENEFITS: Treat people with CVD / blood
clots; No new ones can form; RISKS: Excessive blooding occurs when
injured; Fainting / allergic reactions / osteoporosis;
PLATELET INHIBITORY DRUGS:1. Prevents platelets from clumping;2.
Reduces chances of blood clotting;3. Reduces chance of blood
vessels being blocked; BENEFITS: Treat those with blood clots /
CVD; RISKS: Rashes / nausea / liver function problems / constant
bleeding
Cholesterol in our bodies ensures that we stay healthy1. Cell
membrane structure2. (steroid) hormone production 3. Bile salt
production4. Vitamin D production in the skin;LDL and heart
disease1. High (LDL) cholesterol in blood circulation; 2. Increases
the likelihood of {deposits / plaques / atheroma} on arterial wall;
3. Narrows arteries / blocks arteries / restricts blood flow; 4.
Hardens arteries / makes arteries less elastic; 5. Reference to
atherosclerosis; 6. Increases risk of {CHD / blood clots / angina /
heart attack / eq};
Low cholesterol diet may not lower blood cholesterol level1.
cholesterol synthesized by the body; 2. further detail e.g. made in
liver / cholesterol made from saturated fats; 3. genetic factors;
4. further detail e.g. hypercholesterolaemia / number of LDL
receptors;
Risk factor 1. Anything that {affects / raises} the chance of
harm / eq;
Reduce the development of heart disease 1. {people more aware of
the dangers / better health education} / appropriate named example
/eq ; 2. less stress /eq ; 3. {better / more} screening / eq ; 4.
better treatments / eq ; 5. more exercise being taken / eq ; 6.
changed diet / less obesity / eq ; 7. less alcohol intake / eq ; 8.
decrease in smoking ; 9. change in population genetics / eq
Alveoli and gas exchange1. Alveoli or capillary walls /
epithelium / lining are thin / short distance between alveoli and
blood; 2. Many alveoli / alveoli walls folded provide a large
surface area; 3. Many capillaries provide a large surface area; 4.
ref. to increased diffusion / decreased diffusion distance / eq; 5.
Of {respiratory gases / oxygen / carbon dioxide}; 6. {transport of
(respiratory) gases (ventilation) / movement of blood
(circulation)} maintains diffusion gradient;7. (So) fast
diffusion;
Structure of lungs and gaseous exchange 1. alveoli one cell
thick / thin (epithelium) ; 2. {walls / endothelium } of
capillaries { one cell thick / thin} ; 3. Alveoli covered with
capillaries / eq ; 4. idea of short (diffusion) distance ; 5.
reference to diffusion ; 6. idea of large surface area provided by
{alveoli / capillaries} ; 7. idea that concentration gradient
maintained by {ventilation / breathing /eq } ; 8. ref. to large
numbers of red blood cells OR idea that oxygen combines with
haemoglobin ; 9. idea that concentration gradient maintained by
blood flow ; 10. {reference to / description of} Ficks Law ;
Diffusion rate is proportional to the surface area
How humans achieve efficient gas exchange
1. One cell thick/thin (not thin membrane)/flattened cells for
faster diffusion/shorter diffusion pathway; 2. Large surface area
for faster diffusion; 3. Ventilation to maintain a
diffusion/concentration gradient;
Single cell organism gas exchange (lives in water)1. (gas
exchange) occurs through the {cell membrane / phospholipid bilayer}
; 2. idea that the membrane is thin ; 3. oxygen enters cell (from
water) / eq ; 4. carbon dioxide leaves cell (into water) / eq ; 5.
{O2 / oxygen / CO2 / carbon dioxide} are {small / non-polar}
(molecules) ; 6. reference to diffusion ; 7. {reference to /
description} (suitable) concentration gradient ; 8. reference to
large surface area (to volume ratio) ;
Structure of a triglyceride 1. made of C, H, O; 2. glycerol /
propan (1, 2, 3) triol; 3. three fatty acids; 4. correct location
of ester {bond / link};
Formation & Breaking of triglycerides
1. Made from single glycerol molecule;2. 3 molecules of fatty
acids;3. Ester bonds form between the fatty acid & glycerol;4.
Water molecule produced for each fatty acid;5. Broken up by
hydrolysis ;6. Water molecule added;7. To break up each ester
bond;
Products of the hydrolysis of triglycerides
1. Fatty acids;2. Glycerol;
The type of fatty acid
1. (mono)unsaturated;
Difference between saturated and unsaturated lipids
1. Unsaturated contain one or more (C=C) double bonds / eq;
How the physical properties of triglyceride is affected by a
double bond1. Softer / more likely to be liquid / less densely
packed molecules / eq;2. unsaturated / eq are {liquid at room
temperature / lower melting point} whilst saturated / eq solid at
room temperature;
Saturated lipidsUnsaturated lipids
Found in animal fatsFound in plants
Single bonds in hydrocarbon tailsSome double bonds (which causes
a kink in the chain)
Melt at higher temperaturesMelt at lower temperatures
Function of lipids in mammals FunctionDetail
Energy stores;{More than / twice as much as) carbohydrate OR
Insoluble / compact / minimise mass OR Subcutaneous / adipose /
blubber;
Protection / mechanical insulation;Around {organs / named organ}
OR Reference to adipose tissue OR Ear wax giving protection against
infection;
Waterproofing;Of skin / fur / feathers / insect cuticle / ear
wax OR Hydrophobic / insoluble / repels water;
Electrical insulation;Reference to myelin sheath / nerve cells /
neurones / axons / dendrons OR Non-polar;
Heat insulation;Subcutaneous / adipose / blubber OR Prevents
heat loss from body;
Buoyancy;Less dense than {water / muscle};
Making beeswax;Formation of honeycomb;
Membrane fluidity;Reference to cholesterol;
Cell membrane structure;Reference to phospholipids;
Reference to hormones;As steroids;
Source of metabolic water;Reference to respiration OR Desert
adaptation
Saccharides
1. Monosaccharaides one sugar molecule2. Disaccharides two sugar
molecules joined by condensation3. Polysaccharides many sugar
molecules joined by condensation
Role of starch 1. store energy in plants
Structure and function of starch
1. Contains amylose and amylopectin;
2. Amylose (not a mark) :3. Long and unbranched chains;4. 1-4
glycosidic bonds;5. coiled structure;6. (so) compact;7. (so) can
fit more in a small space;
8. Amylopectin (not a mark) :9. (long), branched chains;10.
(has) 1-4 and 1-6 glycosidic bonds;11. side branches which can be
broken down quickly;12. Insoluble;13. so water doesnt cause it
swell via osmosis
Structure and function of Glycogen
1. Amylopectin;2. 1-4 and 1-6 glycosidic bonds;3. many/lots of
side branches;4. (so) glucose can be released quickly;5.
Insoluble;6. (so) doesnt swell by osmosis;7. Large molecule so can
store lots of energy
Structural difference between starch and glycogen1. glycogen has
side branches only / more side branches; 2. starch composed of two
components / amylose and amylopectin;
Glycogen is used as a storage molecule1. Compact / eq; 2.
{Polymer / eq} of glucose; 3. Can be (easily) hydrolysed / can be
broken down to release energy; 4. Insoluble / does not affect
osmosis / eq; 5. Will not diffuse out of cells / will remain in
cells;
Starch and glycogen are both storage molecules in cells.1.
compact therefore large numbers of molecules can fit in a small
space / eq 2. insoluble therefore osmotically inactive / eq 3.
large molecule therefore remains within cells / cannot pass through
membranes / contains a lot of energy 4. easily hydrolysed when
required for energy /eq
Give an account of the structure and functions of lipids,
including triglycerides and phospholipids.Contain carbon, hydrogen
and oxygen ; Insoluble (in water) / hydrophobic ;Triglycerides
consist of glycerol plus three fatty acids ; Joined by condensation
reactions / formation of ester bonds ; Correct reference to
saturated and unsaturated fatty acids ; Phospholipids consist of
glycerol plus two fatty acids and a phosphate group ; Reference to
non-polar/hydrophobic tails/fatty acids and polar/hydrophilic
heads/phosphates of phospholipids ; Correct orientation of
phospholipids, in cell membrane / phospholipids bilayer ; Role of
phospholipids in cell membrane (fluidity/permeability etc) / role
of surfactants ;Energy stores ; Reference to energy from fats /
oils, compared with carbohydrates ; (mechanical) protection /
packing qualified ;Insulation qualified (either electrical or
thermal) ; Buoyancy ; Qualified reference to waterproofing /
protection against entry of pathogens in plants ;
Water is an effective molecule for transporting other molecules
around living organisms1. idea that water is a solvent ;2. idea
that water is {slightly charged / dipole /polar / eq} ;3. idea that
{polar molecules / ions / eq} can dissolve in water ;4. idea that
water is {viscous / fluid / eq} ;5. idea of water as a liquid
assists mass flow6. correct reference to cohesion / adhesion ;
Water molecules are dipolar 1. Charge is not equally distributed
throughout molecule / one part is positive and the other part is
negative};2. Hydrogen (atoms) have (slight) positive charges; 3.
Oxygen (atom) has a (slight) negative charge ;
High heat capacity of water for organisms in water
1. Idea that a lot of {energy / heat} is needed to change
temperature ;2. Temperature of their {environment / habitat} does
not {fluctuate / change} much / reference to {thermostable /
thermobuffer}; 3. Reference to effect on metabolic {rate /
reactions};
Causation:
when a change in one variable is responsible for a change in
another variable / eq ; Correlation:
(relationship between two variables such that) a change in one
of the variables is reflected by a change in the other variable /
eq ;
M.H