Time after induction (h) Blood propofol concentration (g/m PBPK model Integrative model 0 1 2 3 4 5 6 7 0 2 4 6 8 10
Time after induction (h)
Blo
od
pro
po
fol c
on
cen
trat
ion
(g
/ml)
PBPK model
Integrative model
0
1
2
3
4
5
6
7
0 2 4 6 8 10