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TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital
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TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

Dec 29, 2015

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Page 1: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

TILDA and the HRB

Professor Rose Anne Kenny

Trinity College Mercers Institute St James Hospital

Page 2: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

The Irish LongituDinal study on Ageing

TILDA

Page 3: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

Trinity College Dublin, The University of Dublin

Trinity EngAGE Centre for Research in Ageing

International Impact (2009-2013)

• Geriatrics & Gerontology: % of Papers in Top 1% - InternationalSource/s: InCites/Web of Science/Scopus

Page 4: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

Trinity College Dublin, The University of Dublin

InnoLife Consortium- Health and Ageing European Institute of Technology KIC

EIT Budget €2.7B (2015-2020)

TCDImperialOxfordCambridgeNewcastleKarlinski

Page 5: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

ResearchPolicy

Practice

www.tilda.iewww.tilda.ie

Page 6: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

New knowledgePopulation research

Clinical trialsPolicy needsPolicy impact

Training

www.tilda.iewww.tilda.ie

Page 7: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

8,504Participants

50+

www.tilda.iewww.tilda.ie

Page 8: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

Every 2 years

For 10 years

2010, 2012, 2014, 2016.....www.tilda.iewww.tilda.ie

Page 9: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

Creating Infrastructure

Biobanking,

Population sample,

Multidisciplinary- HUB

Training Education –community

Soft ware

2010, 2012, 2014, 2016. refresh.... www.tilda.iewww.tilda.ie

Page 10: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

Health Wealth

Happiness

www.tilda.iewww.tilda.ie

Page 11: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

GenesGenesGenesGenes

NutritionNutritionNutritionNutrition

Family Family networksnetworksFamily Family

networksnetworks

Social Social participationparticipation

Social Social participationparticipation

EducationEducationEducationEducation

Household Household StructureStructure

Household Household StructureStructure

Marital Marital StatusStatus

Marital Marital StatusStatus

Work &Work &RetirementRetirement

Work &Work &RetirementRetirement

Income Income & assets& assetsIncome Income & assets& assets

HealthHealthHealthHealth

Experience Experience of Ageingof Ageing

Experience Experience of Ageingof Ageing

Mental Mental healthhealth

Mental Mental healthhealth

www.tilda.iewww.tilda.ie

Page 12: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

TILDA Data

Wave 1 Wave 2

Health 2593 2757

Social 898 1725

Economic 867 978

Page 13: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

2014•HRA: Inequalities in Access to GP Care in Ireland: An Analysis using Longitudinal Data €329,988 (€150,424 to TILDA) •HRA: Hypotension, vasoreactivity and white matter intensities in the ageing brain: The Irish Longitudinal Study on Ageing (TILDA) - €330,000•HPF Research Training Fellowships for Healthcare Professionals (2014) - €244,206

2013•HRA: Targeted actions to identify novel inflammatory and immunological factors associated with predisposition to AMD in the TILDA population cohort (2013) [Overall budget  €329,987]

2012•HRB ICE: Interdisciplinary Capacity Enhancement (ICE) Awards 2012- Effecting change in cardiovascular health in older Irish Adults (2012) - €589,327•HRA: Project SADD: Socioeconomic position, anxiety, depression and diabetes in the ageing population in Ireland (2012)- €331,000

2011•HRB ICE: Interdisciplinary Capacity Enhancement (ICE) Awards 2011-  Building research and implementation capacity in the Irish Longitudinal Study on Ageing (TILDA): health inequalities, mental health and opportunities to influence health and social care policies - €794,681• HRA: Frailty and Cognitive impairment in the older population (2011) - €297,750

Page 14: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.
Page 15: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

HRB PhD Scholars programme

6 Ph.D. Scholars (2008-2010)

15 Ph.D. Scholars 2010-

TILDA Core – 10 Ph.D 2009- 2013 4 Ph.D. present

Page 16: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.
Page 17: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

The Active Stand

Page 18: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

Heart Rate Recovery and Mortality6

78

910

11

12

13

14

HR

Diffe

ren

ce fro

m B

ase

line

(B

PM

)

10 20 30 40 50 60 70 80 90 100 110

Recovery Time (secs)

Alive (4yr follow-up) Deceased (4yr follow-up)

Page 19: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

Slow Heart Rate Recovery and Mortality

Page 20: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

(Finucane C et al Circulation 2015)

Orthostatic cardiovascular responses to standing

SBP DBP

Page 21: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.
Page 22: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

Poorer People Have A Higher Resting Heart Rate

Page 23: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

Social Networks are Beneficial for Health

J Geront Series B 2014

Page 24: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

Hypertension prevalence over 50 years (TILDA wave 1)

.

Awareness in hypertensives

Blood pressure controlled to SBP<140 mmHg and DBP<90mmHg

52%52%Treatment in hypertensives BP control in the treated

On antihypertensive medication (ATC codes CO2, CO3, CO7, CO8, CO9)

59%59%

Awareness defined as a self-report of ever having a doctor’s diagnosis of hypertension

55%55%

64% 64% of those aged 50yrs and older were hypertensive

Page 25: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

Statin use in groups at high risk of CVD (50-64 years, W1)

Statin use for secondary prevention (those with existing CVD) is lower than expected given the strength of evidence for the use of statins in this group

– known CVD 68.8% using statins– multiple CVD events 78.6% using statins

.

Page 26: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

Statin use in groups at high risk of CVD (50-64 years, W1)

Statin use for secondary prevention (those with existing CVD) is lower than expected given the strength of evidence for the use of statins in this group

– known CVD 68.8% using statins– multiple CVD events 78.6% using statins

Statin use for primary prevention in those at high risk of CVD is also low

– Known diabetics 57.4% using statins– High or very high absolute risk group 19.0% using statins

.

Page 27: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

Childhood Adversity Increases Risk of Psychiatric Disorders in Later Life

Page 28: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

Risk of Disease Increases as the Number of Adverse Childhood Events Increases

Page 29: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.

Project SADD: Socioeconomic position, anxiety, depression and diabetes in the ageing population

−Diabetes affects 8.3% of adults aged 50+ in Ireland, rising to 12% in those aged 75+

−primary level or no education are 60% more likely to have diagnosed diabetes

−Cross-sectionally, diabetes is not independently associated with depression or anxiety

−those with diagnosed diabetes at Wave 1 reported a Major Depressive Disorder (11.9% vs. 7.4%) or Generalized Anxiety Disorder (12.8% vs. 7.5%) after a two year follow-up

Page 30: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.
Page 31: TILDA and the HRB Professor Rose Anne Kenny Trinity College Mercers Institute St James Hospital.