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Thyroid hormone prevents cognitive deficit in a mouse model of
Alzheimer's diseaseIntroductionMaterials and
methodsMaterialsAnimals and housing conditionsAD model mouse and
L-T4 treatmentWater maze testBiochemistry assayImmunofluorescence
stainingTUNEL stainingStatistical analysis
ResultsPreparation of AD model miceL-T4 improved learning and
memory ability in AD model miceL-T4 increased the ChAT activity and
ACh level of AD model miceL-T4 inhibited the damage of free
radicalsL-T4 elevated ATP content in the cortex and hippocampus of
AD model miceThe anti-apoptotic effects of L-T4
DiscussionL-T4 improved the neurological behavior of an induced
AD mouse modelL-T4 enhanced cholinergic function in AD model
miceL-T4 prevented the brain against the damage of free
radicalsL-T4 restored ATP content in AD model miceL-T4 inhibited
neuronal apoptosis in AD model mice
References