INTRODUCTION Lung cancer is a disease of uncontrolled cell growth in tissues of the lung. This growth may lead to metastasis, invasion of adjacent tissue and infiltration beyond the lungs. The vast majority of primary lung cancers are carcinomas of the lung, derived from epithelial cells. Lung cancer, the most common cause of cancer-related death in men and the second most common in women, is responsible for 1.3 million deaths worldwide annually. The most common symptoms are shortness of breath, coughing (including coughing up blood), and weight loss. The main types of lung cancer are small cell lung carcinoma and non-small cell lung carcinoma. This distinction is important because the treatment varies; non-small cell lung carcinoma (NSCLC) is sometimes treated with surgery, while small cell lung carcinoma (SCLC) usually responds better to chemotherapy and radiation. The most common cause of lung cancer is long term exposure to tobacco smoke. [6] The occurrence of lung cancer in non-smokers, who account for fewer than 10% of cases, appears to be due to a combination of genetic factors, radon gas, asbestos, and air pollution, including second-hand smoke. This is the case of Mr. B.R., 18 years old, male, who was admitted to Mary Johnston Hospital because of joint pains. The group decided to chose this patient because we know that through studying the patient’s case, we will learn
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INTRODUCTION
Lung cancer is a disease of uncontrolled cell growth in tissues of the lung. This
growth may lead to metastasis, invasion of adjacent tissue and infiltration beyond the
lungs. The vast majority of primary lung cancers are carcinomas of the lung, derived
from epithelial cells. Lung cancer, the most common cause of cancer-related death in
men and the second most common in women, is responsible for 1.3 million deaths
worldwide annually. The most common symptoms are shortness of breath, coughing
(including coughing up blood), and weight loss.
The main types of lung cancer are small cell lung carcinoma and non-small cell
lung carcinoma. This distinction is important because the treatment varies; non-small cell
lung carcinoma (NSCLC) is sometimes treated with surgery, while small cell lung
carcinoma (SCLC) usually responds better to chemotherapy and radiation. The most
common cause of lung cancer is long term exposure to tobacco smoke.[6] The occurrence
of lung cancer in non-smokers, who account for fewer than 10% of cases, appears to be
due to a combination of genetic factors, radon gas, asbestos, and air pollution, including
second-hand smoke.
This is the case of Mr. B.R., 18 years old, male, who was admitted to Mary
Johnston Hospital because of joint pains. The group decided to chose this patient because
we know that through studying the patient’s case, we will learn and at the same time
enhance our knowledge and skills in rendering care to patients who are in need of prompt
nursing interventions.
In studying this case, the group came up with different nursing problems, such as:
cancer. Noncancerous conditions that can raise LDH levels include heart failure,
hypothyroidism, anemia, and lung or liver disease.
C. Arterial Blood Gas Analyses
26-Feb-08
Arterial Blood Gas 11PM 11:45PM
Normal
Values
pH 7.42- normal 7.42- normal 7.35 - 7.45
PCO2 37-normal 37-normal 35 - 45
PO2 129.2-increased 129.2-increased 80 - 100
HCO3 23.6- normal 23.6- normal 22 - 26
B.E. 0.4- LO 0.4- LO ± 2 meq/L
O2Sat
98.6%-
increased 98.6%- increased 97%
INTERPRETATION:
The ABG result shows there is a normal arterial blood gas. Wherein, all results had been
compensated and the oxygen has good return to the body since there is more than
adequate oxygen result. There is a balance exchange of gases in the body. While in
Partial Oxygen measures, there is an increased pressure of oxygen dissolved in the blood
and there is increased oxygen moving from the airspace of the lungs into the blood, it
happens to compensate adequacy of oxygen saturation in the blood and the carbon
dioxide as well.
D. Urinalysis
Urinalysis 27-Feb-08 28-Feb-08
Color: Yellow Dark Yellow
Specific Gravity: 1.03 1.025
Characteristic Slightly Turbid Turbid
CHON: .30g/L 0.3
Reaction: 6 6
Sugar: Trace Negative
WBC: 3-5/HPF 3-4/HPF
RBC: 2-3/HPF 2-4/HPF
Epithelial Cells: Few Few
Bacteria: Few Few
Mucus: Moderate Moderate
Other: Amorphous Materials: Few
INTERPRETATION:
Slightly turbid appearance of urine is considered normal, however, turfbidity may
suggest concentrated urine. While urine’s specific gravity is an indication of the kidneys’
ability to reabsorb water and chemicals from the glomerular filtrate. However, specific
gravity is not a true measure of the number or concentration of particles but correlates
well with osmolality. The result shows a normal specific gravity of the patient’s urine,
this indicates that the kidney is able to concentrate or dilute urine and that the renal
tubules are functioning well. Also, there’s appropriate secretion of ADH by the posterior
pituitary gland and that it is in good functioning because it is the one which controls
water reabsorption in the collecting ducts.
Urine normally contains only a scant amount of protein which derives both from
the blood and the urinary tract itself. Proteinuria may indicate serious renal or systemic
disease, its detection on routine urinalysis must always be further evaluated for possible
cause.
Normally, glucose is virtually absent in the urine, the result is abnormal having a
trace of sugar in the patient’s urine. Although nearly all glucose passes into the
glomerular filtrate, most of it is reabsorbed by the proximal tubules through active
transport mechanisms. In active transport, carrier molecules attach to molecules of other
substances and transport them across membranes. Usually there are enough carrier
molecules to transport all of the glucose from the renal tubules back to the blood. If
plasma glucose levels are very high, however such that carrier mechanisms are
overwhelmed, glucose will appear in the urine, the point which called renal threshold
from 160-200 mg/ dl, depending on the individual. That is, the blood sugar must rise to
its renal threshold level before glucose will appear in the urine. The most common cause
of glycosuria is diabetes mellitus and perhaps this is the reason why there are trace of
sugar in the patient’s urine.
Only a few white blood cells are normally found in the urine, the above result is
increased which generally indicate either renal or genitourinary tract infection.
NURSING CONSIDERATION: A higher than normal number of leukocytes
may be seen if the sample is contaminated with genital secretions, also, the nurse must
carefully remind the patient not to allow samples to stand at room temperature for more
than 1-2 hour for this too will give false result.
The presence of Red Blood Cells in the urine which is called hematuria is
abnormal because RBC’s are too large to pass through the glomerulus, this condition
indicates damage to the glomerular membrane or to the genitourinary tract. But there are
some non-renal disorders wherein hematuria occurs, this includes presence of tumor,
blood cell infection and inflammation.
Few epithelial cells in the urine are normal so as rare bacteria, unless bacteria in
the urine are accompanied by excessive number of white blood cells, it may indicate an
infectious or inflammatory process. Amorphous materials as well are not of major
clinical significance.
E. PCR Test
5-Mar-08
PCR Test- NEGATIVE
CHON
Sugar
LDh
All substances are present at the pleural fluid
INTERPRETATION:
This process is artificial DNA replication, used to make copies of DNA that may be
needed for genetic testing and other times when you lots of bits of one part of DNA.
A powerful method for amplifying specific DNA segments which exploits certain
features of DNA replication. For instance replication requires a primer and specificity is
determined by the sequence and size of the primer. The method amplifies specific DNA
segments by cycles of template denaturation; primer addition; primer annealing and
replication using thermostable DNA polymerase. The degree of amplification achieved is
set at a theoretical maximum of 2^N, where N is the number of cycles, eg 20 cycles gives
a theoretical 1048576 fold amplification.
F. Pleural Fluid AFB Smear
28-Feb-08
Pleural Fluid AFB Smear
No Acid Fast Bacilli Seen
The pleural fluid smear is a screening test for the presence of microorganisms or
abnormal cells in pleural fluid in the space around the lungs .A sample of pleural fluid is
examined under the microscope. The test is performed when infection of the pleural
space is suspected, or when an abnormal collection of pleural fluid is noticed by chest x-
ray. There were no organisms present in the pleural fluid such as Mycobacterium
tuberculosis.
G. Pleural Fluid Analysis
28-Feb-08
Specimen - Pleural Fluid Result Normal Values
Rivalta's Test Negative
Ph 7.5-decreased 7.65
Specific Gravity 1.015-normal less than 1.015
Glucose 5.0mmol/L greater than 60 mg/dL
Total CHON 62g/L-increased less 3.0 g/dL
LDH 3,533u/L- increased less than or equal to 200 U/L
WBC 486x109/L-normal less than 1000 per microliter
Differential Count:
Segmentars 0.54- increased less than 50%
Lymphocytes 0.46- normal less than 50%
Pleural fluid analysis examines fluid that has collected in the pleural space. The
pleura is a thin membrane that lines the outside of the lung and the inside of the chest
cavity. The data above ruled out the diagnosis of exudative pleural effusion based on
Light’s criteria. Rivalta reaction is still used as a puncture fluid test for differentiation of
exudate and transudate pleural effusion.
H. Pleural Fluid Gram Stain and Pleural Fluid Culture and Sensitivity
28-Feb-08
Pleural Fluid Gram Stain
WBC-positive
No definite microorganism seen
3-Mar-08
Pleural Fluid Culture and Sensitivity
No growth after 72 hours of incubation (3-1-08)
INTERPRETATION
The pleural fluid gram stain is one of the best techniques for the rapid diagnosis
of bacterial infections. The test is performed when infection of the pleural space is
suspected or when an abnormal collection of pleural fluid is noticed by chest x-ray. There
were no microorganisms seen such as Mycobacterium tuberculosis. The patient’s pleural
fluid is positive to WBC which may indicate presence of infection.
I. Others
2-Mar-08
Result Normal Values
AFP >940- increased 0.0 – 11.3 IU/ml
B-HCG 84.91- increased 0.0 - 5.0 mIU/ml
INTERPRETATION
Alpha-fetoprotein is normally elevated in pregnant women since it is produced by
the fetus. However, AFP is not usually found in the blood of adults. In men, and in
women who are not pregnant, an elevated level of AFP may indicate liver cancer or
cancer of the ovary or testicle. Noncancerous conditions may also cause elevated AFP
levels. A high level of AFP may indicate a problem with the spinal cord, brain, or
digestive system.
HCG may indicate cancer in the testis, ovary, liver, stomach, pancreas, and lung.
Marijuana use can also raise HCG levels.
PROCEDURES
I. CT Scan
It is a special imaging procedure that uses the same X-rays as in a classic X-ray
examination. CT images are much more precise, however. This is because a CT takes
pictures of millimeter-thin layers of a selected region inside the body. The word
tomography comes from the Greek and means ‘depicting in layers or slices’. Various
types of tissue, such as bones, muscles and fat as well as possible changes in tissue, can
be shown much more clearly by a CT than by a simple X-ray. Furthermore, the computer
can subsequently dimensional image, which gives the physician an exact 3D picture of
certain body regions. This can be necessary before sur4gery on a complicated fracture,
for example.
CT Scan of the Chest to include the thoracic spine (non-contrast enhance)
Date: February 27, 2008
Results:
Limited study due to lack of IV contrast. There is a heterogeneous mass lesion
with calcification which appears to be in the right paratracheal space of the mediastinum
displacing the trachea to the left and compressing the underlying right lung parenchyma
as well as the right bronchi. The right lung is opacified. Moderate amount of right side
pleural effusion is present. There is pleural thickening in the right. A subcentimeter
nodule is present in the superior segment of the lower lobe. There is no focal infiltrate
and consolidation in left lung. Parenchymal fibrosis is seen in the left lower lobe. Heart is
within normal size and configuration. Great vessels are unremarkable on the non-contrast
exam. Esophagus shows no intraluminal defects. Walls are not thickened.
Lytic change is seen in the right pedicle of T2 vertebral body. Hyppodense/lytic
change is seen in L3 vertebral body . the rest of the thoracic and visualized lumbar
vertebral bodies and posterior elements are unremarkable. The alignment and
intervertebral disc spaces are unremarkable. There is a 1.2 cm hypodense structure in the
right hepatic lobe and a 2.3 cm hypodense structure in the left hepatic lobe.
Impression:
1. Limited study due to lacking of IV contrast.
2. Heterogenous mass lesion with calcification which appears to be in the right
paratracheal space of the mediastinal mass region such as teratoma with
additional malignant components is considered. Correlation with IV Chest CT
Scan and tissue correlation is suggested.
3. Subcentimeter nodule, left lower lobe.
4. Moderate right side pleural effusion.
5. Pleural thickening, right.
6. Possible metastasis, right pedicles at T2 vertebral body. Possible lytic change, L3
vertebral body.
7. Hypodense structure in the liver. Metastasis is not ruled out. Correlation with
contrast enhance abdominal CT is suggested.
II. X -Rays
It is electromagnetic radiation of extremely short wavelength (beyond the
ultraviolet), with great penetrating powers in matter opaque to light. X-rays are used in
diagnosis in the techniques of radiography and also in certain forms of radiography. Great
care is needed to avoid unnecessary exposure, because the radiation is harmful in large
quantities.
A. Chest AP Right Lateral DEC/TLS
February 26, 2008
Results:
There is hemogenous opaqcities of the right lung obscuring the left hemi
diaphragm and sulcus.
Hazy infiltrates are seen in the left lung base.
Heart size can’t be assessed.
Impression:
Massive pleural effusion
Right Pneumonia, left
Right lateral decubitus shows layering of fluid in its dependent portion.
B. Chest AP CTT insertion
February 27, 2008
Results:
Follow up chest now shows CTT tube on the right. There is very minimal clearing
of massive right side pleural effusion.
The rest of findings are unchanged.
Interpretation:
The patient was diagnosed of having pleural effusion which revealed on the first
x-ray result. The patient undergone CTT insertion that’s why he still need to underwent
Chest X-ray for the second time to determine if he tube is inserted at the right place.
C. X-ray of Thoracolumbar spine:
Lumbar spine is strengthened which can be due to muscle spasm.
Vertebral body heights and intervertebral disc spaces are intact.
III. CTT insertion
The pleural space normally contains a thin layer of lubricating fluid that allows
frictionless movement of the lungs during respirations. An excess of fluid (hemothorax or
pleural effusion), air (pneumothorax), or both in this space alters intrapleural pressure and
causes partial or complete lung collapse.
Chest tube insertion permits the drainage of air of fluid from the pleural space.
Performed by the doctor with a nurse assisting, this procedure requires sterile technique.
The insertion site varies, depending on the patient’s condition and the doctor’s judgment.
For hemothorax or pleural effusion, the sixth to the eight intercostals spaces are common
sites because fluid settles to the lower levels of the intrapleural space. For removal of
both air and fluid, a chest tube is inserted into a high and low site. Following insertion,
the chest tube is connected to a thoracic drainage system that provides for the drainage of
air and/or fluid out of the pleural space, thus promoting lung expansion.
DRUG STUDY
1. MORIAMIN FORTEClassification: Multivitamins, Essential Amino acids, folic acid, 5 oxyanthranillic acidAction: It protects and enhances body’s immune system response against further infectionSide Effects: without any known side effects.Why is it given?: Since the patient was experiencing lung cancer, the patient undergone immune system depression, this drug is given to enhance patient’s response.
2. DEXAMETHASONE SODIUM SUCCINATE 4MG TAB BIDBrand Name: DexamethasoneClassification: An anti inflammatory DrugAction: Glucocorticoids, naturally occurring and synthetic, are adrenocortical steroids that cause varied metabolic effects. In addition, they modify the body's immune responses to diverse stimuli. Naturally occurring glucocorticoids (hydrocortisone and cortisone), which also have sodium-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs including dexamethasone are primarily used for their anti-inflammatory effects in disorders of many organ systems.
Endocrine: Decreased carbohydrate and glucose tolerance, development of cushingoid state, hyperglycemia, glycosuria, hirsutism, hypertrichosis, increased requirements for insulin or oral hypoglycemic agents in diabetes, manifestations of latent diabetes mellitus, menstrual irregularities, secondary adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery, or illness), suppression of growth in pediatric patients.
Fluid and electrolyte disturbances: Congestive heart failure in susceptible patients, fluid retention, hypokalemic alkalosis, potassium loss, sodium retention.
Gastrointestinal: Abdominal distention, elevation in serum liver enzyme levels (usually reversible upon discontinuation), hepatomegaly, increased appetite, nausea, pancreatitis, peptic ulcer with possible perforation and hemorrhage, perforation of the small and large intestine (particularly in patients with inflammatory bowel disease), ulcerative esophagitis.
Musculoskeletal: Aseptic necrosis of femoral and humeral heads, loss of muscle mass, muscle weakness, osteoporosis, pathologic fracture of long bones, steroid myopathy, tendon rupture, vertebral compression fractures.
Contraindication: Hypersensitivity to corticosteroids
Indication: Respiratory diseases: Berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis.
Why is it given?: The patient had lung cancer and experiencing difficulty of breathing, it will help tomopen airway by dilating bronchioles for more oxygen supply. It also prevents inflammation.
3. PARACETAMOL 500MG/TAB Q4 FOR FEVER
Brand Name: Biogesic
Classification: Antipyretic drug
Action: It blocks the hypothalamus to secrete pyrogens a chemical mediator responsible for increasing thermoregulation.
Indication: This drug is indicated to patient with fever and pain
Contraindication: It is contraindicated to repeated administration in anemic patient, Cardiac, Pulmonary, Renal and hepatic disease.
Side Effects: Skin rash and GI disturbances.
Why is it given?: Due to inflammatory responses, the patient experiencing fever, thus, using paracetamol will lower it.
Action: NUBAIN is a potent analgesic. Its analgesic potency is essentially equivalent to that of morphine on a milligram basis. Receptor studies show that NUBAIN binds to mu, kappa, and delta receptors, but not to sigma receptors. NUBAIN is primarily a kappa agonist/partial mu antagonist analgesic.
Indication: NUBAIN is indicated for the relief of moderate to severe pain. NUBAIN can also be used as a supplement to balanced anesthesia, for preoperative and postoperative analgesia, and for obstetrical analgesia during labor and delivery.
Contraindication: NUBAIN should not be administered to patients who are hypersensitive to nalbuphine hydrochloride, or to any of the other ingredients in NUBAIN.
Why is it given?: The patient is experiencing severe bone pain, nalbuphine is given to reduce pain.
5. CIPROFLOXACIN
Brand Name: Ciprobay
Classification: Anti infective drugs
Action: An antibiotics that prevent and blocks further bacterial and viral infection.
Indication: Urinary Tract Infections, Lower Respiratory Tract Infections, Bone and Joint Infections
Contraindication: Ciprofloxacin is contraindicated in persons with a history of hypersensitivity to ciprofloxacin, any member of the quinolone class of antimicrobial agents, or any of the product components.
Concomitant administration with tizanidine is contraindicated.