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Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG Giorgia Mori, Laurent R. Chiarelli, Marta Esposito, Vadim Makarov, Marco Bellinzoni, Ruben C. Hartkoorn, Giulia Degiacomi, Francesca Boldrin, Sean Ekins, Ana Luisa de Jesus Lopes Ribeiro, Leonardo B. Marino, Ivana Centárová, Zuzana Svetlíková, Jaroslav Blaško, Elena Kazakova, Alexander Lepioshkin, Nathalie Barilone, Giuseppe Zanoni, Alessio Porta, Marco Fondi, Renato Fani, Alain R. Baulard, Katarína Mikušová, Pedro M. Alzari, Riccardo Manganelli, Luiz Pedro S. de Carvalho, Giovanna Riccardi, Stewart T. Cole, Maria Rosalia Pasca Chemistry & Biology DOI: 10.1016/j.chembiol.2015.05.016 Copyright © 2015 The Authors Terms and Conditions
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Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG Giorgia Mori, Laurent R. Chiarelli,

Dec 22, 2015

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Page 1: Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG Giorgia Mori, Laurent R. Chiarelli,

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG 

Giorgia Mori, Laurent R. Chiarelli, Marta Esposito, Vadim Makarov, Marco Bellinzoni, Ruben C. Hartkoorn, Giulia Degiacomi, Francesca Boldrin, Sean Ekins, Ana Luisa de Jesus Lopes Ribeiro, Leonardo B. Marino, Ivana Centárová, Zuzana Svetlíková, Jaroslav Blaško,

Elena Kazakova, Alexander Lepioshkin, Nathalie Barilone, Giuseppe Zanoni, Alessio Porta, Marco Fondi, Renato Fani, Alain R. Baulard, Katarína Mikušová, Pedro M. Alzari, Riccardo Manganelli, Luiz Pedro S. de Carvalho, Giovanna Riccardi, Stewart T. Cole,

Maria Rosalia Pasca 

Chemistry & Biology 

DOI: 10.1016/j.chembiol.2015.05.016

Copyright © 2015 The Authors Terms and Conditions

Page 2: Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG Giorgia Mori, Laurent R. Chiarelli,

Figure 1

Chemistry & Biology DOI: (10.1016/j.chembiol.2015.05.016) Copyright © 2015 The Authors Terms and Conditions

Page 3: Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG Giorgia Mori, Laurent R. Chiarelli,

Figure 2

Chemistry & Biology DOI: (10.1016/j.chembiol.2015.05.016) Copyright © 2015 The Authors Terms and Conditions

Page 4: Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG Giorgia Mori, Laurent R. Chiarelli,

Figure 3

Chemistry & Biology DOI: (10.1016/j.chembiol.2015.05.016) Copyright © 2015 The Authors Terms and Conditions

Page 5: Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG Giorgia Mori, Laurent R. Chiarelli,

Figure 4

Chemistry & Biology DOI: (10.1016/j.chembiol.2015.05.016) Copyright © 2015 The Authors Terms and Conditions

Page 6: Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG Giorgia Mori, Laurent R. Chiarelli,

Figure 5

Chemistry & Biology DOI: (10.1016/j.chembiol.2015.05.016) Copyright © 2015 The Authors Terms and Conditions

Page 7: Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG Giorgia Mori, Laurent R. Chiarelli,

Chemistry & Biology DOI: (10.1016/j.chembiol.2015.05.016) Copyright © 2015 The Authors Terms and Conditions