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The Xpert MTB/RIF Research Mapping Project Anne Detjen, The Union/TREAT TB
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The Xpert MTB/RIF Research Mapping Project · • Impact of Xpert MTB/RIF in reducing diagnostic delay and treatment initiation • Impact on treatment access and treatment outcomes,

Aug 24, 2020

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Page 1: The Xpert MTB/RIF Research Mapping Project · • Impact of Xpert MTB/RIF in reducing diagnostic delay and treatment initiation • Impact on treatment access and treatment outcomes,

The Xpert MTB/RIF Research Mapping Project

Anne Detjen, The Union/TREAT TB

Page 2: The Xpert MTB/RIF Research Mapping Project · • Impact of Xpert MTB/RIF in reducing diagnostic delay and treatment initiation • Impact on treatment access and treatment outcomes,

Global collaboration and coordination of Xpert MTB/RIF roll-out

WHO: Monitoring of roll-out, procurement and procurement plans http://www.who.int/tb/laboratory/mtbrifrollout/en/index.html

Page 3: The Xpert MTB/RIF Research Mapping Project · • Impact of Xpert MTB/RIF in reducing diagnostic delay and treatment initiation • Impact on treatment access and treatment outcomes,

Open Research Questions WHO Xpert MTB/RIF Policy Statement

• Interim diagnostic algorithms in different epidemiological and geographical settings and patient populations

• Cost-effectiveness and cost-benefit in different programmatic settings

• Extrapulmonary and paediatric TB

• Impact of Xpert MTB/RIF in reducing diagnostic delay and treatment initiation

• Impact on treatment access and treatment outcomes, especially among hard-to-reach populations

• Operational issues: Calibration, power supply, shelf life, storage, waste management

Page 4: The Xpert MTB/RIF Research Mapping Project · • Impact of Xpert MTB/RIF in reducing diagnostic delay and treatment initiation • Impact on treatment access and treatment outcomes,

Who is doing research? Where? What focus areas? What are the lessons learnt?

Create a platform for researchers, implementers, policy makers Provide information, initiate exchange and discussion Optimize research efforts related to implementation and scale-up

Xpert Research Mapping project

Page 5: The Xpert MTB/RIF Research Mapping Project · • Impact of Xpert MTB/RIF in reducing diagnostic delay and treatment initiation • Impact on treatment access and treatment outcomes,

Xpert MTB/RIF Research Mapping Project

Online questionnaire to capture o Information on research collaborations performing Xpert

research o Basic information on roll-out in the countries where research

is performed Research design (Setting, target populations, algorithms) Research outcomes

o May 2011: Distribution of questionnaire via Union, Stop TB, NDWG and other newsletters and mailing lists

Page 6: The Xpert MTB/RIF Research Mapping Project · • Impact of Xpert MTB/RIF in reducing diagnostic delay and treatment initiation • Impact on treatment access and treatment outcomes,

www.xrmt.treattb.org

Page 7: The Xpert MTB/RIF Research Mapping Project · • Impact of Xpert MTB/RIF in reducing diagnostic delay and treatment initiation • Impact on treatment access and treatment outcomes,

24 projects in 16 countries

Page 8: The Xpert MTB/RIF Research Mapping Project · • Impact of Xpert MTB/RIF in reducing diagnostic delay and treatment initiation • Impact on treatment access and treatment outcomes,

Projects listing

Page 9: The Xpert MTB/RIF Research Mapping Project · • Impact of Xpert MTB/RIF in reducing diagnostic delay and treatment initiation • Impact on treatment access and treatment outcomes,

Project Overview o Project contact & collaborators o Programmatic implementation o Research Location o Timelines o Publications o Study design o Research Setting o Outcomes o Diagnostic algorithms o Other new tools o Source of Funding

Page 10: The Xpert MTB/RIF Research Mapping Project · • Impact of Xpert MTB/RIF in reducing diagnostic delay and treatment initiation • Impact on treatment access and treatment outcomes,

Some Research Details

Target population • All TB suspects (14) • HIV-infected (9) • MDR suspects (7) • Children (4) • Other: EPTB, smear

negative suspects (2)

Most countries: No implementation at programme level

Page 11: The Xpert MTB/RIF Research Mapping Project · • Impact of Xpert MTB/RIF in reducing diagnostic delay and treatment initiation • Impact on treatment access and treatment outcomes,

Level

o Point of care (14) o District (11) o Central (7)

Page 12: The Xpert MTB/RIF Research Mapping Project · • Impact of Xpert MTB/RIF in reducing diagnostic delay and treatment initiation • Impact on treatment access and treatment outcomes,

Outcomes (selected)

o Case finding compared to smear or culture o Comparison of diagnostic algorithms o Time to detection, time to treatment o Mortality o Yield from other samples (EPTB, blood, children) o Xpert as rule-out test (pre IPT) o Public Health implications

Page 13: The Xpert MTB/RIF Research Mapping Project · • Impact of Xpert MTB/RIF in reducing diagnostic delay and treatment initiation • Impact on treatment access and treatment outcomes,

Impact assessment

• Health system costs (13) • Patient costs (12) • Health system requirements (12) • Equity issues: gender inequality, access etc. (3)

Page 14: The Xpert MTB/RIF Research Mapping Project · • Impact of Xpert MTB/RIF in reducing diagnostic delay and treatment initiation • Impact on treatment access and treatment outcomes,

Conclusions

o Multiple research projects ongoing o There must be more! o Comprehensive information on research

approaches and anticipated outcomes o Is it useful? o Potential to inform research community and

policy makers alike

Page 15: The Xpert MTB/RIF Research Mapping Project · • Impact of Xpert MTB/RIF in reducing diagnostic delay and treatment initiation • Impact on treatment access and treatment outcomes,

Participate and enter your Xpert MTB/RIF research project:

www.xrmt.treattb.org

For questions: [email protected]

Thank you: all the participants in the project Christine Hunt, Cathriona MacCauley, Don Koller

Page 16: The Xpert MTB/RIF Research Mapping Project · • Impact of Xpert MTB/RIF in reducing diagnostic delay and treatment initiation • Impact on treatment access and treatment outcomes,