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Essentials of Anatomy & Physiology, 4th EditionMartini /Bartholomew
PowerPoint® Lecture Outlines prepared by Alan Magid, Duke University
The Tissue Levelof OrganizationThe Tissue Levelof Organization
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Slides 1 to 64
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Overview of Tissue Science
Histology
The study of tissues
Four Basic Tissue Types• Epithelial• Connective• Muscular• Neural
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Overview of Tissue Science
Key NoteTissues are collections of cells and extracellular material that perform a specific but limited range of functions.The four tissue types, in varying combinations, form all of the structures of the human body.
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Overview of Tissue ScienceAn Orientation to
the Tissues of the Body
Figure 4-1
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Epithelial Tissue
EpitheliumAn avascular layer of cells that forms a barrier that covers internal or external surfaces
GlandsSecretory structures derived from epithelia
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Epithelial Tissue
Characteristics of Epithelia• Cells closely packed• Apical cells exposed to external or
internal surface• Cells attached to basement
membrane• Lack blood vessels• Cells continually replaced
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Epithelial Tissue
Functions of Epithelia• Physical protection• Permeability control• Sensation trigger• Specialized secretions
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Epithelial Tissue
Two Classes of Glandular Secretion• Exocrine secretion—Secretion onto a
body surface• Endocrine secretion—Secretion (of
hormones) into neighboring tissues and blood
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Epithelial Tissue
Intercellular Connections• Cell adhesion molecules• Cell junctions
• Tight junctions• Gap junctions• Desmosomes
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Epithelial Tissue
IntercellularConnections
Figure 4-2
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Epithelial Tissue
The Epithelial Surface• Microvilli
• Abundant on transport cells• Dramatically increase surface area• Found in intestinal lining, kidney
tubules• Cilia
• Beat in coordinated fashion• Move fluid along surface• Found in airways, oviduct
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Epithelial TissueThe Surfaces of Epithelial Cells
Figure 4-3
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Epithelial Tissue
The Basement Membrane• Noncellular meshwork
anchors basal cells• Underlies all epithelia• Hemidesmosomes attach
basal cells• Resists passage of large
molecules• Strengthens against
distortion
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Epithelial Tissue
Epithelial Renewal and Repair• Exposure shortens cell life• Epithelium needs constant repair and
replacement• Epithelial stem cells undergo mitosis• Epithelium grows up from base
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Epithelial Tissue
Classifying Epithelia• Number of layers
• Simple (one cell thick)• Stratified (multiple cells thick)
• Cell shape• Squamous (flat)• Cuboidal (cubic)• Columnar (tall columns)
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Epithelial Tissue
Table 4-1
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Epithelial Tissue
Simple Squamous Epithelium
Figure 4-4(a)
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Epithelial Tissue
Simple Cuboidal Epithelium
Figure 4-4(b)
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Epithelial Tissue
Simple Columnar Epithelium
Figure 4-4(c)
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Epithelial Tissue
Pseudostratified Ciliated Columnar
Figure 4-5(a)
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Epithelial Tissue
Transitional Epithelium
Figure 4-5(b)
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Epithelial Tissue
Stratified Squamous Epithelium
Figure 4-5(c)
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Epithelial Tissue
Glandular Epithelia• Three secretion mechanisms
• Merocrine• Exocytosis of vesicles
• Apocrine• Release of apical cytoplasm
• Holocrine• Burst of entire contents
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Epithelial TissueMechanisms of Glandular Secretion
Figure 4-6PLAY Glandular Secretions
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Connective Tissues
Connective Tissues Components• Specialized cells• Extracellular matrix
• Protein fibers• Fluid phase (the ground substance)
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Connective Tissues
Functions• Structural framework• Fluid and solute transport• Physical protection• Tissue interconnection• Fat storage• Microorganism defense
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Connective Tissues
Classifying Connective Tissues• Connective tissue proper• Fluid connective tissues• Supporting connective tissues
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Connective Tissues
Major Types of Connective Tissue
Figure 4-7
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Connective Tissues
Connective tissue properContains varied cell populations and fiber types surrounded by a syrupy ground substance
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Connective Tissues
Connective Tissue Proper• Resident and migrating cells
• Fibroblasts• Macrophages• Fat cells• Mast cells• Other white cells
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Connective Tissues
Connective Tissue Proper• Protein fibers
• Collagen fibers• Provides toughness
• Reticular fibers• Supports cells
• Elastic fibers• Provides resilience
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Connective TissuesCells and Fibers of Connective Tissue Proper
Figure 4-8
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Connective Tissues
Connective Tissue Proper• Three types
• Loose connective tissue• Example: beneath dermis of skin
• Adipose tissue• Example: “love handles”
• Dense connective tissue• Examples: dermis, tendons,
ligaments
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Connective Tissues
Loose Connective Tissue
Figure 4-9(a)
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Connective Tissues
Adipose Tissue
Figure 4-9(b)
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Connective Tissues
Dense Connective Tissues
Figure 4-9(c)
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Connective Tissues
Fluid Connective Tissues• Cells + a liquid ground substance
• Blood• RBCs, WBCs, platelets + plasma
• Lymph• Lymphocytes + lymph fluid
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Connective Tissues
Supporting Connective Tissue• Support the body
• Bone (osseous tissue)• Osteocytes + collagen +
calcium salts• Cartilage
• Chondrocytes + firm gel
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Connective Tissues
Supporting Connective Tissue• Cartilage
• Avascular• Covered by a fibrous perichondrium• Three types of cartilage
• Hyaline cartilage• Elastic cartilage• Fibrocartilage
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Connective Tissues
Hyaline Cartilage
Figure 4-10(a)
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Connective Tissues
Elastic Cartilage
Figure 4-10(b)
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Connective Tissues
Fibrocartilage
Figure 4-10(c)
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Connective Tissues
Bone (Osseous Tissue)• Matrix provides unique properties
• Collagen fibers resist bending• Calcium salts resist compression
• Diffusion through canaliculi nourishes osteocytes
• Covered by periosteum
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Connective Tissues
Bone
Figure 4-11
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Membranes
Properties of Membranes• Barrier or interface• Cover and protect• An epithelium plus
connective tissue• Four types of membranes
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Membranes
Types of Membranes• Mucous
• Lines cavities that connect to exterior• Mucus moistens surface• Examples: oral cavity, airways
Serous• Line internal cavities• Watery fluid moistens surface• Example: peritoneal membrane
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Membranes
Types of Membranes (continued)• Cutaneous
• Covers body surface• Dry surface waterproofs the body• Example: the skin
• Synovial• Lines joints• Secretes slippery synovial fluid• Lubricates joints• Examples: knee, elbow
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MembranesMembranes
Figure 4-12
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Muscle Tissue
Properties of Muscle Tissue• Capable of contraction
• Actin filaments• Myosin filaments
• Three types of muscle tissue• Skeletal muscle• Cardiac muscle• Smooth muscle
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Muscle Tissue
Skeletal Muscle Tissue• Contains elongated cells (fibers)
• Fibers tied together by loose connective tissue
• Possesses microscopic striations• Contains many nuclei• Controlled by voluntary nervous
system• Moves and stabilizes the
skeleton
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Muscle Tissue
Skeletal Muscle Tissue
Figure 4-13(a)
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Muscle Tissue
Cardiac Muscle Tissue• Only in heart• Short, branched fibers• Single nucleus• Striated• Involuntary contraction• Blood circulation• Blood pressure
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Muscle Tissue
Cardiac Muscle Tissue
Figure 4-13(b)
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Muscle Tissue
Smooth Muscle Tissue• Short, tapering cells• No striations• Involuntary contraction
• Blood vessels• Urinary bladder• Digestive organs• Uterus
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Muscle Tissue
Smooth Muscle Tissue
Figure 4-13(c)
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Neural Tissue
Properties of Neural Tissue• Conduct electrical impulses• Transfer, process, and
store information• Comprises neurons and
neuroglia
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Neural Tissue
Neurons• Dendrites
• Information entry• Cell body
• Information integration• Axon (nerve fibers)
• Information transmission• Synaptic terminals
• Information transfer
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Neural Tissue
Neuroglia• Several types of neuroglia• Provide physical support• Maintain extracellular chemistry• Supply nutrients• Defend against infection
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Neural Tissue
Neural Tissue
Figure 4-14
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Tissue Injuries and Repair
• An injury harms multiple tissues simultaneously
• Tissues make coordinated response• Responses restore homeostasis• Two response types
• Inflammation• Restoration
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Tissue Injuries and Repair
Inflammation• Isolation of injured area• Cleanup of damaged tissue• Four signs of inflammation
• Warmth• Redness• Swelling• Pain
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Tissue Injuries and Repair
Regeneration• Repair/replacement of damaged tissue• Restoration of tissue function• Scar tissue from fibroblast activity• Complete, partial, or no regeneration• Tissue fibrosis common outcome
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Tissues and Aging
Tissues Change with Age• Healing slows• Epithelia become thinner• Connective tissues become more fragile• Bones weaken, become brittle• Neuron and muscle fiber losses
accumulate• Lifestyle interventions slow decline
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Tissues and Aging
Aging and Cancer Incidence• 25% develop cancer• Cancer risk rises with age• After heart disease, cancer second
leading cause of death• Smoking linked to 40% of cancers• 75% caused by environment
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Tissue Regeneration!!