The separation of pharmacy and medicine in Europe Edict of Salerno, 1241 Edict of Salerno, 1241 Frederick II (1194-1250) Holy Roman Emperor King of Sicily,

The separation of pharmacy and medicine in EuropeThe separation of pharmacy and medicine in Europe Edict of Salerno, 1241Edict of Salerno, 1241

Frederick II (1194-1250)Frederick II (1194-1250)Holy Roman EmperorHoly Roman EmperorKing of Sicily, Germany, and King of Sicily, Germany, and JerusalemJerusalem

Frederick II issued a number of rules aimed at Frederick II issued a number of rules aimed at protecting the patient such asprotecting the patient such as

Supervision of both professions bySupervision of both professions by governmental agenciesgovernmental agencies

Fixed pices (tariff) for drugs, preparationsFixed pices (tariff) for drugs, preparations and servicesand services

Prohibition of shared practice settings for Prohibition of shared practice settings for physicians and pharmacistsphysicians and pharmacists

http://en.wikipedia.org/wiki/Image:Frederick_II_and_eagle.jpg

Dept. of Experimental and Clinical Pharmacology (Tim Tracy)

Dept. of Pharmaceutics (Ron Siegel)

Dept. of Medicinal Chemistry (Gunda Georg) Dept. of Pharmacy Practice and Pharmaceutical Sciences – Duluth

(Randy Seifert)

Dept. of Pharmaceutical Care & Health Systems (Steve Schondelmeyer)

MedicineMedicine

Public Health Public Health

PharmacyPharmacy

DentistryDentistry

NursingNursing

Vet. MedicineVet. Medicine

(2009)

http://www.ahc.umn.edu/home.html

http://www.umn.edu/

Students in the Pharm.D. programStudents in the Pharm.D. program648 professional students648 professional students1.100 applicants competed for 167 spots1.100 applicants competed for 167 spots

Graduate studentsGraduate students104 students in 4 graduate programs104 students in 4 graduate programsFew, if any, Pharm.D.s enroll in grad. Few, if any, Pharm.D.s enroll in grad. programs!programs!

College of Pharmacy (CoP) student numbersCollege of Pharmacy (CoP) student numbers

Employee Health and Wellness Center

http://www.d.umn.edu/

FacultyFaculty97 voting faculty97 voting faculty

Research fundingResearch fundingFederal Federal $6,647,293$6,647,293State State $2,385,739 $2,385,739Other $3,144,520Other $3,144,520

Development Development $3,449,113$3,449,113(UMF year-end gift activity report for FY ’08)(UMF year-end gift activity report for FY ’08)

College of Pharmacy (CoP) numbers: College of Pharmacy (CoP) numbers: faculty and financesfaculty and finances



Dept. of Medicinal Chemistry (Gunda Georg) Dept. of Pharmacy Practice and Pharmaceutical Sciences – Duluth

(Randy Seifert)


MedicineMedicine


PharmacyPharmacy

DentistryDentistry

NursingNursing


(2008)


http://www.umn.edu/

What does a Linguist do in Pharmacy?What does a Linguist do in Pharmacy?

Serguei Pakhomov Assistant Professor CoP, PCHS

Education: M.A. and Ph.D. in English/LinguisticsPetrozavodsk Pedagogical University, Russia - 1992U of M 1994, 1999

Assessing linguistic manifestations of cognitive Assessing linguistic manifestations of cognitive impairment resulting from neurodegenerative impairment resulting from neurodegenerative disorders as well as exposure to medicationsdisorders as well as exposure to medications

Using natural language processing and machine Using natural language processing and machine learning in analyzing unstructured text of clinical learning in analyzing unstructured text of clinical notesnotes

… …results in inexpensive and scalable methods results in inexpensive and scalable methods for risk factor and quality assessment at the point for risk factor and quality assessment at the point of care of care



Dept. of Medicinal Chemistry (Gunda Georg) Dept. of Pharmacy Practice and Pharmaceutical Sciences – Duluth (Randy Seifert)


MedicineMedicine


PharmacyPharmacy

DentistryDentistry

NursingNursing


(2008)


http://www.umn.edu/

Agency for Healthcare Research and Quality (AHRQ)new FOAP, AR-08-270

Title: Utilizing Health Information Technology (IT) to Improve Health Care Quality (R18)

Real world demonstration projects that evaluate factors associated with successful health IT implementation and ultimately improve health care outcomes.

……such as “Medication Therapy Management (MTM) in a rural such as “Medication Therapy Management (MTM) in a rural setting using ITV or similar telemedical approaches - comparison setting using ITV or similar telemedical approaches - comparison with conventional in-person counseling”with conventional in-person counseling”

Collaborative funding opportunities for PharmacyCollaborative funding opportunities for Pharmacy(Twin Cities/Duluth) and Public Health (Twin Cities/Duluth) and Public Health

Duluth Pier Duluth Pier LighthouseLighthouse





MedicineMedicine


PharmacyPharmacy

DentistryDentistry

NursingNursing


(2008)


http://www.umn.edu/

Developing probes to seek out DNA damage by carcinogensDeveloping probes to seek out DNA damage by carcinogens

Shana SturlaAssistant ProfessorCoP, Med. Chem. B.S., UC Berkeley, 1996Ph.D., MIT, 2001

Luminescent jack-o'-lantern mushrooms Luminescent jack-o'-lantern mushrooms contain DNA alkylating acylfulvenes contain DNA alkylating acylfulvenes

BULKY BINDING. BULKY BINDING. Acylfulvenes form adducts with DNA.Acylfulvenes form adducts with DNA.

Gong, J.; Sturla, S. J. A Synthetic Nucleoside Probe that Gong, J.; Sturla, S. J. A Synthetic Nucleoside Probe that Discerns a DNA Adduct from Unmodified DNA. J Amer Discerns a DNA Adduct from Unmodified DNA. J Amer Chem Soc, 2007, 129, 4882-4883 Chem Soc, 2007, 129, 4882-4883

Institute for Therapeutics Discovery & Development

ITDD High Throughput Screening Instrumentation

Plate Management/Automation• Thermo/CRS Dimension 4 robotic system

Resea

rch

Targe

t Id

Lead

Opt

im

HTS

Pharm

acol

Toxico

lPha

se 1

Phase

2Pha

se 3

Tamiasyn in TraumaTriptolide in Cancer

Treg in Diabetes-TransplantGM-Endostatin in Cancer

Pro-Triptolide in Cancer

DRUG DEVELOPMENT PIPELINE OF THE AHC-UMN

Aquavan in Pain

Gamendazol in ContraceptToxoflavin in Contraception

TX-67 in Alzheimer’sTH-2-237 in Alzheimer’s

Iminosugars in Contracept

Cardenolides in ContraceptKinase Inhib in Contracept

LDH-C in ContraceptionDMRTI in Contraception

Vaccine AdjuvantsAC in Contraception

GMPManuf





MedicineMedicine


PharmacyPharmacy

DentistryDentistry

NursingNursing


(2008)


http://www.umn.edu/

Drug/Device combination products will change the face of healthcare.

Why Establish a Center for the Integration of Drugs and Devices (CIDD)?

“The future is combining devices and drugs.” -- Ralph Larson, Chairman & CEO of J&J

BRAIN CANCERBRAIN CANCER

100,000 Patients in USA – 20,000 Children

Median Survival: 12 months

GLIOBLASTOMA

BLOOD BLOOD

Cancer Drug Cancer Drug + Inhibitor

0

1

2

3

TU

MO

R S

IZE

[m

m3]

Efflux Pump

Pump InhibitorDrug

Drug

Overcoming Barriers in Treating Brain DiseasesOvercoming Barriers in Treating Brain DiseasesCoP Brain Barriers Research Center, since 8/2008CoP Brain Barriers Research Center, since 8/2008

William ElmquistWilliam Elmquist(director)(director)

Les DrewesLes Drewes

Anika Hartz Anika Hartz

Bjoern BauerBjoern Bauer

Grant AndersonGrant Anderson

Stephen HainesStephen Haines

2 Schools, 2 Campuses Pharmacy/Medicine, Twin Cities/Duluth2 Schools, 2 Campuses Pharmacy/Medicine, Twin Cities/Duluth

Haim EinatHaim Einat

John OhlfestJohn Ohlfest

Matthew AndrewsMatthew Andrews

Bob CormierBob Cormier

Ken DornfeldKen Dornfeld

Joe ProhaskaJoe Prohaska

Cornelius LamCornelius Lam





MedicineMedicine


PharmacyPharmacy

DentistryDentistry

NursingNursing


(2008)


http://www.umn.edu/

ECP Research Focus Areas (Disease States)

Hematology/Oncology Infectious Disease Cardiovascular Disease Epilepsy Critical Care Renal Transplantation

CoP Center for Forecasting Drug Response

• Pharmacometrics– Clinical Trial Simulation– Trial Design– Limited Sampling

Methodologies– Population

Pharmacokinetics– Pharmacokinetic-

Pharmacodynamic Analyses 0

1

2

3

4

5

24 28 32 36 40 44 48

10 mg/kg Q6H15 mg/kg Q8H

TIME

#3 Ranking in U.S.News, up from #4

Out of 100 Pharmacy SchoolsOut of 100 Pharmacy Schools::

Top 5 schools ScoreUniversity of CA-SF 4.7University of N.C.- 4.4

Chapel HillUniversity of Minnesota 4.3University of TX-Austin 4.2Ohio State University 4.1

The separation of pharmacy and medicine in Europe Edict of Salerno, 1241 Edict of Salerno, 1241 Frederick II (1194-1250) Holy Roman Emperor King of Sicily,

Documents

pharmacy practice

employee health

health care outcomes

successful health

separation of pharmacy

point of care slide

health information technology

pharmacy twin citiesduluth