m w 1 iabl . - - Contents ....... *% ..- .- .... .. ... - - .... - ....... reface t o the First Edition xix - . - I I Drug invention and the Pharmaceutical Suzanne M. Rivera and Alfred Goodman Gilman .~pharmaookipe~cs: he Dynamics of Drug Absorption, Distribution, Metabolism, ....................................................... ,and Elimination 17 Pain L. Buxton and Leslie Z. Benet Phannadynamics: MoIeeular Mechanisms I . o f Dmg Action .................................. ................. 41 .Donald IC Bhmenthal and ;lam6 C Garrison prug Toxicity and Poisoning ............... .. ................ 73 Kevin C . Osterhoudt and Trwor M. Penning , 5 Membrme Transporters and Response ka~lleen . Giammini and Yuichi Sugiyam i 6 Drug Metalmlism ................................................. 123 I Frank J. Gonzalez, Michael Coughtrie, ?and Robert H . Tukey I., , .. : 7. Phnrrnacogenetics., .... .. . .;..<> ... .; ............. ........... 145 Mary V. Relling and Kathleen M. Giacomini beurottansmission: The Autonomic grid Somatic Motor Nervous Systems ................... 17 1 Thomas C. westfall and David P Westfall I . I .. I 9 Muscarinic ~eceptor ~orfi gk , ' . , ' ' I I I . . - - , , . ; -. , , 4 , , ;.:1q223 and Antagonists .... r ? .... 1 . . 1 Joan Hetler Brown and Nora Laiken .... ..... 0. Anticholinesterslse Agents .............. , .... 239 Palmer Taylor 1 1. Agents cting at the Neuromusculor Junction and Autonomic Gangh .......................... 255 Ryan E. tlibbs and Aknder Zambon 1 2. Admergic Agonists and Antagonists ................... 77 Thomas C. Weiffatl and Oarid P WestFall 13.5-Hydroxy try ptamine Seraonin) and Dapamine ................................................... 335 EIaine Sanders-Bush and Lisa Haxelwd 14. Neurotransrnission and the Central . 1 ., Nervous System .;k~c~::4j:;:~;;?.; .... ,.;:.i ;*:t~;~,~.363 Peny B. Molinoff , - , , I . , ,: :.iimKri i;,+l: , 15. Drug Therapy o Depression , > ... I and Anxiety Dkders ........... . ..................... 2 7 James M. O DonneU and Richard C. Shdton , 16. Pharmacotherapy o Psychosis m and Mania .............. .............. ............. ...................... 4 7 Jonathan H. Meyer 17. Hypnotics and Sedatives ....................................... 457 S. John Mihic and R Admn ktarris 18 Opioids, Analgesia, and Pain Management .............. ............... ........ ~ ...... ..... ~, ..... 481 Tony 1 . Yaksh and Hark S. Wake 1 8 General Anesthetics and Therapeutic Gnst ...... 527 Piyurh M. PateL Hemal H. Patel and David M. Roth 20 Local Anesthetics .................................................. 565 William A. CattewU and Kbnneth bdde ....................... J PRannacotherapy o f he Epilepsies 583 ;James 0 McNamara
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31.Drugmerapy f ~ rypercholesterolemiaandDyslipidemia ..........................................%.......7'7Thomas P. +ot
and Hematopoiesis 909
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