The ‘omics Data Tsunami » Non-stop revolution of high-throughput technology fuels unprecedented growth of ‘omics data » Researchers struggling with the.

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Supercharging ‘omics Research with a Library-based Bioinformatics Service

Yi-Bu Chen, Ph.D.Meng Li, Dual M.S.

Bioinformatics Service, Norris Medical LibraryUniversity of Southern California

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The ‘omics Data Tsunami

»Non-stop revolution of high-throughput technology fuels unprecedented growth of ‘omics data

»Researchers struggling with the increasingly complex ‘omics data» Lack of high-quality tools» Lack of bioinformatics know-

how

Number of public genomic data records @ GEO

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100,000

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Click to edit Master title styleFragmented and Limited Bioinformatics Support @ USC

» USC/CHLA Affymetrix Microarray Core» Cancer Center Molecular Genomics Core» Proteomics Core» USC Epigenome Center» Computation Biology and Bioinformatics Group» Cancer Center Division of Bioinformatics

» Service often fee-based» Limited accessibility, especially for small research labs» No access to any commercial bioinformatics tools» No bioinformatics training or consultation support

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It All Started in the Spring of 2004….

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2005—The Start!»Norris Medical Library hired its first

non-librarian Ph.D. » Several bioinformatics workshops developed

and taught» User consultations offered

Bioinformatics service offered by the library?Really??

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2008—We Got the Tools! »NML purchased 3 commercial

bioinformatics tools

»Training workshops on the software were developed and offered

»A series of PR efforts were made to raised the awareness of the bioinformatics service and offering

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Vector NTI Advance®

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2009—Turn Crisis into Opportunities!

» Surging user needs exacerbated the shortage of both personnel and software tools

» Embarked on a series of meetings with high-level school and university administrators to gain support on expanding the program

» A bioinformatics committee was established by USC VP of Research to evaluate bioinformatics needs and possible solutions

» A software was developed in-house to assist microarray data analysis by users with no programming background.

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2010—Yipee!»Hired the second non-librarian

specialist with advanced degrees in both bioinformatics and biochemistry

»USC VP of Research decided to provide annual funding for licensing bioinformatics tools following a recommendation by the bioinformatics committee

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Norris Medical Library Bioinformatics Service

»Article about the service published in October 2013 issue of the Journal of the Medical Library Association JMLA

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Bioinformatics Service Staff

www.usc.edu/bioinformatics

»Yibu Chen, Ph.D. in Biology

Program Coordinator

»Meng Li, Dual M.S. (Bioinformatics/Biochemistry)

Bioinformatics Specialist

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NML Bioinfo Service—Top Tasks

»Develop workshops and conduct training on using bioinformatics software and database

»Provide consultation on applying bioinformatics tools for biomedical research

»Support and manage access of in-house bioinformatics computing resources and licensed commercial bioinformatics tools.

»Provide collaborative bioinformatics data analysis and support grant applications

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NML Bioinfo Service—Key Bioinformatics Tools

High-throughput Data Analysis

Literature Study/Data Mining

Functional Genomics Analysis

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NML Bioinfo ServiceBioinformatics Computing Resources

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Yes, They LOVE the Tools!

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NML Bioinformatics Service Annual Activity Stats

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Closing Remarks

»The bioinformatics needs in academia environment will continue its torrid growth in coming years.

»The current fragmented approaches in most academic institutions are unable to address such needs effectively.

»With right strategies, library-based bioinformatics service programs can become a key player in the era of big-data