The Neolithic Revolution and the Evolution of Life Expectancy Oded Galor “It is not the strongest of the species that survive, nor the most intelligent, but the one most responsive to change” Charles Darwin
Jan 03, 2016
The Neolithic Revolution and the Evolution of Life Expectancy
Oded Galor
“It is not the strongest of the species that survive, nor the most intelligent, but the one most responsive to change”
Charles Darwin
Objectives
The origin of the rise in life expectancy since the Neolithic Revolution
Natural selection vs. Technological advancements, income, education,…
The role of natural selection in the non-monotonic evolution of life expectancy in the process of development
The effect of differential timing of the Neolithic Revolution across countries and regions on the emergence of sustained differences in life expectancy across countries and ethnic groups
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Mesolithicperiod
Neolithicperiod
Copper age Bronze-Ironage
The evolution of life expectancy17,000 – 1,000 BCE
The evolution of life expectancyin the process of urbanization (England)
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1560 1600 1640 1680 1720 1760 1800 1840 1880
The evolution of life expectancyEngland, 1580-2000
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1580 1630 1680 1730 1780 1830 1880 1930 1980
Theories of Aging
The Mutation Accumulation Theory [Medawar, 1946]
Aging is an inevitable outcome of the declining force of natural selection in older age
Adverse mutations in the post-reproductive age have a smaller negative effect on the survival of the genes
…Theories: Evolution of Life Expectancy
The Antagonistic Pleiotropy Theory [Williams, 1957]
Late-activating harmful genes may be favored by natural selection if they have a beneficial reproductive effects in early stages of life.
(Pleiotropy - multiple effects of a single gene)
…Theories: Evolution of Life Expectancy
The Disposable Soma Theory
[Kirkwood and Holliday, 1979]
Optimal allocation of metabolic resources between reproduction and maintenance.
The Disposable Soma Theory
Evolutionary trade-off between:
Resources channeled toward:
current reproduction
& somatic investment
longevity & future reproduction
…The Disposable Soma Theory
Evidence:
Longevity is correlated with resources devoted to cellular repair and maintenance
Capacity of somatic cells to carry out effective maintenance and repairs (e.g., DNA repairs, accurate gene regulation, tumor suppression, and antioxidants), governs the time taken for damage to accumulate
[Kirkwood (1998), Williams and Day (2003)]
Main Hypotheses
The Neolithic Revolution increased the extrinsic mortality risk
- rise in population density
- domestication of animals
- increase work effort
- poorer nutrition (e.g., reduced meat intake, reduced mineral absorption by the cereal-based diet)
Time Trend in Pre-Columbian Health
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-6000 -4000 -2000 0 2000
BC AD
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Source: Richard H. Steckel
Health Index
Skeletal infections - inflammatory responses to bacterial invasion
Iron deficiency anemia - nutritional deprivation, low body weight, chronic diarrhea, parasite infections
Dental health -- indicator both of oral and general health
Degenerative joint disease -- mechanical wear and tear on the joints of the skeleton due to physical activity
Enamel hypoplasias - enamel deficiency commonly found in the teeth of people whose early childhood was biologically stressful
Trauma
…Main Hypothesis
This deterioration in the health environment increased the evolutionary optimal allocation of resources towards somatic investment, repairs, and maintenance (e.g., enhanced immune system, DNA repairs, accurate gene regulation, tumor suppression, and antioxidants)
Short-run: (the composition of the population is unchanged) Life expectancy declined
Long-run: (an evolutionary process)Evolutionary advantage to individuals who were genetically pre-disposed towards higher somatic investment
Increased representation of individuals who are genetically pre-disposed towards higher somatic
investment Life Expectancy increases
…Main Hypotheses
The deterioration in the health environment:
triggered the observed improvement in life expectancy since the Agricultural Revolution
was a necessary condition for the dramatic recent improvement in life expectancy
…Main Hypotheses
Differences in the timing of the Neolithic Revolution across regions led to sustained differences in life expectancy across countries.
…Main Hypothesis
The rise in the extrinsic mortality risk
enhanced the genetic potential for longer life expectancy (i.e., life expectancy in a risk-free environment)
enabled the dramatic impact of recent improvements in health infrastructure on the prolongation of life
Rapid Evolutionary Changes in Humans in the past 10,000 years
Lactose Tolerance Variations in the ability to tolerate lactose across regions is inversely
related to the differences in timing of the transition to agriculture across regions and thus in the domestication of dairy animals in the Neolithic revolution
Gluten Tolerance Variations in the ability to tolerate a protein present in wheat, rye,
barley, and some oats, first domesticated in the course of the agricultural revolution, is inversely related to the distance from the Fertile Crescent
Genetic immunity to malaria - Sickle Cell Trait Variations in natural immunity to malaria is related to the engagement
in slash-and-burn agriculture
…Rapid Evolutionary Changes in Humans in the past 10,000 years
700 regions of the human genome have been reshaped by natural selection within the past 5,000 to 15,000 years
Voight et al. (2006)
ASPM (a specific regulator of brain size in the lineage leading to Homo sapiens) arose in humans merely about 5800 years ago and has since swept to high frequency under strong positive selection
Mekel-Bobrov et. al (2005)
Testable prediction
Populations that experienced the Neolithic Revolution earlier have higher life expectancy
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Life
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2 4 6 8 10Weighted Timing Since Neolithic
Fig.1 - Life Expectancy and Timing Since Neolithic
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Covariates AdjustedFig.2 - Life Expectancy and Timing Since Neolithic
Evidence (other species):
The effect of a rise in extrinsic mortality risk on life expectancy is ambiguous [Williams and Day (2003)]
Recent study: Guppies that were exposed to higher extrinsic mortality risk had a higher life expectancy in a risk-free environment (i.e., lower intrinsic mortality rate) [Reznick et al. (Science, 2004)]