11/9/2015 1 The Low-Down on an Evidence-Based Approach to Short Stature AKASH SINHA MBBS, MD/PHD, MRCPCH, FRCPC PAEDIATRIC ENDOCRINOLOGIST/ PAEDIATRICIAN ABBOTSFORD 2015 Disclosures I have none to declare Introduction Important in all areas of medicine dealing with children Perceived or real impairment of growth Referred due to physical, psychological or social difficulties In most it is a variation of normal physiology rather than a pathological cause However all need logical process of assessment
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The Low-Down on an Evidence-Based Approach to ShortStature 2015... · Evidence-Based Approach to ShortStature AKASH SINHA MBBS, MD/PHD, MRCPCH, FRCPC PAEDIATRIC ENDOCRINOLOGIST/ PAEDIATRICIAN
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11/9/2015
1
The Low-Down on anEvidence-Based Approachto Short Stature
Introduction Important in all areas of medicine dealing with children
Perceived or real impairment of growth Referred due to physical, psychological or social difficulties In most it is a variation of normal physiology rather than a
pathological cause However all need logical process of assessment
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Background
Phases of growth
Prenatal Genetics Maternal size Maternal health Nutritional supply
Postnatal
Predominantly interested in postnatal growth Different influences
Example of prenatal influencesInfant of a diabetic mother Congenital hypothyroidism
FASCongenital infection
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Phases of growth
Prenatal
Postnatal Genetics
Parental size
Nutrition
Health
Hormones
Phases of linear growth
Height velocity curves Individual height curves
Nutrition
Growthhormone
Sex steroids
Early wobble
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Finding your centile
Pubertal growth♀: Growth spurt 2 yearsbefore boys, at start of clinicalpuberty
Peak height velocity ~12 years
Followed by menarche
Peak height velocity ~8 cm/yr
♂: Growth spurt when pubertyalready well established(testicular volume 10-12 mls)
Peak height velocity ~14 years
Peak height velocity ~10cm/yr
♂>♀ height by ~13-13.5 cm
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Causes of short stature
Causes of short stature
Familial(short parents)
Delayed puberty
SGA
ChronicillnessChromosomes
Syndromes
Bony dysplasias
Nurture
Hormones
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Familial short stature
Familial(short parents)
CalculateMidParentalheight
Boy: Father + [Mother+13cm]/2+/- 8.5cm
Girl: [Father-13cm]/2+ Mother+/- 8.5cm
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Constitutional delay of growthand puberty
Familial(short parents)
Delayed puberty
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Small for gestational age
Familial(short parents)
Delayed puberty
SGA
85% show‘catch-up’growth..
the rest staysmall =15%
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Chronic illness
Familial(short parents)
Delayed puberty
Chronicillness
SGA
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Chromosomes
Familial(short parents)
Delayed puberty
Chronicillness
SGA
Chromosomes
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SHOX gene
DownsDownsSyndromeSyndrome
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Syndromes
Familial(short parents)
Delayed puberty
Chronicillness
SGA
Chromosomes
Syndromes
PraderPrader WilliWilliSyndromeSyndrome
NoonanNoonanSyndromeSyndrome
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SilverSilverRussellRussell
SyndromeSyndrome
Bony dysplasias
Familial(short parents)
Delayed puberty
Chronicillness
SGA
Chromosomes
Syndromes
Bonydysplasias
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Nurture
Familial(short parents)
Delayed puberty
Chronicillness
SGA
Chromsomes
Syndromes
Bonydysplasias
Nurture
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Hormones
Familial(short parents)
Delayed puberty
SGA
ChronicillnessChromosomes
Syndromes
Bony dysplasias
Nurture
Hormones
Endocrine disorders
Growth hormone insufficiency
Pseudohypoparathyroidism
Hypothyroidism
Cushing’s syndrome
GH resistance (Laron syndrome)
** Height/weight comparison **
Causes GH insufficiency
GeneticGH-1 or GHRH receptor mutations Pit-1, Prop-1 mutations