Page 1
,**-�� ������ ,�� � �
� � : �� +/� ++� ,0� ��� �� .��0�� � : ������� .*-
� : �� ������������� �������� ����� ����� ����� ������� �� !��"� # �$� %�&'� ��(� ��)�� ��*+ � !�� "� +0,
#-./� : 0� 1� 23 4� 5$ 1� 678'�%�9:� "� /,
&'()*)� : +,�;��,**.�<-=>��?��@� � ���-�!A./01��%�B� �C!?DE�� "� -,
� �
��� ��
+� �234 �F5� : ��C!?��234�6�G789.-,H�IJ:;<=>�2K :
+/1-,� ?L'@ABCDE
,� ,**-�<�>M,F5 �F5� : ��C!�,**-� ++� /�3F?�>M,F5GHIJ� NAKO:MPGL'@ABCDE QR� LMNGOPSQGRSJTTUCJIVE �WUVWX��YZ[-�W@-=\]XG^Y:Z_DDTG[AIE `)ab)cdeWXfC\C]?DTG>�BCJIAIE -=>�^_gX` 1hicia�bcjYZ[��?k7@9]lmSDnMAo:pdqJerAst]BCDE
-� ��YZ[-�WU].4 �F5� : %�C!?fC���C!�GW?U].4MSY@F5BCDE g>:�G ,hh<uvwVSYlmVE ixj8?[ABy?kzGHIJ� {|}~@ABCDE
.� ` +1h��YZ[-�-=>� �F5� : �� ,**-
�<-=>��?�` 1hicia�bcjYZ[��?k7GlI�` +1h��YZ[-�-=>�X -�,?�7Ao� m�n9?��.4GASDnM@F5BCDE �/�c�aAolo?p�AN?MASDnM� -=>�^_g?�q?�rAo@L'BCDE �D� -�st>X-�u�?vwMA9� -�G��qA�SD�2GX��VxBCVE
/� ` +2h��YZ[-�-=>� �F5� : +,� ,**.
�<-=>��?�` +2h��YZ[-�-=>�?yz.4@F5BC
DE �7X ,**.� +,� 3� ����++� �{�� ��X|��?��/���lmVE `)ab)c� ����a:X�T}~Gyz@T�lIVE ��WX!]�t@ 2���u���@ +���-�@ /��MAV|��lmVE
0� ` +3h��YZ[-�-=>� �F5� : ��C!?� ��C!�` +3h��YZ[-�-=>��?MqJ� ���-
�-�����-?�� �C!:�^�MwVnM@��BCDE ,**/� +,� +� ����-� �{� G��l��wV��l��BCJIVE
1� �?�+� `)ab)c23C!�U?��G89� `)ab)c?�Z/� /¡:¢�G#�BCDnM@F5BCDE ��YZ[-�WGuvBCD £HIV-+�,���?��� ,**-� ���YZ[-�����¤ GHIJX���y?¥F?*r��U� �2"¦?§�:¨�MwVDTG©¡ª)«Aql`)ab)cGuvwVnM@��BCDE uv�U +�:f¬qD-�WGHIJN� ©¡ª)«AqluvwVnMMASDE `)ab)c?CGHIJ� uv5�?�s@-�W?®¯lmVnM�U� �uª)°/��±)�:��wVAo?F9�:� �>#2�@��wVnMMASDE ©¡ª)«Aql`)ab)cGuvwVnM?���²GHIJN�>#2�l��wVnMMASDE
,� ` 1hicia�bcjYZ[����C!�U�G��: ,**/� 1� +��/�G��l��wV��lyz@TTUCJIVnM@F5BCDE ��YZ[-�?L³@r�BCDE
-� �?���C!?�U� �-��Ur E:/qD�´ac/? +� +hi¡� µ±¶· ¸±? +� ,hi¡@��BCDnM@F5BCDE
��� ��
+� ,**.�<SQ¹GHIJ,**.�<SQ¹GHIJ���C!�UL'@ABC�G¹@��BCDE ,**-�<SQM¢ºJ� �WUVW@-=\]XMASDnM�U»¼� `)ab)cdeW@
�,**. The Japanese Society for AIDS Research The Journal of AIDS Research
� /. �54
Page 3
,**-����������
�������� � /� ,**-� ������� ������������������� �!" #$%�&�'( )"
*+,- �./01 � 2�34 �5�6�789 � �:;< �=> � �+? �@AB> � CDE �F> � CG�H �I�JKL�MN � C O? �P> � QR�S< �>TU � VGWX ��> � YZ[\ �]^_> � `ZaX �bc> � d+e��F> � fghi �F�> � f�jk �lZm> � nop\ �F�> � :Zqr �s�> � �t u ��v_> � wxy4 �F=_> � z{ | �}~_�> � ~����F=_>
������ ���
�������������� � 5 � � � � F=>�
Aikichi IWAMOTO
���5 C � � H ��01Kenichi KOJIMA
� � � � � F=��./01Atsushi AJISAWA
D ' ��< ���)F=Chizuko IKEGAMI
B � � H �Q�B�>�Seiichi ICHIKAWA
V f � � ��_�>�Hidemi TAKAHASHI
� Y � ¡�¢£¤N¥9Mitsuo HONDA
G Z ¦ � §=>�Juzo MATSUDA
¨ © 3 k �ª«>�Eiji MARUI
~ � h X F=_�¬�>�Naoki YAMAMOTO
��������������
,-������ ® : ,**-� +*¯ -+�° 9 : ���±²³´µ¶�·¸¹º� : ����5� C����5� ��� D'� B��
Vf� GZ»��¼º� : �Y� ¨©� ~�»��
,.������ ® : ,**.� +¯ ,-�° 9 : ���±²³´µ¶�·¸¹º� : ����5� C����5� ��� Vf� GZ�
¨©»��¼º� : D'� B�� �Y� ~�»��
� /0 /0
Page 4
�������������������� ����� -������ ������������ ���� �� �������� ��� !�"#��$������"�����%�&�����'() �%*��#���+,%-.�/���' ��0�� 1��������'2,%��3�*0 �����4� 5%��������6����0 7� �%*8 ��9�� �*�����:;���<�%*��#�� ���� -�.=>%������?@ABCD�E����; F���G& ���HIJ'������� =�KLM'N��O =���� 0*08 P�QRISMT����; F���8 U��V& ���%� �'���4�QRISMT� !*<����3"��WRX?'5���� 9�"#�WRX?�#&%�&�����Y$%0 ����8 ������4���&�"# ��<�Z���� ��������3'(�)��[��*��'\+���:;��] �%^,��� 5���� 8 _��5%�3`��-.�/��-.� 0&%12�5%a.�:b���5c%���,2�Zd����3,$e6�fXg�4.�0 Science +h
i� Policy Forum jBurton DR et al. : -*-�-+0,
,**.k 5� c<��ALVAClgp+,*?B�
CmIngopqr3J�� Phase�gB�sM'tu�O �%�**d<v8 9�opqrYw�_��67'87x 3��*��#9:DPy�HIVopqrgB�sM=� ����*�a.��;� <z<� ������-.=0 3{E��?@|n 4>0 ��J�D?{�AMI?8 UNAIDS�AMI?��<'6 � �%���@A����� Py�opqr}��~���0 �%B��� !�"#opqr}��C&%*3{E��DEF03C&%��' ����G�0 ���� ��-.3{���� ����%���H �7)0�-.��Z���� I�HIV�J����'��� HIV�K��rg@IM�&�0 �%���7)�a.�0 L,<�%� 3��*�Z��0��{M�,2�-.�0 3HIV�d%��
�NO`�PQR*<�=4 ��S�HIVT��KU�V���0��� ������np�W*<\X�WTHIV�K'��03z&�����0 ���� �Y�3 ,**-������Z�@[ 3 ,*+*�3HIV�KU'+*\��]^�%��#����4.'���� ���� ��������3�*'=+, 0�#*� 9�=���_�+,%����`0 =���� =+,�=a*�����
j!��bk
������ j��k
c 0 c +i,**.� ,h ,* ���d¡ -5/**¢ jefk
�����U
g £
¤ ¥ h
Z i j !�����¦++-�20,, k§lm§¨!©ª /�+0�3��|rJI C,+
«Wn� !���o|rJI Mp4 *-�/2+.�/2*+5 FAX *-�/2+.�/2,*
«Wn� �����|rJI¦++-�**-, k§lm§¨qQ ,�.�+0
p4 *-�-2+1�/2,+
rm¤¥¬®¯�/
�������!�°±���s£t�uv0��R38 s£²U*<uv²w��x�y> �%³�WY*<´z�y> �����{s£²µ�¦+*1�**/, k§l¶¨|· 3�0�.+}Z·¸M - F
TEL : *-�-.1/�/0+2 FAX : *-�-.1/�/0+3��08 s¹�º»~{=>%uv�� 38�¼T�
Copyright Clearance Center, Inc.
,,, Rosewood Drive, Danvers, MA *+3,-, USA
Phone : (312) 1/*�2.**, FAX : (312) 1/*�.1..
Notice about photocopying
In order to photocopy any work from this publication,you or your organization must obtain permission fromthe following organization which has been delegatedfor copyright for clearance by the copyright owner ofthis publication.
Except in the USAThe Copyright Council of the Academic Societies3�.+�0 Akasaka, Minato-ku, Tokyo +*1�**/,, JapanTEL : 2+�-�-.1/�/0+2 FAX : 2+�-�-.1/�/0+3In the USACopyright Clearance Center, Inc.,,, Rosewood Drive, Danvers, MA *+3,-, USAPhone : (312) 1/*�2.**, FAX : (312) 1/*�.1..
Page 7
Instructions for Authors
The Journal of AIDS Research, the o$cial journal of the Japanese
Society for AIDS Research, remains devoted to the publication of
studies relating primarily to HIV infection from the medical and
social scientific aspects.
Submission of Manuscripts and Review Process
The journal is published quarterly (February, May, August, and
November). The editors invite the submission of manuscripts com-
prising original research reports, reviews, technical notes, news, and
editorial letters. In the case of questions, please feel free to call the
Editorial O$ce.
All authors, with the exception of invited contributors, must be
registered members of the Japanese Society for AIDS Research.
Only unpublished data will be considered for publication. Manu-
scripts submitted to the journal must not be under consideration for
publication elsewhere. A copy of an agreement, executed and signed
by all of the authors, is required with each manuscript submission.
The form to be used is available from the Editorial O$ce, and will be
sent upon receipt of a manuscript. No manuscript can be accepted for
publication without a signed copyright transfer.
All submissions will be peer-reviewed by members of the Editorial
Board, and possibly by other specially qualified individuals as well.
All accepted manuscripts including electronic form (o%ine, online)
become the property of the Society, and may not be reproduced or
published without the written permission of the Editor-in-Chief and
the Society.
Manuscript Style
Manuscripts should be submitted in English in triplicate, one
original and two copies, on A. (standard ,+�,2 cm) paper with ,./cm margins. All copy, including captions, footnotes and references,
must be typed double-spaced on one side of the sheet only. Manu-
scripts prepared on a word processor should be printed using a
letter-quality printer.
The manuscript should be divided into sections with appropriate
section headings. The sequence of the manuscript should be as
follows : title page, abstract and key words page, introduction, mate-
rials and methods, results, discussions, acknowledgements, references,
tables and figure captions. All pages must be numbered sequentially
with the title page being page +. The first page should contain the
title, a list of authors and their a$liations, the full address including
telephone, fax and e-mail numbers of the author to whom requests for
proofs, correspondence and reprints are to be sent, and a running
head (less than .* letters). The abstract and key words (limited to /words) should begin on the second page, followed by the introduc-
tion, materials and methods, results, discussion, acknowledgements,
and references sections. The abstract should be limited to -** words
or less.
Standard metric units are used for reporting length, weight and
volume. For these units, use cm, mm, l, ml, g, mg and so on.
Tables
All tables should be cited sequentially in the text, numbered,
supplied with suitable explanatory legends and column headings, and
provided at the end of the manuscript following the references. Table
should not be integrated into the body of the manuscript. They
should be self-explanatory and should supplement, rather than dupli-
cate, the data in the text.
Figures
All figures must be cited in the text, numbered, and supplied with
captions. All captions should appear together on a separate sheet
following the tables and references.
Legends should be brief and specific. Do not indicate the magnifi-
cation for light photomicrographs unless visual inspection is inade-
quate for judging relative or absolute size. The use of scale markers
in an image is suggested for electron micrographs.
All artwork must be submitted in triplicate in camera-ready form
with all figures marked (lightly in pencil) on the back with the main
author’s name, the figure number, and the orientation of the image.
Inappropriately-sized figures will be cropped by the Editorial O$ce
or reduced by the publisher. The author is responsible for the costs
associated with reproducing illustrations in color.
References
References are to be numbered in order of citation and cited in text
by number. The reference section should be typed at the end of the
text, following the sample formats given below. Journal titles should
be abbreviated according to the abbreviations approved by Index
Medicus. All single-word journal titles should be spelled out. Com-
plete information should be provided for each reference, including
titles of journal articles, all authors and editors, and inclusive pagina-
tion. Sample references are given below for a journal article, a book,
and a chapter in a book :
+� Badder R, Montana J, McDonald M, Zolinger F, Quinn TC :
Frequent detection of HHV2 in AIDS patients with Kaposi’s
sarcoma. J AIDS +2 : +-/�+0/, +330.
,� Sambrook J, Fritsch EF, Maniatis T : Molecular cloning : a
laboratory manual(,nd ed), Cold Spring Harbor Laboratory
Press, +323.
-� Firkin BJ : Alternative treatment of patients with HIV who
became resistant to previous anti-HIV drugs (Goglan M, Salz-
man EW eds), Manual of HIV Therapeutics, Lippincott, pp
10,�130, +330.
Upon acceptance, authors are requested to submit a floppy disk for
the manuscript in text file format together with the information on
type of computer and software used.
Proofs
Authors will be supplied with page proofs to check the accuracy of
typesetting. Proofs must be checked carefully and returned within
three days of receipt.
Page charges and Reprints
Authors may be charged for any excess pages beyond / pages
(approx. +*,*** Japanese yen per page). A reprint order form will be
sent to the corresponding author together with the page proofs.
Those wishing to order reprints must return this form with payment
when returning their corrected proofs.
Mailing Address
All materials submitted for publication in the journal should be sent
to : Editorial O$ce of The Journal of AIDS Research, c/o Center for
Academic Publications Japan, ,�.�+0 Yayoi, Bunkyo-ku, Tokyo ++-�**-,, Japan (Tel. �2+�-�-2+1�/2,+ ; Fax �2+�-�-2+1�/2-*).