The Indian Polycap Study (TIPS). Lancet 2009 Mar 30 [Epub]

The Indian Polycap Study (TIPS). Lancet 2009 Mar 30 [Epub]

Trial profile The number of people screened for eligibility was not recorded. BP=blood pressure. HR=heart rate


Baseline characteristics


Reasons for permanent discontinuation of study drugs


Selected adverse effects


Rates of discontinuation of study drug by categories of reasons


Mean changes in systolic blood pressure (SBP) and diastolic blood pressure (DBP)


Changes in systolic blood pressure (SBP) and diastolic blood pressure (DBP) after randomisation over time

Most of the reduction in blood pressure was detected early and was sustaineduntil the end of active treatment.

As=aspirin. T=thiazide. R=ramipril.At=atenolol. S=simvastatin. P=Polycap.

*End of treatment.


Changes in lipids in each of the nine groups


Changes in heart rate compared with baseline


Changes in urinary 11-dehydrothromboxane B2 concentrations


Changes in blood pressure in subgroups based on baseline systolic blood pressure (A), diabetes (B), and use of calcium-channel blockers (C)


Changes in LDL cholesterol in subgroups on the basis of baseline concentrations and diabetes


Projected and estimated eff ects of a polypill, comparing estimates from Wald and Law6–8 versus that obtained in the Polycap study


The Indian Polycap Study (TIPS). Lancet 2009 Mar 30 [Epub]

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