The Human Phenotypic Disease Network

Cesar A. HidalgoCenter for Complex Network Research, University of Notre Dame / Northeastern University

The Human PhenotypicDisease Network

CollaboratorsNicholas ChristakisLaurie MeneadesJason Block

Dept. of Health Policy,Harvard Medical School

Laszlo BarabasiNicholas BlummDeok-Sun LeeJ Park

Center for Network Science,Northeastern University

Christine Teutsch

Massachusetts General HospitalHarvard Medical School

Some Diseases are known to be related

ENPP1 HFCS SLS

Ectonuclide Pyrophosphate

Phosphodiesterase 1

High FructoseCorn Syrup

SedentaryLife Style

There are no single causes for each disease

DiabetesObesity

Determining causes is labor and capital intensive

Disease 2Disease 1

Disease 1 Disease 2Affect Same Individuals

Significantly more than Random

C12

P1 P2

N

))(( jiji

jiijij

PNPNPP

PPNC

Building a Net

~ 13’039’018 patients58.3% females,90.1% white7.5% black

~ 32’341’348 records (hospitalizations)

Up to 10 diagnosis (from ~950 cat (3digit) / ~14000 (5digit) )

Disease 2Disease 1

CHF

CONCLUSIONS• We introduced the concept of a phenotypic

disease network.

• This network can be used to help explore life cycle strategies for drug companies and hospital design.

• This network can be used to perform comparative studies.

• Ultimately, the goal is to help determine disease ontology based on their comorbidity patterns

http://www.nd.edu/~chidalgo

Or Google: CA Hidalgo

http://www.nd.edu/~networks

Or Google: CCNR