THE HISTORY OF INJECTABLES THE REVOLUTION IN FACIAL REJUVENATION Injectable treatments such as wrinkle fillers & wrinkle relaxers have revolutionized facial rejuvenation. Collagen was the first FDA-approved filler in 1981, but was soon replaced with better, safer, longer-lasting fillers in the early 2000s. Here's a look at the history of these products. WRINKLE RELAXERS WRINKLE FILLERS Infographic by: Sources: http://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/CosmeticDevices/WrinkleFillers/ucm227749.htm ZYDERM ® 1981 ZYPLAST ® 1985 1988 2002 2003 2003 2004 2004 Hyla form ® 2004 2006 2006 2006 2006 2008 2008 2009 2009 2011 2011 2012 2013 FIBREL ® Cosmoderm ® Captique TM e l evess TM PREVELLE ® SILK EVOLENCE ® -L VOLUMA TM XC wrinkle relaxers wrinkle fillers • Products relax muscles that cause wrinkles • Products contain a purified form of neurotoxin • Results develop within a few days to a week • Results last from 3 to 6 months • Products fill wrinkles and provide volume • Products contain a variety of substances • Results often seen immediately • Results last from 6 months to several years, based on product