The Gazette

151414

our 40th year

Covering Homewood, East Baltimore, Peabody,

SAIS, APL and other campuses throughout the

Baltimore-Washington area and abroad, since 1971.

april 18, 2011 the newspaper of the Johns hopkins university Volume 40 No. 31

Job Opportunities

Notices

Classifieds

reCoGNItIoN

Public Health honors former

NBA player Mutombo with its

humanitarian award, page 6

LeaDerS + LeGeNDS

Chair of Nuclear Regulatory

Commission to speak in Carey

Business School series, page 7

I N B r I e f

‘Stress and the Brain’ national summit; STEM

activities for out-of-school kids; call for posters

C a L e N D a r

E2SHI kickoff event; ‘The Future of

Teaching’; Google apps; blood drive2 16

A taste of Spring Fair E V E N T

New grants for KSAS undergradsB y G r e G r i e n z i

The Gazette

Already permeated with a culture of exploration, Johns Hopkins has just added to its portfolio

of research opportunities for under-graduates. The Krieger School of Arts and Sci-

ences recently announced a new grant program for its students to support either their senior thesis research or their work as a research assistant for a faculty member. The Dean’s Undergrad-uate Research Awards program, which will launch in the fall, will

allow students to compete for grants in the range of $500 to $3,000. The pro-gram will fund up to 25 students annu-ally for at least the next two years. Steven David, vice dean for under-graduate education, will oversee the pro-gram, which was made possible through a generous gift from two university alumni. The new offering builds upon the tradition created by the Provost’s Undergraduate Research Awards and Woodrow Wilson Fellowships, which are open to all Johns Hopkins under-graduates. Each program annually sup-ports dozens of students conducting original research. In announcing the program, Kath-erine Newman, the James B. Knapp Dean of the Krieger School, said that independent research could be the first step on the long road to a career as a professional scholar, or simply a natural extension of the curiosity that brings students to a demanding university like Johns Hopkins. “With this program, we want to encourage students to pursue original research and advance knowledge for the world,” she said. “We also hope this experience helps a student develop a close and mature bond with a faculty member as he or she develops their own research or assists a faculty-led project

Continued on page 7

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Targeting city’s top 911 callers can trim costs and improve patient care, pilot program finds

R E P O R T

Continued on page 5

B y e k a t e r i n a P e s h e v a

Johns Hopkins Medicine

Repeated unnecessary 911 calls are a common drain on the manpower and finances of emergency medical

services, but a pilot program that identified Baltimore City’s top 911 callers and coupled them with a case worker has succeeded in drastically cutting the number of such calls while helping callers get proper care.

The program, called Operation Care, was conceived and implemented by the non-profit agency Baltimore HealthCare Access and ran as a three-month pilot in 2008. Now, a newly published report of its results appearing in The American Journal of Emer-gency Medicine can help illuminate strate-gies for other emergency medical services departments around the country that may be plagued by the same problem, said the report’s lead author. “The original idea was to help these fre-

quent callers get better access to medical and other care, and in doing so, Baltimore City ended up saving money and resources, a welcome side effect,” said lead author Michael Rinke, a pediatrician and quality and safety expert at Johns Hopkins Chil-dren’s Center. As fire departments around the country continue to get their budgets slashed, find-ing ways to trim costs while maintaining

B y G r e G r i e n z i

The Gazette

They came. They saw. They ate. Lunchtime patrons devoured fun-nel cakes, pulled pork sandwiches,

alison Wampler and Julie Morgan

Flintstone-size turkey legs, fried Oreos and all manner of foodstuff at the 40th annual Johns Hopkins University Spring Fair. The inimi-table carnival corn dog? Alive and well in all its cornmeal-battered goodness. The festivities began at noon on Friday, when Spring Fair’s arts and crafts vendors and extensive food

court opened for business. What followed was three days of fun, food, games and shopping. More than 50 musicians were invited to play throughout the fair in four locations across the Homewood campus. Ah, the sweet sounds and smells of spring.

Jerry Schydman and Phil tang

al fresco meal plan Sean Gao and Mark Bennett

Sayeed Choudhury

2 THE GAZETTE • April 18, 2011

I N B R I E F

JHU to host national summit on ‘Stress and the Brain’

Johns Hopkins will host a two-day nation-al summit next week on the topic of “Stress and the Brain: Implications for

Health, Development and Learning.” Lead-ing researchers and practitioners will discuss the latest research on how stress impacts brain growth and development in children and adolescents. Sir Michael Rutter, a leading researcher and author in child psychiatry, will begin the summit with a talk on Thursday, April 28, in Hodson Hall on the Homewood campus. On Friday, April 29, three panels of experts will convene in Turner Hall on the East Bal-timore campus to discuss the implications of stress research for interventions at three stages: parent and infants, early childhood and adolescence. The summit is co-sponsored by the Bloomberg School of Public Health’s Urban Health Institute, the School of Education’s Neuro-Education Initiative, the School of Medicine’s Brain Science Institute, the JHU Council for PK-12 Education and the Lud-wig Family Fund. “This will be an important summit for educators, public health professionals and other practitioners interested in seeing the important links between neuroscience, behavioral research, intervention strategies and public policy,” said Robert Blum, of the Urban Health Institute. The conference is free, but registration is required. For more information or to register, go to tinyurl.com/4hlp984. For questions, call 410-516-0375 or email ccombs@jhu .edu.

Posters wanted for symposium on cancer nanotechnology

Cancer nanotechnology forms the focus of the fifth annual symposium of the Johns Hopkins Institute for

NanoBioTechnology, set for Friday, May 13, in Shriver Hall on the Homewood campus. Talks begin at 9 a.m. in the auditorium, and a poster session will be held from 1:30 to 3:30 p.m. in the Clipper Room. Poster titles may be submitted online until Thursday, May 5, and research topics from engineering, sci-ence and medicine are welcomed. Prizes will be awarded to top poster presenters. This year’s keynote speaker is Stephen B. Baylin, the Virginia and D.K. Ludwig Professor of Oncology and Medicine in the School of Medicine and deputy director of the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. He is also chief of the Cancer Biology Division and the cen-ter’s associate director for research. To see the full agenda of speakers, to regis-ter or to submit a poster, go to inbt.jhu.edu/outreach/symposium/twentyeleven.

Applied Physics Laboratory Michael Buckley, Paulette CampbellBloomberg School of Public Health Tim Parsons, Natalie Wood-WrightCarey Business School Andrew Blumberg, Patrick ErcolanoHomewoodLisa De Nike, Amy Lunday, Dennis O’Shea,Tracey A. Reeves, Phil SneidermanJohns Hopkins MedicineChristen Brownlee, Stephanie Desmon, Neil A. Grauer, Audrey Huang, John Lazarou, David March, Vanessa McMains, Ekaterina Pesheva, Vanessa Wasta,Maryalice YakutchikPeabody Institute Richard SeldenSAIS Felisa Neuringer KlubesSchool of Education James Campbell, Theresa NortonSchool of Nursing Kelly Brooks-StaubUniversity Libraries and Museums Brian Shields, Heather Egan Stalfort

e d i t o r Lois Perschetz

W r i t e r Greg Rienzi

Pr o d u c t i o n Lynna Bright

co P y ed i t o r Ann Stiller

Ph o t o G r a P h y Homewood Photography

ad v e rt i s i n G The Gazelle Group

Bu s i n e s s Dianne MacLeod

ci r c u l at i o n Lynette Floyd

We B m a s t e r Lauren Custer

c o n t r i B u t i n G W r i t e r s

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‘STEM Over Spring Break’ planned for young science buffs

The Center for Educational Outreach, affiliated with the university’s Whit-ing School of Engineering, will con-

duct its first “STEM Over Spring Break” event today, April 18, through Thursday, April 21. The center will offer activities for kindergarten through 12th-grade students on topics related to science, technology, engineering and math. More than 30 students have signed up for the activities, which will be offered free of charge from 1:30 to 3:30 each day at Home-wood’s Charles Commons.

SAIS to hold conference on demographic trends and BRICs

As part of its Year of Demography, SAIS this week will hold a daylong conference called “Demographic

Trends and the BRICs.” With dynamic economies, a quarter of the world’s land and 40 percent of the human population, the BRICs—Brazil, Russia, India and China—have the poten-tial to dominate the global economy by the middle of this century. Each BRIC faces a different population dynamic. Taken together, their demographics are instru-mental to the growth of the international economy. The conference, to be held from 8:30 a.m. to 3 p.m. on Tuesday, April 19, will bring together regional policy experts, demog-raphers and leading market analysts. Nick Eberstadt, the Henry Wendt Scholar in Political Economy at the American Enter-prise Institute, will give the conference’s luncheon keynote address at 12:30 p.m. For a complete agenda, go to www.sais-jhu.edu/demography/conference. The event will be held in the Nitze Build-ing’s Kenney Auditorium. Non-SAIS affili-ates should RSVP to [email protected]. A live webcast will be available at www .sais-jhu.edu. The speakers begin at 9 a.m.

Investigative journalist to speak on MMR vaccine and autism

Brian Deer, a respected investigative journalist who recently wrote a series in the British Medical Journal exposing

the fraud in the link between MMR vac-cine and autism, will speak this week at the Johns Hopkins Bloomberg School of Public Health. Deer’s talk, scheduled for noon to 1:30 p.m. on Tuesday, April 19, in Sommer Hall, is part of the celebration of the 50th anni-versary of the Department of International Health. His lecture is titled “An Elaborate Fraud: Vaccines and Autism.”

April 18, 2011 • THE GAZETTE 3

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B y F e l i s s a n e u r i n G e r k l u B e s

SAIS

The Hassenfeld Family Foundation has committed $2.2 million to the Johns Hopkins University Paul H. Nitze

School of Advanced International Studies to establish a social enterprise competition and fellowships at the Hopkins-Nanjing Center for Chinese and American Studies in China. The Hassenfeld Social Enterprise Fund will enable Chinese, American and other international graduate students to work together to develop real-world outcomes through innovative projects, while the Has-senfeld Fellowships will ensure that the center attracts the best candidates for its two-year master’s degree program awarded jointly by SAIS and Nanjing University. “We are not only pleased but so proud of

our partners at SAIS for having the vision to collaborate on this new innovative pro-gram,” said Alan Hassenfeld. “Hopefully through this initiative we will bring more hands-on understanding of the global world we now inhabit.” University President Ronald J. Daniels said, “We are grateful for the steadfast and visionary support of the Hassenfeld family, a vital partner in Johns Hopkins’ pioneering joint venture in China.” SAIS Dean Jessica P. Einhorn added, “This thoughtful gift engages our student community in putting their learning to practice, while also providing much-needed support for our core requirement for finan-cial aid.” The Hassenfeld Social Enterprise Fund will support an annual competition at the center to identify a project valued for its social impact and innovation, its potential to make a lasting contribution to social out-

Foundation commits $2.2 mill for efforts at Hopkins-Nanjingcomes and its promise for nurturing a sense of community between Chinese and inter-national members of the Hopkins-Nanjing Center. A committee will select a team com-prising Chinese and international students who propose an innovative and sustainable project with concrete deliverables to address a social need or challenge in China that helps foster community entrepreneurship. As part of the project, the center plans to invite leading social entrepreneurs and social enterprise experts to conduct seminars for students. The other portion of the gift will support the existing Stephen D. Hassenfeld Fellow-ship program, providing significant schol-arship awards to about 40 master’s degree students over the next five years. After this time period, an endowment will continue to support three to five Hassenfeld Fellows each year, in perpetuity. Established in 1986, the Hopkins-Nan-

jing Center, located in Nanjing, China, is a graduate-level educational joint venture between Johns Hopkins and Nanjing uni-versities, providing more than 180 students from the United States and other countries and China with the unique opportunity to live and study together. American and international students take the majority of their courses in Mandarin, while Chinese students study mostly in English. More than 2,000 center graduates work throughout the world, contributing to the multilateral rela-tions between the United States and China. SAIS administers the center’s activities on behalf of Johns Hopkins. The Hassenfeld Family Foundation is focused on reducing the dire needs of chil-dren the world over, empowering women globally in order to break the cycle of vio-lence and serving as a catalyst for young social entrepreneurs to improve the world through their involvement.

G I F T

B y P h i l s n e i d e r m a n

Homewood

Top university administrators and two prominent guest speakers will par-ticipate in an inauguration event on

Wednesday, April 20, to celebrate the estab-lishment of The Johns Hopkins University’s Environment, Energy, Sustainability and Health Institute. The event will take place in Mason Hall on the Homewood campus from 2:15 to 4 p.m., followed by a reception. The institute’s purpose is to coordinate and encourage innovative research and teaching that address health, technology and sustainability challenges posed by the changing global environment. These proj-ects are intended to involve Johns Hopkins faculty with a wide array of expertise, cutting across disciplines and divisions. The institute, called E2SHI for short (and pronounced eh-shee), began taking shape late last year, when the Provost’s Office

contributed startup funds. Then the deans at the Whiting School of Engineering, Krieger School of Arts and Sciences and Bloomberg School of Public Health approved E2SHI’s charter and agreed to provide financial sup-port. The official kickoff celebration was sched-uled this week to coincide with Earth Week. At Wednesday’s event, brief remarks will be delivered by Ronald J. Daniels, president of the university; Nick Jones, the Benjamin T. Rome Dean of the Whiting School; Michael Klag, dean of the Bloomberg School; and Katherine S. Newman, the James B. Knapp Dean of the Krieger School. Guest speaker Kathleen Hogan, deputy assistant secretary for energy efficiency at the U.S. Department of Energy, will talk about nationwide efforts aimed at improving energy efficiency. A second speaker, Van R. Reiner, president and CEO of the Maryland Science Center, will discuss key environmental issues affecting the state of Maryland. The kickoff event is open to the entire university community.

Environment-focused institute gets Earth Week kickoff

B y s t e P h a n i e d e s m o n


Coupling an electronic prescrip-tion drug–ordering system with a computerized method for reporting

adverse events can dramatically reduce the number of medication errors in a hospital’s psychiatric unit, suggests new Johns Hop-kins research. “Medication errors are a leading cause of adverse events in hospitals,” said study leader Geetha Jayaram, an associate profes-sor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine. “With the use of electronic order-ing, training of personnel and standardized information technology systems, it is possible to eliminate dangerous medication errors.” The findings, published in the March issue of The Journal of Psychiatric Practice, outline how the 88-bed psychiatric unit at The Johns Hopkins Hospital went from a medi-cation error rate of 27.89 per 1,000 patient days in 2003 to 3.43 per 1,000 patient days in 2007, a highly significant rate reduction. Jayaram noted that during the study period, there were no medication errors that caused death or serious, permanent harm. Medication errors, which can be lethal, are known to be caused by illegible handwriting, misinterpretation of orders, fatigue on the part of medical personnel, pharmacy dis-pensing errors and administration mistakes. A pharmacy may misread what a physician has written or give the wrong medication or the wrong drug dose to a patient. “Having something typed eliminates bad writing—and most errors—immediately,” she said. “It’s a good reason for going electronic.”

The computer program used in the psy-chiatric unit, and hospitalwide at Johns Hopkins, also includes integrated decision support for drug dosage selection, drug allergy alerts, drug interactions, patient identifiers and monitoring—things that can be lost with a manual system that relies on layers of human beings to ensure the correct decisions are made, Jayaram said. The more steps involved in the process, the greater the likelihood of mistakes. At the same time that the drug-ordering system was put in place, Johns Hopkins insti-tuted the use of the Patient Safety Net error reporting system. The hospitalwide PSN is an online, Web-based reporting tool that is accessible to all caregivers, regardless of dis-cipline. Whenever a mistake is made, big or small, it is to be reported on the PSN. This system allows for follow-up, corrective action and the ability to learn from common mis-takes. It also categorizes unsafe conditions and near-miss events, and this can aid in future improvements. Near misses are more likely to be readily reported by frontline staff. Another key to the success of both pro-grams, Jayaram said, is the creation of a “culture of safety” throughout the psychiatry department. This is done through annual safety training, reporting of all adverse events as they occur and feedback that focuses not on blaming or shaming but on how to use education and corrective actions to prevent an error from happening again. In a psychiatric department, she said, medi-cation mistakes involving psychotropic drugs are rarely deadly. But psychiatric patients also take other kinds of medication—insulin, blood thinners and others—that can be lethal if given in the wrong doses or in the wrong combination. In a psychiatric depart-

Computerized ordering systems reduce psychiatric drug errorsment, some nonpsychotropic medications are considered high-risk and, as a precaution, two nurses must check them off before they are administered, Jayaram said. Jayaram said that even with computerized backstops, complacency is the enemy of safe care. Errors can still slip through in ways

no one has thought of yet, she said, so the system is constantly evolving. “You have to be vigilant for new problems that might come up,” she said. In addition to Jayaram, Johns Hopkins researchers involved in the study are Donald Steinwachs and Jack Samuels.


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Process has implications for understanding cancers, other diseases and disorders

B y m a r y a l i c e y a k u t c h i k


Using human kidney cells and brain tissue from adult mice, Johns Hop-kins scientists have uncovered the

sequence of steps that makes normally stable DNA undergo the crucial chemical changes implicated in cancers, psychiatric disorders and neurodegenerative diseases. The pro-cess may also be involved in learning and memory, the researchers say. A report on their study appeared online April 14 in Cell. While DNA is the stable building block of all of an individual’s genetic code, or genome, the presence or absence of a methyl group at specific locations chemically alters DNA and changes the expression of the genes. In a series of experiments, the Johns Hopkins team identified a step-by-step pro-cess involving a previously unknown step and two molecules for DNA to change from a methylated to demethylated state. Both

methylation and demethylation have long been linked to genetic alterations and a wide range of diseases. “Anything we can learn from these stud-ies about how to manipulate the process of changing DNA methylation status is going to have implications for human development and disease, including cancer and degenerative disorders,” said Hongjun Song, professor of neurology and neurosci-ence and director of the Stem Cell Program in the Institute for Cell Engineering in the Johns Hopkins University School of Medi-cine. First, using human kidney cells in a dish, the Johns Hopkins team focused its investi-gation on a tiny region of DNA in the cells’ nuclei, specifically watching the actions of one particular chemical base known as cytosine (C). The team added different chemicals to force methylation changes and, after watching the fate of methylated cytosine (mC) for two days and noting that nothing had changed, it then added a protein called TET1 to the cell. As a result, some of the mC became hydroxymethy-lated (hmC) and some reverted to plain C, indicating loss of the methyl group from C in the DNA. “What this told us was TET1 promotes this process of DNA changing status from methylated to demethylated,” Song said. While only about 5 percent of human cells progress from hmC to C under natural conditions, the researchers found that they could enhance the demethylation process by adding another protein called Apobec1. “That suggested another clear step in DNA demethylation,” Song said. “Cells go from mC to hmC by TET1, and then from hmC to C involving Apobec1.” Next, the researchers followed up on their previously published work showing that electrical stimulation like that used in electroconvulsive therapy, or ECT, resulted in increased brain cell growth in mice, which likely was an effect of changes in

Hopkins team discovers how DNA changesDNA methylation status. They used a genetic tool and PCR-based approach to amplify a tiny region of the genome in dozens of mice, some exposed to ECT-like electrical stimulation and some not, to compare the status of cytosine at similar stretches of DNA in brain tissue. By using genetic sequencing technology to analyze the various states of methylation—simple C, methylated C or hydroxymethylated Cs—in the specific regions of DNA from brain cells of ECT-exposed mice versus other animals, they found evidence that ECT indeed induces DNA demethylation and identified TET1 as a critical factor for this to happen. “By identifying two molecules and tying together two pathways needed for DNA methylation status to change, we believe we have shown a unified mechanism that regulates DNA as it goes from a methylated state to a demethylated state,” Song said. “This new knowledge gives us an entry point to someday manipulating this fundamentally important process for treating patients with diseases associated with epigenetic abnor-mality.” Support for this research came from the National Institutes of Health, Johns Hop-kins Brain Science Institute, National Alli-ance for Research on Schizophrenia and Depression, and Adelson Medical Research Foundation Authors of the paper, in addition to Song, are Junjie U. Guo, Yijing Su, Chun Zhong and Guo-li Ming, all of Johns Hopkins.

Related websiteshongjun Song lab: neuroscience.jhu.edu/ HongjunSong.php

‘Cell’: www.cell.com/current

Need extra copies of ‘the Gazette’?

A limited number of extra copies of The Gazette are available each week in the Office of Government, Com-munity and Public Affairs, Suite 540, 901 South Bond St., in Fells Point. Those who know they will need a large number of newspapers are asked to order them at least a week in advance of publication by calling 443-287-9900.


* To be considered for the $4,000/$5,000 homebuying awards, you must attend this event and have a valid homeownership counseling certi�cate. Home sales contracts signed prior to event date are not eligible for award funds. Only 50 awards are available to qualifying participants who buy in the designated geographic area. West/East boundary is de�ned by the following streets: From the north city/county line proceed south on Charles Street to west on 29th Street to south on Howard Street to west on Camden Street to south on Russell Street. See website for full eligibility requirements and event details, or call 410.637.3750.

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Continued from page 1

911 callers

the same level of service will be increasingly important, the researchers said. In three months, the program generated savings of more than $14,300, more than $6,300 of which was for the city fire depart-ment. The real savings are probably greater, as this number did not factor in any money saved from unnecessary trips to the emer-gency room and freeing up ambulances for other callers. The Baltimore City Fire Department, which responds to nearly 150,000 emer-gency calls each year, has continued to fund the program, providing a nurse and a case manager for repeat 911 callers. In 2007, two Baltimore City residents were responsible for more than 60 emergency calls, another resident made 110 calls to 911, and yet another made 147 such calls, the investigators said. Each 911 call requires EMS to dispatch an ambulance to the caller. Repeat 911 callers, the researchers rea-soned, may face problems such as lack of health insurance and access to routine medi-cal care, or an inability to navigate the laby-rinth of health care services. The findings of the study suggest they were mostly right. Examining a year’s worth of 911 call logs, the researchers identified Baltimore City’s 25 most frequent 911 callers, 10 of whom enrolled in the three-month program for weekly sessions with a case worker who assessed their medical needs, taught them how to navigate the health care system, put them in touch with primary care physicians and specialists, referred them to various sup-port programs and educated them on ways to limit 911 calls to true emergencies.

Collectively, the 10 callers made 520 calls to 911 in the year preceding their enroll-ment. Based on their call pattern from the previous year, the researchers estimated that these 10 people would make 100 calls to 911 during the three months of the program. Somewhat to the researchers’ surprise, there were only 57 calls, nearly half as many as they had predicted. Nine of the 10 patients had insurance, mostly through Medicare. All 10 patients had two or more chronic conditions, includ-ing hypertension, diabetes and heart disease. Seven had a mental health or substance abuse problem or both. The average age was 60 years, ranging from 39 to 89 years. The case manager referred patients to insurance assistance programs, medical specialists, adult-care services, food services like Meals on Wheels, psychiatric evaluation and sup-port groups for substance abuse. Nearly 70 percent of the referrals were to nonmedical services. “This program highlights the importance of simple interventions that can yield pow-erful results,” said co-investigator Kathleen Westcoat, of Baltimore HealthCare Access. “For example, making sure that a diabetic patient doesn’t run out of strips for the glu-cose monitor can prevent a frantic 911 call for a nonemergency.” None of the patients reported that they hesitated to call 911 in true emergencies, and said that they experienced no adverse health effects as a result of the program. The investigators caution that though these findings are insightful, their relevance is difficult to gauge because they are based on a small number of patients. Co-investigators on the report are Elisa-beth Dietrich, of the Baltimore City Health Department, now at the University of Cali-fornia, San Francisco; and Traci Kodeck, of Baltimore HealthCare Access. G

‘Problem-solving’ approach sustains benefits to patient after program’s end



An intensive program that taught low-income poorly educated diabetics to better manage their disease resulted

in significantly improved long-term blood sugar control, according to Johns Hopkins researchers who designed and implemented the program. The findings, published online in the Journal of General Internal Medicine, offer clinicians a proven new tool to help those with poorly controlled diabetes make life-style changes to improve their health, the researchers say. They note that many edu-cational programs for people with diabetes typically have little impact, and the benefits wear off after the programs end. “We know that people need information to manage their disease, but having knowl-edge of the facts is not enough for behavioral change,” said Felicia Hill-Briggs, an associate professor in the Division of General Internal Medicine at the Johns Hopkins University School of Medicine and the study’s lead author. “With this novel approach, we have found a way to give people the skills to solve problems in all areas of their lives so that they can take diabetes off the back burner and start caring for their health.” In the small study, 56 participants were randomized into one of two groups. One got the intensive, nine-session, problem-solving course that covered not only standard dia-betes self-management and care but taught

problem solving as a skill to help manage the financial, social, resource and interper-sonal issues that often stand in the way of managing their diabetes. The other group got a condensed, two-session, version of the program. Three months after the end of the pro-gram, participants in the intensive group saw their hemoglobin A1C levels—a long-term measure of blood sugar—fall by an average of .7 as compared with their levels before the start of the program. (Levels below 5.7 are considered normal, while the target for people with diabetes is below 7.0.) One participant stopped needing insulin after the completion of the program, Hill-Briggs says. The participants in the condensed program saw no improvement in their A1C levels. Many who took part in the intensive program saw high cholesterol and high blood pressure drop as well. What struck Hill-Briggs most about her research was that A1C levels improved three months after the program was over. This is in contrast to many diabetes interventions, particularly with lower socioeconomic groups. “When the program stops and support is taken away, the behavior stops and the benefits stop,” she said. Hill-Briggs says she thinks that one of the reasons for the sustained improvement in her study is that if problem solving has been taught successfully, people see that skill improve as they use it more. More than 25 million Americans have type 2 diabetes, and the number of diagnoses has been steadily rising, with 1.9 million new cases diagnosed in 2010. Like many chronic illnesses, diabetes disproportion-ately affects older people, and its prevalence is higher among racial and ethnic minorities. The annual economic burden of diabetes is an estimated $132 billion and increasing,

New diabetes education yields improved blood sugar controlmostly attributable to costly complications of the disease. Hill-Briggs says that the intensive pro-gram, like many other diabetes education programs, first focused on how to better manage the disease and prevent further dangerous complications such as kidney disease, poor circulation that requires ampu-tations and blindness. Facilitators explained the importance of a healthy diet, exercise, adherence to medication and self-monitor-ing. They did so using materials designed for a fifth-grade reading level to better reach this group, in which one in three partici-pants had very low literacy skills. But the program didn’t stop there. It went on to ask why participants were having diffi-culty making lifestyle changes and adhering to care. Some said they didn’t have access to healthy foods near their homes. Others said that healthful eating was too expensive. Some said that they didn’t take their medi-cations because they couldn’t afford them. Many had family challenges, caretaking demands and even neighborhood violence that affected their ability to manage their diabetes. In response, the program taught problem solving as a way to manage these challenges. Participants applied their problem-solving skills in individual ways to address their unique life situations. Some, for example, began to see their budgets in terms of must-haves and wants. Often, Hill-Briggs says, participants saw rent and electricity as must-haves but not diabetes medication, because their chronic disease didn’t bother them enough to be considered an urgent need. With an understanding of the role of their medicines, participants described moving them to the must-have list and taking off something else that was a want. For those who thought medication did not work, possible solutions they came up with included taking it consistently as pre-scribed for a week, then testing blood sugar

to see what had happened. When results were good, subjects were encouraged, and the results reinforced the need for consistent self-care. Participants also were taught about mak-ing the best choices when foods such as fresh fruits and vegetables were not available. Often, only canned products are available in neighborhoods with little access to large grocery stores. Two participants, on their own, convinced their small local grocers to stock the low-sodium varieties of vegetables, enabling them to make healthier choices. “We helped people integrate diabetes care into everything else that was going on in their lives and in the context of how those things affected their health,” Hill-Briggs said. “The struggle is [that] these other things seem more immediate; if today they’re hav-ing a crisis, that is the focus. The diabetes is always there. We helped them understand that their diabetes can be a priority, and problem solving lets us meet them where they are. We help them improve their diabe-tes self-care by using a reliable skill to tackle the problems that come up every day that used to throw them off their game plan.” This study was funded by grants from the National Heart, Lung and Blood Institute; American Diabetes Association; National Center for Research Resources; and National Institute of Diabetes and Digestive and Kid-ney Diseases. The other authors of the study, all of Johns Hopkins, are Mariana Lazo, Mark Peyrot, Angela Doswell, Yi-Ting Chang, Martha N. Hill, David Levine, Nae-Yuh Wang and Frederick L. Brancati.

Related websitefelicia hill-Briggs: www.hopkinsmedicine.org/gim/ faculty/hill_briggs.html

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Bloomberg School of Public Health

The Johns Hopkins Bloomberg School of Public Health has presented the Goodermote Humanitarian Award

to NBA legend Dikembe Mutombo for his efforts to reduce polio globally, and for his work improving the health of neglected and underserved populations in the Democratic Republic of the Congo. Mutombo received the award at a ceremony held at the school on April 13. “Mr. Mutombo is a winner in many ways—on the court and as a humanitarian. His work has improved the health of the people of the Democratic Republic of the Congo, and the Biamba Marie Mutombo Hospital and Research Center is a model for the region,” said Michael J. Klag, dean of the Bloomberg School. “Likewise, Mr. Mutombo has been instrumental in the fight against polio by bolstering vaccination efforts and bringing treatment to victims of the disease.” A former all-star and the NBA’s first Global Ambassador, Mutombo began his career in 1991 as a center for the Denver Nuggets. He went on to play for teams in Atlanta, Phila-delphia, New Jersey and New York before retiring in 2009 as a Houston Rocket. A native of the Democratic Republic of the Congo, Mutombo came to the United States on an academic scholarship to attend

Georgetown University in Washington, D.C., and during his second year was invited to try out for the basketball team. After becoming a player, he redirected his pre-med ambitions and graduated with degrees in linguistics and diplomacy. Mutombo has long been dedicated to improving the health, education and quality of life for the people of Congo and glob-ally. The Dikembe Mutombo Foundation was created in 1997 to eradicate childhood diseases that have virtually disappeared in developed countries, as well as to improve health outcomes in Congo. The Goodermote Humanitarian Award was established in 2008 by Dean Gooder-mote and the Goodermote family to support the Bloomberg School’s training and educa-tion mission and to honor the commitment of the school’s alumni to advancing public health worldwide. Dean Goodermote chairs the advisory committee for the school’s Center for Refugee and Disaster Response. The first recipient of the Goodermote Award was CNN anchor Soledad O’Brien, who was honored for her coverage of Hurri-cane Katrina and the 2004 Asian tsunami. In addition to creating the award, the Goodermote family has established a schol-arship for students studying international health who are committed to addressing the needs of displaced people and to furthering the mission of the Center for Refugee and Disaster Response.

SPH awards Goodermote Award to Dikembe Mutombo

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School of Public health student hannah tappius, Dikembe Mutombo and Dean Goodermote at the award ceremony held Wednesday.


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Johns Hopkins Medicine International has signed an agreement with Fundacion Santa Fe de Bogota, one of Colombia’s

leading health care institutions, to collabo-rate on knowledge transfer projects, training and education, and clinical services. In a letter sent last week to colleagues, Edward D. Miller, the Frances Watt Baker, M.D., and Lenox D. Baker Jr., M.D., Dean of the Medical Faculty at the Johns Hop-kins School of Medicine and CEO of Johns Hopkins Medicine, said, “For more than a century, Hopkins has been recognized as a national and global leader in patient care, research and education, and we’re excited to add this opportunity to our existing portfolio of affiliations and strategic collaborations in Latin America—Hospital Punta Pacifica in Panama City, Panama (2001), Instituto Tecnologico y de Estudios Superiores de Monterrey in Monterrey, Mexico (2005), and Clinica Las Condes in Santiago, Chile (2007). We firmly believe that this project will bolster our historic and vital mission of helping to raise the standard of health care around the world.” Fundacion Santa Fe de Bogota, founded in 1972, is a private not-for-profit organization. It owns the 205-bed University Hospital, the first Joint Commission International–

accredited hospital in Bogota and second in the country, provides undergraduate and graduate medical training, and conducts research projects and public health programs in cooperation with the Universidad de Los Andes. Under the agreement, Miller said, Johns Hopkins faculty and Johns Hopkins Inter-national experts will have the option of advising FSFB on the development of certain clinical programs related to a planned facili-ties expansion. The Johns Hopkins team also will assess opportunities to advance nursing services and provide assistance in the plan-ning and implementation process. In addition, JHI will guide FSFB during planning and architectural design phases for a new hospital project in northern Colombia. Other planned activities include customized training, observerships and joint symposia—similar to one held last year in the field of neurosciences—as well as opportunities for case review and patient referrals. “This initial two-year collaboration agreement is intended to create the basis for a long-term strategic affiliation, and promises to bring a range of opportunities to Johns Hopkins departments, faculty and other experts here in Baltimore,” Miller said.

JHM International inks agreement with health care leader in Bogota


KSAS

from beginning to end. We feel this faculty adviser role is integral to the program.” Newman said that she hopes to help usher in the day when all Krieger School under-graduates can stake a claim to original ideas brought to fruition. “The experience of presenting original ideas to an audience—in forms ranging from essays, to films, to academic articles or poster sessions—builds skills that matter for virtu-ally all professional endeavors,” Newman said. While the program will be generally known as the Dean’s Undergraduate Re -search Awards, Newman said the hope is that departments will name their awards after retired colleagues or prominent scholars.

David said that the program could become a popular choice for seniors, as virtually every department requires some version of a senior thesis or capstone project for honors recipients. In a recent sampling of projects, students studied the counterinsurgency in Afghanistan, urban planning in modern-day Shanghai and soil cropping in agro-ecologi-cal zones. Students receiving grant money will use it for travel, equipment, data collection and other purposes, David said. He said that students will be judged on the feasibility of their project and its cre-ativity and worthwhileness in advancing knowledge. A program website will be launched sometime this summer, and applications will be due in early fall. David said that for the program’s second year, he anticipates spring and fall deadline periods. For more information on the program, contact David at [email protected]. G

B y a n d r e W B l u m B e r G

Carey Business School

Gregory B. Jaczko, chairman of the U.S. Nuclear Regulatory Commis-sion, is the featured speaker at the

Johns Hopkins Carey Business School’s Leaders + Legends lecture series on April 21. The event will take place at 7:30 a.m. in the Legg Mason Tower in Harbor East. The title of his remarks is “The Past, Present and Future of Nuclear Power: A Regulator’s Perspective.” Jaczko was first sworn in as a commissioner of the NRC on Jan. 21, 2005, and he was designated chairman by President Barack Obama on May 13, 2009. His current term runs through June 2013. In his position, Jaczko has focused on the NRC being a strong and decisive safety regu-lator possessing the confidence of the public, and has worked to have the agency clearly communicate with the public and its licens-ees. He is committed to the safety of existing nuclear reactors and radioactive materials sites, an effective and efficient safety review

process for license applications, thorough environmental reviews, and strong enforce-ment and accountability. Jaczko previously served as science policy adviser and appropriations director for U.S. Sen. Harry Reid and as a congressional sci-ence fellow in the office of Rep. Edward Markey. He also has been an adjunct profes-

sor at Georgetown University, teaching in the areas of science and public policy. Jaczko holds a bachelor’s degree in physics and philoso-phy from Cornell University and a doctorate in physics from the University of Wisconsin, Madison. The Leaders + Legends monthly breakfast series, which

features today’s most influential business and public policy leaders addressing top-ics of global interest and importance, is designed to engage business and community professionals in an examination of the most compelling issues and challenges facing soci-ety today. Admission to the lecture, which includes breakfast, is $35. To register and for more infor-mation, go to carey.jhu.edu/leadersandlegends.

Nuclear Regulatory Commission head to speak at Leaders + Legends

Gregory Jaczko

Researchers at the Johns Hopkins Bloomberg School of Public Health have developed a nonsteroid-based

strategy for improving the lung’s innate immune defense and decreasing inflam-mation that can be a problem for patients with chronic obstructive pulmonary dis-ease, known as COPD. In a study published in the April 13 edition of the journal Science Transla-tional Medicine, the researchers targeted the Nrf2 pathway using sulforaphane, an ingredient that is present in broccoli in a precursor form, to enhance the Nrf2 path-way in the lung that mediates the uptake of bacteria. Exacerbation of symptoms due to bacterial lung infection is a com-mon problem for many COPD patients. The current study used inflammatory cells from lungs of COPD patients and mice. The experimental therapy is also being studied in a clinical trial. COPD is a major public health problem for both the developed and developing worlds. Characterized by chronic bron-chitis and emphysema, COPD affects 24 million Americans and 210 million worldwide, and is the third-leading cause of death in the United States. Current treatments are largely symptomatic and supportive, and do not reverse the under-lying biological defect in the lung. For the study, the researchers examined macrophages—white blood cells that kill bacteria—isolated from lungs of COPD patients. The researchers also examined mice exposed to cigarette smoke, which mimicked the immunocompromised con-ditions in the lungs of COPD patients. The study showed that sulforaphane could increase expression of receptors that improve macrophage phagocytic func-

tion. However, further study is needed to determine if a sulforaphane-rich diet could be an effective treatment. “Our findings suggest that macrophages from the lungs of patients with COPD have a defect in a process called phago-cytosis involved in the uptake of bacteria. We discovered that activation of the Nrf2 pathway induced by sulforaphane restored the ability of lung macrophages to bind and take up bacteria,” said Shyam Biswal, a professor in the Bloomberg School’s Department of Environmental Health Sciences and senior author of the study. “The study provides proof of concept that activating the Nrf2 pathway can restore the ability of macrophage to phagocytose, or bind with bacteria, and clear it from the lungs of patients with COPD.” Robert Wise, co-author of the study and a professor of medicine at the Johns Hopkins School of Medicine, said, “This research may help explain the long-established link between diet and lung disease, and raises the potential for new approaches to treatment of this often-devastating disease.” Authors of the study are Christopher J. Harvey, Rajesh K. Thimmulappa, Xianoni Kong and Robert Brown, all of the Johns Hopkins Bloomberg School of Public Health; Sanjay Sethi, of the Uni-versity of Buffalo; and Lonny Yarmus and David Feller-Kopman, both of the Johns Hopkins School of Medicine. The research was funded by a National Heart, Lung and Blood Institute Spe-cialized Centers of Clinically Oriented Research grant, the Flight Attendant Medical Research Institute and the Dor-ney-Koppel Family Foundation.

—Tim Parsons

Experimental treatment for COPD is in development


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New from JHU PressSetting the Table for Julia Child: Gourmet Dining in America, 1934–1961By David Strauss

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the tastes and techniques cultivated at din-ing clubs and in the pages of Gourmet maga-zine helped prepare affluent Americans for Julia Child’s education in French cuisine. Strauss argues that the country’s appetite for haute cuisine had been growing since the repeal of Prohibition, with Americans dazzled by visions of the good life presented in luxury lifestyle magazines, influenced by practices of the upper class who had slowly begun to adopt European taste and fashion, and enamored by the talents of the great French chef Auguste Escoffier. Strauss presents impressive archival research that illuminates themes of gender, class, con-sumerism and national identity, all of which influenced the course of gourmet dining in America. It was during this food movement

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B y e k a t e r i n a P e s h e v a


The recent flurry of highly pub-licized cases of young athletes dying suddenly on the playing field has prompted Johns Hop-kins Children’s Center cardi-

ologists to discuss the medical significance of a child’s sudden death for the rest of the family. Because most cases of sudden cardiac death in young athletes stem from an under-lying heart condition, a child’s sudden death or resuscitation from cardiac arrest should always prompt medical evaluation for the whole family, starting with parents and sib-lings and possibly extending to other family members. “Because several types of inherited, and often lethal, heart conditions can manifest themselves in sudden death or fainting dur-ing exercise, the story doesn’t end with the child being successfully brought back to life or with the postmortem results,” said Anne Murphy, a pediatric cardiologist at Johns Hopkins. Once the initial shock is over, the family should talk with its physician about further evaluation to rule out inherited forms of heart disease, she advises. Who should be tested and when? Pediatricians should refer to a pediatric cardiologist any child with chest pain and/or fainting that occurs during exercise. Tests may include an electrocardiogram and an echocardiogram. An ECG captures the electrical activity of the heart and can reveal some abnormalities that can cause fatal arrhythmias; most people with such conditions have normal heart structure. The echocardiogram, on the other hand, uses ultrasound to check for abnormali-ties of the heart’s structure, including any

thickening of the heart muscle, called hypertrophic cardiomyopathy, the top killer in young athletes who die from heart disease. Any child with a family history of sudden cardiac death not caused by common types of coronary heart disease that occurred in a parent or sibling should see a pediatric cardiologist. Referral is a good idea even if an autopsy was never performed, or if the postmortem exam didn’t find a clear cause of death, Johns Hopkins experts say. Most

people who die of heart-rhythm disor-ders have structurally normal hearts, and the autopsy is often unrevealing, Mur-phy explains. Any children with family members who develop coronary heart disease before age 50 should

have a cholesterol check at a minimum. If the test shows unusually high levels, the child should undergo further evaluation for inherited cholesterol disorders, Murphy adds. Genetic testing: To do or not to do? Genetic testing can identify the genetic mutations behind some types of inherited heart disease. People with symptoms sugges-tive of such conditions are good candidates for genetic testing, as are their symptom-free family members. Testing the rest of the family can help cardiologists determine who needs therapy, lifestyle changes and close clinical monitoring to ward off sudden cardiac events in the future, Murphy says. A negative test can be reassuring, and a positive test can lead to lifesaving treatment with medication or an implantable defibril-lator. Experts warn, however, that genetic test-ing has its own pitfalls and should be done

Young athlete’s sudden death may warrant checkups for entire familyonly in the context of a full clinical evalu-ation along with thorough genetic counsel-ing. “Genetic tests should never be the first step in evaluating a patient,” Murphy said. “They should come last to confirm a sus-pected diagnosis, and only once the cardi-ologist has specific genetic test targets in mind.” There are two important caveats, cardi-ologists warn. Because multiple genes are tested, there’s always a chance of detecting a variation, but a variation doesn’t always mean disease, nor will it necessarily explain

certain symptoms. In such cases, Murphy says, clinical evaluation and family history become even more important. On the flip side, genetic tests may not detect any muta-tion in some people with clear signs of heart disease, but that doesn’t mean they don’t have a disorder. “All it means is we have not found the genetic mutation responsible for their symptoms,” Murphy said. This is why a session with a genetic counselor before the test is critical. “We must prepare patients for the possible outcomes of the test,” she said.Cardio docs

advise who

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BayVIeW MeDICaL CeNterIlene Browner , an instructor of geriatric oncology; Michael Crocetti , an assistant professor of pediatrics; and Judy huang , an associate professor of neurosurgery, were inducted into the Miller-Coulson Academy of Clinical Excellence during the Excellence in Patient Care Symposium held April 26. John Burton , the Mason F. Lord Profes-sor of Geriatric Medicine in the Department of Medicine, and allan Gelber , associate professor of medicine in the Division of Rheumatology, were recently inducted into the Alpha Omega Alpha Medical Honor Society.

hoMeWooD StuDeNt affaIrSBenedict Dorsey , associate director of Financial Aid, recently wrote and directed his first feature film, The Human Web, which was nominated as one of the “Big 8” films at the San Diego Black Film Festival. It also was accepted into the North Carolina Film Festival.

KrIeGer SChooL of artS aND SCIeNCeSerin Chung , the Charles D. Miller Assis-tant Professor of East Asian Studies in the Department of Political Science, was awarded the William Holland Prize for the best article published in 2010 at the annual meeting of the Association for Asian Stud-ies. Her article, which appeared in the December issue of Pacific Affairs, is called “Workers or Residents? Diverging Patterns of Immigrant Incorporation in Korea and Japan.”

PeaBoDy INStItuteJudah adashi , a faculty member and DMA candidate, has received grants from Meet the Composer and the American Com-posers Forum in support of upcoming perfor-mances of his Songs and Dances of Macondo by the Quintet of the Americas. The wood-wind quintet will perform the work May 11 at Symphony Space in New York. Guitarist Petrit Ceku , a Gradu-ate Performance Diploma candidate, won the Schadt String Competition in Allen-town, Pa., on March 7 and performed later that week with the Allentown Symphony Orchestra. Artist Diploma candidate I lyich rivas , the second Baltimore Symphony Orchestra–Peabody Conducting Fellow, was one of the conductors of this year’s YouTube Symphony Grand Finale concert, held March 20 at the Sydney Opera House. Master of Music candidate ronaldo rolim , a student of Benjamin Pasternack,

won the Bosendorfer US-ASU Interna-tional Piano Competition at Arizona State University in January. Ten Peabody students were first-place winners in the Baltimore Music Club’s 2011 competition. The categories and performers are as follows. Professional age: Kyungwha Chu , piano; eunice Lee , viola; and elena yakovleva , flute. One age: Shuang Liu , harp. Senior age: hanol Lee , flute; tian Lu , piano; and Dimitry Volkov , cello. Student age: Jennifer N. Campbell , piano; alexandra razskazoff , soprano; and robert Sirois , bassoon. Three students of Phyllis Bryn-Julson won prizes in the National Association of Teachers of Singing Mid-Atlantic Regional Vocal Competition, held April 1 and 2 at Shenandoah University in Winchester, Va. First-place for college senior went to

Marie Marquis , also a student of William Sharp. Sarah hayashi and francesca Di Domenico placed second and third, respectively, in the college sophomore cat-egory.

SChooL of eDuCatIoNChristina harnett , an assistant professor in the Department of Public Safety Leader-ship and a licensed clinical psychologist, has been awarded the State of Maryland Meri-torious Service Medal, the second-highest military medal issued in Maryland. Harnett received this honor for her “exceptional service to the warriors of the Maryland National Guard as they resume their civil-ian lives following deployment.” Harnett has been providing the National Guard with behavioral health services for more than four years as a member of the Mary-land Defense Force and a faculty member of the Maryland National Guard Yellow Ribbon Reintegration Program, which helps transition soldiers returning from Iraq and Afghanistan. She heads a team that devel-oped the program’s resilience curriculum and provides ongoing reintegration training and support.

CheersCheers is a monthly listing of honors and awards received by faculty, staff and students plus recent appoint-ments and promotions. Contributions must be submitted in writing and be accompanied by a phone number.

F O R T H E R E C O R D

SChooL of MeDICINeedward Bernacki , associate professor of medicine, director of the Division of Occu-pational Medicine and executive director of Health, Safety and Environment, has received the Robert A. Kehoe Award of Merit from the American Occupational Health Conference. At Johns Hopkins since 1991, Bernacki has more than 30 years’ experience in managing occupational health and safety programs and has written many peer-reviewed articles for scientific publica-tions. James C. harris , a professor of psy-chiatry and behavioral sciences, pediatrics and mental health, has received the Leon Eisenberg Award from the Mental Health & Developmental Disabilities Program at Children’s Hospital Boston and Harvard Medical School in recognition of outstand-

Barbara Slusher , an associate profes-sor of neurology and chief scientific offi-cer for the Brain Science Institute Neu-roTranslational Program, has been named the recipient of the 2011 Rev. Charles K. Riepe Alumni Award, given each year to a graduate of The John Carroll School in Bel Air, Md. It is the school’s highest honor. A 1982 graduate, Slusher is being recognized for her professional and personal achieve-ment, which includes work as a community leader. She will receive the award at the school’s June 5 commencement, where she will be the keynote speaker. Cornelia trimble , an associate pro-fessor of gynecology/obstetrics, oncology and pathology, and director of the Cervi-cal Dysplasia Center, will serve a four-year term on the Cancer Immunopathology and Immunotherapy Study Section of the National Institutes of Health Center for Scientific Review. Trimble will review and make recommendations on grant applica-tions submitted to the NIH and will survey the state of immunology research. Her term begins July 1.

SherIDaN LIBrarIeS/Jhu MuSeuMSJennifer Darragh , librarian for data services and government information, has been elected to the Regional Committee of the International Association for Social Sci-ences Information Services and Technology. Darragh is one of three members represent-ing the United States, joining two from Europe and one from Canada. IASSIST is the primary organization for data librarians, data archivists and other data services pro-fessionals in the social sciences. ellen Keith , reference services coordi-nator and librarian for sociology, has been named the 2011 recipient of the Rachel S. Core Award, which was instituted by the Graduate Representative Organization to honor those who provide an outstanding contribution to the Homewood graduate student community.

uNIVerSIty aDMINIStratIoNStephanie reel , vice provost for infor-mation technology and chief information officer, has been named one of Informa-tionWeek Healthcare’s top 25 leaders of the health care IT revolution.

WhItING SChooL of eNGINeerINGMarc Donohue , a professor in Chemical and Biomolecular Engineering and vice dean for research, has been elected vice chair of the Council for Chemical Research’s board of directors; in that position, he will be responsible for organizing CCR’s annual meeting. In 2013, he will assume the posi-tion of board chair. Joelle frechette , an assistant professor in Chemical and Biomolecular Engineer-ing, is one of only 21 recipients of the 2011 Office of Naval Research Young Investi-gator Award, which recognizes outstand-ing scientists and engineers who, early in their academic careers, demonstrate excep-tional promise for doing creative research. Frechette’s award is given for her proposal “Understanding the Role of Hydrodynamic Forces on Wet Adhesion.” Kalina hristova , associate professor in Materials Science and Engineering, has been named the inaugural Marlin U. Zim-merman Jr. Faculty Scholar. Faculty Scholar status, which is awarded for a three-year term, provides a senior assistant professor or associate professor who has exhibited exceptional achievement in their area of expertise with flexible financial support to promote their innovative research, teaching activities and entrepreneurial thinking. For Hristova, the award recognizes her research in the structure and assembly of biological membranes, including the structural prin-ciples that underlie membrane protein fold-ing and signal transduction across biological membranes, and her contributions to teach-ing and mentoring. The award was estab-lished by the estate of Marlin U. Zimmer-man, an alumnus who received his degree in chemical engineering in 1944 and went on to a distinguished career at Standard Oil of Ohio.

B y l i s a d e n i k e

Homewood

W. Austin Elam and Preston Moon, Johns Hopkins doc-toral students in the Krieger

School’s T.C. Jenkins Department of Biophysics and in the universitywide Program in Molecular Biophysics, were among 20 students nationwide select-ed to receive the Biophysical Society’s 2011 Student Research Achievement Awards. Elam won in the category of “Intrinsi-cally Disordered Proteins” and Moon in the category of “Membrane Structure and Assembly” at the annual meeting of the 9,500-member Biophysical Society, held last month in Baltimore. Judges from the society selected the winners from among 390 entrants. Elam works in the laboratory of Vin-cent Hilser, a professor in Biology, focus-ing on the characterization of universal features of locally unfolded and disor-

dered proteins. His work takes biophysi-cal measurements to the scale of the human proteome, the entire set of human proteins. His work has implications for the understanding of protein function and may help shed light on diseases associated with protein misfolding, such as Alzheimer’s disease and Parkinson’s disease. Moon works in the laboratory of Karen G. Fleming, an associate professor in Biophysics, focusing on oily membranes and the specialized proteins embedded in them that provide each cell with com-munication, defense and a way to trade molecules with other cells. Moon and Fleming’s goal is to measure just how oily these membranes are, with an eye to the better design of new membrane proteins for medical use. “Austin and Preston are doing para-digm-changing research,” said Bertrand Garcia-Moreno, chair of Biophysics. “These awards are very well-deserved and a strong endorsement of both the students and their mentors.”

Two JHU doctoral candidates win Biophysical Society awards

K U D O S

ing leadership and stewardship in the field. Eisenberg, a professor emeritus at Harvard when he died in 2009, was the former direc-tor of Child and Adolescent Psychiatry at Johns Hopkins. Harris received the award April 12 at Harvard and gave the inaugu-ral Ludwik Szymanski lecture April 13 at departmental grand rounds at Children’s Hospital Boston. Mouen Khashab , assistant professor and director of therapeutic endoscopy, has been named one of the top reviewers of 2010 for the American Society of Gastroin-testinal Endoscopy’s monthly peer-reviewed journal, Gastrointestinal Endoscopy, which is the leading international publication on the specialty. The most successful reviewers of articles receive the most assignments, and prior to his award, Khashab reviewed 19 articles over 14 months. Jeffrey rothstein , professor of neurol-ogy and director of the Robert Packard Cen-ter for ALS Research, has been appointed director of the Brain Science Institute. He succeeds John “Jack” Griffin, founder of the four-year-old BSi, who will remain part of the institute’s leadership team. Richard Huganir, professor and director of the Solo-mon H. Snyder Department of Neurosci-ence, will remain as BSi’s co-director. Lillie Shockney , associate professor and administrative director of the Avon Founda-tion Breast Center, has received the 2010 National Award from the Amoena Corp. for outstanding contributions to the breast cen-ter industry. Shockney also has been named editor in chief of the new Journal of Oncology Navigation and Survivorship and is serving on the Leadership Council of the Academy of Oncology Nurse Navigators.

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B y c h r i s t e n B r o Wn l e e


Drugs already in development to treat Alzheimer’s disease may eventually be tapped for a different purpose alto-

gether: regrowing the ends of injured nerves to relieve pain and paralysis. According to a new Johns Hopkins study, experimental compounds originally designed to combat a protein that builds up in Alzheimer’s-addled brains appear to make crushed or cut nerve endings grow back significantly faster, a potential boon for those who suffer from neuropathies or traumatic injuries. The new drugs target a protein known as beta-site amyloid precursor protein cleav-ing enzyme 1, or BACE1, which plays a key role in generating the amyloid protein plaques that are thought to gum up nor-mal nerve signaling in the brain. Previous laboratory research showed that BACE1 also is involved in creating the insulation material known as myelin, which coats the projections that nerve cells extend to con-nect with each other, as well as generating a molecular cascade that causes these projec-tions to degenerate when they’re injured.

Given these earlier findings, Mohamed Farah, an assistant professor of neurology, and John Griffin, a professor of neurol-ogy, and their colleagues tried blocking the action of BACE1 to analyze the effect on injured axon projections. The researchers started their experiments with mice whose ability to make BACE1 had been geneti-cally knocked out. After these animals’ sciatic nerves were cut or crushed, the scien-tists closely watched what happened as the axons regenerated. Compared to normal mice that make BACE1, the animals lacking this protein cleaned up the debris around the injury site significantly faster. Since this debris can inhibit regeneration, Farah and his colleagues expected that the axons would regrow faster. Sure enough, the cut ends of the animals’ nerve cells generated more new sprouts, which grew into extensions that reached their targets—muscles or other nerve cells—days faster than those of the mice that made BACE1. Hopeful that compounds able to block BACE1 activity would have a similar effect, Farah and Griffin’s team worked with two experimental drugs already developed to target Alzheimer’s disease: BACE1 inhibi-

Experimental Alzheimer’s drugs might help with nerve injuriestor IV, produced by Calbiochem, and WAY 258131, a Wyeth compound that was syn-thesized by researchers at the Johns Hopkins Brain Science Institute for this study. Mice given either of the two drugs systemically after nerve injuries had a similar increase in regrowth, though less pronounced. This was expected, Farah said, since the drugs dampen the effect of BACE1 without removing it entirely as in the genetic knockout mice. The Johns Hopkins researchers said that their proof-of-principle work, published in the Journal of Neuroscience on April 13, was reason to celebrate. “Anything that speeds nerve regrowth could be enormously helpful to people with nerve injuries caused by a range of injuries and diseases, from diabetic neuropathy to motorcycle accidents,” Farah said. “After an injury, the environment around nerves and their target tissue sometimes degenerates before the nerves can heal, which kills the chances that the nerves will regrow,” he said. “If we can help nerves regrow faster, we increase the chances that they can reach their target and become healthy again after injury.” As a next step, the researchers plan to test the experimental compounds in other

animal models of nerve injury, including neuropathies and spinal cord injuries. “BACE1 inhibitors are a major drug target for many drug companies for Alzheimer’s,” Griffin said. “Our work may suggest that these drugs could have great utility in a very large clinical population with tremendous unmet need. Validation of our early research in other animal models of nerve injury will set the stage for further clinical investiga-tion.” Other Johns Hopkins researchers who participated in this study are Bao Han Pan, Paul N. Hoffman, Dana Ferraris, Takashi Tsukamoto, Thien Nguyen, Philip C. Wong, Donald L. Price and Barbara S. Slusher.

Related websitesJohn Griffin: neuroscience.jhu.edu/JohnGriffin .php

Neurology and Neurosurgery at Johns hopkins: www.hopkinsmedicine.org/ neurology_neurosurgery



A P R I L 1 8 – 2 5


Calendarden will discuss and sign copies of his new book, The Compass of Pleasure. Barnes & Noble Johns Hopkins. hW

S e M I N a r S

Mon., april 18, noon. “The Origin Recognition Complex in DNA Replication and Chromo-some Segregation,” a Biochemis-try and Molecular Biology seminar with Bruce Stillman, Cold Spring Harbor Laboratory. W1020 SPH. eB

Mon., april 18, noon. “Mira-cles and Literary Representation in Sono Ayako’s Kiseki,” an East Asian Studies seminar with Kevin Doak, Georgetown University. 366 Mergenthaler. hW

Mon., april 18, 12:10 p.m. “Safe Kids Worldwide: A Vac-cine for Childhood Injury,” a Graduate Seminar in Injury Research and Policy with Martin Eichelberger, founder, Safe Kids Worldwide. Sponsored by Health Policy and Management and the Center for Injury Research and Policy. W4013 SPH. eB

Mon., april 18, 12:15 p.m. “Tissue Stem Cells in Aging and Cancer,” a Carnegie Institution Embryology seminar with Amy Wagers, Harvard University. Rose Auditorium, 3520 San Martin Drive. hW

Mon., april 18, 12:15 p.m. “Computational Toxicology: New Approaches to Hazard, Exposure and Risk Assessment,” an Environmental Health Sci-ences seminar with Richard Jud-son, the Environmental Protec-tion Agency. Co-sponsored by the JHU Center for Alternatives to Animal Testing. W3008 SPH. eB

Mon., april 18, 12:15 p.m.

“On the Tribulations of NOT Performing Randomized Trials: Helping Smart Doctors Stop Pre-scribing Dumb Treatments,” a Center for Clinical Trials semi-nar with David Sackett, the first CCT Visiting Scholar. (Dr. Sack-ett will be at the School of Public Health through Wed., April 20, taking part in prepared activities and seminars by SPH students and faculty members.) E2014 SPH. eB

Mon., april 18, 1:30 p.m. “Neonatal EEG—From Signal Generation to Seizure Treat-ment,” a Biomedical Engineering seminar with Tammy Tsuchida, Children’s National Medical Cen-ter, Washington D.C. 709 Tray-lor. eB (Videoconferenced to 110 Clark. hW)

Mon., april 18, 3:30 p.m. “Prediction and Causation in Functional Neuroimaging,” a Biostatistics seminar with Martin Lindquist, Columbia University. W2030 SPH. eB

Mon., april 18, 4 p.m. “Prob-ing Plant Cell Wall Structure With Wall Loosening Enzymes,” a Biophysics seminar with Dan-iel Cosgrove, Pennsylvania State University. 50 Gilman. hW

tues., april 19, 10 a.m. “Nano-photonic Structures for Efficient Characterization of Single InAs Quantum Dots,” an Electrical and Computer Engineering seminar with Marcelo Davanco, Univer-sity of Maryland. 320 Hackerman. hW

tues., april 19, noon. “Mecha-nisms of Lymphocyte Signaling in Immunity and Cancer,” a Bio-logical Chemistry seminar with Joel Pomerantz, SoM. 612 Physi-ology. eB

tues., april 19, 4 p.m. “A Chemical Turn: Thinking Phar-maceutical Politics Anew,” an Anthropology seminar with Cori

Hayden, University of California, Berkeley. 400 Macaulay. hW

tues., april 19, 4:30 p.m. “Inte-grating History-Length Interpo-lation and Classes in Language Modeling,” a Center for Language and Speech Processing seminar with Hinrich Schuetze, Univer-sity of Stuttgart. B17 Hackerman. hW

Wed., april 20, 12:15 p.m. Wednesday Noon Seminar—“Autoimmunity and Immunity Among Individuals Diagnosed With Schizophrenia: Clinical Correlations and Co-Morbidity by Markers for Celiac Disease and Gluten Sensitivity” with Patri-cia Gregory, SPH. Sponsored by Mental Health. B14B Hampton House. eB

Wed., april 20, 2 p.m. “Lamin B3: Connecting the Spindle Matrix and Spindle Assembly,” a Carnegie Institution Embryol-ogy thesis defense seminar with Ben Goodman. Rose Auditorium, 3520 San Martin Drive. hW

thurs., april 21, noon. The Bromery Seminar—“Radwaste: Transportation and Other Issues” with Ruth Weiner, Sandia National Laboratories. Sponsored by Earth and Planetary Sciences. Olin Auditorium. hW

thurs., april 21, noon. “Bio-logical Espionage: Bacterial Use of Host Biochemistry for Patho-genic Purposes,” a Molecular Microbiology and Immunology/Infectious Diseases seminar with Erec Stebbins, Rockefeller Uni-versity. W1020 SPH. eB

thurs., april 21, 1 p.m. “Genet-ic Modulation of Mosquito Host-Seeking Behavior,” a Neurosci-ence research seminar with Leslie Vosshall, Rockefeller University. West Lecture Hall (ground floor), WBSB. eB

thurs., april 21, 3 p.m. “Neu-rally Inspired Computational Methods: From Algorithms to Neuromimetic Systems,” an Elec-trical and Computer Engineering seminar with Alexander Russell, WSE. 316 Hodson. hW

thurs., april 21, 3:30 to 6 p.m., and fri., april 22, 9

a.m. to 12:30 p.m. The Futures Seminar—Department of Eco-nomics, with panelists Markus Brunnermeier, Princeton Univer-sity; Glenn Ellison, MIT; Jonathan Levin, Stanford University; and Ken Wolpin, University of Penn-sylvania. Mason Hall Auditorium (Thursday) and Charles Commons (Friday). hW

thurs., april 21, 4 p.m. “Link-ing G Protein Signaling, EGF Receptor Trafficking and Cancer Metastasis,” a Biology seminar with Marilyn Farquhar, Univer-sity of California, San Diego. 100 Mudd. hW

fri., april 22, 11 a.m. “Large Eddy Simulations of Mixed Layer Instabilities and Sampling Strat-egies,” a CEAFM seminar with Tamay Ozgokmen, University of Miami. 50 Gilman. hW

Mon., april 25, 12:10 p.m. “Road Safety in Latin America,” a Graduate Seminar in Injury Research and Policy with Euge-nia Rodriguez, Pan American Health Organization. Sponsored by Health Policy and Manage-ment and the Center for Inju-ry Research and Policy. W4013 SPH. eB

Mon., april 25, 12:15 p.m. “Making the Mouse Blastocyst—Cell Lineages to Stem Cells,” a Carnegie Institution Embryology seminar with Janet Rossant, Uni-versity of Toronto. Rose Auditori-um, 3520 San Martin Drive. hW

Mon., april 25, 4 p.m. “Phar-maceutical Politics and Regulatory Reform in Post-War America,” a History seminar with Dominque Tobbell, University of Minnesota. 308 Gilman. hW

S P e C I a L e V e N t S

Wed., april 20, 2:15 to 4 p.m. Inauguration of E2SHI (the Envi-ronment, Energy, Sustainability and Health Institute), featuring presentations by JHU Presi-dent Ronald J. Daniels; Kath-leen Hogan, U.S. Department of Energy; Nicholas Jones, WSE dean; Michael Klag, SPH dean; Katherine Newman, KSAS dean; and Van Reiner, president and

CEO, Maryland Science Center. Reception follows. Mason Hall. hW

Sat., april 23, 10 a.m. to noon. Johns Hopkins Interna-tional Society Easter Egg Hunt, with the Easter Bunny, games, prizes and fun for all. Decker Garden. hW

Sat., april 23, 10 p.m. “Pajam-my Jam: House Party Style,” a fundraising event sponsored by the Sigma Sigma chapter of the Alpha Phi Alpha Fraternity, in collabora-tion with the JHU Black Student Union. $10 admission; wear PJs. Glass Pavilion, Levering. hW

S y M P o S I a

thurs., april 21. A Graduate Students of the Humanities Cen-ter symposium with Sarah Beck-with, Duke University. 10 a.m. A discussion of precirculated texts by Shakespeare, Arendt and Aus-tin. 4 p.m. Lecture titled “Shake-speare, Tragedy and the Names of Action.” 208 Gilman. hW

fri., april 22, 9 a.m. to 6 p.m. Humanities Center sympo-sium celebrating the publication of Little Did I Know: Excerpts From Memory, and its author, Stanley Cavell, with Cavell, Sarah Beck-with, James Conant, Veena Das, Byron Davies, Michael Fried, San-dra Laugier, Paolo Marrati, Yi-Ping Ong, Hent de Vries and Michael Williams. 50 Gilman. hW

W o r K S h o P S

thurs., april 21, 1 p.m. “Intro-duction to Google Applications,” a Bits & Bytes workshop. To regis-ter, go to www.cer.jhu.edu/events .html. The training is open to Homewood faculty, lecturers and TAs; staff are also welcome to attend. Sponsored by the Center for Educational Resources. Gar-rett Room, MSE Library. hW

thurs., april 21, 4:30 p.m. “Ref-works,” an MSE Library workshop on the secrets of organized cita-tions and quick, easy bibliogra-phies. To register, go to www.library .jhu.edu/researchhelp/workshops .html. Electronic Resource Cen-ter, M-Level, MSE Library. hW



Johns Hopkins researchers report the discovery of a molecular switch that regulates the behavior of a protein that,

when altered, is already known to increase human susceptibility to schizophrenia and mood disorders. The findings, published online in the journal Nature, expand the possibility of creating biomarkers that can better diagnose those with mental illnesses and track their treatment. Building on previous studies at Johns Hopkins, the new research further offers clues to why the Disrupted In Schizophre-nia gene, known as DISC1, and its protein product play so many distinct roles in the development and functioning of the brain. The scientific team was led by Akira Sawa, a professor of psychiatry and behav-

ioral sciences at the Johns Hopkins Univer-sity School of Medicine. The researchers found one specific pro-tein modification that governs DISC1’s two most important functions: regulation of new neuron production in the cerebral cortex, or thinking part of the brain, and the programmed migration of these neurons, essential in the formation of the brain’s architecture. If the switch malfunctions—if it allows too many new neurons, or there’s not enough migration, for example—the brain may not develop properly, leaving it ripe to develop mental illness. Sawa said that the switch appears to change the function of DISC1 from its role in building new neurons to its role in neu-ron migration. This change occurs, he said, when the protein is modified through a bio-chemical process called phosphorylation, or attachment of a phosphate to the protein. “It seems that just one specific protein modification is a key determinant that

Study solidifies role of DISC1 in risk for mental illnessesaccounts for the two most important func-tions of this molecule,” Sawa said. The discovery is important, Sawa said, because having a means of identifying and tracking this molecular switch may strengthen diagnostic efforts, which cur-rently rely mostly on patient behavior. To find the switch, Sawa’s team used mass spectrometry to look at tissue samples. Using an antibody they generated, Sawa’s team realized that some of the protein had been modified and some had not. It then deter-mined that the unmodified DISC1 and not the modified version was needed to regulate new neurons. The reverse was true for neu-ral cell migration: The modified version of DISC1 bound to other proteins involved in facilitating cell movement but not the unmodified one. The researchers validated their findings by using their antibody, which can spe-cifically detect this protein modification in mouse models. They used the antibody to

probe the brains of fetal mice at embryonic day 14, when neurons are being generated. Results showed that unmodified DISC1 was the predominant form of the protein. At day 18, when the mouse brain neurons typically are migrating, the team found mostly modi-fied DISC1. This led the researchers to con-clude that the modification acts as a switch to determine whether DISC1 is involved in neurogenesis or cell migration. Sawa said that these findings are likely to be similar in humans because mouse models of schizophrenia closely mimic some key biological processes of human schizophrenia. Sawa’s team has already developed a version of the antibody that can be used to look at human brain tissue to test for the presence of the protein there. Other Johns Hopkins researchers involved in the study are Koko Ishizuka, Atsushi Kamiya, Mariela Zeledon and Saurav Seshadri. Nicholas Katsanis, formerly of Johns Hopkins and now at Duke University, also contributed.


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Office of Human Resources: Suite W600, Wyman Bldg., 410-516-8048JoB# PoSItIoN

46386 Sponsored Project Accountant47333 Assistant General Counsel47350 Systems Administrator47391 Sr. Writer47404 Sr. Administrative Coordinator47421 Director, FASAP47449 Sr. Instructional Facilitator47458 Sr Benefits Specialist47469 Curatorial Assistant47490 LAN Administrator47495 Research Program Assistant II47506 Executive Director47515 Sr. HR Coordinator47529 Research Technologist47534 Laboratory Coordinator47568 HR Specialist47609 Writer

Office of Human Resources:2021 East Monument St., 410-955-3006JoB# PoSItIoN

44976 Food Service Worker44290 LAN Administrator III44672 Administrative Secretary41388 Program Officer44067 Research Program Assistant II44737 Sr. Administrative Coordinator44939 Student Affairs Officer44555 Instructional Technologist

44848 Sr. Financial Analyst44648 Assay Technician44488 Research Technologist43425 Research Nurse43361 Research Scientist44554 Administrative Specialist44684 Biostatistician42973 Clinical Outcomes Coordinator43847 Sr. Programmer Analyst45106 Employment Assistant/Receptionist45024 Payroll and HR Services Coordinator42939 Research Data Coordinator42669 Data Assistant44802 Budget Specialist44242 Academic Program Administrator

P O S T I N G S

S c h o o l o f M e d i c i n e

Office of Human Resources: 98 N. Broadway, 3rd floor, 410-955-2990JoB# PoSItIoN

39157 Compliance Specialist Trainer41735 Research Technologist42411 Financial Analyst45275 Laboratory Technician45401 Compliance Specialist Trainer45465 Compliance Specialist Trainer45691 Immunohistotechnologist45791 Flow Cytometry Lab Manager45811 Sr. Medical Office Coordinator46084 Case Manager46280 Ophthalmic Technician46320 Receptionist46412 Research Service Analyst46509 Programmer Analyst

46527 ICTR Communications Coordinator

46536 Laboratory Manager46614 CME Assistant Coordinator46615 Financial Manager46783 Medical Transcriptionist46839 Sr. Payroll/Financial Project Service

Analyst46852 Sr. Research Service Analyst46942 Veterinary Technician47032 Sr. Research Program Manager47037 Academic Program Coordinator47057 Disclosure Specialist47061 Neuro Access Manager47287 Clinical Skills Coordinator47331 Research Assistant47383 Medical Simulation Training

Technician47442 Nurse Practitioner or

Physician Assistant

B U L L E T I N B O A R D

410-243-1216105 West 39th St. • Baltimore, MD 21210

Managed by The Broadview at Roland ParkBroadviewApartments.com

• Large airy rooms• Hardwood Floors• Private balcony or terrace• Beautiful garden setting• Private parking available• University Parkway at West 39th St.

2 & 3 bedroom apartments located in a private park setting. Adjacent to JohnsHopkins University Homewood Campus and minutes from downtown Baltimore.

Woodcliffe Manor ApartmentsSPA C I O U S G A R D E N A PA RT M E N T L I V I N G I N RO L A N D PA R K

NoticesSpring toiletry Drive — Through April 22, SOURCE and the JHU Women’s Net-work are collecting new and unopened toiletries to benefit local community-based organizations. Suggested contributions are shampoo, soap, deodorant, shaving cream, razors, Q-tips, lotions, sanitary products, toothpaste, mouthwash and baby products

such as diapers, powder and wipes. Dropbox locations are the School of Nursing’s lobby, the School of Medicine’s Armstrong Build-ing lobby, the Bloomberg School’s student lounge and room E1002, and the SOURCE office at 2017 E. Monument St. For more information, contact SOURCE at 410-955-3880 or [email protected]. Co-sponsored by the SoM Student National Medical Association, the SoM InterAction Council and the JHSPH Anna Baetjer Society.

B y d a v i d m a r c h


A Johns Hopkins study of 769 men from across the United States recently diagnosed with low-grade

prostate cancer shows that forgoing immedi-ate radiation or surgery to remove the tumor poses no added risk of death. Delaying treat-ment is fine, the results show, so long as the cancer’s progression and tumor growth are closely monitored through “active surveil-lance,” and there is no dramatic worsening of the disease over time. None of the men, mostly 65 and older, have so far died from prostate cancer since the study began in 1995. However, one-third of study participants, monitored for as long as 15 years, eventually underwent treatment, primarily because annual biopsy results showed more cancer. The study, to be published in the Journal of Clinical Oncology and posted online ahead of print, is believed to be the largest and longest study of men initially diagnosed with a slow-growing, very nonaggressive form of prostate cancer. This means they stand very little chance of dying from the disease, which was classified as very low risk, in its earliest stage, called T1c. “This study offers the most conclusive evi-dence to date that active surveillance may be the preferred option for the vast majority of older men diagnosed with a very low-grade or small-volume form of prostate cancer,” said urologist H. Ballentine Carter, the study’s senior investigator. “These are men with a favorable risk disease profile to begin with.” Carter, director of Adult Urology at The Johns Hopkins Hospital and a professor at the Johns Hopkins University School of Medicine and its Brady Urological Institute, acknowledged that “for some of these men, the prospect of living with prostate cancer is unbearable, and the tumor has to go.” But, he added, “the vast majority of these men are ideal candidates for active surveillance because they are older and are able to avoid the risks and complications associated with surgery and radiation.” The best candidates for surveillance programs, he said, are those who can be relied on to keep their medical appointments. Some 217,000 men in the United States are diagnosed each year with prostate can-cer, the majority of them older than 65 and with a low risk of dying from the disease if treatment is deferred, Carter said. Yet, more than 90 percent of these men with low-risk disease, including some 80 percent of those over 75, are likely to choose some form of treatment instead of surveillance. “Our findings really underscore the need to address excessive treatment of this milder stage of the disease in older men, especially seniors,” Carter said. Possible complications from surgery or radiation to treat tumors, he said, primar-ily include incontinence and other bowel, urinary or sexual problems. Just as significantly, Carter and his team noted, the study highlights the importance of carefully selecting patients who are least likely to benefit from treatment. The study showed that men who strictly

met all study criteria for very low-risk disease were 30 percent less likely to be reclassified to a high-risk category during surveillance and to need subsequent surgery or radiation than men who did not meet one or more study criteria. All study participants, 90 percent white and 6 percent black, met the key criteria of having a prostate cancer Gleason score of 6 or less. The score is used to rate the severity of the disease. Higher scores, typically from 7 through 10, suggest a more-aggressive form of the disease that in most cases would require treatment. Eighty percent of men involved in the latest analysis met at least one or more other study criteria for small-volume tumors. These included the amount of cancer found on biopsy of the prostate gland plus a ratio of blood levels of a protein linked to the cancer, called prostate-specific antigen, to gland size, or PSA density. Fewer than three biopsy cores could have cancer, with the disease present in no more than half of any core. Most study participants had a PSA density of less than 15 percent. Men were enrolled in the study from 1995 through 2010 and are being monitored through semiannual checkups and yearly biopsies. Carter’s team plans to expand the surveil-lance study program to other medical cen-ters, including Cedars-Sinai Medical Center in Los Angeles, to further refine the selec-tion criteria. Current guidelines endorsed by the National Comprehensive Cancer Network, he said, could be broadened as a result of the study and already list active surveillance as a preferred course of action for many older men, especially seniors. The Johns Hopkins team and the Pros-tate Cancer Foundation, which helped fund the latest study, have plans to develop a Web-based educational program to directly promote active surveillance to men newly diagnosed with the disease. Another of the team’s goals, he said, is to develop better screening tests for identifying men best-suited to a surveillance program. Additional funding support for the study was provided by the Patrick C. Walsh Pros-tate Cancer Research Fund. Johns Hopkins investigators involved in this study, in addition to Carter, were lead investigator Jeffrey Tosoian, Bruce Trock, Patricia Landis, Zhaoyong Feng, Jonathan Epstein, Alan Partin and Patrick Walsh.

Related websitesh. Ballentine Carter: urology.jhu.edu/about/faculty .php?id=53

Johns hopkins active Surveil-lance Program: urology.jhu.edu/prostate/advice1

.php

‘Journal of Clinical oncology’ early release articles:

jco.ascopubs.org/content/early/recent

‘Active surveillance’ successful with low-risk prostate cancer


ClassifiedsaPartMeNtS/houSeS for reNt

Bayview, efficiency apt, mins walking to Bayview campus. $450/mo + utils. 443-386-8471 or [email protected].

Bayview, 2BR, 1BA house, CAC, front/back porches, yd, shed, quiet neighborhood, walking distance to Bayview. $1,100/mo + utils. 410-633-2064.

Bolton Hill (Park Ave), beautiful 2BR, 1BA apt, 8 rms, 1,300 sq ft, separate office + dining rm, gorgeous shared yd. $1,595/mo. [email protected].

Bolton Hill, 3BR Victorian brownstone, 3 full BAs, 1 half-BA, 2 kitchens, upgraded appls, W/D, top flr deck off master BR, hdwd flrs, backyd, prkng in rear, on quiet, cobbled street, email to request pics and arrange viewing. $1,910/mo. [email protected].

Charles Village, spacious, bright 3BR apt in secure bldg, nr Homewood campus. $1,350/mo. 443-253-2113 or [email protected].

Charles Village, luxury 2BR, 1BA apt, hdwd flrs, modern updated kitchen, CAC, off-street prkng, deck, avail June 1. $1,200/mo + utils. Christopher, 410-292-6656.

Deep Creek Lake/Wisp, cozy 2BR cabin w/full kitchen, call for wkly/wknd rentals, pics avail at [email protected]. 410-638-9417.

Ednor Gardens, clean, peaceful 3BR, 2BA house, W/D, dw, pets OK, close to JHU/JHMI, avail August 1. $1,400/mo. [email protected].

Federal Hill brownstone, 1BR, 1BA, dw, W/D, CAC/heat, hdwd flrs, pets OK, 1-car garage. $1,550/mo. [email protected].

Hampden, 3BR, 2BA TH, dw, W/D, nr lt rail. $1,100/mo + utils. 410-378-2393.

Homeland, 2BR, 2BA condo in gated com-munity, 15 mins to JHMI, renov’d kitchen and BAs, balcony, CAC, W/D, storage in bsmt, pool, exercise rm, prkng, avail May 15 (flexible). $1,300/mo incl heat. [email protected].

Lake Lure, NC, 2BR mountain cabin, avail June 24-July 1, pools, golf, spa, tennis, more amenities. $800. 301-865-0610 or http://rumblingbald.com.

Mt Washington, stunning, short-term rental w/parquet flrs, patios, baby grand piano, 15 mins to JHU. $2,400/mo. 915-718-3180 or [email protected].

Ocean City, 2BR, 2BA condo on 120th St, sleeps 6, immaculate, new appls, flrs, living rm furniture, enclos’d courtyd, 2 blks to beach, indoor/outdoor pools, tennis, racket-ball. 410-992-7867.

Ocean City, Md, 3BR, 2BA condo on 137th St, ocean block, steps from beach, off-street prkng (2 spaces), lg pool, walk to restau-rants/entertainment. 410-544-2814.

Riverside/Federal Hill, updated 2BR, 1.75BA RH, 2 half-BAs, hdwd flrs, stain-

M A R K E T P L A C E

less steel appls, dw, microwave, W/D, closet space, partly fin’d bsmt, covered front porch, prkng pad, 1-yr lease req’d w/1-mo sec dep, avail end of July. $1,600/mo. June or Rishi, 267-250-1434 or [email protected].

Rodgers Forge, 3BR TH w/new kitchen, AC, W/D, deck, no pets/no smoking, avail July 1. $1,650/mo. [email protected].

Stoneleigh, 3BR, 2.5BA house, 12-month lease starting July or August, rent deal con-tingent on caring for 4 cats (possibly 1 dog), only lg furniture will remain, nr great public school system, 5 mins north of Homewood. $1,000/mo. Nicole Warren, 443-509-0552.

Towson/Rodgers Forge, 3BR, 1.5BA TH, renov’d kitchen, W/D, CAC, deck, prkng pad, no smoking/no pets, avail May 15. $1,600/mo. [email protected].

Towson-Stoneleigh school district, 3BR single-family house, avail May. [email protected].

Wyman Park, sunny 2BR apt, AC, laundry in bldg, easy walk to Homewood campus/JHMI shuttle, avail May 15. $1,150/mo. 443-615-5190.

4BR, 3.5BA house on quiet cul-de-sac, 3,400 sq ft of living space, plenty of storage, stainless kitchen w/granite and tile, laundry rm, 2 lg decks, 2-car attached garage, park-like setting nr Homewood campus, pets OK, avail July. $2,600/mo + utils. Archna, 443-466-6487 or [email protected].

Beautiful 3BR, 2BA condo w/garage, spa-cious, great location, walk to Homewood campus. $1,800/mo. 443-848-6392 or sue [email protected].

houSeS for SaLe

Canton, beautifully renov’d 2BR, 2.5BA RH, huge master suite, open floor plan, roof-top deck, nr JHH/Bayview. 443-527-1643.

Edgemere, 5BR waterfront house on .8 acre. $750,000. 410-830-1785.

Gardens of Guilford, lg, newly renov’d 2BR, 2BA condo in elegant setting, easy walk to Homewood campus. 410-366-1066.

Gardenville, 3BR, 1.5BA RH in quiet neigh-borhood, new kitchen and BA, CAC, hdwd flrs, club bsmt w/cedar closet, maintenance-free yd, carport, 15 mins to JHH. $139,500. 443-610-0236 or [email protected].

Springdale, 4BR, 2.5BA house, nr Dulaney High, walk to Loch Raven Reservoir. $370,000. 410-560-3556.

Waverly, 4BR, 2BA TH, EOG unit, fin’d bsmt, wooden deck, fenced yd, great neigh-bors. $125,000. Randy, 410-456-3775 or [email protected].

Luxury 1BR condo in high-rise, secure bldg w/doorman, W/D, CAC/heat, swimming pool, exercise rm, nr Guilford/JHU. $179,000. 757-773-7830 or [email protected].

3402 Mt Pleasant Ave, stunning, completed rehabbed house, nr everything in the city. $165,900. Pitina, 410-900-7436.

3612 Greenmount Ave, charming, renov’d 4BR house, over 1,900 sq ft, CAC, hdwd flrs, perfect home for entertaining, garage. $180,000. 410-812-9070.

rooMMateS WaNteD

Unfurn’d BR and priv BA avail in 2BR, 2.5BA home, 2nd flr, share w/F prof’l and friendly dog, hdwd flrs, expos’d brick, fin’d bsmt, lots of extra storage space, sm patio in back, sec sys, street prkng. $600/mo + share of utils + sec dep. [email protected].

Summer sublet: Rms in DeSoto Apts (across the street from Homewood campus on Greenway), 2 other roommates will be gone, you or group can have 3 available rms, cheap, spacious, good area. 321-501-0178.

Single F wants to share 2BR house w/same. 410-913-5801.

Big furn’d BR in new TH, walking distance to JHMI, pref nonsmoker/no pets. $550/mo. 301-717-4217 or [email protected].

1BR and common areas of furn’d 3BR, 2BA house in Original Northwood, new BA, full kitchen, backyd + patio, ample street prkng, direct bus to JHMI/JHU. $600/mo + utils. [email protected].

Furn’d 1BR in 3BR, 2BA apt in Fells Point, W/D, free Internet access, quiet street, best neighborhood, close to everything, free shuttle to SoM. $350/mo to $400/mo + utils. [email protected].

CarS for SaLe

’05 Subaru Forester X, automatic, silver, in excel cond, Carfax Md inspection, orig owner, 100K mi. $10,200. 410-833-5781.

IteMS for SaLe

Bedroom dresser, antique oak, some inlay, 3-drawer, in excel cond, nr JHU Homewood. $75. Judy, 410-889-1213 or judybyen@ hotmail.com.

Guitar, Yamaha 12-string in excel cond. $200. [email protected].

Taylor commercial soft ice cream twist machine. $2,500/best offer. [email protected].

Bassinet, Carter’s Soothe ’n’ Sleep, like new, w/2 sheets, only used a few times. $80. [email protected].

Fisher-Price open top Take Along swing, for babies 3 mos and older, $15; folding guest bed, $30; Ikea “Jules” swivel chair, $20. 410-889-2830 or [email protected].

Dinette set, octagonal table w/4 chairs, blond/black, you haul. $120. 443-983-2362.

Conn alto sax, best offer; exercise rowing machine, $50; excel cond. 410-488-1886.

Several pieces of nicely kept, high-quality furniture. www.apt5Efurnituresale.blogspot .com (for pics/details).

2005 Honda 450 dirt bike, in great cond. $2,500. 240-755-4954 or 443-423-3410.

SerVICeS/IteMS offereD or WaNteD

College student available to house-sit for summer, long- or short-term, in Roland Park or Charles Village area. 443-848-3983.

Classified listings are a free ser-vice for current, full-time Hop-kins faculty, staff and students only. Ads should adhere to these general guidelines:

• Oneadperpersonperweek.A new request must be submitted for each issue. • Adsarelimitedto20words, including phone, fax and e-mail.

• WecannotuseJohnsHopkins business phone numbers or e-mail addresses.• Submissionswillbecondensedat the editor’s discretion. • DeadlineisatnoonMonday, one week prior to the edition in which the ad is to be run.• Realestatelistingsmaybeoffered only by a Hopkins-affiliated seller not by Realtors or Agents.

(Boxed ads in this section are paid advertisements.)Classified ads may be faxed to 443-287-9920;e-mailedinthebody of a message (no attach-ments)[email protected];ormailed to Gazette Classifieds, Suite540,901S.BondSt.,Bal-timore,MD21231.Topurchasea boxed display ad, contact the GazelleGroupat410-343-3362.

PLaCING aDS

Graduate student offering house- or pet-sitting services. holly.michelle.wood@gmail .com.

Free vintage Steinway upright piano, built 1890, mahogany veneer, original ivories, beautiful exterior, playable but needs work; piano is heavy, must be moved by profes-sionals. 202-251-3972, rsbclark@comcast .net or http://bit.ly/i2Gs6D (for pics).

Bodywork massage studios for prof’l massage services; gift certificates available. 443-983-7987.

Affordable and professional landscaper/cer-tified horticulturist available to maintain existing gardens, also designing, planting or masonry; free consultations. David, 410-683-7373 or [email protected].

Need a photographer or videographer for headshots, weddings or other events? Edward S Davis photography and videog-raphy. 443-695-9988 or [email protected].

Clarinet and piano lessons by Peabody clari-net master’s student, have been teaching for 7 yrs, am available now and throughout the summer. [email protected].

Entrepreneurial volunteer wanted for ambi-tious ecology project involving social net-works. Mark, 410-464-9274.

Licensed landscaper avail for spring/sum-mer lawn maintenance, yd cleanup, other services incl’d fall/winter leaf and snow removal, trash hauling. Taylor Landscap-ing LLC. 410-812-6090 or [email protected].

Need help with your JHU retirement plan investments portfolio? Free consultation. 410-435-5939 or [email protected].

Tutor for all subjects/levels; remedial and gifted; also help w/college counseling, speech and essay writing, editing, proofreading, database design and programming. 410-337-9877 (after 8pm) or [email protected].

Resident assistants needed, July 22-29, to supervise 120 high school students for 1-wk camp at Homewood campus. Shanna, [email protected].

Mama, do you want your body back? Eight-week weight loss and fitness program, prov-en results. [email protected].

Mobile detailing and power wash service. Jason, 443-421-3659.

Peabody grad student offering private French horn/trumpet lessons, affordable rates. [email protected].

Masterpiece Landscaping: knowledgeable, experienced individual, on-site consulta-tion, transplanting, bed preparation, instal-lation, sm tree and shrub shaping; licensed. Terry, 410-652-3446.

Affordable, professional mobile auto detail-ing, we come to you. Erik, 443-934-3750.

Do you speak Chinese/Arabic/Russian? Earn $20/hr for participating in my survey, will pay for interview to be used for research purposes, simple questions, can complete by e-mail, phone or in person. 443-471-6121 or [email protected].

Seamstress available for sewing and altera-tions. 410-404-3548 or [email protected].

Greek Orthodox Cathedral of the Annunciation Corner of Maryland & Preston Streets

Come one come all-Free Parking Sat., APRIL 30, 2011- eat in/carry out! 5 pm – 8 pm $10/Dinner Children $6

Pastitsio & Greek Salad Drinks & Dessert Al-La-Cart

WYMAN COURTJust Renovated!

HICKORY HEIGHTSA lovely hilltop setting on

Hickory Avenue in Hampden!

2 BD units from $750 w/Balcony - $785!

Shown by appointment - 410-764-7776

www.BrooksManagementCompany.com

Beech Ave. adj. to JHU! Studios - $595 - $630 1 BD Apts. - $710-740

2 BD from $795

Renovated 3br/2.5ba townhouse, roofdeck, whirlpool tub, granite & stainlesskitchen, AC, private backyard, & more!Big rooms, lots of closets.$325,000. Call 410-467-8950.

5 Minutes from JHH


Calendar B L o o D D r I V e S

Mon. , apr i l 25 ( through apr i l 27) , 7 :30 a .m. to 5 p .m. JHU/American Red Cross blood drive. For eligibil-ity requirements, go to www .hopkinsworklife.org/community/blood_drive_locations.html. To schedule a donation, call 410-550-0289. Francis X. Knott Con-ference Center. Bayview

C o L L o Q u I a

Wed., april 20, 3:30 p.m. “Pan-STARRS,” an STSci colloquium with John Tonry, University of Hawaii Institute for Astronomy. Bahcall Auditorium, Muller Bldg. hW

Wed., april 20, 4 p.m. “Indi-vidual Differences in Attentional Control Over Primary and Sec-ondary Memory,” a Psychological and Brain Sciences colloquium with Edward Vogel, University of Oregon. 234 Ames. hW

thurs., april 21, 3 p.m. “Ele-mentary Particles of Superconduc-tivity,” a Physics and Astronomy colloquium with Assa Auerbach, Technion. Schafler Auditorium, Bloomberg Center. hW

thurs., april 21, 3 p.m. “Bridg-ing the Divide: Enlightenment Science, Scientific Voyaging and the Straits of Magellan in Bour-bon Spain,” a History of Science, Medicine and Technology col-loquium with Matthew Franco, KSAS. 300 Gilman. hW

thurs., april 21, 4 p.m. “Poetry on the Page: Visual Strategy and the Mind’s Ear,” an ELH collo-quium with J. Paul Hunter, Uni-versity of Virginia. Sponsored by English. 130D Gilman. hW

fri., april 22, 2 p.m. “The Agility Imperative,” an Applied Physics Laboratory colloquium with David Alberts, OSD-CIO. Parsons Auditorium. aPL

C o N f e r e N C e S

tues., april 19, 8:30 a.m. to 3 p.m. “Demographic Trends and the BRICs,” a SAIS Office of Development and Alumni Rela-tions conference with various speakers including Nicholas Eber-stadt, American Enterprise Insti-tute. A Year of Demography event. (See In Brief, p. 2.) A live webcast will be accessible at www.sais-jhu .edu. For more information, go to www.sais-jhu.edu/demography/conference. To RSVP, email [email protected] or call 202-663-5636. Kenney Auditorium, Nitze Bldg. SaIS

D I S C u S S I o N S /t a L K S

Mon., april 18, noon. “Pub-lic Diplomacy of the United States and China: A Compara-

Mon., april 25, 6:30 p.m. “The Future of Teaching: New Common Core Standards, New Assessments and New Evaluations—What Does It All Mean for Students and Teachers?” a School of Educa-tion panel discussion with Randi Weingarten, president, American Federation of Teachers; Michael Cohen, president, Achieve Inc.; Richard Lemons, Education Trust; and Sonja Santelises, Baltimore City Public Schools. Q&A session will follow. Part of the Shaping the Future series. To RSVP, go to www .education.jhu.edu/shaping_future/index.html. Shriver Hall Auditorium. hW

f o r u M S

Wed., april 20, 1:30 p.m. “A Conversation With Ambassador Ron Kirk,” a dialogue with the U.S. trade representative for the Obama administration and SAIS professorial lecturer Matthias Metthijs. Kenney Auditorium, Nitze Bldg. SaIS

G r a N D r o u N D S

Wed., april 20, 3:45 p.m. “Wearable Computing in Epi-demiology: Predicting Activity Type From Accelerometer Data,” a Biostatistics and Johns Hop-kins Center on Aging joint grand rounds with Thomas Glass, Cip-rian Crainiceanu, Karen Bandeen-Roche, and Judy Kasper, all of SPH. W2030 SPH. eB

L e C t u r e S

tues., april 19, noon. “An Elab-orate Fraud: Vaccines and Autism,” an International Health lecture by investigative journalist Brian Deer. (See In Brief, p. 2.) Part of the celebration of the Department of International Health’s 50th anni-versary. Reception follows. E2014 SPH. eB

tues., april 19, 12:15 p.m. The Annual Lectureship in Social Epidemiology—“Causal Models in Epidemiology: The Need for Some New Thinking” by Leonard Syme, University of California, Berkeley (emeritus). Sponsored by Epidemi-ology. W1214 SPH. eB

tues., april 19, 3 p.m. The Earnest and Agnes Gloyna Distin-guished Lecture in Environmental Engineering—“The Past, Present and Future of Potable Water Reuse” by David Sedlak, University of California, Berkeley. Sponsored by Geography and Environmental Engineering. 234 Ames. hW

tues., april 19, 6:15 p.m. “Donatello and Sculptural Aske-sis,” a History of Art lecture by Adrian Randolph, Dartmouth College. Part of the Graduate Stu-dent Lecture Series. 110 Mary-land. hW

Wed., april 20, 4 p.m. “From One’s and Another’s Point of View: Intentionality and Perspectivism,” a Humanities Center lecture by Jocelyn Benoist, Universite de Paris-I, Pantheon-Sorbonne and University of Chicago. 208 Gil-man. hW

thurs., april 21, 7:30 to 9 a.m. Leaders & Legends Lecture—“The Past, Present and Future of Nuclear

A P R I L 1 8 – 2 5

Power: A Regulator’s Perspective” by Gregory Jaczko, chairman, Nuclear Regulatory Commission. (See story, p. 7.) Legg Mason Tower, Harbor East.

thurs., april 21, 1:30 p.m. The 2010/2011 John C. and Susan S.G. Wierman Lecture—“Human Health Effects of Air Pollution: Statistics and Public Policy” by C. Arden Pope III, Brigham Young University. Sponsored by Applied Mathematics and Statistics. 304 Whitehead. hW

the George Kempf Lectures by Fedor Bogomolov, Courant Insti-tute. Sponsored by Mathematics. hW

• thurs., april 21, 4:30 p.m. “Kummer Theorem and Projective Geometry.” Part 1. 300 Krieger.

• thurs., april 22, 4:30 p.m. “Kummer Theorem and Pro-jective Geometry.” Part 2. 304 Krieger.

thurs., april 21, 5:15 p.m. “ ‘Ich trete umgeben auf’: Figur and Grund in Goethe’s Weimarer Dra-men,” a German and Romance Languages and Literatures lecture by Juliane Vogel, University of Konstanz. 479 Gilman. hW

thurs., april 21, 5:15 p.m. “Anna Maria Ortese (1914–98): Reality and Fiction,” a German and Romance Languages and Lit-eratures lecture by Andrea Baldi, Rutgers University. 288 Gilman. hW

thurs., april 21, 6 p.m. “Global Med Tech: Clinical Pull and Co-Creation,” a Center for Bioengi-neering Innovation and Design lecture by Kristian Olson, CIMIT. 210 Hodson. hW

fri., april 22, noon. “Go Green and Boost Productivity With a Paperless Office,” a Johns Hop-kins Medicine Green Team lec-ture and “Earth Day” presentation by George Dimopoulos, SPH. Hurd Hall. eB

Mon., april 25, 4:30 p.m. The Provost’s Lecture Series—“The Epigenetic Basis of Com-mon Human Disease” by Andrew Feinberg, SoM. Q&A session and reception to follow. RSVP to [email protected]. 50 Gil-man. hW

r e a D I N G S / B o o K t a L K S

thurs., april 21, 7 p.m. School of Medicine Professor David Lin-

(Events are free and open to the public except where indicated.)

aPL Applied Physics LaboratoryBrB Broadway Research BuildingCrB Cancer Research BuildingeB East BaltimorehW HomewoodKSaS Krieger School of Arts and SciencesNeB New Engineering BuildingPCtB Preclinical Teaching BuildingSaIS School of Advanced International StudiesSoM School of MedicineSoN School of NursingSPh School of Public HealthWBSB Wood Basic Science BuildingWSe Whiting School of Engineering

CalendarKey

Continued on page 13

School of Medicine Professor David Linden’s new book, ‘the Compass of Pleasure,’ explores how the brain makes fatty foods, exercise, marijuana, vodka and gambling feel so good. See read-ings/Book talks.

tive Study,” a SAIS China Studies Program discussion with Chaob-ing Qiu, SAIS visiting scholar. For information email [email protected] or call 202-663-5816. 806 Rome Bldg. SaIS

tues., april 19, 5 p.m. “The Wellspring: Economic Power and Weakness in Europe and the United States,” a SAIS European Studies Program discussion with Erik Jones, Bologna Center. Co-sponsored by the SAIS Center for Transatlantic Relations. For infor-mation, email [email protected] or call 202-663-5796. 806 Rome Bldg. SaIS

Wed., april 20, 12:45 p.m. “Challenges Facing Hedge Fund Investors in Latin America: The Restructuring of Mexican Glass-maker Vitro,” a SAIS Latin Amer-ican Studies Program discussion with Paul Fratamico, Resurgence Asset Management. (Event is open to the SAIS community only.) For information or to RSVP, email [email protected] or call 202-663-5734. 517 Nitze Bldg. SaIS

Wed., april 20, 4:30 p.m. “Is COIN a Passing Fad?” a SAIS Alexander Hamilton Society panel discussion with Charles Dunlap Jr., Duke University; Michael O’Hanlon, Brookings Institution; and Thomas Mahnken (moder-ator), visiting scholar at SAIS. To RSVP, email hamilton.society [email protected]. Rome Audito-rium. SaIS

thurs., april 21, 12:30 p.m. “Strong State, Feeble Population: China’s Health Care Governance Crisis,” a SAIS Grassroots China Initiative discussion with Yan-zhong Huang, Seton Hall Uni-versity. (Event is open to SAIS community only.) To RSVP, email [email protected] or call 202-663-5816. 806 Rome Bldg. SaIS

thurs., april 21, 4:30 p.m. “Commercial Imperialism? U.S. Influences and International Trade During the Cold War,” a SAIS International Economics Program discussion with Nathan Nunn, Harvard University. (Event is open to the SAIS com-munity only.) For information or to RSVP, email [email protected] or call 202-663-7787. 714 Bernstein-Offit Bldg. SaIS

fri., april 22, 7 p.m. “Tale of the PHirst Dynasty: Debunking Myths About Black Greek Let-ter Organizations,” a Alpha Phi Alpha Fraternity, Sigma Sigma chapter, roundtable discussion. Multipurpose Room, Charles Commons. hW

Mon., april 25, 9 a.m. to 3 p.m. “Plausibility of Malaria Eradication Given Our Current Tools and the Possible Develop-ment of Eradication Tools,” a Johns Hopkins Malaria Research Institute panel discussion and poster session in recognition of World Malaria Day. Regis-tration required; go to http://malaria.jhsph.edu/events/2010/world%20malaria%20day%202011/worldmalariadayspeaker .index. E2030 SPH. eB

Mon., april 25, 12:30 p.m. A discussion of SAIS Professor Francis Fukuyama’s new book The Origins of Political Order: From Prehuman Times to the French Revolution with Fukuy-ama; Adam Garfinkle, editor, The American Interest; Michael Woolcock, World Bank; and Cinnamon Dornsife (modera-tor), SAIS. A live webcast will be accessible at www.sais-jhu .edu. For more information or to RSVP, email [email protected] or call 202-663-5648. Kenney Auditorium, Nitze Bldg. SaIS

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