What are immune-mediated inflammatory diseases? Your immune system is your body's defence against infection and illness. i It contains T-cells, which directly attack cells infected with viruses, and act as regulators of the immune system. ii For people who are affected by diseases linked to the imune system, their bodies attack healthy tissue, causing inflammation, pain and damage in different parts of the body. iii Inflammatory bowel disease, rheumatoid arthritis, MS, asthma, Crohn’s disease, ulcerative colitis, psoriasis and uveitis are all common types of immune mediated diseases. iv So far, over 80 types of autoimmune diseases have been identified. iv The Future of Immunology i. UK Science Museum. What does your immune system do? Available at: http://whoami.sciencemuseum.org.uk/whoami/findoutmore/yourbody/whatdo- esyourimmunesystemdo. Accessed October 2018. ii. Immune Deficiency Foundation. The Immune System and Primary Immunodeficiency. Available at: https://primaryimmune.org/about-primary-immunodeficien- cies/immune-system-and-primary-immunodeficiency. Accessed October 2018 iii. National Health Service (2016). Causes Rheumatoid arthritis. Available at: https://www.nhs.uk/conditions/rheumatoid-arthritis/causes/. Accessed October 2018. v. Asthma Statistics, https://statistics.blf.org.uk/asthma iv. British Society for Immunology (2016). Autoimmunity: policy briefing. Available at: https://www.immunology.org/sites/default/files/autoimmunity-briefing. pdf. Accessed October 2018. References
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What are immune-mediated inflammatory diseases?
Your immune system is your body's defence against infection
and illness.i
It contains T-cells, which directly attack cells infected with viruses, and act as
regulators of the immune system.ii
For people who are affected by diseases linked to the imune system, their bodies attack healthy tissue, causing inflammation, pain and damage in different parts of
the body. iii
Inflammatory bowel disease, rheumatoid
arthritis, MS, asthma, Crohn’s disease,
ulcerative colitis, psoriasis and uveitis are
all common types of immune mediated
diseases.iv
So far, over 80 types of autoimmune diseases have been identified.iv
The Future of
Immunology
i. UK Science Museum. What does your immune system do? Available at: http://whoami.sciencemuseum.org.uk/whoami/findoutmore/yourbody/whatdo-esyourimmunesystemdo. Accessed October 2018.
ii. Immune Deficiency Foundation. The Immune System and Primary Immunodeficiency. Available at: https://primaryimmune.org/about-primary-immunodeficien-cies/immune-system-and-primary-immunodeficiency. Accessed October 2018
iii. National Health Service (2016). Causes Rheumatoid arthritis. Available at: https://www.nhs.uk/conditions/rheumatoid-arthritis/causes/. Accessed October 2018. v. Asthma Statistics, https://statistics.blf.org.uk/asthma
iv. British Society for Immunology (2016). Autoimmunity: policy briefing. Available at: https://www.immunology.org/sites/default/files/autoimmunity-briefing.pdf. Accessed October 2018.
References
70 years of immunological research
1948 Astrid Fagraeus’s PHD thesis
describes antibody production by B plasma cells.i
1957 Rheumatoid Arthritis found to be an autoimmune disease.i
1960 Nobel Prize in Physiology or Medicine awarded to Peter
Medawar & Frank Macfarlane Burnet for the discovery
of acquired immunological tolerance.i
1980The world’s first immunosuppressant drug was first used for organ transplant. i
1987 Intravenous immunoglobulin
first used to treat autoimmune-like disorder.i
1993 First successful clinical use of anti-TNF antibodies to treat Rheumatoid Arthritis.i2003
Human Genome Project completed – scientists
now use this to map specific gene mutations to
inflammatory disorders.i
2011 IL-17 is associated with
a range of autoimmune conditions defining it as a new therapeutic target.i
2004 Psoriasis first described as an autoimmune disease.i
2018 Creation of the world’s largest Immune Mediated Inflammatory Disease Biobank. i
i. The Future of Immunology (2018). Shaping the future of immunological research in the UK together. Booklet available on request.
References
Current research & the Future of Immunology
For the past 70 years, academic institutions and the life sciences industry in the UK have led in immunological research.
Research findings have resulted in increased understanding of, and new ways to manage autoimmune diseases.
But it is critical that we advance our research efforts and understanding of the causes and management of these debilitating conditions.
Our joint vision sets out to shape the future of immunology in the UK.
1. More research investment
3. Timely diagnosis
2. Improved experience for people living with diseases linked to the immune system