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The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1 , 11-21 (2000) Speed Amplitude Spatio-temporal patt ern
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The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

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Page 1: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

The four units of the Ca2+ signalling network

Nature Rev. Mol. Cell Biol. 1, 11-21 (2000)

Speed

Amplitude

Spatio-temporal pattern

Page 2: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

Spatial aspects of Ca2+ signalling

Nature 395, 645 - 648 (1998)

Page 3: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

Nature 395, 645 - 648 (1998)

Basic Mechanisms of Ca2+ Signalling

Page 4: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

Elements of the Ca2+ signalling toolkit

Nature Rev. Mol. Cell Biol. 1, 11-21 (2000)

Page 5: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

quarks/sparksblips/puffs

Page 6: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.
Page 7: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

[IP3] and lumenal Ca2+ modulate the shape of the bell-shaped curve

Current Biology 1999, 9:R876-R878

Page 8: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

The steps leading to activation or inactivation

of IP3 receptors

Current Biology 1999, 9:R876-R878

Page 9: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

Ca2+ signalling by conformational coupling using macromolecular complexes

Nature Rev. Mol. Cell Biol. 1, 11-21 (2000)

1s

Page 10: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

Application of the Ca2+ signalling toolkit to regulate different cellular processes

Nature Rev. Mol. Cell Biol. 1, 11-21 (2000)

Page 11: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

The spatial organization of Ca2+ release from internal stores

Nature Rev. Mol. Cell Biol. 1, 11-21 (2000)

Page 12: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.
Page 13: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

Schematic representation of the mitochondrial Ca2+ transport pathways in energized mitochondria

Page 14: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.
Page 15: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

3-D imaging of mitochondrial and ER structure in living HeLa cells

M

ER

Page 16: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.
Page 17: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.
Page 18: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.
Page 19: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

Structural Organization of

the Endoplasmic Reticulum in Neurons

Neuron, 21, 13–26, (1998)

Page 20: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

Binary Membrane System of Neural Calcium Signaling

Neuron, 21, 13–26, (1998)

Page 21: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

Proposed Role of Ca2+ Signaling in Neuronal Gene Transcription

Neuron, 21, 13–26, (1998)

Page 22: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

Compartmentalization of Ca2+ signals in neurons

Nature 395, 645 - 648 (1998)

Page 23: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

A Ca2+ nexus — crosstalk between signalling pathways  

L-VDCC IP3R

Nature Rev. Mol. Cell Biol. 1, 11-21 (2000)

Page 24: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.
Page 25: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

Schematic structures and sequences of cameleons

Nature (1997) 388, 882-887

Page 26: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

Nature Reviews Neuroscience (2002) 3, 175-190

Page 27: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

Nature Reviews Neuroscience (2002) 3, 175-190

Page 28: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

Nature Reviews Neuroscience (2002) 3, 175-190

Page 29: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

Immobilization and superfusion of CaM kinase II

Science 279, 227-230 (1998)

Page 30: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

Properties of immobilized CaM kinase II

Science 279, 227-230 (1998)

Page 31: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

Stimulation of CaM kinase II by pulse flow

Science 279, 227-230 (1998)

Page 32: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

Modulation of the frequency response of CaM kinase II

Science 279, 227-230 (1998)

Page 33: The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

Calcium rollercoaster

Science 279, 191-192 (1998)