The epidemiological evidence linking endocrine disrupting chemicals and male reproductive disorders Jens Peter Bonde Professor of occupational medicine Bispebjerg Frederiksberg Hospital Department of occupational and environmental medicine Slide 1 Legislation on endocrine disrupters in EU. KU-Life november 9th 2018
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dato og ”Enhedens
The epidemiological evidence linking endocrine disrupting chemicals and male reproductive disorders
Jens Peter BondeProfessor of occupational medicineBispebjerg Frederiksberg Hospital
Department of occupational and environmental medicine
Slide 1
Legislation on endocrine disrupters in EU. KU-Life november 9th 2018
Tekst starter uden
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Globule
The endocrine disruption hypothesis
Systematic review
Conclusion
Enhedens navn
Sted og datoSlide 2
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C ClBr
Br
C C
HH
HH
H
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Dibromochloropropane 1977
•Severe toxicity at low exposure levels following short periods of exposure (months)
•Irreversible effects (azoospermia or oligospermia)
•Banned in 1978 in US
•Reminder that occupational exposure to toxic compounds may have severe effects
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Navn på enhed (Indsæt --> Diasnummer)
Bispebjerg HospitalCopenhagen 5-7.12.2012Dias 5
dato og ”Enhedens Riga september 19-22 2001Bispebjerg HospitalCopenhagen 5-7.12.2012Dias 6
Beronius A and Vandenberg LN. Using systematicreviews for hazard and risk assessment of endocrinedisrupting chemicals. Rev Endocr Metab Disord 2015; 16:273-287.
Navn på enhed (Indsæt --> Diasnummer)
Levine H et al 2017
Median sperm counts in Danish Army Conscripts1996-2010 (Jørgensen BMJ Open 2012)
Navn på enhed (Indsæt --> Diasnummer)
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SYSTEMATIC REVIEW WITH META-ANALYSIS
risk of male reproductive disorders
cryptorchidism
hypospadias
low sperm counts
testicular cancer
following in utero or infant exposure
chemicals included on the European Commission’s list of Category 1 endocrine disrupting chemicals
(documented adverse effects due to endocrine disruption in at least one intact organism)
Enhedens navn
Sted og datoSlide 12
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Definition of en endocrine disruptingxenobiotic substance
i. Chemicals where at least one study has shownendocrine effects in an intact organism (The European Commission, McCarthy 2011)
ii. More than 500 compounds fullfill this broaddefinition
iii. 60 category 1 compounds with high currentproduction volume and/or are highlypersistency in nature and in living organisms
Enhedens navn
Sted og datoSlide 13
Tekst starter uden
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Systematic review: Inclusion criteria
Category 1 EDC chemicals (60 compounds)
Outcomes
Testicular cancer
Cryptorchidism
Hypospadias
Sperm count
Prenatal or early postnatal exposure in humans
Measurements of compounds in biologicalmedia
Risk estimates or tests of association
No requests with respect to design or quality
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International Symposium of Reproductive Hazards in the Workplace (RICOH),Barcelona, September 5-6 2016
Slide 14
Sted og dato
Enhedens navn
Slide 15
SYSTEMATICLITERATURE SEARCH
Meta-analysis of risk of cryptorchidism, hypospadias or testis cancer by prenatal EDC exposure