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The Endomembrane System and image sources are included using the notes function of the .ppt
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The Endomembrane System Text and image sources are included using the notes function of the.ppt file.

Jan 24, 2016

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Page 1: The Endomembrane System Text and image sources are included using the notes function of the.ppt file.

The Endomembrane System

Text and image sources are included using the notes function of the .ppt file

Page 2: The Endomembrane System Text and image sources are included using the notes function of the.ppt file.

Cellular MembranesEndomembrane Structure % total membrane in

Hepatocyte% total in Pancreatic Exocrine Cell

Endoplasmic Reticulum (smooth)

16 <1

Endoplasmic Reticulum (rough)

35 60

Golgi 7 10

Plasma membrane 2 5

Lysosomes 0.4 N.D.

Peroxisomes 0.4 N.D.

Endosomes 0.4 N.D.

Mitochondria 39 21

Nuclear envelope (inner only)

0.2 0.7

Page 3: The Endomembrane System Text and image sources are included using the notes function of the.ppt file.

Pulse-Label Autoradiography

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3 minutes 7 minutes

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Pulse-Label Autoradiography

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37 minutes 117 minutes

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The Endoplasmic Reticulum

DiOC6(3)

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ER dynamics

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ER / Mitochondria

Video

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“Smooth”ER

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Abnormal Pathology

sER from a chondrocyte of a patient with pseudoachondroplasia

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Transition zones

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SER

RER

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The rER

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Supplying the NE

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Movin’ on

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Note points of vesicle formation

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Vesicular Traffic

donor membrane

recipient membrane

vesicle type

cell surface endosomes clathrin-coated

rER Golgi coatomerII-coated

Golgi Golgi coatomerI-coated

Golgi lysosomes clathrin-coated

Golgi cell surface coatomerI-coated

There are at least several (probably many more) distinct classes of vesicle coats/sorting mechanisms that function at different

places in the cell

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coatomer-,smooth-coated vesicles

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Biochemical isolation of clathrin- coated vesicles

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Clathrin QuickTime™ and aTIFF (Uncompressed) decompressor

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Animation

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Dynamin

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200 nm 100 nm

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shits wt

Breakin’ up is hard to do

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Fusion

Just as there are specific mechanisms for sorting and vesicle formation, there are equally specific mechanisms for vesicle delivery

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VSVGts::GFP transport

Vesicular stomatitis virus glycoprotein, temp-sensitive folding mutant

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Video

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The Golgi

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Perinuclear Golgi

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Biochemical stratification

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Post-Golgi transport tubules

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Video

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Coatamer I Dynamics at the Golgi

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Fluorescence Recovery After Photobleaching (FRAP) of COPI::GFP

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Lysosomes

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Exocytosis/Endocytosis

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Peroxisomes

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