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The elderly: Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research
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The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

May 30, 2020

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Page 1: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

The elderly:Major trauma andSevere traumatic brain injuryDr Ben BeckDeputy Head Prehospital, Emergency and Trauma Research

Page 2: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck2

Overview

Background Victorian State Trauma Registry The elderly and major trauma Severe traumatic brain injury

Page 3: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck3

Warning

Page 4: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck4

Background

Ageing population Increased health at older age

– Greater participation in activities with the potential for injury

What has this meant for health care utilisation?

Page 5: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck5

Background

Ambulance service utilisation

Lowthian et al. (2011)

Page 6: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck6

Background

ED presentations

– 32% rise in rate of presentation from 1999-00 to 2008-09– Elderly disproportionately represented

Page 7: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

Major trauma

Page 8: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck8

VSTR

Victorian State Trauma Registry (VSTR)– Population-based– Patient, clinical and outcomes– Patients followed up at 6, 12 and 24 months post injury

Inclusion – any of:– Death after injury– Injury severity score (ISS) > 12– Admission to ICU for >24 hours, requiring mechanical ventilation– Urgent surgery

Page 9: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck9

VSTR

VSTR in the context of all hospitalisations– Major trauma

10% of injury hospital presentations > 1 day 16% of all injury-related bed days

Hospital admissions

Minor injuries

Major trauma

Page 10: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck10

Major trauma in Victoria

Major trauma increased 2.4% per year

0

10

20

30

40

50

60

2006 2007 2008 2009 2010 2011 2012 2013 2014 2015

Inci

denc

e pe

r 100

,000

pop

ulat

ion

(95%

CI)

Overall Unintentional Intentional

Page 11: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck11

Major trauma in Victoria

0

2

4

6

8

10

12

14

16

18

2006 2007 2008 2009 2010 2011 2012 2013 2014 2015

Inci

denc

e pe

r 100

,000

pop

ulat

ion

(95%

CI)

MVC Motorcycle Low falls High falls

+6.6%

0%

Page 12: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck12

Major trauma in Victoria

Trauma Audit Research Network (TARN)– Low falls most common cause of major trauma in UK (39%)

– Increasing age of major trauma patients 1990: mean age = 36 years 2013: mean age = 54 years

Kehoe A, et al. (2015)

Page 13: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck13

Major trauma in Victoria

Major trauma in the elderly (65 plus)

24%

66%

10%

Transport Low fall High fall

Page 14: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck14

Major trauma in Victoria

Incidence of low falls in the elderly

0

50

100

150

200

250

300

2006 2007 2008 2009 2010 2011 2012 2013 2014 2015Inci

denc

e pe

r 100

,000

pop

ulat

ion

(95%

CI)

35 to 64 65 to 74 75 to 84 85 plus

+5.9%

+7.2%

+5.5%

Page 15: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck15

Major trauma in Victoria

Low falls in the elderly – place of event

Home

59%

Residential Care Facility

20%

Road/street

7%

Page 16: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck16

Major trauma in Victoria

Low falls in the elderly – discharge direction

– In-hospital mortality 65-74 years: 19% 75-84 years: 29% 85 plus: 41%

Discharge direction Percentage

In-hospital death 32%

Rehabilitation 33%

Hospital for convalescence 8%

Nursing home 4%

Home 20%

Page 17: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck17

Major trauma in Victoria

Summary– Low falls account for 2/3 of major trauma in the elderly

– Incidence of low falls is on the rise

– Poor outcomes 1/3 in-hospital mortality Only 20% discharged home

Page 18: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

Severe traumatic brain injury

Page 19: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck19

Severe TBI

Severe traumatic brain injury (TBI)

Page 20: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck20

Severe TBI

Severe TBI– Represent 8.5% of the major trauma population

– Victorian State Trauma Registry: 2006-2015

– Inclusion criteria Head AIS ≥ 3 GCS < 9

– n = 2280

Page 21: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck21

Severe TBI

0

1

2

3

4

5

6

2006 2007 2008 2009 2010 2011 2012 2013 2014 2015

Inci

denc

e pe

r 100

,000

pop

ulat

ion

(95%

CI)

Overall Unintentional Intentional

Severe TBI declined 5% per year

Page 22: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck22

Severe TBI

0

0.5

1

1.5

2

2006 2007 2008 2009 2010 2011 2012 2013 2014 2015

Inci

denc

e pe

r 100

,000

pop

ulat

ion

(95%

CI)

MVC Motorcycle Low falls High falls

+3%

-9%

0%

-6%

Page 23: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck23

Severe TBI

Low falls– 68% of low falls occurred in those aged 65 years and greater

Low falls in the elderly - where are they happening?– Home: 56%– Residential care facilities: 24%

Page 24: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck24

Severe TBI

Low falls in the elderly – injury types

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

Brainstem injury Subdural haematoma Subarachnoidhaemorrhage

Page 25: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck25

Severe TBI

Low falls in the elderly – injury types

Harvey & Close (2012)

Page 26: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck26

Severe TBI

Low falls in the elderly– What is the role of anticoagulants and antiplatelets in falls?

Clear benefits in multiple conditions However, increased complexity of managing trauma patients

– Warfarin associated with increased mortality (AOR = 2.14)

Lecky F, et al. (2015). Model adjusted for age, injury severity and GCS.

Page 27: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck27

Severe TBI

Low falls in the elderly – discharge directionDischarge direction Percentage

Home 3%

Rehabilitation 10%

Hospital for convalecence 4%

Nursing home 3%

In-hospital death 80%

Page 28: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck28

Severe TBI

Low falls in the elderly – outcomes (GOS-E)– 70 patients discharged alive

32% 29% 9% 3% 7% 12% 7%

0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

Dead Vegetative state Lower severe disability Upper severe disability

Lower moderate disability Upper moderate disability Lower good recovery Upper good recovery

6 months

40% 2% 22% 3% 6% 19% 6%

0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

12 months

Page 29: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck29

Severe TBI

Summary– Incidence of severe TBI resulting from low falls on the rise

Now the leading cause of unintentional severe TBI

– Elderly severe TBI Most commonly intracranial haemorrhages

– Role of anticoagulants?

80% in-hospital mortality

Poor long-term outcomes– 40% of those discharged alive have died at 12 months– 35% are left with moderate/severe disability

Page 30: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

Summary

Page 31: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck31

Conclusion

Low falls– Largest cause of major trauma

– Incidence of major trauma and severe TBI resulting from falls increasing at alarming rates

– High mortality and poor long-term outcomes

Page 32: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck32

Call to arms

Page 33: The elderly: Major trauma and Severe traumatic brain injury€¦ · Major trauma and Severe traumatic brain injury Dr Ben Beck Deputy Head Prehospital, Emergency and Trauma Research.

@drbenbeck33

Contact details

Dr Ben BeckDeputy Head Prehospital, Emergency and Trauma Research

Department of Epidemiology and Preventive MedicineMonash University

[email protected]

@drbenbeck

@EmergTrauma