The Do’s and Don’ts of Antidotes · The Do’s and Don’ts of Antidotes ... •List other antidotes used for poisonings and overdoses and their ... unfamiliar with poisons/drugs
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Lisa Booze, PharmDCertified Specialist in Poison Information
PharmCon is accredited by the Accreditation Council for Pharmacy Education as a provider of
continuing pharmacy education
Legal Disclaimer: The material presented here does not necessarily reflect the views of Pharmaceutical Education
Consultants (PharmCon) or the companies that support educational programming. A qualified healthcare professional
should always be consulted before using any therapeutic product discussed. Participants should verify all information and data before treating patients or employing any therapies described in this educational activity.
This program has been brought to you by PharmCon
This program has been brought to you by PharmCon
Accreditation:
Pharmacists: 0798-0000-10-026-L04-P
Pharmacy Technicians: 0798-0000-10-026-L04-P
Nurses: N-593
CE Credits: 1.0 contact hour
Target Audience: Pharmacists, Technicians
& Nurses
Program Overview:
Home is where the poisons are. It's not that we stock them intentionally. It's just that so many things that
we use around the house--medicines, cleaners, painting supplies, perfumes, insecticides, even vitamins--
can be toxic if swallowed or if taken in excess. This program is designed to give pharmacists the do’s and
don’ts of antidotes for many of the common poisonings that can occur in everyday life
Objectives:
• Know the indications, routes and dosages for the use of acetylcysteine in treating acetaminophen
overdoses
• Identify the antidotes used in the treatment of calcium channel blocker, beta blocker and sulfonylurea
overdoses
• Describe the differences between the Cyanide Antidote Kit and hydroxocobalamin
• Review the indications and dosing for fomepizole
• List other antidotes used for poisonings and overdoses and their indications
Speaker: Dr. Lisa Booze is the Clinical Coordinator and a Certified Specialist in Poison Information at the
Maryland Poison Center, a division of the University Of Maryland School Of Pharmacy. She is responsible for
developing and implementing toxicology continuing education programs for health professionals in Maryland. She
is a co-coordinator of the Poison Center Surveillance for Chemical and Bioterrorism and Public Health Program,
supported by the Maryland Department of Health and Mental Hygiene. Dr. Booze is a member of the American
Association of Poison Control Centers, the American Academy of Clinical Toxicology, and the Expert Consensus
Panel that develops Out-of-Hospital Management Guidelines for U.S. poison centers.
Speaker Disclosure: Dr Booze has no actual or potential conflicts of interest in relation to this program
This program has been brought to you by PharmCon
PharmCon is accredited by the Accreditation Council for Pharmacy Education as a provider of
continuing pharmacy education
Legal Disclaimer: The material presented here does not necessarily reflect the views of Pharmaceutical Education
Consultants (PharmCon) or the companies that support educational programming. A qualified healthcare professional
should always be consulted before using any therapeutic product discussed. Participants should verify all information and data before treating patients or employing any therapies described in this educational activity.
“Substances which can counteract a form of poison”.
Few antidotes
Not always indicated
Many pharmacists and physicians are unfamiliar with poisons/drugs and their antidotes
Reproduction in whole or in part without permission is prohibited.
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Insulin enhances cardiac carbohydrate metabolism + inotropic effects, increases BPUsed if severe or persistent hypotension & in conjunction with other drug therapy1 unit/kg regular human insulin bolus; followed by 0.5 unit/kg/hrGive dextrose bolus: 1 amp (25 mL) D50 (peds: 0.25 g/kg D25W); follow with D5W
>8,000 poisonings each year
Ethylene glycol, methanol
Toxic metabolites
Toxic dose of ethylene glycol: > 0.2 mL/kgA mouthful in an adult or child
Toxic dose of methanol: > 0.1 mL/kg
Toxic effects: Initial GI upset and intoxication, then delayed metabolic acidosis, cardiac & pulmonary toxicity, renal failure (EG), blindness (methanol)
Competitive inhibitor of alcohol dehydrogenase; blocks metabolism of EG and methanol
Not FDA-approved
IV or PO
Difficult to dose; requires frequent monitoring of blood ethanol levels