The causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomization Short: Alzheimer’s PRS PheWAS Roxanna Korologou-Linden, MSc 1,2 , Laura D Howe, PhD 1,2 , Louise A C Millard, PhD 1,2,3 , Yoav Ben-Shlomo, PhD 2 , Dylan M Williams, PhD 4,5 , George Davey Smith, PhD 1,2 , Emma L Anderson † , PhD 1,2 , Evie Stergiakouli † , PhD 1,2 , Neil M Davies † , PhD 1,2,6 1 Medical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, BS8 2BN, United Kingdom. 2 Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom. 3 Intelligent Systems Laboratory, Department of Computer Science, University of Bristol, Bristol, UK 4 MRC Unit for Lifelong Health and Ageing at UCL, University College London, London, UK. 5 Department of Medical Epidemiology & Biostatistics, Karolinska Institutet, Stockholm, Sweden. 6 K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Norway. Corresponding author: Roxanna Korologou-Linden, Office BF8, Oakfield House, Oakfield Grove, Clifton, BS8 2BN email: [email protected] † Contributed equally Key Words: Alzheimer’s disease, phenome-wide association studies, PRSs, Mendelian randomization. Word count: 2,959 . CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review) The copyright holder for this preprint this version posted September 2, 2020. ; https://doi.org/10.1101/2019.12.18.19013847 doi: medRxiv preprint NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.
Welcome message from author
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Related Documents
