Why are Zinc Oxide Sunscreens the best? cyber derm the sunscreen company Thursday, February 23, 2012
The Benefits of Zinc Oxide in Sunscreen Formulations
Mar 22, 2016
the benefits of zinc and the potential implications of using other UV absorbers. Considerations behind formulating our Simply Zinc Sun Whip SPF 30 and our Every Morning Sun Whip SPF 25.
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Why are Zinc Oxide Sunscreens the best?
cyberdermthe sunscreen company
Thursday, February 23, 2012
DERMATOLOGIC FIRST PRINCIPLES
• Topical agents should act locally and not achieve tissue or blood levels by absorption
• Ideal topical therapy should have zero risk for photo-allergy or photo-contact dermatitis
cyberdermthe sunscreen company
Thursday, February 23, 2012
THE MEDICAL BASIS FOR A SAFE AND EFFECTIVE SUNSCREEN
• Safety
• Exclude all active ingredients that are absorbed, i.e. those with a molecular weight < 500 Daltons
• Efficacy
• Provide broad spectrum UVA and UVB protection with the minimum number of active ingredients
• All ingredients should be photo-stablecyberdermthe sunscreen company
Thursday, February 23, 2012
EXCLUSION FACTOR #1: ABSORPTION
cyberdermthe sunscreen company
0
175
350
525
700
Oxybenzone Octisalate Avobenzone Octinoxate Mexoryl XLMexoryl SX Tinosorb S Tinsorb M
Molecular Weight (Daltons) of Commercially Available Active Ingredients
Min. Molecular Weight of 500 Daltons
Thursday, February 23, 2012
EXCLUSION FACTOR #2: PHOTO-ALLERGIC/ALLERGIC
Photo-Allergic
• Oxybenzone
• PABA
• Avobenzone (Parsol)
• Homosalate
• Octinoxate (Non-Encapsulated)
• Octisalate
cyberdermthe sunscreen company
In descending order of frequencyLevel of risk less than 1%
Allergic• Oxybenzone• Octyl PABA• Octinoxate (Non-Encapsulated)• Avobenzone• Octisalate
Thursday, February 23, 2012
ACTIVE INGREDIENTS THAT MEET THE SAFETY CRITERIA
• Zinc Oxide and Titanium Dioxide
• Tinosorb S and Tinosorb M
• Proprietary to Johnson and Johnson, limited availability,
• Requires adjunctive agents that do not meet the criteria
• Mexoryl SX and Mexoryl XL
• Proprietary to L’Oreal, limited availability,
• Requires adjunctive agents that do not meet the criteria
cyberdermthe sunscreen company
Thursday, February 23, 2012
EFFICACY: BROAD SPECTRUM PROTECTION*
•
Sample Sunscreen with 18% Zinc Oxide, SPF 30 Sample Sunscreen with 3% Avobenzone, 6%
Oxybenzone, 15% Homosalate, 5% Octisalate, 10% Octocrylene, SPF 100
Sample Sunscreen with 2% Avobenzone, 3% Mexoryl SX, 10% Octocrylene, TiO2 5%, SPF 45
cyberdermthe sunscreen company
*Source: Environmental Working Group Skin Deep Database
Thursday, February 23, 2012
CYBERDERM SUNSCREENS:COMING SUMMER 2012
Every Morning Sun Whip SPF 25
• 15 % Zinc Oxide
• 7.5% Encapsulated Octinoxate
cyberdermthe sunscreen company
Simply Zinc Sun Whip SPF 30
• 22% Zinc Oxide
Thursday, February 23, 2012
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