The ABC of Animal Experiments 2012

The ABC of Animal The ABC of Animal Experiments Experiments

20122012

European competenceEuropean competence

FELASA categoriesFELASA categories A. Animal techniciansA. Animal technicians

http://www.felasa.eu/working-groups B. Research techniciansB. Research technicians

http://la.rsmjournals.com/cgi/reprint/34/3/229 C. ScientistsC. Scientists

http://la.rsmjournals.com/cgi/reprint/29/2/121 D. SpecialistsD. Specialists

http://la.rsmjournals.com/cgi/reprint/33/1/1 In FinnishIn Finnish

http://www.uku.fi/jarjestot/FinLAS/

Category C competenceCategory C competence

FELASA guidelines FELASA guidelines Multilateral consultations in Council of Multilateral consultations in Council of Europe (CoE) 1993Europe (CoE) 1993

80 h80 hTopicsTopics

UK / Home officeUK / Home officeEuropean Science Foundation (ESF)European Science Foundation (ESF) ’’accredited courses’accredited courses’ www.esf.org

FELASA Accreditation – FELASA Accreditation – quality system for educationquality system for education

‘FELASA Accredited Training’

Maintaining accreditation•A & D – 10 years•B & C – 5 years

Applicant

Application & fee

Accreditation board•Nomination: FELASA board•Processes applications

YES NOannual (B,C) or biannual (A,D) reports

Working methodsWorking methods

LecturesLecturesAnalgesia exerciseAnalgesia exerciseDesign group tasksDesign group tasksCost-benefit group taskCost-benefit group taskRefereeing exerciseRefereeing exerciseEthics committee applicationEthics committee application

Laboratory Animal Science ?Laboratory Animal Science ?

Jann Hau: Jann Hau: Basic LAS: Concerns the animals Basic LAS: Concerns the animals

themselvesthemselves Applied LAS: Deals with the animal as a Applied LAS: Deals with the animal as a

scientific modelscientific model

Laboratory Animal Science ?Laboratory Animal Science ?

K-J. Öbrink:K-J. Öbrink: Laboratory animal science is a science auxiliary to Laboratory animal science is a science auxiliary to

biological and medical research, but still a well biological and medical research, but still a well demarcated discipline in research and teaching.demarcated discipline in research and teaching.

It consists of four main parts:It consists of four main parts:genetics and characteristics of laboratory animalsgenetics and characteristics of laboratory animalseffect of homeostatic mechanisms on animal experimentseffect of homeostatic mechanisms on animal experimentslaboratory animal husbandry and basic animal experiment laboratory animal husbandry and basic animal experiment methodologymethodologylegislation, decrees and laboratory animal ethics legislation, decrees and laboratory animal ethics

LAS / PhilosophyLAS / PhilosophyLong historyLong history Aristoteles (384-322 B.C.): Experiment with Aristoteles (384-322 B.C.): Experiment with

groups before explanation attemptgroups before explanation attempt Galen (130-200 A.D.), Harvey 1657), Boyle Galen (130-200 A.D.), Harvey 1657), Boyle

(1627-1691), Hunter (1728-1823), Jenner (1627-1691), Hunter (1728-1823), Jenner (1749-1823), Darwin (1809-1882), Pasteur (1749-1823), Darwin (1809-1882), Pasteur (1822-1895), Koch (1843-1910), Banting and (1822-1895), Koch (1843-1910), Banting and Best (1922)Best (1922)

Nobel price in medicine 58 timesNobel price in medicine 58 times

LAS / PhilosophyLAS / Philosophy

Animals can be used for establishment of Animals can be used for establishment of hypotheses, but verification requires hypotheses, but verification requires experiments on humansexperiments on humans

LAS Environment LAS Environment TodayToday

Research is in unbelievable paceResearch is in unbelievable paceExpectations of society may be unrealisticExpectations of society may be unrealisticDespite increased number of projects, animal Despite increased number of projects, animal numbers per project are decreasingnumbers per project are decreasingExpectations for work quality of LAS personnel Expectations for work quality of LAS personnel is higher than everis higher than everEmphasis on 3RsEmphasis on 3RsThe way to cope with this is educationThe way to cope with this is education

Animals used in Finland 2010Animals used in Finland 2010

Europe 2005Europe 2005

Europe 2005Europe 2005

Rabbit / Council of EuropeRabbit / Council of Europe

The final bodyweight kg that anyrabbit will reach inthis housing

Minimum floor areafor one or twosocially harmoniousanimals cm2

Minimum height cm

< 33-5> 5

350042005400

454560

The table is to be used for both cages and pens. In cages a raised area must beprovided (see Table 11). Pens should contain structures that subdivide the space toallow animals to initiate or avoid social contacts. The additional floor area is 3000 cm2

per rabbit for the third, the fourth, the fifth and the sixth rabbit, while 2500 cm2 must beadded for each additional rabbit above a number of six.

Rabbit pairhousing / CoERabbit pairhousing / CoE

LAS / InstitutionsLAS / Institutions

University and research institute facilitiesUniversity and research institute facilities Grass root levelGrass root level Education and trainingEducation and training ResearchResearch

LAS SocietiesLAS SocietiesFELASA (FELASA (www.felasa.org ) )GV-SOLAS GV-SOLAS LASA UKLASA UKScand-LASScand-LASFinLASFinLASBaltLASABaltLASAESLAV / ECLAM / FALAV ESLAV / ECLAM / FALAV EstLASAEstLASA

Animal experiments - politics ?Animal experiments - politics ?

Pro research (NSMR, Understanding Animal Pro research (NSMR, Understanding Animal research, FBR, AMP, research, FBR, AMP, www.animalresearchcures.org/ )www.animalresearchcures.org/ )Laboratory Animal CentersLaboratory Animal CentersAlternative centers (ECVAM, NC3R, CAAT)Alternative centers (ECVAM, NC3R, CAAT)Welfare (UFAW, FRAME, SEY)Welfare (UFAW, FRAME, SEY)Antivivisection (RSPCA, Eurogroup, Animalia)Antivivisection (RSPCA, Eurogroup, Animalia)Terrorist (ALF, PETA, EVR, EVRT)Terrorist (ALF, PETA, EVR, EVRT)

LAS / TrainingLAS / Training

Complementary coursesComplementary coursesCompetence courses A-DCompetence courses A-D Scientists courses such as thisScientists courses such as this Specialization / D categorySpecialization / D category

University of Copenhagen

BooksBooks

Handbook of Laboratory Animal Science, Second Edition: Essential Principles and Practices, Volume IJann Hau, Gerald L Van Hoosier, Jr. (Eds) CRC Press

http://netvet.wustl.edu/e-zoo.htm http://netvet.wustl.edu/e-zoo.htm