Teratogenecity

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Effect of augmenting cumulative toxicity on progeny

By,

Dr.Shwetha.K

II yr PG Scholar

Dept.of Agadatantra

SDMCA,Udupi

Under the guidance of,Dr.K.Shobha Bhat

Associate professorDept.of Agadatantra

SDMCA,Udupi

Introduction

• To become a mother of a healthy child - most cherished desire of every woman.

• She bears the entire responsibility of progeny from conception to the maturity of fetus.

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• ...ऋतु के्षत्राम्बुबीजानाां सामाग्र्यादन्कुरो ुथा य ा |(सु.शा.२/३३)

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• The drastic change in lifestyle and habits of people during present modern era - sufferings from many angles, most alarming being their health & health of their offsprings.

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• Maternal exposure to different mediums like

alcohol

tobacco

harmful medications accumulation

certain chemicals of environment of toxins

the incompatible foods inside the

the high doses of radiation body

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An estimated 270000 newborns die during the first

28 days of life every year from congenital anomalies.

In 2010, 2.7 million neonatal deaths documented in 193

countries.

Globally, 10 million infants & children die each year before

5th birthday.

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Modes of exposure

Occupa tional

Environmental

Food & drinks

Chemical & drugs

Metals & minerals

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Environmental cause

Polluted water

Polluted air

Radiational

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• Hiroshima & Nagasaki

• Minamata syndrome

• Endosulfan issue

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• Mobile phone radiation exposure in the womb can affect the brain development of offspring and potentially lead to neurobehavioral disorders (in mice).

(www.nature.com/srep/2012)

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Eating Habits

Junk foods/fast food

Carbonated Beverages

Incompatible foods

Fruits & vegetables

Soft drinks - ↑asthma &

↓ bone development

(sciencenordic.com)

(www.families.com/blog)

Junk food – alter brain chemistry as opium & heroine

Alter dopamine secretion, ↑tolerance to sugar & fats

(http://www.hindustantimes.com)

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Exposure of mother/father to pesticides before conception or during pregnancy

In utero exposure Congenital anomalies

fetal death growth retardation eye defects,

spontaneous abortion a small-for-gestational age baby

limb reduction

early childhood cancer low birth weight urogenital defects

reduced length hypospadias

small head circumference.

cryptorchidism

orofacial clefts

heart defects

CNS defects (www.who.int/ceh)11/27/2014 13

Effect of augmenting cumulative toxicity on progeny

Prenatal exposure→ fetal brain →both structurally & functionally

Child suffers from fetal alcohol syndrome

Anatomical changes in brain- basal ganglia, corpus callosum, cerebellum and hippocampus

Functionally→ deficits in cognitive & behavioral functions,

learning & memory

(www.niaaa.nih.gov/alcohol-health)11/27/2014 14

Effect of augmenting cumulative toxicity on progeny

Tobacco

Prenatal exposure

to tobacco

Low birth weight,

Intrauterine death

Anxiety & depression of

early childhood

Signs of CNS stress

Low IQ level

More excitable, ↑

muscle tension

( Salihu and Wilson, 2007)(Robinson et al., 2008)(Law et al., 2003)(Fried, 2002; Herrmann, King &Weitzman, 2008)

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आयुरे्वदन्कुीय वर्वमशश

यत ्स् ार्वथां जङ्गम ृत्रत्रमां र्वा देन्कुहादन्कुशेषां यदन्कुननगशतां तत ्।जीर्णंवर्वषघ्नौषधिभिहशतां र्वा दन्कुार्वाग्ननर्वातातपशावषतां र्वा ॥स्र्विार्वता र्वागुर्णवर्वप्रहीनां वर्वषां हह दन्कुषूीवर्वषतामुपैनत ।र्वीयाशल्पपिार्वारोनननपातयेत्तत ् फाव्रुतां र्वषशगर्णानुबग्रोि ॥(सु. .२/२५,२६ अ.हु्र.उ ३५/३३ अ.सां.उ ४०/२४)

सर्वशमनतगुरुष्र्णतीक्ष्र्णम ्दन्कुारुर्णाश्च चेष््ााः.... न थक्तानन र्वसाांभस त्रबियृारोन मदन्कु थाणर्ण मध्यारोयभ्यर्वहथेरोन ......परथर्वजशयेत|्|

(च.शा ४/१८) 11/27/2014 16

Effect of augmenting cumulative toxicity on progeny

The Diseases caused due to विरुद्दाहार:-षार्णढयारोध्यवर्वसपशदन्कु ादन्कुथार्णाां वर्वस्फा् ारोमादन्कु िगरोदन्कुथार्णाां |मूर्ाशमदन्कुाध्मानगलग्रहार्णाां पाण्ड्र्वामयस्यामवर्वषस्य चैर्व ||क लास ुष््ग्रहर्णीगदन्कुानाां शा ाम्लवपत्तज्र्वथपीनसानाां |सांतानदन्कुाषस्य त ैर्व मतृ्यावर्वशरुद्दन्कुमरोनां प्रर्वदन्कुग्रोत हेतुम ्||

(च.सू.२६/१०२-१०३)11/27/2014 17

Effect of augmenting cumulative toxicity on progeny

सहज व्याधि

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Management

Nidanaparivarjana

Dooshivishaline of

treatment

Garbhasthapana oushadhiwith vishagna

property

Agadapanawith

garbhasthapana property

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Conclusion

• It was always assumed that “The fetus is isolated in the womb from things in the environment."

• But every exposure either good or bad has close relation with a new innocent life ….

• Let us avoid harmful effects over tiny beautiful buds….

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