Tensor decomposition-based unsupervised feature extraction identifies candidate genes that induce post-traumatic stress disorder-mediated heart diseases Y-h. Taguchi, Dept. Phys., Chuo Uinv., Tokyo, Japan Best Paper Awards of BMC Track of InCoB 2017 (BMC Med. Geno., Silver)
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genes that induce posttraumatic stress disordermediated heart diseases
Yh. Taguchi, Dept. Phys., Chuo Uinv., Tokyo, Japan
Best Paper Awards of BMC Track of
InCoB 2017 (BMC Med. Geno., Silver)
1. Introduction PTSD (Post Traumatic Stress Disorder) is primarily a mental disease that can mediate other physical diseases, e.g., diabetes (Roberts et al., JAMA Psychiatry, 2015).
In this study, we study how PTSD mediates heart failure in spite of the remote distance between heart and brain where PTSD primarily takes place.
We hypothesize that similar gene expression between heart and brain might mediate PTSD mediated heart diseases.
2. Methods
Applying tensor decomposition (TD) based unsupervised feature extraction (FE) to gene expression tensor, treatments treatments tissuestissues genesgenes, identify genes coexpressed between brain and heart, but differentially between control and treated samples.
Tensor
GenesGenesTiss
ues
Tissues
Treatm
entsT
reatments
Genes expressive selectively at the specific combination of tissues and conditions