- D A N I S H A G I N G R E S E A R C H C E N T E R - www.sdu.dk/darc Telomeres in aging Telomeres in aging Universal STELA – a method to measure Universal STELA – a method to measure telomeres telomeres Why do we age so differently? Laila Bendix, MD VELUX FONDEN Funded by:
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Telomeres in aging Universal STELA – a method to measure telomeres
Telomeres in aging Universal STELA – a method to measure telomeres. Laila Bendix, MD. VELUX FONDEN. Why do we age so differently?. Funded by:. Telomeres - structure. Telomeres - function . Shorten with cell aging. Differentiating from DSB. End replication problem. - PowerPoint PPT Presentation
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- D A N I S H A G I N G R E S E A R C H C E N T E R -www.sdu.dk/darc
Telomeres in agingTelomeres in agingUniversal STELA – a method to measure Universal STELA – a method to measure
telomerestelomeres
Why do we age so differently?
Laila Bendix, MD
VELUX FONDEN
Funded by:
- D A N I S H A G I N G R E S E A R C H C E N T E R -www.sdu.dk/darc
Telomeres - structureTelomeres - structure
- D A N I S H A G I N G R E S E A R C H C E N T E R -www.sdu.dk/darc
Telomeres - function Telomeres - function Differentiating from DSB Shorten with cell aging
Harley et al 1990, Nature
End replication problem
- D A N I S H A G I N G R E S E A R C H C E N T E R -www.sdu.dk/darc
Telomeres relate to human Telomeres relate to human aging aging
Kimura et al 2008
Halaschek-Wiener et al 2008
- D A N I S H A G I N G R E S E A R C H C E N T E R -www.sdu.dk/darc
Do telomeres also shorten Do telomeres also shorten abruptlyabruptly
Signal free ends
Graakjaer et al, Aging Cell 2004
12 kb
8 kb
4 kb
1.6 kb
0.6 kb
0.1 kb
Very short telomeres
Baird et al, Nat Genet 2003
- D A N I S H A G I N G R E S E A R C H C E N T E R -www.sdu.dk/darc