Team m patch aid v5 aug 31

• 1. Bio-Patch: Team MMicroneedle/Microchip Enabled BiosensorDaily Contact Count: 23Total Contact Count: 49 Joan AffleckMike DimitriKirim Kim John Marshall Matt Nudell

2. Insulin Injection! Wireless Data Transmission! 3. Business Model Canvas Day 1HP ProductionSmart drug InventoryMedical delivery Controlsupply Platform /system companies networkingchip andCo-creation needle Insurance companies HP patent Direct sales CMOs CMOs,DataData sales team,collection Direct DDS collection generaltoolssalesfees admin 4. Discovery & Research 5. Business Model Canvas Day 2 -- Smart drug-- Inventory delivery systemControlHP ProductionMed supply (chip and needle)-- Co-creation companies` -- PersonalizedHospitals / doctor Platform /medicine entry -- BrandingofficesnetworkingPharma-- Various uses -- Smart delivery companiesInsuranceLicensing system may-- Personalizedcompaniesextend patent lifedata monitoring Patients -- Ease of use,FDA time mgmt Doctors -- ControlledCMOs pain-free deliveryInsurance HP patentDirect sales companies -- Lower patient Cloud service care costs HP -- Purchasing CMOsFDA -- Regulatory CMOs, salesDirect DDS team, generalsales adminData collection Data collectionfees tools 6. FDA and PATENT Time and $$??? 7. Business Model Canvas Day 3-- Smart drug-- Inventory Production delivery systemHospitals / doctor ControlMed supply(chip and needle)-- Co-creationofficesPlatform / companies`-- Personalized networking medicine entry -- BrandingPharmaPharmacompanies-- Various uses Licensing-- Smart delivery companiessystem may-- PersonalizedInsuranceProcure HP extend patent lifedata monitoring Patientscompaniespatent-- Ease of use,HPtime mgmt Doctors-- ControlledFDA pain-free deliveryInsurance HP patent Direct sales companies-- Lower patientCMOs Cloud servicecare costs BI Application HP-- Purchasing CMOs FDA-- Regulatory CMOs, sales Direct DDS team, general sales admin Data collection Data collection fees tools 8. Drug Delivery/Insulin InjectionBioSensor Only 9. Business Model Canvas Day 4Med DevicePlatform / networking-- Smart drug delivery-- InventoryCompanies Software development system Biosensor (chipControl Med Supply/ integrationand needle) -- Co-creationDevice -- Personalized CompaniesPharma companiesPatent development biomarkers-- Branding -- Clinical Studies PharmaHospitals / Doctor CompaniesProcure HP patent-- Smart delivery systemoffices-- PersonalizedProduction -- Preventative data monitoring PatientsInsurance companies healthcare -- Controlled pain-free Hospitals /HP Needle & chip mfg Doctors deliverySoftware DeveloperHP patentInsurance -- Lower patient care Direct sales costs CompaniesCloud serviceFDAPatented softwareWeb-based HP -- PurchasingCMOs softwareManufacturingdownload -- Regulatory FDA Hardware costs, CMOs, sales team, generalDirect DDS Biosensor sales adminData collection fees Data collection tools Biosensor customizationApplication development Software development, patents, legal fees 10. MVP DVTPatients Only 11. Business Model Canvas Day 5Med DeviceSoftware developmentCompanies Biosensor Med Device/ integration Co-creationCompaniesPersonalized biomarkersPharma companiesPatent Filing Clinical StudiesPharmaPreventative healthcare CompaniesHospitals / DoctorProductionPersonalized dataoffices monitoringPatientsLower patient care costsInsurance companiesHospitals /RegulatoryDoctorsNeedle & chip mfgInsuranceSoftware DeveloperDirect salesCompaniesPatented softwareFDAWeb-based FDACMOsManufacturing softwaredownloadHardware costs, CMOs, sales team, general adminDirect Biosensor salesBiosensor customizationSoftware development, patents, legal Application development fees 12. Getting out of the building Total number of contacts: 49 Pharma industry subject matter experts in IT, businessdevelopment, pharmacokinetics, clinical researchdirectors Medical device experts Physicians specializing in diabetes, immunology,geriatrics Life Science consultants Private equity expert Venture capital experts Patients 13. Hypothesis Testing HypothesisTest ResultMicro-needle self- Interviewed Doctors, Board TRUE-Patients dread selfapplication patches aremember of Medical Device pricking & inaccurate testingpreferred over at-home and Company, Pharmaceuticalhospital blood tests Reps and PatientsMIXED-Would require proofof concept, safety studiesand cost effectivenessFDA regulation period will Interviewed Consultant and TRUE- 510(K), Class IIbe less rigorous for online researchdevice will take 3 to 5 years,biosensor than drug deliveryapproximately $30 millionvs. 7 to 10 years costingmore than $100 millionFiling for patent will Interviewed current patent TBD - Microneedlesdifferentiate us fromownercombined with integratedcompetitors alert system could be apotentially patented productat a cost of $20,000 to$100,000 taking from 2 to15 months 14. HypothesisTestResultChannels: Direct Sales tomedical device companies Confirmed by experts TRUEis most efficientin fieldRevenue: Revenue streamis generated through sale of TBDTBDbiosensor as well asapplication fees forintegrating with doctorsoffices 15. What to do next?? Day 6+Micro-needle and Micro-chip enabled patch providing periodic monitoringof anti-coagulant efficacy (prothrombin time).Data is wirelessly transmitted to patients phone and/or to hospitalsystems.EnsureContact Engage Evaluatepatent regulatorysoftwareCMOsprotection consultantdeveloper 16. 110 Million People Worldwide AtRisk of Thrombosis Target Market: 2,000,000 DVT US patients perannum $800 for current monthly testing kit TAM:SAM:Target Market: Finger prick test Medical Device Potential insurance cost ofPeople atSuppliers DVT occurs in$1,600,000,000 risk 2,000,000 perforCo vidien annum thrombosis: Johnson & Johnson $100 for new continuous testing kitBaxter 600,000 are Potential insurance cost of110 million hospitalized w/ Meditronic worldwideBoston Scientific$200,000,000affected DVT/PEAbbott Labs 17. Marketing approachMedical CommunityInsuranceMedical journal publicationsResults Oriented DataKey opinion leadersComparative Product CostsAmerican Society ofPrevention of Acute CareHematology Conferences Patients EpisodesEducation sessions DVT Awareness Month (March) American Public Health Assoc. Trusted educational online info MD Office 18. Channels with Capital Flow$$ Insurance $$$$ClaimRegulatorsMed Device$$Bio-PatchClaim SuppliersRx Approval Patch$$ Shipper PatchPatchPatientShipper$$Rx $$ $$ RxPharmacy Patch CMO NetworkDoctor$$ Needles, ChipsChip / Needle Producers 19. Getting Customers/Acquisition 20. I want to be there for my family. Biopatch helps me monitor my DVT condition so I can worry less and be with my grandchildren Meet Dave Retiree, Grandfather Age 60+ Former McKinsey Consultant Purchases 120 BioPatchs annuallyDemographic:Traits:Condition:Male/Female Ages Loves to travel (forBedridden due to60+ business and recent hippleasure) sittingreplacement (onBudget: down on flightsgeneralFixed Income No history of anesthetic)High Insurance familial cancer or CalfCosts thrombosis swelling/LocalizedSpends $100 dollarsUsed to be avid swelling in legsannually on Biopatchhiker before hip venuous systeminjury Weight gain 21. Day in a life-Remote Monitoring Bio PatchCurrent On line order On line orderPatient gets Direct from pharmacyPatient gets Direct from pharmacy materialsmaterials Peel off adhesive Finger prickPatient Apply patchPatient does Reader with stripsapplies patchfinger prick Electronic results for Electronic read out on device immediate use and e-records No long term electronicPatient gets Patient getsresults Call MD office if neededresultsrecord 22. Customer Interaction HOSPITAL MONITORPATIENTS MOBILE A 23. Financial AnalysisAfter 3 years in market, IRR is roughly 50%, sales of $170 mm and net profit of $68 mmYear 0Year 1Year 2Year 3Year 4 Year 5 Year 6 Year 7Patent Pending(100,000)FDA Approval (7,500,000) (7,500,000) (7,500,000) (7,500,000)Sales59,500,000 110,500,000 170,000,000Program Expense (40,000)(10,000) (10,000) (10,000)App Store Costs(1,000)(1,000)(1,000)Mfg / CMO Expense $ (27,216,000) $ (50,544,000) $ (77,760,000)Distribution(10,000) (10,000) (10,000)Sales(283,000)(487,000)(725,000)Customer Acq Cost (59,500)(110,500)(170,000)Support(8,164,800) (15,163,200) (23,328,000)Admin (60,000) (25,000)(25,000)(25,000)(25,000) (75,000) (75,000)(100,000)Total Cash Flows (200,000) (7,525,000) (7,525,000) (7,525,000) (7,525,000) 23,680,70044,099,30067,896,000 Assumes 2 MM patients in its 3rd year (Yr 7 of analysis) Assumes 35% penetration in year 5, 65% penetration in year 6 and 100%penetration in year 7 of newly recognized DVT patients Costs are estimates developed through getting out of the building $0.325 for each purchasing and manufacturing of patch after inventory-financing Outsourced support and service based off of 30% of manufacturing/CMO expenses