TDMS No. P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date …Date Report Reqsted: 06/15/2006 : Test Type: 26-WEEK : TEF TRANSGENICS (PECDF) Time Report Reqsted: 12:44:12 : Route:

TDMS No 20201 - 03

Test Type 26-WEEK

Route SKIN APPLICATION

SpeciesStrain MICETGAC HEMI

C Number

Lock Date

Cage Range

Date Range

Reasons For Removal

Removal Date Range

Treatment Groups

P04 NEOPLASMS BY INDIVIDUAL ANIMAL TEF TRANSGENICS (PECDF)

CAS Number 57117-31-4

Date Report Reqsted 06152006

Time Report Reqsted 124412

First Dose MF NA 042103

Lab BAT

C20201C

07242004

ALL

ALL

ALL

ALL

Include ALL

TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006

Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412

Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103

SpeciesStrain MICETGAC HEMI Lab BAT

1 1 1 1 1 1 1 1 1 1 1 0 1 0 1 1 1 1 1 1 DAY ON TEST 8 8 8 8 8 8 8 6 8 8 8 7 8 8 8 8 8 8 8 8

7 3 5 5 6 6 5 5 6 3 5 4 7 1 3 4 6 6 4 4

TGAC (FVBN) HEMIZYGOUS MICE FEMALE

ANIMAL ID 0 NGKG

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS

ALIMENTARY SYSTEM

Liver + + + + + + + + + + + + + + + + + + + + 20

Leukemia Erythrocytic X 1

Mesentery + 1

Salivary Glands + 1

Squamous Cell Carcinoma X 1

Stomach Forestomach + + + + + + 6

Squamous Cell Papilloma X X X X 4

Squamous Cell Papilloma Multiple X 1

Stomach Glandular + 1

Tooth + + + + + + 6

Odontogenic Tumor X X X X X 5

Odontogenic Tumor Multiple X 1

CARDIOVASCULAR SYSTEM NONE

ENDOCRINE SYSTEM

Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue

Control data contained within this report was collected on study 20201-01 Page 2

TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006

Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412

Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103

SpeciesStrain MICETGAC HEMI Lab BAT

1 1 1 1 1 1 1 1 1 1 1 0 1 0 1 1 1 1 1 1 DAY ON TEST 8 8 8 8 8 8 8 6 8 8 8 7 8 8 8 8 8 8 8 8

7 3 5 5 6 6 5 5 6 3 5 4 7 1 3 4 6 6 4 4

TGAC (FVBN) HEMIZYGOUS MICE FEMALE

ANIMAL ID 0 NGKG

NONE

GENERAL BODY SYSTEM NONE

GENITAL SYSTEM

Ovary

+ 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS

HEMATOPOIETIC SYSTEM

Lymph Node Mesenteric + 1

Spleen + + + + + + + + + + + + + + + + + + + + 20

Leukemia Erythrocytic X 1

Thymus + + + + + + + + + + + + + + + + + + + + 20

INTEGUMENTARY SYSTEM

Skin + + + + 4

Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20

Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20

Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue

Control data contained within this report was collected on study 20201-01 Page 3

TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006

Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412

Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103

SpeciesStrain MICETGAC HEMI Lab BAT

1 1 1 1 1 1 1 1 1 1 1 0 1 0 1 1 1 1 1 1 DAY ON TEST 8 8 8 8 8 8 8 6 8 8 8 7 8 8 8 8 8 8 8 8

7 3 5 5 6 6 5 5 6 3 5 4 7 1 3 4 6 6 4 4

TGAC (FVBN) HEMIZYGOUS MICE FEMALE

ANIMAL ID 0 NGKG

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS

Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20

Squamous Cell Papilloma X 1

Skin Soa No Mass + + + + + + + + + + + + + + + + + + + + 20

MUSCULOSKELETAL SYSTEM NONE

NERVOUS SYSTEM NONE

RESPIRATORY SYSTEM

Lung

AlveolarBronchiolar Adenoma

Leukemia Erythrocytic

+ + + + + + + + + + + + + + + + + + + + 20

X 1 X 1

SPECIAL SENSES SYSTEM NONE

URINARY SYSTEM NONE

Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue

Control data contained within this report was collected on study 20201-01 Page 4

TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006

Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412

Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103

SpeciesStrain MICETGAC HEMI Lab BAT

1 1 1 1 1 1 1 1 1 1 1 0 1 0 1 1 1 1 1 1 DAY ON TEST 8 8 8 8 8 8 8 6 8 8 8 7 8 8 8 8 8 8 8 8

7 3 5 5 6 6 5 5 6 3 5 4 7 1 3 4 6 6 4 4

TGAC (FVBN) HEMIZYGOUS MICE FEMALE

ANIMAL ID 0 NGKG

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS

SYSTEMIC LESIONS

Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Erythrocytic X 1

Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue

Control data contained within this report was collected on study 20201-01 Page 5

TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006

Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412

Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103

SpeciesStrain MICETGAC HEMI Lab BAT

1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8

3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4

TGAC (FVBN) HEMIZYGOUS MICE FEMALE

ANIMAL ID 72 NGKG

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS

ALIMENTARY SYSTEM

Liver + + + + + + + + + + + + + + + + + + + + 20

Mesentery + 1

Pancreas + 1

Stomach Forestomach + + 2

Squamous Cell Papilloma X 1

Squamous Cell Papilloma Multiple X 1

Tooth + + + + + + 6

Odontogenic Tumor X X X X X 5

Odontogenic Tumor Multiple X 1

CARDIOVASCULAR SYSTEM NONE

ENDOCRINE SYSTEM NONE

GENERAL BODY SYSTEM NONE

Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue

Control data contained within this report was collected on study 20201-01 Page 6

TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006

Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412

Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103

SpeciesStrain MICETGAC HEMI Lab BAT

1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8

3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4

TGAC (FVBN) HEMIZYGOUS MICE FEMALE

ANIMAL ID 72 NGKG

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS

GENITAL SYSTEM

Ovary + 1

HEMATOPOIETIC SYSTEM

Lymph Node Mandibular + 1

Lymph Node Mesenteric + 1

Spleen + + + + + + + + + + + + + + + + + + + + 20

Thymus + + + + + + + + + + + + + + + + + M + + 19

INTEGUMENTARY SYSTEM

Skin + + + + 4

Squamous Cell Papilloma X X X X 4

Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20

Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20

Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20

Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue

Control data contained within this report was collected on study 20201-01 Page 7

TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006

Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412

Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103

SpeciesStrain MICETGAC HEMI Lab BAT

1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8

3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4

TGAC (FVBN) HEMIZYGOUS MICE FEMALE

ANIMAL ID 72 NGKG

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS

Keratoacanthoma

Squamous Cell Carcinoma

Squamous Cell Papilloma

Squamous Cell Papilloma Multiple

Skin Soa No Mass

X 1 X 1

X X X X X 5 X X X X X X X X X X 10

+ + + + + + + + + + + + + + + + + + + + 20

MUSCULOSKELETAL SYSTEM NONE

NERVOUS SYSTEM NONE

RESPIRATORY SYSTEM

Lung

+ + + + + + + + + + + + + + + + + + + + 20

SPECIAL SENSES SYSTEM NONE

URINARY SYSTEM NONE

Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue

Control data contained within this report was collected on study 20201-01 Page 8

TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006

Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412

Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103

SpeciesStrain MICETGAC HEMI Lab BAT

1 1 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 1 1 DAY ON TEST 3 8 7 8 8 8 2 5 9 8 8 5 8 8 8 8 8 9 8 8

3 5 8 3 6 5 7 4 7 3 5 7 6 5 5 7 3 4 3 4

TGAC (FVBN) HEMIZYGOUS MICE FEMALE

ANIMAL ID 72 NGKG

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS

SYSTEMIC LESIONS

Multiple Organ + + + + + + + + + + + + + + + + + + + + 20

Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue

Control data contained within this report was collected on study 20201-01 Page 9

TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006

Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412

Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103

SpeciesStrain MICETGAC HEMI Lab BAT

1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8

3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7

TGAC (FVBN) HEMIZYGOUS MICE FEMALE

ANIMAL ID 242 NGKG

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS

ALIMENTARY SYSTEM

Liver + + + + + + + + + + + + + + + + + + + + 20

Stomach Forestomach + + 2

Squamous Cell Papilloma X 1

Squamous Cell Papilloma Multiple X 1

Tooth + + + 3

Odontogenic Tumor X X 2

CARDIOVASCULAR SYSTEM NONE

ENDOCRINE SYSTEM

Pituitary Gland

+ 1

GENERAL BODY SYSTEM NONE

GENITAL SYSTEM NONE

Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue

Control data contained within this report was collected on study 20201-01 Page 10

TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006

Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412

Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103

SpeciesStrain MICETGAC HEMI Lab BAT

1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8

3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7

TGAC (FVBN) HEMIZYGOUS MICE FEMALE

ANIMAL ID 242 NGKG

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS

HEMATOPOIETIC SYSTEM

Spleen + + + + + + + + + + + + + + + + + + + + 20

Thymus + + + M + + + + + + + + + + + + + + + + 19

INTEGUMENTARY SYSTEM

Skin + + + + + + + + 8

Squamous Cell Papilloma X X X 3

Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20

Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20

Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20

Spindle Cell Carcinoma X 1

Squamous Cell Carcinoma X X 2

Squamous Cell Papilloma X 1

Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X 16

Skin Soa No Mass + + + + + + + + + + + + + + + + + 17

MUSCULOSKELETAL SYSTEM

Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue

Control data contained within this report was collected on study 20201-01 Page 11

TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006

Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412

Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103

SpeciesStrain MICETGAC HEMI Lab BAT

1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 4 7 8 1 8 8 8 8 8 8 8 2 8 8 8 8 8 8 8 8

3 1 5 4 5 3 6 6 6 4 6 7 5 4 4 6 3 4 5 7

TGAC (FVBN) HEMIZYGOUS MICE FEMALE

ANIMAL ID 242 NGKG

NONE

NERVOUS SYSTEM NONE

RESPIRATORY SYSTEM

Lung

+ + + + + + + + + + + + + + + + + + + + 20

SPECIAL SENSES SYSTEM NONE

URINARY SYSTEM NONE

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS

SYSTEMIC LESIONS

Multiple Organ + + + + + + + + + + + + + + + + + + + + 20

Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue

Control data contained within this report was collected on study 20201-01 Page 12

TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006

Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412

Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103

SpeciesStrain MICETGAC HEMI Lab BAT

0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4

0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3

TGAC (FVBN) HEMIZYGOUS MICE FEMALE

ANIMAL ID 720 NGKG

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS

ALIMENTARY SYSTEM

Liver + + + + + + + + + + + + + + + + + + + + 20

Leukemia Erythrocytic X 1

Stomach Forestomach + + + + + 5

Squamous Cell Papilloma X X X X X 5

Tooth + 1

CARDIOVASCULAR SYSTEM NONE

ENDOCRINE SYSTEM

Pituitary Gland

Leukemia Erythrocytic

+ 1 X 1

GENERAL BODY SYSTEM NONE

GENITAL SYSTEM NONE

Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue

Control data contained within this report was collected on study 20201-01 Page 13

TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006

Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412

Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103

SpeciesStrain MICETGAC HEMI Lab BAT

0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4

0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3

TGAC (FVBN) HEMIZYGOUS MICE FEMALE

ANIMAL ID 720 NGKG

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS

HEMATOPOIETIC SYSTEM

Lymph Node + + + + + + + + 8

Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application

Squamous Cell Carcinoma Metastatic X 1 Lymph Node

Squamous Cell Carcinoma Metastatic X X X 3 Skin

Lumbar Leukemia Erythrocytic X 1

Mediastinal Squamous Cell Carcinoma X 1 Metastatic Skin

Renal Leukemia Erythrocytic X 1

Lymph Node Mandibular + + + 3

Leukemia Erythrocytic X 1

Squamous Cell Carcinoma Metastatic X 1 Skin

Lymph Node Mesenteric + + 2

Spleen + + + + + + + + + + + + + + + + + + + + 20

Leukemia Erythrocytic X 1

Thymus + + + + + + + + + + + + + + + + + + + M 19

Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue

Control data contained within this report was collected on study 20201-01 Page 14

TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006

Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412

Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103

SpeciesStrain MICETGAC HEMI Lab BAT

0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4DAY ON TEST 0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3

TGAC (FVBN) HEMIZYGOUS MICE FEMALE

ANIMAL ID 720 NGKG

0 0 3 4 1

0 0 3 4 2

0 0 3 4 3

0 0 3 4 4

0 0 3 4 5

0 0 3 4 6

0 0 3 4 7

0 0 3 4 8

0 0 3 4 9

0 0 3 5 0

0 0 3 5 1

0 0 3 5 2

0 0 3 5 3

0 0 3 5 4

0 0 3 5 5

0 0 3 5 6

0 0 3 5 7

0 0 3 5 8

0 0 3 5 9

0 0 3 6 0 TOTALS

INTEGUMENTARY SYSTEM

Skin + + + + + + + 7

Squamous Cell Papilloma X 1

Squamous Cell Papilloma Multiple X X X 3

Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20

Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20

Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20

Keratoacanthoma X 1

Spindle Cell Carcinoma X 1

Squamous Cell Carcinoma X X X X X 5

Squamous Cell Carcinoma Multiple X X X X 4

Squamous Cell Papilloma X 1

Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X 19

Skin Soa No Mass + + + + + + + + + + + + + 13

MUSCULOSKELETAL SYSTEM NONE

Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue

Control data contained within this report was collected on study 20201-01 Page 15

TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006

Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412

Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103

SpeciesStrain MICETGAC HEMI Lab BAT

0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 6 8 6 8 8 8 8 8 8 2 8 8 8 8 5 8 8 8 4

0 3 3 3 3 4 6 3 5 7 2 5 4 7 7 5 3 4 3 3

TGAC (FVBN) HEMIZYGOUS MICE FEMALE

ANIMAL ID 720 NGKG

NERVOUS SYSTEM NONE

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 6 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS

RESPIRATORY SYSTEM

Lung + + + + + + + + + + + + + + + + + + + + 20

AlveolarBronchiolar Adenoma X 1

Leukemia Erythrocytic X 1

Squamous Cell Carcinoma Metastatic X 1 Skin

SPECIAL SENSES SYSTEM NONE

URINARY SYSTEM NONE

SYSTEMIC LESIONS

Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Erythrocytic X 1

Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue

Control data contained within this report was collected on study 20201-01 Page 16

TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006

Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412

Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103

SpeciesStrain MICETGAC HEMI Lab BAT

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5

5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0

TGAC (FVBN) HEMIZYGOUS MICE FEMALE

ANIMAL ID 1520 NGKG

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS

ALIMENTARY SYSTEM

Liver + + + + + + + + + + + + + + + + + + + + 20

Leukemia Granulocytic X 1

Stomach Forestomach + + + + + + + + 8

Squamous Cell Papilloma X X X X 4

Squamous Cell Papilloma Multiple X X X X 4

Tooth + + 2

Odontogenic Tumor X X 2

CARDIOVASCULAR SYSTEM

Blood Vessel + 1

Heart + 1

ENDOCRINE SYSTEM

Adrenal Cortex + 1

Adrenal Medulla + 1

Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue

Control data contained within this report was collected on study 20201-01 Page 17

TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006

Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412

Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103

SpeciesStrain MICETGAC HEMI Lab BAT

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5

5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0

TGAC (FVBN) HEMIZYGOUS MICE FEMALE

ANIMAL ID 1520 NGKG

GENERAL BODY SYSTEM NONE

GENITAL SYSTEM NONE

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS

HEMATOPOIETIC SYSTEM

Bone Marrow + 1

Lymph Node + + + + 4

Spindle Cell Carcinoma Metastatic Skin X 1 Site Of Application

Squamous Cell Carcinoma Metastatic X X X 3 Skin

Thoracic Squamous Cell Carcinoma X 1 Metastatic Skin

Lymph Node Mandibular + + + 3

Squamous Cell Carcinoma Metastatic X 1 Skin

Lymph Node Mesenteric + 1

Spleen + + + + + + + + + + + + + + + + + + + + 20

Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue

Control data contained within this report was collected on study 20201-01 Page 18

TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006

Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412

Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103

SpeciesStrain MICETGAC HEMI Lab BAT

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5

5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0

TGAC (FVBN) HEMIZYGOUS MICE FEMALE

ANIMAL ID 1520 NGKG

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS

Leukemia Granulocytic X 1

Thymus + + + M + + + + + + + + + + + M + + + + 18

INTEGUMENTARY SYSTEM

Skin + + + + + + + + + + + + + 13

Squamous Cell Papilloma X X X X X X X 7

Squamous Cell Papilloma Multiple X X X X X 5

Skin Control Dermis + + + + + + + + + + + + + + + + + + + + 20

Skin Control Epidermis + + + + + + + + + + + + + + + + + + + + 20

Skin Site Of Application + + + + + + + + + + + + + + + + + + + + 20

Spindle Cell Carcinoma X X X 3

Spindle Cell Carcinoma Multiple X 1

Squamous Cell Carcinoma X X X X X 5

Squamous Cell Carcinoma Multiple X X X X X X X 7

Squamous Cell Papilloma Multiple X X X X X X X X X X X X X X X X X X X X 20

Skin Soa No Mass + + + + + + + + + + + + 12

MUSCULOSKELETAL SYSTEM

Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue

Control data contained within this report was collected on study 20201-01 Page 19

TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006

Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412

Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103

SpeciesStrain MICETGAC HEMI Lab BAT

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5

5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0

TGAC (FVBN) HEMIZYGOUS MICE FEMALE

ANIMAL ID 1520 NGKG

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS

Bone + 1

NERVOUS SYSTEM

Brain + 1

RESPIRATORY SYSTEM

Lung + + + + + + + + + + + + + + + + + + + + 20

AlveolarBronchiolar Adenoma X 1

Leukemia Granulocytic X 1

Squamous Cell Carcinoma Metastatic X X 2 Skin

SPECIAL SENSES SYSTEM

Eye + 1

URINARY SYSTEM

Kidney + 1

Leukemia Granulocytic X 1

Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue

Control data contained within this report was collected on study 20201-01 Page 20

TDMS No 20201 - 03 P04 NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Reqsted 06152006

Test Type 26-WEEK TEF TRANSGENICS (PECDF) Time Report Reqsted 124412

Route SKIN APPLICATION CAS Number 57117-31-4 First Dose MF NA 042103

SpeciesStrain MICETGAC HEMI Lab BAT

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 DAY ON TEST 8 8 8 7 8 5 5 7 5 2 8 8 8 8 8 8 8 8 8 5

5 3 3 5 4 7 7 2 7 1 5 7 5 4 4 3 7 4 3 0

TGAC (FVBN) HEMIZYGOUS MICE FEMALE

ANIMAL ID 1520 NGKG

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 8 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 TOTALS

SYSTEMIC LESIONS

Multiple Organ + + + + + + + + + + + + + + + + + + + + 20 Leukemia Granulocytic X 1

Myelodysplasia X 1

END OF REPORT

Total animals with tissue examined microscopically Total animals with tumor M Missing tissue + Tissue examined microscopically A Autolysis precludes evaluation x Lesion present BLANK Not examined microscopically I Insufficient tissue

Control data contained within this report was collected on study 20201-01 Page 21