Targeting sickle pain with novel therapies and developing methods to quantify pain • Kalpna Gupta • Vascular Biology Centre • Division of Hematology, Oncology and Transplantation • Department of Medicine • University of Minnesota Medical School • Minneapolis, MN • Email: [email protected]
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Targeting sickle pain with novel therapies and developing methods to quantify pain Kalpna Gupta Vascular Biology Centre Division of Hematology, Oncology.
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Targeting sickle pain with novel therapies and developing methods to quantify pain
• Kalpna Gupta
• Vascular Biology Centre• Division of Hematology, Oncology and
Transplantation• Department of Medicine
• University of Minnesota Medical School• Minneapolis, MN
Pain in Sickle Cell Disease: A complex synergism between peripheral and central mechanisms
• How do we quantify pain?
• How do we convey the “pain” as soon as it starts to the healthcare providers?
• Can diet and alternative therapies help reduce pain?
• What are the potential novel therapies to treat pain without an inadvertent effect?
Recognizing the problem and finding solutions to treat sickle pain
Action Units Normal (~22˚C) Cold (4˚C)
Eyes are more circular and open
Eyes are tightly squeezed, and oval shape
Ears erect & perpendicular to the neck line
Ears are parallel to the neck line
Nose is smooth without skin tightening
Tightening of nose with an extension of skin visible
Cheek is smooth
Convex, similar to “puffing” of cheeks
Orbital Tightening
Ear Position
Cheek Bulge
Nose Bulge
Cold leads to changes in facial expressions
Facial expression readout to quantify pain from remote access?
Goal: To develop pain quantification on images transmitted through a cell phone from the patient’s home to the healthcare provider at a distant location.Lucey et al. Int Conf Affect Comput Intell Interact Workshops. 2009:1-8
Thakur AS, et al. Hematological Parameters and RBC TBARS Level of CoQ10 Supplemented Tribal Sickle Cell Patients: A Hospital Based Study. Indian J Clin Biochem. 2013 Apr;28(2):185-8