Targeted Alpha Therapy - International Atomic Energy Agency · Targeted Alpha Therapy Maria Betti Director European Commission Joint Research Centre Directorate Nuclear Safety and

Targeted Alpha Therapy

Maria BettiDirector

European Commission Joint Research Centre Directorate Nuclear Safety

and Security

Prostate Cancer Incidence

1.1 million men worldwide

WHO, GLOBOCAN 2012

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Prostate Cancer Mortality

307,000 deaths

6.6% total men deathsWHO, GLOBOCAN 2012

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Targeted Therapy

Selective killing tumor cells

Limited side effects (healthy tissue)

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High energyHigh ionisation density

Clinical Testings

Before treatmentDec. 2014

After 4 treatmentsSept. 2015 

Complete response

Life expectation considerably

increased

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Secure supply of 225Ac (IAEA TCP) - Production

Case Study 1 – Argentina

Training

Know-How transfer

Hosting staff at JRC

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Case Study 2 – South AfricaKnowledge Transfer in the Hospitals

Education to use of radio isotopes

Building capacity to treat prostate cancer

Establishing Regional Training Centre in Africa

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2017‐09‐21 8

225Ac‐PSMA617: Pretoria experience

1 x225Ac‐PSMA

(10 MBq)

Case Study 2 – South Africa

April 2017PSA = 2280 ng/ml

July 2017 PSA = 205 ng/ml

Follow-up Clinical trials

Specific Regulations

Pharmaceutical Industry Involvement

Looking forward to the future2017‐09‐21 9

THANK YOU

2017‐09‐21 10