Top Banner
T CELL IMMUNE RESPONSES TO WILMS TUMOR PROTEIN (WT1) IN MYELODYSPLASIA RESPONSIVE TO IMMUNOSUPPRESSIVE THERAPY (IST) Elaine M. Sloand 1 , MD J. Joseph Melenhorst 1 , PhD Zachary C. G. Tucker 1 Loretta Pfannes 1 Jason M. Brenchley 2 , PhD Agnes Yong 1 , MD PhD Emma Gostick 3 Daniel C. Douek 4 , MD PhD David A. Price 3, 4 , MD PhD A. John Barrett 1 , MD Neal S. Young 1 , MD 1 Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health (NIH), Bethesda, MD 20892; 2 Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892; 3 Cardiff University School of Medicine, Cardiff CF14 4XN, UK; 4 Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.    N   a    t   u   r   e    P   r   e   c   e    d    i   n   g   s   :    h    d    l   :    1    0    1    0    1    /   n   p   r   e  .    2    0    1    0  .    4    1    5    4  .    1   :    P   o   s    t   e    d    1    2    J   a   n    2    0    1    0
44

T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

Apr 09, 2018

Download

Documents

biosynthesis12
Welcome message from author
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
Page 1: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 1/44

Page 2: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 2/44

Page 3: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 3/44

Page 4: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 4/44

Page 5: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 5/44

Page 6: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 6/44

Page 7: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 7/44

Page 8: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 8/44

Page 9: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 9/44

Page 10: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 10/44

Page 11: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 11/44

Page 12: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 12/44

Page 13: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 13/44

Page 14: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 14/44

Page 15: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 15/44

Page 16: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 16/44

Page 17: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 17/44

Page 18: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 18/44

Page 19: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 19/44

Page 20: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 20/44

Page 21: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 21/44

Page 22: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 22/44

Page 23: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 23/44

Page 24: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 24/44

Page 25: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 25/44

Page 26: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 26/44

Page 27: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 27/44

Page 28: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 28/44

Page 29: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 29/44

Page 30: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 30/44

Page 31: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 31/44

Page 32: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 32/44

Page 33: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 33/44

Page 34: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 34/44

Page 35: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 35/44

Page 36: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 36/44

Page 37: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 37/44

Page 38: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 38/44

Page 39: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 39/44

Page 40: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 40/44

Page 41: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 41/44

Page 42: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 42/44

Page 43: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 43/44

Page 44: T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

8/8/2019 T Cell Immne Responses to Wilms Tumor Protein (WT1) in Myelodysplasia Responsive to Immunosuppressive Therapy (IST)

http://slidepdf.com/reader/full/t-cell-immne-responses-to-wilms-tumor-protein-wt1-in-myelodysplasia-responsive 44/44