Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreading process. Copyright © 2019 the authors This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version. A link to any extended data will be provided when the final version is posted online. Research Articles: Neurobiology of Disease Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and Behavior Avanti Gokhale 1 , Cortnie Hartwig 1 , Amanda A. H. Freeman 1,2 , Julia L. Bassell 1 , Stephanie A. Zlatic 1 , Christie Sapp Savas 3 , Trishna Vadlamudi 3 , Farida Abudulai 3 , Tyler T. Pham 13 , Amanda Crocker 4 , Erica Werner 5 , Zhexing Wen 6 , Gabriela M. Repetto 7 , Joseph A. Gogos 8 , Steven M. Claypool 9 , Jennifer K. Forsyth 10 , Carrie E. Bearden 10 , Jill Glausier 11 , David A. Lewis 11 , Nicholas T. Seyfried 12 , Jennifer Q. Kwong 13 and Victor Faundez 1 1 Departments of Cell Biology, Emory University, Atlanta, GA, USA, 30322 2 Center for the Study of Human Health, Emory University, Atlanta, GA, USA, 30322 3 Department of Chemistry, Agnes Scott College, Decatur, Georgia 30030. 4 Program in Neuroscience, Middlebury College, Middlebury, VT 05753. 5 Radiation Oncology, Emory University, Atlanta, GA, USA, 30322 6 Psychiatry, Emory University, Atlanta, GA, USA, 30322 7 Centro de Genética y Genómica, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago, Chile. 8 Departments of Neuroscience and Physiology, Columbia University, New York, NY 10032. 9 Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205. 10 Semel Institute for Neuroscience and Human Behavior and Department of Psychology, UCLA, Los Angeles, CA, 90095. 11 Departments of Psychiatry and Neuroscience, University of Pittsburgh, Pittsburgh, PA, 15213. 12 Biochemistry, Emory University, Atlanta, GA, USA, 30322 13 Pediatrics, Emory University, Atlanta, GA, USA, 30322 https://doi.org/10.1523/JNEUROSCI.1983-18.2019 Received: 2 August 2018 Revised: 18 January 2019 Accepted: 15 February 2019 Published: 4 March 2019 Author contributions: A.G., C.H., A.F., S.A.Z., A.C., Z.W., C.E.B., D.A.L., J.Q.K., and V.F. designed research; A.G., C.H., A.F., J.L.B., S.A.Z., C.S.S., T.V., F.A., T.T.P., A.C., E.W., Z.W., G.M.R., J.K.F., C.E.B., J.G., D.A.L., N.T.S., and J.Q.K. performed research; A.G., C.H., A.F., J.L.B., S.A.Z., C.S.S., T.V., F.A., T.T.P., A.C., E.W., Z.W., G.M.R., J.K.F., C.E.B., J.G., D.A.L., J.Q.K., and V.F. analyzed data; A.G., C.H., A.F., J.L.B., S.A.Z., J.A.G., S.C., J.K.F., C.E.B., D.A.L., N.T.S., J.Q.K., and V.F. edited the paper; J.A.G., S.C., and N.T.S. contributed unpublished reagents/analytic tools; V.F. wrote the first draft of the paper; V.F. wrote the paper. Conflict of Interest: The authors declare no competing financial interests. This work was supported by grants from the National Institutes of Health R56 MH111459 to VF and Emory Catalyst Grant, Fondecyt-Chile grant 1171014 to GMR, R01HL108882 to SMC, R01MH097879 to JAG. CH is supported by the FIRST postdoctoral fellowship NIH 5K12GM000680. We thank members of the Faundez Lab for their comments and insight. Stocks obtained from the Bloomington Drosophila Stock Center (NIH P40OD018537) were used in this study. This study was supported in part by the Emory HPLC Bioanalytical Core (EHBC) and the Emory Imaging Core. EHBC is supported by the Department of Pharmacology, Emory