Systematic Review of Systematic Review of Dietary Supplement Dietary Supplement Efficacy and Safety Efficacy and Safety Paul M. Coates, Ph.D. Office of Dietary Supplements Office of Dietary Supplements National Institutes of Health National Institutes of Health Department of Health and Human Department of Health and Human Services Services AHRQ Annual Meeting AHRQ Annual Meeting September 2008 September 2008
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Systematic Review of Dietary Supplement Efficacy and Safety Paul M. Coates, Ph.D. Office of Dietary Supplements National Institutes of Health Department.
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Systematic Review Systematic Review of Dietary of Dietary
Supplement Efficacy Supplement Efficacy and Safetyand Safety
Paul M. Coates, Ph.D.Office of Dietary SupplementsOffice of Dietary SupplementsNational Institutes of HealthNational Institutes of HealthDepartment of Health and Human Department of Health and Human ServicesServices
Congressional Language for FY Congressional Language for FY 2001 ODS Appropriation2001 ODS Appropriation
“The Office is encouraged, in consultation with NCCAM, AHRQ, and FDA to review the current scientific evidence on the safety and efficacy of dietary supplements now on the market, which could then form a basis for further research, education of practitioners and consumers, and whether further regulatory requirements are necessary.”
Evidence-Based Review Program
Systematic review of the literature, with meta-analysis as appropriate, on DS efficacy and safety
In collaboration with the Agency for Healthcare Research and Quality (AHRQ) Evidence-Based Practice Center Network
Major reason for conducting these reviews is to assist NIH in the development of research agendas
Ephedra for weight management and athletic performance enhancement* (with NCCAM)
Omega-3 fatty acids for cardiovascular disease prevention* (with NHLBI) and other health indications
Health effects of soy (with NCCAM)
Antioxidant phytochemicals/B vitamins and neurodegenerative diseases*(with NCCAM)
Multivitamins/multiminerals and chronic disease prevention (with OMAR)
Coagulation, diet, and dietary supplements
Health effects of vitamin D (with multiple partners)*Congressional mandate
Health Effects of Omega-3 Fatty Acids
Asthma Cancer Cardiovascular Disease Cardiovascular Disease Risk Factors Arrhythmogenic Mechanisms Child and Maternal Health Cognitive Function Eye Health Type II Diabetes, Rheumatoid Arthritis, and Other
Diseases Mental Health Organ Transplantation
Health Effects of Omega-3 Fatty Acids
Secondary CVD Prevention Reduces all cause mortality and
other CVD outcomes (sudden death, cardiac death, MI)