The Wollman lab measures, models, and manipulates signaling activities at the single-cell level to understand Dynamic Cellular Information Processing. We strive to understand cellular decision-making, biological variation, and biological noise using multidisciplinary approaches. We develop methods in single-cell fluorescence microscopy in combination with computational image analysis to evaluate the distribution of cellular responses in real-time. We use mathematical modeling based on signaling pathway mechanisms to infer and predict the details of mechanistic cellular signaling. We experimentally investigate a cellular signaling system by manipulating the internal and external cellular environment both spatially and temporally at the single-cell level. Specific approaches include microfluidic devices, genetic and pharmaceutical perturbations, and optogenetics. COMPUTATIONAL AND SYSTEMS BIOLOGY SEMINAR SERIES “Cellular Variability and Information Flow in Signal Transduction Networks” Computational & Systems Biology Track Roy Wollman, PhD · University of California at Los Angeles Lunch with speaker to follow in ND11 atrium JUNE 18 11AM - 12PM ND11.218