Sustainability Report 2016–2017 - About GMT · Statement from Top Management ..... 5 Our first Sustainability Report ... by EDQM in Europe 2011 • Cerbios-Pharma SA acquires GMT

SustainabilityReport2016–2017

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1GRI 102 - 1

SustainabilityReport2016–2017

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API Active Pharmaceutical Ingredient CEO Chief Executive Officer CFO Chief Financial Officer cGMP Current Good Manufacturing Practice COO Chief Operating Officer COS Certificate of Suitability DMF Drug Master File DRA Drug Regulatory Affairs EDQM European Directorate for the Quality of Medicines FDA Food and Drug Administration FOCA Federal Office of Civil Aviation GRI Global Reporting Initiative HR Human Resources HS Health and Safety HSE Health Safety and Environment ICT Information and Communications Technology J-DMF Japan Drug Master File KPI Key Performance Indicator LOG Logistics PMDA Pharmaceuticals and Medical Devices Agency PROD Production QA Quality AssuranceQC Quality Control R&D Research and Development SDGs Sustainable Development Goals US-DMF United States Drug Master File VOC Volatile Organic Compound GRI Global Reporting Initiative

a Acronyms List

3

t Table of contents

Statement from Top Management ......................................................................5

Our first Sustainability Report ................................................................................6

About us ....................................................................................................................................7

Organizational Profile ...................................................................................................8

Ethical code......................................................................................................................... 10

Supply Chain ..................................................................................................................... 12

Products ............................................................................................................................... 14

Governance, Commitments and Engagements ..................................... 17

Sustainability ..................................................................................................................... 18

Our stakeholders ............................................................................................................. 19

Material aspects ..............................................................................................................20

The Sustainable Development Goals ...............................................................22

Economic Responsibility ........................................................................................... 24

Infrastructure Investments ......................................................................................25

Environmental Responsibility ..............................................................................26 Paper ............................................................................................................................26

Origin of electricity ..............................................................................................27 Water ............................................................................................................................27 Emissions ..................................................................................................................28 Waste ...........................................................................................................................28

Social Responsibility ..................................................................................................29 Years of Employment .........................................................................................29 Pension Benefits ...................................................................................................30 Staff residence .....................................................................................................30 Hours of Training ..................................................................................................30

Health and Safety .......................................................................................................... 31

Memberships ......................................................................................................................32

Audits .......................................................................................................................................33

GRI content index ...........................................................................................................34

Impressum ...........................................................................................................................40

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Statement from Top Management

Dear Stakeholder,

We believe it is an ethical and moral duty for every organization to take responsibility for its social and environmental impacts and adopt a pro-active attitude to tackle them. This is becoming increasingly important to ensure long-term prosperity and a positive environmental, social and economic legacy for our company.

With this first report, we wanted to identify and measure our impacts and create the starting point of our journey towards becoming more sustain-able, every day. We believe our stakeholders will be increasingly supportive of our efforts towards open and transparent communication and our ef-forts to embed sustainability in our operations.

In the canton of Neuchâtel , where our production unit is based, the local government actively supports all initiatives aimed at increasing the com-petitiveness of the region and the creation of highly qualified jobs in competitive and high-added value sectors. This increases local job oppor-tunities outside of the traditional sectors of agriculture and watchmaking and curbs the migration of the local population towards urban areas.

We seek to constantly improve the standards of our products and ser-vices to ensure the highest quality and safety, and since our beginnings we have been working according to the most stringent ethical and quality standards: we believe now the time has come to integrate sustainability into our daily activities in a more structured and cohesive manner.

Our aim is to create value for all our stakeholders, because we are con-vinced that only by pursuing the Triple Bottom Line of Economic, Social and Environmental results will we be able to be successful in the long run.

We hope you will enjoy reading our report and look forward to receiving your feedback and question.

Sincerely yoursGMT Fine Chemicals SA

Gabriel Haering Anton van Troostenburg de BruynCEO Chairman

s

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Our first Sustainability Report

This is our first sustainability report. The information provided pertains to 2016-2017 calendar years and, whenever possible, contains references to 2015. This report has been prepared in accordance with the GRI Standards: Core option. We decided to adhere to the GRI Standards Framework to ensure that our performance can be measured and com-pared objectively by our stakeholders.

The report has not been externally checked, as most information con-tained is already either audited, verified by external parties or complies with the most stringent regulations. The report was submitted to GRI for the ‘Content Index Service’, which was successfully completed.

This is one of GRI’s Alignment service, which aim to assist reporting organizations using the GRI Sustainability Reporting Standards to im-prove their report’s navigability and clarity. The GRI is an independent non-profit organization that helps businesses, governments and other organizations understand and communicate their impacts on issues such as climate change, human rights and corruption. The GRI Standards are the first global standards for sustainability reporting, featuring a modular, interrelated structure, and represent the undisputed, global best practice for reporting on a range of economic, environmental and social impacts. We have made our best effort to highlight the areas where we intend to focus our sustainability effort in our materiality analysis, which can be found on page 21.

In the course of our activities we want to make sure we are aligned with and contribute towards the achievement of the Sustainable Development Goals (SDGs), the blueprint conceived by the United Nations to set a global framework of the most urgent development challenges as well as specific and measurable targets. This report highlights the SDGs and briefly explains how we contribute towards their advancement.

o

GRI 102 - 5 7

ExcellenceIn working together

with our partners and colleagues

InnovationThrough continuous

improvements at all levels by promoting innovation

RespectPeople as individuals

and team members for who they are

Opencommunication

Sharing information and advice frequently and constructively

About us a

Very flexible and reliable supplier

Highly qualified and committed team

Cerbios-Pharma SA Majority shareholder

>98%

Customer centricityEliminating all “non-value”

activities and applying all the previous values consistently

OurValues

Specialized in manufacturing Reduced Folates for the Pharma Industry world-wide since 1998

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o Organizational Profile

GMT Fine Chemicals SA (GMT) is a Swiss privately held company founded in 1998 and located in the industrial area of Couvet, a village located in Val-de-Travers, canton of Neuchâtel, in the western region of Switzerland.

GMT is specialized in the production of Reduced Folates as Active Phar-maceutical Ingredients (APIs), sold to our partners world-wide, mostly global pharmaceutical companies. Our size allows for a high flexibility and speed in responding to our partners’ needs and requests. We tailor our services to each and every client, with whom we build a close rela-tionship based on trust and reliability of our products and related services.

We fully comply with, and exceed, the most stringent quality regulations and do our utmost to safeguard the health and safety of our personnel, our production plant and the environment.

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Since the beginning of our operations, Swissmedic – the Swiss Agency for Therapeutic Products –granted the current Good Manufacturing Practice (cGMP) certification, renewed every two years after an in-depth inspection.

The cGMP regulations for drugs contain the requirements regarding meth-ods, facilities, and controls used in manufacturing, processing, and packing of a drug substance. The regulations make sure that a product is safe for use, and that it has the ingredients and strength it claims to have.

We are accredited as authorized Foreign Manufacturer by the Japanese Pharmaceuticals and Medical Devices Agency (PMDA) since 2005 and have been present on the Japanese market since 2006.

Last but not least, in 2016, the US Food and Drug Administration (FDA) successfully inspected our production site.

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Main subjects of the training sessions were in the areas of HSE, QC, QA, and in the technical domain.

1. Person Centrality

2. Personal Integrity Protection

3. Fairness and Impartiality

4. Human Resources Development

5. Transparency and Correctness

6. Health and Safety

7. Environmental Protection

e Ethical code

As subsidiary of Cerbios-Pharma SA in Ticino, we abide to the following ethical code:

OCTOBER

1997GMT Fine Chemicals SA is officially registered

2005• Accreditation of Foreign Manufacturer PMDA (Japan)

• Certificate of Suitability for Calcium Folinate by the European Directorate for the Quality of Medicines (EDQM) in Europe

2006• PMDA Japan-DMF approval for Calcium Levofolinate

• Patent submission for the diastereoisomeric separation

2010• Patents granted in EU, CH, USA, Japan, Australia, Canada

• Certificate of Suitability for Calcium Levofolinate by EDQM in Europe

2011• Cerbios-Pharma SA acquires GMT and

consolidates the leadership in Reduced Folates

• US-DMF for Levoleucovorin Calcium submitted to the FDA

2015 Calcium Folinate DMF submitted in Japan

2016 First FDA inspection successfully passed

2017 The Board of Directors approves major investment in the new building and acquisition of a neighboring plot of land

Construction of the production unit with Laboratories (Research Development and Quality Control) Development of production process for Calcium Folinate

1997 – 1998

Development of productionprocess for Calcium Levofolinate 1999 – 2003

Manufacturing authorization and Swissmedic Certificate of cGMP Compliance for manufacturing and distributing APIs

1999

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Stainless steel (3’000 lt and 4’000 lt) and Glass lined (2’500 lt) reactors

Our manufacturing plant is designed to perform multistep processes for the production of APIs. All equipment and technologies are state-of-the-art and comply with the current standards.

Our offices are based in the village of Couvet and we will relocate into new buildings in the second half of 2019.

Warehouses for Starting Materials and Solvents

Supply Chain s

170 Total suppliers

22 Qualified suppliers16 With ISO certification15 With ISO 90018 With ISO 140013 With OHSAS 18001

Quality Control Laboratories

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Warehouses

300 kg Horizontal–peeler centrifuge

Separate waste storage area

1’000 lt Conical dryer coupled with a granulator

Quality Assurance Authorities

Partner

Patient

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Thanks to our state-of-the-art equipment and production processes, GMT offer the following products with specifications that meet the re-quirements of the different countries of destination, providing access letters to the Drug Master File (DMF) of the desired registration country. It is our aim to continuously improve the process and the quality of our products within the current regulatory framework and to follow our Qual-ity by Design approach. Furthermore, we are considering adopting new technologies and innovative practices that were unavailable when we started our activities twenty years ago.

GMT has a global presence and our products are sold in the following countries or regions:

p Products

North America Canada, USA

South AmericaBrazil, Argentina,Uruguay, Paraguay

OncologyOur products are mainly used:

• as antidotes to Folic Acid antagonists, such as Methotrexate (“rescue therapy”), used in the treatment of certain neoplastic diseases, psoriasis and rheumatoid arthritis;

• as biochemical modulators prescribed in synergistic combination with the chemotherapy agent 5-Fluorouracil in treating and Oxaliplatin (FOLFOX) or Irinotecan (FOLFIRI) in first line treatment of colorectal cancer.

Nutritional deficiencies Folate deficiencies can occur in several different situations, like:

• Inadequate nutrition Inadequate absorption or utilization (i.e. after treatment with high doses of the antimetabolite Methotrexate)

• Increased requirements Pregnancy, lactation, malignancy

EuropeGermany, France, Italy,Austria, Spain, Greece, Romania, Greece, Cyprus, Ukraine

AsiaTaiwan, Indonesia, Vietnam, Malaysia, India, Japan, Australia, New Zealand

Middle East North AfricaEgypt, Jordan, Tunisia

15

CALCIUM LEVOFOLINATELevoleucovorin Calcium

PackagingThe primary packaging made of Polyamide and Polyethylene bag is placed in a alumi-nium bag as secondary packaging under vacuum

Calcium Levofolinate is the natural, biologically active, diastereoisomer of Calcium Folinate. The carbon at position 6 is an asymmetric center and the product only contains the pure (6S)-isomer.

Use Calcium Levofolinate is used primarily to produce injectable (liquid or lyo) galenic forms

FormCalcium Levofolinate active substance manufactured by GMT is a powder having a stable crystalline form

RegulatoryGMT is the holder of theCOS a J-DMF and a US-DMF, granted by the European Directorate for the Quality of Medicines (EDQM) and a US-DMF available forReference as Type II DMF

Calcium Folinate, also known as Folinic acid Calcium salt, is a 5-formyl derivative of tetrahydrofolic acid. After administration, it is readily con-verted into other reduced folic acid derivatives.

CALCIUM FOLINATELeucovorin Calcium

PackagingThe primary packaging made of double, low- density polyethylene bagsis placed in a high-densitypolyethylene containersassecondary packaging

Use Calcium Folinateis used for theproduction of oraland injectable finished dosage forms

FormCalcium Folinate is a powder with a stable crystalline form

RegulatoryGMT is the holder of the COS a J-DMF and a US-DMF, granted by the EDQM and a US-DMF available for Reference as Type II DMF

GRI

Our plant is fully dedicated to the production of Reduced Folates

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PROD & Tech Services

We adhere to the following principles of good governance:

• Fairness• Accountability• Responsibility • Transparency

in all our activities and interactions.

Our organizational structure is shown in the graph below.

Some services are provided by the headquarter Cerbios, included but not limited to: Finance & Administration, Human Resources and IT.

g Governance, Commitments and Engagements

CEO

CFO

IT

accounting

HRCOO (QP)

LOG

LOG & Sales

PROD & Tech Services

QU(QP)

QA

QC

DRA

HSE

ENG

Marketing & Sales

QC

DRA

HSE

QA

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Cerbios provides full support to all positions to maintain the highest standards and harmonize procedures and strategy at corporate level.

Our comprehensive Quality System is based on current pharmaceutical guidelines promoted by the FDA, the European Medicines Agency (EMA), the Pharmaceutical Inspection Co-operation Scheme (PIC/S) and the In-ternational Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH).

The site has been inspected and approved by Swissmedic since 1999 every two years.

The following is the track record of the last three years:

Sustainabilitys

Known Consignor (FOCA)We are a certified member of the Swiss National Security Program, since 2011 covering physical security of buildings and cargo transportation, facility access control, security operations, documentation security and IT security managed by the Federal Office for Civil Aviation (FOCA).

For GMT, sustainability means managing our social, economic and envi-ronmental impacts with responsibility and inclusiveness, and a special attention towards the local community. We want to be an attractive em-ployer in our region by offering good job opportunities as well as innovative products and services, training our employees to the highest standards, generating and redistributing our economic value created, and minimizing our impacts on the environment.

2015

2016

2017

• cGMP Audit Swissmedic• Several customer audits and pre-audits• Lachmann consultants Mock-up Inspection

• Successful FDA inspection• Several customer audits and pre-audits

• cGMP Audit Swissmedic• Several customer audits and pre-audits• Several new DMF submitted

(USA, Japan, Canada, Brasil Taiwan)

Federal Office of Civil Aviation FOCA

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ShareholdersBoard meetings, reporting on business progress, annual meeting, casual meetings

EmployeesCEO presentations, corpo-rate intranet, newsletters, company events, code of conduct, staff meetings, management seminars, training programs, project/product management meet-ings, quality, safety, compliance systems, etc.

Local authoritiesPeriodic meetings, ongoing discussions, collaboration of innovation

Local communities Hiring and training of apprentices, school visits, sponsoring, contribution to charities, internships offered to local students

Associations Periodical meetings, trade shows

Suppliers of goods and servicesPartner selection meetings,audits, quality and Health, Safety and Environment (HSE) inspections, business terms discussions

Pharma authoritiesand regulators Inspections, meetings, ongoing communications with regulatory authorities, environmental health and safety reports

PartnersRegular meetings, con-gresses and exhibitions, ongoing interactions with KAMs, scientific trainings, website

Our stakeholders provide us with useful recommendations and new perspectives, which are highly valued to achieve the constant improve-ments needed to be successful. Paramount to this is to identify and measure our social, environmental and economical impact effectively in order to support the definition of a long-term business strategy and a well-structured dialog with our stakeholders.

Only by engaging with our stakeholders on a regular basis can we cre-ate shared value for our company and the territory in which we operate. Furthermore, this allows us to better understand who they represent and the expectations they hold regarding our business practices.We have therefore mapped the main groups of stakeholders with whom we interact and described the manners in which we engage with them.

o Our stakeholders

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As this is our first sustainability report, defining the most relevant areas of action for our business and our stakeholders is essential.

We have therefore conducted a materiality analysis, which is the corner-stone of a sustainability plan, that incorporates the most significant values for both a company and its stakeholders.

It consists of identifying the social, environmental and economic as-pects that can impact a company’s performance or influence the way its stakeholders interact with it. It is a useful practice to monitor the level of alignment between the stakeholders’ expectations and our per-spective. We have therefore assessed these aspects in terms of priority both for our stakeholders and for our business strategy, and of their potential impact on the creation of economic, social, and environment value. We have applied this principle as illustrated by the guidelines of GRI Standards after having analyzed the industry practices.

These aspects:

• Are related to laws, standards, regulations and international agreements

• Affect stakeholders or their evaluations and decisions

• Have an influence on our values, policies, strategies and objectives

• Represent a concern or expectation of our stakeholders or are a matter of discussion with them

• Are a risk or an opportunity for GMT

• Are an industry issue reported by our peers and competitors

After defining our material aspects, we have asked our senior team to fill out an internal survey to estimate the relevance of each material aspect for our company and for our stakeholders, and whether the relevance of these aspects is going to increase, decrease or remain equal in the fu-ture. With this set of data, we have created our materiality matrix, which portrays the areas of relevance that are at the centre of our sustainabil-ity strategy and define the way in which we will implement our future initiatives.

Ten aspects are considered relevant from a sustainability standpoint. Long-term growth is the most important aspect, unsurprisingly so due to the small dimension of our company in an industry that is dominated by large conglomerates. Of high importance are also the safety, health and well-being of our staff, waste management, continuous training of our team and the work environment and sense of belonging that is one of the main reasons for our success.

m Material aspects

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Internal External

Environmental

1 Reduction of VOC emissions and wastewater

2 Reduction of CO2 emissions, water and energy consumption in our operations

Social1 Gender equality in compensation and opportunity

2 Training of apprentices and contribution to youth education

3 Regular employee training

4 Positive working environment, employees commitment, respect and transparency

Economic1 Preference to local suppliers

2 Long-term business growth

3 Value creation for customers through innovative products and services

Combined1 Employees health, safety and well-being

2 Supply chain sustainability and transparency

soc2

soc 4

Importance for the future DECREASESTABLEINCREASE

FOR INTERNALImportant Very Important

Very ImportantFO

R E

XTE

RN

AL

soc3

soc1eco 1

env1

com 1

eco 2

com 2

eco 3

env2

At GMT, we are persuaded that only by uniting our efforts at government, business and civil society level, can we achieve the SDGs by 2030.

We give our small but committed contribution towards the SDG through the following actions and behaviors:

• Improve working conditions for employees

• Improve safety and resilience of staff with the adoption of outstanding HSE Management System

• Same opportunities and wages

• No gender discrimination

• Reduce water consumption: Year after year we strive to reduce our water consumption by adopting technological and equipment improvements

• Promote skills training: training hours have significantly increased since 2016

• Preference to local suppliers

• Provide excellent working conditions

• Grow as a company and create new jobs and opportunities for the local community

• Improved processes to reduce waste, increase reuse and recycle

• Traceability of products (parts, materials)

• We strive to improve the energy efficiency of our operations and activities

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The Sustainable Development Goalst

GRI 23

Our commitment: Responsiveness and fast decision making to support our partners

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As a privately-owned company, for confidentiality reasons we prefer not to disclose our turnover. However, we are pleased to declare that in 2017 we were able to confirm the positive trend of the previous year with a growth of 29% in turnover compared with the 2015 base year.

Furthermore, the Total production output (in kg) had a positive growth of 23% compared to the previous year.

Our main markets are Europe and Asia Pacific, with an important growth in the Rest of the World.

Total turnover index 1.17 1.29

201520162017

e

2015 2016 2017

1

1

1.18 1.27

1 1.16 1.43

Total number of batchesproduced index

Total productionquantity index

(Base 2015 = 1)

Economic Responsibility

ROW

17 %10 %14 %

Europe

43 %43 %34 %

Asia

40 %47 %52 %

We believe it is important to contribute towards redistributing the value generated in the local economy: therefore we select suppliers as close to our location as possible. In 2017 we sourced 94% of all our purchases in Switzerland, out of which 15% in the Neuchâtel region.

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In 2015 and 2016 we received a financial support from the Canton of Neuchâtel to support our US FDA certification, in the framework of a plan to incentivize innovation and competitiveness.In addition to that, the Canton of Neuchâtel were very supportive and responsive in our extension project by selling over 1’000 m2 of land and reallocating the agricultural areas to industrial areas. Thanks to this, the new building will be ready in summer 2019.

Infrastructure Investmentsi

GMT continuously invest in order to maintain a state-of-the-art facility. In the coming years 2018-2020 larger infrastructure and equipment purchases of goods and services are planned in order to improve the company sustainability and productivity.

Rendering of the new future building ready in 2019

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Climate change and environmental degradation have been recognized as crucial issues which we, and above all future generations, must tackle. At GMT, we are committed to the protection of the environment and in making responsible use of natural resources. We do our best to reduce our environmental footprint by minimizing risks of pollution, improving re-source efficiency, and reducing our energy and water consumption, as well as our emissions of CO2 and VOCs and waste production. In 2017 we witnessed a significant increase in production activities due to increased sales. In addition to that, major equipment re-qualification processes were performed, as required by our technical guidelines. Tests were carried out to check the flawless performance of our equip-ment at maximum capacity, for which significant quantities of water and energy were used, with the subsequent increase in CO2 emissions, hence altering the KPIs of such measurements.

We strive to always increase our efficiency: our use of energy in relation to the kg produced decreased in 2016 and remained almost stable in 2017, while the ratio between the turnover index and the energy con-sumption index (both with base 2015 = 100) was very encouraging for 2016 to grow again in 2017, but only due to the reasons cited above. In 2017 both gas and electricity use grew, with a much higher proportion of gas in the mix.

e Environmental Responsibility

800

700

600

500

400

300

200

100

0

Energy in MWh

24.9%33.6%

1 0.8 1

Origin from Renewable sources

Electricity

Natural Gas

Total energyconsumption index/turnover (Base 1=2015)

21.5%

542.5 556.8MWh MWh

701.6MWh

2015 2016 2017

Paper The increase in office paper consumption goes hand in hand with the growth of our business. In 2017 the total and per capita increase is due, again, to the spike in maintenance activities. It is our goal to re-duce the consumption of paper by increasing the use of e-documents from 2018 onwards.

27GRI 303 - 1 | 306 - 1

0 5 10 15 20 25 30

10.91.4

From Non-specified origins (non-nuclear, non-waste)

From waste

From fossil fuels

From nuclear

From renewables

Water The water we use comes from the local groundwater aquifers in Val-de-Travers. Most of it is used to cool the heat exchangers. This water does not come into contact with our products and does not require any treat-ment; hence it is sent into the municipal sewage system. An important amount of water is used by the purified water system, which supplies the ultra-pure H2O that goes in the production of our APIs.Similarly to our energy consumption, we managed to increase our effi-ciency for 2016, but in 2017, only for the reasons cited on page 26, our performance decreased.

13’900m3

14’800m3

29’200m3

index/turnover(Base 1=2015)

Origin of electricity The mix we purchase from our provider, Groupe E, has a percentage coming from unspecified sources. In 2017 E-Group supplied a large part of electricity coming from renewable sources. From 2019 onwards we will buy only electricity coming from certified renewable sources, hence increasing our commitment to become more sustainable, every day.

2015

2016

38.3% 9.5%

0.4%

2.2% 49.6%

2015

43.5% 15.4%

0.3%

1.8% 38.9%

2016

68.2% 17.8%

0.2% 1.2%

12.6%

2017

2017

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Emissions Only a small part of our waste evaporates. We pay a tax when we buy solvents, which contain VOCs, and we are able to get around 95% reim-bursement of such tax by recovering most of the solvents we use.

0 10 20 30 40 50 60 70 80

1

1

0.86

1.03

1.09

0.94

Waste Our waste is managed by a specialized company, Thommen Furler AG. It is mainly composed of waste water: most waste water is mixed with salt and may be decontaminated, whereas the small part that contains etha-nol (solvents) is recycled and sent to cement factories in Switzerland to be used as fuel for their energy intensive production.

0 50 100 150

CO2Total Emissions from stationary combustion gas

RSU includingpaper, wood, etc.

Special andcontrolled waste

Of which special andcontrolled waste incinerated

index/turnover(Base 1=2015)

The water that does not enter the production process and is used for cooling purposes only is discharged in the municipal sewage system, while 100% of the water residues that are used in production is sent to Thommen Furler SA for destruction.

index/quantity(Base 1=2015)

2015

2015

2016

2016

2017

2017

97.7Tons

142.1Tons

117.3Tons

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Part TimeFull Time

Team Leaders Employees Top Management

10employees

60% of employees working with us from more than 6 years

PhD or equivalent***

***

***

Tech. school degree*

* * * * *

University Degree****** **

Years of Employment

There is a clear prevalence of males in our staff, which is rather normal for a small chemical production company. Every member of our team is highly qualified and has at least a technical school degree. All age groups are represented, and the turnover rate is very low.

At GMT, we are committed to taking care of the local community and our employees. We want to be a good corporate citizen, and a good example of how business can be a positive actor. We are a small team and have developed excellent interpersonal relationships during the years we have been working together. The size of our company allows for the develop-ment of close bonds and a sense of belonging that is more difficult to find in larger companies. We are also close to the community where we operate and where many of us live with our families, and we want to con-tribute to the economic and social growth of the Val de Travers region. We want to be an attractive employer and provide excellent benefits and development opportunities to our staff. We do so by providing good compensation, excellent training and development systems, together with a pleasant work environment. Our remuneration policy does not dis-criminate between genders or residency. It is based on the skills, performance and years of service of the employees, as well as in the performance of our company.

s Social Responsibility

16–20

12–15

6–11

0–5

2015 2017

11%

11%

33%

44% 40%

40%

20%

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Staff residence Couvet is located very close to the French border, and as it is often the case for many companies in our region, we employ several non-resi-dents. As a general rule, whenever possible, we look for the best and most qualified staff locally. Due to the very specific and highly technical skills required, it is often difficult to find the necessary manpower among the local population.

Hours of Training In a highly advanced industry like ours, continuous training and develop-ment are a key priority for our long-term success. Every year each employee attends training sessions, both internal and external. In 2017 we have invested an average of CHF 1’900 in training activities per capita, not including the time invested away from the workplace.

2015 2017

0 50 350hrs 250150 300200100

2015

2016

2017

2’300 chf / person / year



50%

Pension Benefits Our pension benefits are superior to the legal norm. The percentage paid by the company is superior to the 50% required by law.

44%Swissresident

60%Swissresident

56%Resident Abroad 40%

Resident Abroad

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Consistently meeting high HSE perfomance levels

Health

Safety

Environment

HSE

h Health and Safety

Main subjects of the training sessions were in the areas of HSE, QC, QA, and in the technical domain. In recent years, we have developed an out-standing Health & Safety (HS) Management System to ensure that all HS issues are tackled effectively and to foster constant improvement of this sector within our company. Our goal is to prevent accidents, injuries and pollution and to maintain a world-class HS performance. Only through quality design of risk assessment practices and continuous training can we ensure these targets are met. While in 2015 we had a minor accident in our production site, we are very proud to say we have not recorded a single accident in the past two years, neither work-re-lated nor outside of work. This is an excellent result and we are doing our utmost to maintain this track record in the future.

32 102 - 13 GRI

m Memberships

Our active engagement with associations is part of our commitment to col-laborating with our peers, competitors and other stakeholders to create synergies and shared value.

We are active members of the following associations:

At Cantonal level

ANC Association Neuchâteloise pour la Chimie

CALC Commission d'Apprentissage de Laborantin en Chimie

At National level

Eco-SuisseManages and centralizes safety within industrial groups working in biological and chemical sectors

ASITAssociation Suisse Inspections TechniquesManages the prevention of accidents, breakdownsand damage and guarantees the safety oftechnical equipment and machinery

A3POrganizes training sessions and courses to meettechnological and regulatory requirements

Swiss Biotech Association

33GRI 102 - 13

With an international presence with the supply or our Drug Substance, the site is regularly inspected by the following institutions:

National and International inspection institutions

SwissmedicSwiss Agency for Therapeutic Products

Swiss-PRTRSwiss Pollutant Release and Transfer RegisterMakes sure that waste and waste transportation arecarried out safely and legally

FOCAFederal Office of Civil Aviation Enables us to transport our products by plane in a safe andcontrolled way, keeping track of contamination and security risks

FDA U.S. Food & Drug AdministrationAudit in order to authorize the importation of APIs to be used in medicines for the US Market

PMDAPharmaceutical and Medical Devices Agency (Japan)

a Audits

Federal Office of Civil Aviation FOCA

34 102 - 55 GRI

GRI Standard

Disclosure Reason /Page

Omission

GRI 101 Foundation 2016

General Disclosures

Organizational profile

GRI 102

General Disclosures 2016

102 - 1 Name of the organization Front cover, 1

102 - 2 Activities, brands, products, and services 8, 9

102 - 3 Location of headquarters 8, 10

102 - 4 Location of operations 8

102 - 5 Ownership and legal form 7, 8

102 - 6 Markets served 8, 9, 11, 14

102 - 7 Scale of the organization 24

102 - 8 Information on employees and other workers 29-30

102 - 9 Supply chain 12-13

102 - 10 Significant changes to the organization and its supply chain

This is ourfirst report

102 - 11 Precautionary Principle or approach 5, 8, 17-18

102 - 12 External initiatives 22

102 - 13 Membership or associations 32-33

Strategy

102 - 14 Statement from our Leadership 5

Ethics and integrity

102 - 16 Values, principles, standards, and norms of behavior

10, 17

Governance

102 - 18 Governance structure 17

g GRI contentIndex

35GRI 102 - 55

GRI Standard


Omission

Organizational profile

GRI 102

General Disclosures 2016

Stakeholder engagement

102 - 40 List of stakeholder groups 19

102 - 41 Collective bargaining agreements No collective bargaining agreements are in place

102 - 42 Identifying and selecting stakeholders 19

102 - 43 Approach to stakeholder engagement 18-19

102 - 44 Key topics and concerns raised 19

Reporting practice

102 - 45 Entities included in the consolidated financial statements

8

102 - 46 Defining report content and topic Boundaries 20-21

102 - 47 List of material topics 20-21

102 - 48 Restatements of information This is ourfirst report

102 - 49 Changes in reporting This is ourfirst report

102 - 50 Reporting period 6

102 - 51 Date of most recent report This is ourfirst report

102 - 52 Reporting cycle Biennial

102 - 53 Contact point for questions regarding the report 40

102 - 54 Claims of reporting in accordance with the GRI Standards

6

102 - 55 GRI content index 34-39

102 - 56 External assurance 6

36 102 - 55 GRI

GRI Standard


Omission

GRI 200 Economic Standard Series

Material Topics

GRI 103Management Approach 2016

103 - 1 Explanation of the material topic and its Boundary 20-21

103 - 2 The management approach and its components 20-21

103 - 3 Evaluation of the management approach 20-21

GRI 201Economic Performance 2016

201 - 3 Defined benefit plan obligations and other retirement plans

30

201 - 4 Financial assistance received from government 25

Indirect Economic Impacts

GRI 103

Management Approach 2016




GRI 203Indirect Economic Impacts 2016

203 - 1 Infrastructure investments and services supported 25

Procurement practices





GRI 204: Procurement practices 2016

204 - 1 Proportion of spending on local suppliers 24

37GRI 102 - 55

GRI Standard


Omission

GRI 300 Environmental Standards Series

Energy





GRI 302Energy2016

302 - 1 Energy consumption within the organization 26

302 - 3 Energy intensity 26

302 - 4 Reduction of energy consumption 26

Water





GRI 303Water 2016

303 - 1 Water withdrawal by source 27

Emissions





GRI 305Emissions 2016

305 - 1 Direct (Scope 1) GHG emissions 28

305 - 4 GHG emissions intensity 28

Effluents and Waste





GRI 306Effluents and Waste2016

306 - 1 Water discharge by quality and destination 27

306 - 2 Waste by type and disposal method 28

306 - 4 Transport of hazardous waste 28

38 102 - 55 GRI

GRI Standard


Omission

GRI 400 Social Standards Series

Employment





GRI 401 Employment 2016

401 - 1 New employee hires and employee turnover 29

Occupational Health and Safety





GRI 403Occupational Health and Safety 2016

403 - 2 Types of injury and rates of injury, occupational diseases, lost days, and absenteeism, and number of work-related fatalities

31

Training and Education





GRI 404Training and Education 2016

404 - 1 Average hours of training per year per employee 30

39

GRI Standard


Omission

GRI 400 Social Standards Series

Diversity and Equal Opportunity





GRI 405Diversity and Equal Opportunity 2016

405 - 1 Diversity of governance bodies and employees 29

405 - 2 Ratio of basic salary and remuneration of women to men

29

GRI 102 - 55

40 102 - 53 GRI

i Impressum

GMT Fine Chemicals SA Sustainability Report 2016–2017

Published November 2018 Project Team Gabriel Haering Pascal Jequier Flavia Angela De Marco Marco Serafin Sustainability Consulting Giovanni Facchinetti B4B - Consulting Copyright © GMT Fine Chemicals SA Rue des Iles 62108 Val-de-Travers, NESwitzerland Contact pointPascal Jequier, COO http://gmtfinechemicals.ch/contact.html

Book Features Format 170 x 240 mm 40 pages Inside Paper Cocoon 120 gr – Recycled

Cover Cocoon 300 gr – Recycled Font Theinhardt by Optimo Type Foundry Typefaces Ryman Eco by Type Director Dan Rhatigan

Graphic Design Gebel Design [email protected] Picturespg: 8-9, 31 Vincent Bourrut Photographerhttp://vincentbourrut.ch Printing Tipografia Torriani SA Via Pizzo di Claro 3 6500 Bellinzona

GRI 41

Sustainability Report 2016–2017 - About GMT · Statement from Top Management ..... 5 Our first Sustainability Report ... by EDQM in Europe 2011 • Cerbios-Pharma SA acquires GMT

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