Surveillance – an introduction Preben Aavitsland
Mar 26, 2015
Surveillance – an introduction
Preben Aavitsland
Surveillance
n. Close observation, especially of a suspected spy or criminal
ORIGIN C19: from Fr., from sur- 'over' + veiller 'watch'
Source: The Concise Oxford Dictionary. Ed.
Pearsall J. Oxford University Press, 2001.
Surveillance – original use
Close observation of individuals suspected of incubating serious infectious diseases in order to detect initial symptoms of disease in time to institute treatment and isolation.
Until 1950s
Origins of surveillance
• 1839-79 William Farr– collected, analysed, interpreted vital statistics,
– plotted rise and fall of epidemics of infectious diseases
– disseminated information in weekly, quarterly, and annual reports, medical journals, public press
• 1880-90s In Europe and USA doctors must reported communicable diseases
• 1923 Sanepid system started in the Soviet Union
• 1925 National surveillance system in USA
Towards a new concept
Alexander Langmuir (1910 – 1993)
• Continued watchfulness over the distribution and trends of incidence through the systematic collection, consolidation and evaluation of morbidity and mortality reports and other relevant data together with the timely and regular dissemination to those who need to know
• General practice of “epidemiologic intelligence”
• In 1963
In the words of WHO
World Health Assembly in 1968:
• Systematic collection of pertinent data
• Orderly consolidation and evaluation of these data
• Prompt dissemination of the results to those who need to know
"Information for action"
Surveillance
Systematic ongoing collection, collation and analysis of data and the timely dissemination of information to those who need to know so that action can be taken.
Source: A Dictionary of Epidemiology. 4th edition. Ed. Last J. Oxford University Press, 2001
Surveillance
• World Health Assembly 2005 with the new International Health Regulations
• ”The systematic ongoing collection, collation and analysis of data for public health purposes and the timely dissemination of public health information for assessment and public health response as necessary.”
Surveillance
Surveillance is the ongoing systematic collection, collation, analysis and
interpretation of data; and the dissemination of information (to those
who need to know) in order that action may be taken
Information for action!
The surveillance loop
Event
Action
Data
Information
Health care system
Surveillance centre
Reporting
Feedback, recommendations
An
alysis, in
terpretation
Rationale for surveillance
The disease
• Severity
• Frequency
• Communicability
• International obligations
• Costs
• Preventability
Society
• Public and mass media interest
• Will to prevent
• Availability of data
Priority setting – which diseases?
• Incidence / prevalence• Severity• Epidemic potential• Socio-economic impact• Cost• Preventability • Public concern and news-worthiness• Feasibility
Possible objectives of surveillance
• Monitor trends (by time, place, person)– towards a control objective
– as programme performance
– as intervention evaluation
• Detect outbreaks
• Estimate future disease impact
• Collect cases for further studies
….in order to [action]
Actions resulting form surveillance
…in order to:
• implement control measures (rapid response)
• prioritise public health resources
• design and plan public health programmes
• plan and conduct research
• …
SMART objectives
Specific
Measurable
Acceptable and Action-oriented
Realistic
Time-related
Examples
Vague...• To estimate the frequency of hepatitis C• To detect outbreaks of measles
Specific and action-oriented• To measure the incidence of hepatitis C in
France in order to allow planning of specific health care needs for the coming 20 years
• To detect early time and place clustering of measles cases in order to ensure timely control of outbreaks
Ex: To monitor progress towards polio eradication by monitoring the incidence of poliomyelitis where wild
poliovirus is isolated in children under 14 years
0
50
100
150
200
250
80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96
National immunisation days
Cases of poliomyelitis where wild poliovirus was isolated in children in a rural district, 1980-1996
Ex: To measure the incidence of AIDS to predict future trends and facilitate health service planning
0
100
200
300
400
500
600
700
90 91 92 93 94 95 96 97 98 99 0 1 2 3 4
Cases of AIDS in a city district, 1990-2004
Ex: To monitor trends in the proportion of resistant gonorrhoea in order to guide empiric antibiotic therapy
0
10
20
30
1975 1980 1985 1990 1995 2000
0
100
200
300
400
% No./100 000
PPNG proportion
Incidence of gonorrhoea and proportion with PPNG in Norway 1975-2003
The surveillance loop
Event
Action
Data
Information
Health care system
Surveillance centre
Reporting
Feedback, recommendations
An
alysis, in
terpretation
Event and population under surveillance
Population and time• Everyone in the
country or defined part of the country
• Patients in hospitals• Employees in a factory• All children in the
winter months• …
Event• Disease• Syndrome
– Accute flaccid paralysis– Influenza-like illness– Diarrhoea
• Infection• Public health issue
– Antimicrobial resistance• Environment
– Vector population– Water quality
• …
Exposed
Clinical specimen
Symptoms
Pos. specimen
Infected
Seek medical attention
Diagnosis
Exposed
Clinical specimen
Symptoms
Pos. specimen
Infected
Seek medical attention
DiagnosisLab-confirmed disease
Severe disease
Mild diseaseAsymptomatic infection
Syndrome
What is better: A system based on clinical cases or a sysem based on
laboratory confirmed cases?
Indicators
• A calculated measure that indicates the changes you want to monitor
• Decide one or more indicators that sums up the surveillance results
• For example– Number of cases– Number of cases per 100 000 population per year
(incidence rate)– Percentage children under 1 year among meales
cases– Median age at first sexual intercourse– Percentage unemployed among 50 year olds
The surveillance loop
Event
Action
Data
Information
Health care system
Surveillance centre
Reporting
Feedback, recommendations
An
alysis, in
terpretation
Case definition
Includes• (Time, place, person)• Clinical featuresand /or• Laboratory resultsand/or• Epidemiological features
Should be• Clear, simple• Field tested• Stable and valid
Ex. Meningococcal disease is any person with symptoms of meningitis or septicaemia and Neisseria meningitidis detected from blood or cerebrospinal fluid by culture or PCR.
Sensitivity versus specificity
Sensitivity versus specificity
Sens
Spec
Sensitivity and predicitive value
Sensitivity
• = reported true cases total true cases
• = proportion of true cases detected
Positive predictive value
• = reported true cases total reported cases
• = proportion of reported cases are true cases
The tiered case definition
Confirmed
Probable
Possible
Features of different definitions
• “Confirmed” (specific) case-definition– low sensitivity - includes few cases
– high specificity - includes mostly true cases
– few false positive cases
• “Possible” (sensitive) case-definition– high sensitivity - includes almost all cases
– low specificity - includes also many non-cases
– many false positive cases
Exposed
Clinical specimen
Symptoms
Pos. specimen
Infected
Seek medical attention
DiagnosisConfirmed case
Probable case
Do you want a mainly sensitive or a mainly specific case definition for
measles?
Case definitions and reporting criteria
Case definition
Measles
Confirmednnn nnn nnnn nn
Probablenn nnn nnn nnnn
Possiblennnnnn nn n nnn
Reporting criteria
”Measles”
OutputMeasles
The surveillance loop
Event
Action
Data
Information
Health care system
Surveillance centre
Reporting
Feedback, recommendations
An
alysis, in
terpretation
Data sources
• Hospitals• Ambulatory clinics• General practitioners• Clinics for sexually
transmitted diseases• Laboratories• Selected sites -
sentinel surveillance system
• Schools• Work places• Existing data collection
systems (death certificates, sick leave system etc)
• Public sector • Private sector• Non-governmental
organisations
Exposed
Clinical specimen
Symptoms
Pos. specimen
Infected
Seek medical attention
DiagnosisLaboratories
Schools, work places
General practitioners
Hospitals
Issues with differen data sources
• Cost
• Representativeness
• Acceptability
• Data quality
• Timeliness
• Confidentiality
Data collection instrument
• Data form or no specified format?
• Open or closed questions?
• Data requirements specified?
Reporting form
Reporting form
Database
Database
Copy
Interpretation
Information versus acceptability
Info
Accept
Aggregation of data
• Individual data– Identified – name, personal id number
– Non-identified – but possible to trace back
– Anonymous – impossible to trace back
• Aggregated data– Numbers
– Tabulated numbers – by sex, age group etc
Reporting (data transfer)
Data transfer method
• Paper by mail
• Telephone
• Telefax
• Internet
• Protected net
Data transfer frequency
• For every case
• Daily
• Weekly
• Monthly
• Zero reporting
Active versus passive surveillance
Passive
• Wait for reporters to report
• May have low sensitivity
• Used in most surveillance systems
Active
• Reach out to potential reporters regularly
• More sensitive
• More resource-demanding
• Used for special diseases or periods
Quality checking
• Reporting regularity
• Report quality
• Follow up procedures
The surveillance loop
Event
Action
Data
Information
Health care system
Surveillance centre
Reporting
Feedback, recommendations
An
alysis, in
terpretation
Data analysis and interpretation
From data to indicators to interpretation• Data validation (completeness + validity)• Descriptive analysis: time, place, person• Generating and testing hypotheses related to
time, place, person– Advanced analyses
• Time series analysis• Cluster analysis
• Interpretation– Using supporting information
The surveillance loop
Event
Action
Data
Information
Health care system
Surveillance centre
Reporting
Feedback, recommendations
An
alysis, in
terpretation
Information and feedback
• Contents– Surveillance information– Interpretations– Recommendations– Other information
• Format– Text– Tables– Figures
• Target audience– Public– Professionals– Policy makers
• Medium– Newsletter
• Paper• Fax• E-mail• Internet
– Web-tool
• Frequency– Immediately– Daily– Weekly– Monthly
Web tool – example from Norway
Feedback has its own value
• Shows respect for those who report
• Increases adherence to system
• Forces you to analyse and interpret
What is the feedback from the surveillance system in your country?
The surveillance loop
Event
Action
Data
Information
Health care system
Surveillance centre
Reporting
Feedback, recommendations
An
alysis, in
terpretation
Information for action!
• Surveillance is not for archives!
• Action– implement control measures
• rapid response
– prioritise public health resources• policy change?
– design and plan public health programmes
If there is no action..
..it isn’t surveillance
Ethical issues: right or wrong
• Build trust between public health practitioners and the society
• Issues:– Self-interest or desire to benefit society?– Potential benefits and harms. For whom?– Maximise benefits. Minimise harms– Involvement of community representatives– Rights of people
• Confidentiality – share only with those who have permission from patient or legal right to know
– Respect for people
Legal issues
• Surveillance systems should have a legal foundation that specifies– How to collect information– How to use information
• Not for other purposes– How to safeguard and store information– How to allow individuals to see and correct information
• Main principles– Collect only what you need– Choose the lowest level of identification needed– Analyse and publish rapidly
Functions
Core functions
• Detection
• Reporting
• Investigation & confirmation
• Analysis & interpretation
• Action/response
Support functions
• Training
• Supervision
• Resources
• Standards/guidelines
Who does what?
Resources for system operation
• Funding sources• Personell time• Other costs
– Training– Mail– Forms– Computers– ...
Your most important assets
• A good network of motivated people
• Clear case definition and reporting mechanism
• Efficient communication system
• Basic but sound epidemiology
• Laboratory support
• Good feedback and rapid response
Rapid reporting Analysis Action
Identify two major weaknessesin the surveillance system
for communicable diseasesin your country
Evaluation of surveillance systems
• Systematic investigation of the merit of the surveillance system in order to increase its usefulness and efficiency
Importance of evaluatingsurveillance systems
• Quality– Often neglected
– Basis for improvements
• Obligation– Does the system deliver?
– Credibility of public health service
• Learning process– ”Do not create one until you have evaluated one”
General framework for evaluation
• A. Engagement of stakeholders
• B. Evaluation objective
• C. System description
• D. System performance
• E. Conclusions and recommendations
• F. Communication
C. System description
• 1 Public health rationale (why?)
• 2 Objectives (what?)
• 3 Operations (how?)
• 4 Resources (how much?)
Extreme learning value!!!!
D. System performance
Does it work?System attributes• Simplicity• Flexibility• Data quality• Acceptability• Sensitivity• Positive predictive value• Representativeness• Timeliness• Stability
Is it useful?
Use of information• Users
• Actions taken
Link to objectives
Timeliness
Occurence of event
Recognition of event
(diagnosis)
Reporting of event
Action taken
E. Conclusions and recommendations
• Proper rationale?
• Attributes – Balance of attributes and costs
• Fulfilling objectives?
• Recommendations– Continue
– Revise: specify
– Stop
Surveillance – a big challenge
• Crude
• Inaccurate
• Incomplete
• Cumbersome
• Complex