Supporting Cancer Management: Conceptual Framework TCM

Supporting Supporting CCancerancer MManagementanagement ::Conceptual Framework TCMConceptual Framework TCM

Prof. YunmingProf. Yunming••••••

Nanjing Medical University Affiliated Hospital of Yangzhou Nanjing Medical University Affiliated Hospital of Yangzhou (Yangzhou, China 225009)(Yangzhou, China 225009)

PrefacePreface§§ Chinese medicine treatment of cancer has a long Chinese medicine treatment of cancer has a long

history history §§ the ancient chinese Oracle already has a record the ancient chinese Oracle already has a record

of "tumor" of "tumor"

the ancient Chinese Medical script "Huang Di Nei the ancient Chinese Medical script "Huang Di Nei Jing" already have specialised doctors and tumor Jing" already have specialised doctors and tumor classification classification

for 2000 years TCM has abundant experience for 2000 years TCM has abundant experience in clinical cancer practicein clinical cancer practice

§§ A historic breakthrough in the past 60 years is the A historic breakthrough in the past 60 years is the Integrate theory and method of conventional Integrate theory and method of conventional medicine with TCM medicine with TCM

§§ Modern experimental methods (from the system to Modern experimental methods (from the system to the tissues and organs, cells, molecular level) the tissues and organs, cells, molecular level)

§§ EvidenceEvidence--based medicine approach based medicine approach

§§ Innovation in traditional Chinese medicine as the Innovation in traditional Chinese medicine as the concentrated herbal granulesconcentrated herbal granules

The characteristics of traditional Chinese medicine The characteristics of traditional Chinese medicine -- Has their own theoretical system Has their own theoretical system -- Emphasis on human internal factors Emphasis on human internal factors -- Mainly Using natural medicines (herbal, animal Mainly Using natural medicines (herbal, animal

drugs, mineral drugs, etc.) and combination with drugs, mineral drugs, etc.) and combination with acupuncture theraphy, pshycotherapy, acupuncture theraphy, pshycotherapy, dietotheraphy, exercise therapy, etc.dietotheraphy, exercise therapy, etc.

1 .Classifications of Types of adjuvant 1 .Classifications of Types of adjuvant therapy for tumors of Chinese medicine therapy for tumors of Chinese medicine

§§ Features: Features:

-- Reducing surgery, radiotherapy, chemotherapy side effects Reducing surgery, radiotherapy, chemotherapy side effects

-- Enhanced the sensitivity of chemotherapy, and radiation Enhanced the sensitivity of chemotherapy, and radiation

-- Many reasons for inoperable lesions, radiotheraphy, Many reasons for inoperable lesions, radiotheraphy, chemotheraphy, the patients administered with TCM can chemotheraphy, the patients administered with TCM can improve living quility, prolong survival rateimprove living quility, prolong survival rate

1 several categories of Chinese 1 several categories of Chinese medicine treatment of cancer medicine treatment of cancer

§§ 1.1.11 clearing away the heatclearing away the heat--evil and toxic materialsevil and toxic materialsex: herba taraxaci ( ex: herba taraxaci ( Pu Gong YingPu Gong Ying••

rhizoma smilacis glabrae (Tu Fu Ling)rhizoma smilacis glabrae (Tu Fu Ling)

1 Several categories of Chinese 1 Several categories of Chinese medicine treatment of cancermedicine treatment of cancer

§§ 1. 2. dissipating a mass1. 2. dissipating a mass

1 Several categories of Chinese 1 Several categories of Chinese medicine treatment of cancermedicine treatment of cancer

1.3 supporting healthy energy and building up 1.3 supporting healthy energy and building up foundationfoundation

1 Several categories of Chinese 1 Several categories of Chinese medicine treatment of cancer medicine treatment of cancer

1.41.4.. AActivating blood circulation to dissipate ctivating blood circulation to dissipate blood statis blood statis

1.1. Several categories of Chinese 1.1. Several categories of Chinese medicine treatment of cancer medicine treatment of cancer

§§ Mechanism: Mechanism: --AntiAnti--tumor activity tumor activity (directly terminate cancer cells) (directly terminate cancer cells) --Regulate the immune function Regulate the immune function --Regulate metabolismRegulate metabolism(autonomic, endocrine)(autonomic, endocrine)

--Promote tumor cell differentiation Promote tumor cell differentiation --Inhibit tumor thrombus formation Inhibit tumor thrombus formation

Several categories of Chinese Several categories of Chinese medicine treatment of cancermedicine treatment of cancer

§§ CCruciality of efficacy ruciality of efficacy -- Diagnosing the individual indications Diagnosing the individual indications -- Drug combinations Framework Drug combinations Framework -- Dose administration Dose administration -- Accumulated doctors experience and basic Accumulated doctors experience and basic theories of TCM theories of TCM

2. Methodes of integrated TCM and 2. Methodes of integrated TCM and conventional medicine on cancer treatment conventional medicine on cancer treatment

2.1. Combination of surgery and TCM 2.1. Combination of surgery and TCM 2.1.1. P2.1.1. Prere--operative : Objective: to improve operative : Objective: to improve

the physical condition and create better the physical condition and create better conditions for surgeryconditions for surgery

§§ 2.2.1.21.2. post. post--operative recoveryoperative recoveryObjective: To promote tissue repair, adjust bodily Objective: To promote tissue repair, adjust bodily

functions to deal with complications functions to deal with complications --, to improve post, to improve post--operative gastrointestinal operative gastrointestinal

dysfunction dysfunction --, regulate autonomic nerve function: post, regulate autonomic nerve function: post--

operation sweating, sweating after movement. operation sweating, sweating after movement. --, regulate water and electrolyte disorders: in , regulate water and electrolyte disorders: in

gastrointestinal surgeries, especially those with gastrointestinal surgeries, especially those with fistula formation, a large number of digestive fistula formation, a large number of digestive juice is lost.juice is lost.

2.1.3 Long2.1.3 Long--term postterm post--operative treatment operative treatment 2.1.3.1. early stage, radical surgery, without radiotherapy or 2.1.3.1. early stage, radical surgery, without radiotherapy or

chemotherapy may be pure traditional Chinese medicine chemotherapy may be pure traditional Chinese medicine treatment, longtreatment, long--term followterm follow--up.up.

2.1.3.2. patients who need chemotherapy and radiotherapy , 2.1.3.2. patients who need chemotherapy and radiotherapy , TCM herbal may reduce side effects, increased efficacy( TCM herbal may reduce side effects, increased efficacy( ex: lung cancer ex: lung cancer IIIIBB TT22 NN11MM00))

2.1.3.3. after surgery for various reasons can not accept 2.1.3.3. after surgery for various reasons can not accept chemotherapy, radiotherapy , may have a longchemotherapy, radiotherapy , may have a long--term term maintenance treatment of traditional Chinese medicine to maintenance treatment of traditional Chinese medicine to improve the quality of life and prolong survival timeimprove the quality of life and prolong survival time

2.2. Chinese medicine combined with chemotherapy 2.2. Chinese medicine combined with chemotherapy and radiotherapyand radiotherapy

2.2.1. The clinical problems faced by chemotherapy 2.2.1. The clinical problems faced by chemotherapy and radiotherapy and radiotherapy --Toxicity: skin and mucous membrane radiation Toxicity: skin and mucous membrane radiation damage and nerve injury, pneumonia and damage and nerve injury, pneumonia and pulmonary fibrosis, colitis and digestive tract pulmonary fibrosis, colitis and digestive tract ulcers, cystitis; gastrointestinal response to ulcers, cystitis; gastrointestinal response to chemotherapy, bone marrow suppression, chemotherapy, bone marrow suppression, immune suppression, neurological damage, organ immune suppression, neurological damage, organ damage and skin, hair damage and so on. damage and skin, hair damage and so on.

2.2.1. The clinical problems faced by 2.2.1. The clinical problems faced by chemotherapy and radiotherapy chemotherapy and radiotherapy

--Desensitization and drug resistance: Desensitization and drug resistance: radiationradiation--induced tumor blood supply induced tumor blood supply shortage, hypoxic tumors cells on the shortage, hypoxic tumors cells on the radiation induced multiradiation induced multi--drug resistivity drug resistivity resistance (MDR) and so on.resistance (MDR) and so on.

2.2.2. TCM reduces radiation toxicity 2.2.2. TCM reduces radiation toxicity

-- Prevention and control of radiationPrevention and control of radiation--induced induced skin reactions and ulcers: skin reactions and ulcers:

-- Treatment of radiation proctitis and Treatment of radiation proctitis and -- Radiation cystitis;Radiation cystitis;

2.2.3. TCM reduces chemotherapy toxicity 2.2.3. TCM reduces chemotherapy toxicity

--Reduces Chemotherapy induced gastrointestinal Reduces Chemotherapy induced gastrointestinal reactions (nausea, vomiting, poor appetite, reactions (nausea, vomiting, poor appetite, abdominal distension, etc.; abdominal distension, etc.;

--Improve the bone marrow suppression; Improve the bone marrow suppression;

--Reduce nerve injuryReduce nerve injury

2.2.4 Mechanisme of TCM synergistic effect to 2.2.4 Mechanisme of TCM synergistic effect to chemotherapy and radiaotheraphychemotherapy and radiaotheraphy

--Mechanisme :Mechanisme :

-- Reversal of multidrug resistance (MDR) Reversal of multidrug resistance (MDR) -- Affecting the cell cycle distributionAffecting the cell cycle distribution-- Improve the tumor surrounding tissue and tumor Improve the tumor surrounding tissue and tumor

microcirculation:microcirculation:

2.2.2.2.44. Researches Result of Synergistic effect of . Researches Result of Synergistic effect of TCM to chemotherapy and radiotherapy TCM to chemotherapy and radiotherapy

-- Research resultsResearch resultsOver the years, in TCM to enhance tumor Over the years, in TCM to enhance tumor

chemotherapy and radiotherapy effects, our chemotherapy and radiotherapy effects, our clinical and experimental studies have conducted clinical and experimental studies have conducted extremely broad, deep and intriguing results. Here extremely broad, deep and intriguing results. Here are some of the introduction.are some of the introduction.

Experimental data (1) Beijing Chinese Medicine Experimental data (1) Beijing Chinese Medicine Hospital with building up healthy energy and Hospital with building up healthy energy and activating blood circulation and dissipate blood activating blood circulation and dissipate blood statis, combined with chemotherapy, not only statis, combined with chemotherapy, not only reduced chemotherapy side effects, but also reduced chemotherapy side effects, but also improved the successful completion rate of improved the successful completion rate of chemotherapy (treatment group completed the chemotherapy (treatment group completed the rate of 79.59% in the control group 52.63, P rate of 79.59% in the control group 52.63, P <0.05, statistically significant differences), and <0.05, statistically significant differences), and also improved the cancer patient's blood also improved the cancer patient's blood hypercoagulability, improved cellular immune hypercoagulability, improved cellular immune function in patients: compared to chemotherapy function in patients: compared to chemotherapy alone, there are obvious advantages;alone, there are obvious advantages;

§§ Data (2) Liu Jiaxiang, etc. with the formula Data (2) Liu Jiaxiang, etc. with the formula "anti"anti--tumor Yifei Yin" Treatment of 271 tumor Yifei Yin" Treatment of 271 cases of noncases of non--small cell lung cancer, small cell lung cancer, §§ group 1: "antigroup 1: "anti--tumor Yifei Yin“group: tumor Yifei Yin“group: §§ group 2: "antigroup 2: "anti--tumor Yifei Yin" plus tumor Yifei Yin" plus

chemotherapy group, chemotherapy group, §§ group 3: chemotherapy group, group 3: chemotherapy group,

randomized controlled. randomized controlled.

the results showed :the results showed :A. TCM group and TCM plus chemotherapy group was significantly A. TCM group and TCM plus chemotherapy group was significantly

superior to chemotherapy group. superior to chemotherapy group.

B. TCM group and TCM plus chemotherapy group significantly inhibit B. TCM group and TCM plus chemotherapy group significantly inhibit metastasis of lung cancer in stage III.metastasis of lung cancer in stage III.

C. TCM group 1,2,3,5C. TCM group 1,2,3,5--year survival rates were 73.21%, 33.06%, year survival rates were 73.21%, 33.06%, 13.96% and 11.1713.96% and 11.17%%, with a median survival time of 406 days; , with a median survival time of 406 days;

D. TCM plus chemotherapy group 1,2,3,5D. TCM plus chemotherapy group 1,2,3,5--year survival rates were year survival rates were 73.24% and 40.54%, 52.0473.24% and 40.54%, 52.04%% and 18.43and 18.43%%, the median survival , the median survival period 449 daysperiod 449 days

E. Chemotherapy group 1,2,3,5E. Chemotherapy group 1,2,3,5--year survival rates 39.03% and year survival rates 39.03% and 11.06%, 35.78% and 011.06%, 35.78% and 0%%, the median survival period 267 days. , the median survival period 267 days. Has Has significant statistic diferences. significant statistic diferences.

F. The result Showed that antiF. The result Showed that anti--tumor Yifei can prolong survival and tumor Yifei can prolong survival and improve life span, improving symptoms and quality of life, combined improve life span, improving symptoms and quality of life, combined with chemotherapy for lung cancer significantly attenuated the with chemotherapy for lung cancer significantly attenuated the synergistic effect. synergistic effect.

§§ Data (3) the author himself in Nanjing University Data (3) the author himself in Nanjing University of Traditional Chinese Medicine Hospital with of Traditional Chinese Medicine Hospital with Astragalus, Ganoderma lucidum etc in formula Astragalus, Ganoderma lucidum etc in formula "Rectifying Xiaoliu" combined with "Rectifying Xiaoliu" combined with chemotherapy for 69 cases diagnostically chemotherapy for 69 cases diagnostically confirmed by pathology or CT examination as confirmed by pathology or CT examination as advanced cancer patients were randomly advanced cancer patients were randomly divided as treatment group and the divided as treatment group and the chemotherapy control group, chemotherapy control group, §§ treatment group, the effective (CR + PR) is treatment group, the effective (CR + PR) is

31.58% in the control group effective rate was 31.58% in the control group effective rate was 22.58%, statistically significant differences (P 22.58%, statistically significant differences (P <0.05 ). Immune function before and after <0.05 ). Immune function before and after treatment is seen in the table below:treatment is seen in the table below:

Comparison of immune function in both Comparison of immune function in both groups before and after treatment (X groups before and after treatment (X ±± S)S)

groupgroup timetime T L c T R(%) T L c T R(%) N K c A(%) N K c A(%)

TCMTCMPlusPluschemchem

oo

beforebefore 49.3849.38±±4.02 4.02 9.399.39±±4.38 4.38

afterafter 53.7253.72±±5.285.28•••• 12.7112.71±±4.714.71••••

chemchemoo

BeforeBefore 47.5947.59±±0.61 0.61 9.349.34±±4.66 4.66

afterafter 49.8149.81±±3.513.51•• 10.2110.21±±5.575.57••

Compared with TCM plus chemotherapy group : before treatment, •P <0.01; compared with chemotherapy group after treatment ,compared to • P <0.01;

Compared with chemotherapy group before treatment, € P> 0.05

§§ Data (4) Beijing Guang An Men Hospital, observed 669 Data (4) Beijing Guang An Men Hospital, observed 669 cases of advanced gastric cancer patients with cases of advanced gastric cancer patients with "Jianpiyishenfang powder" (from Codonopsis, Atractylodes, "Jianpiyishenfang powder" (from Codonopsis, Atractylodes, Ligustrum lucidum, etc) into the attenuated toxicity effect of Ligustrum lucidum, etc) into the attenuated toxicity effect of chemotherapy, suggesting that usage of the formula can chemotherapy, suggesting that usage of the formula can elevate patients chemotherapy complition rate to 94.44 elevate patients chemotherapy complition rate to 94.44 percent, while chemotherapy alone is only 73.73%. percent, while chemotherapy alone is only 73.73%. Gastrointestinal reactions, systemic reactions, blood and Gastrointestinal reactions, systemic reactions, blood and immune indicators shows that the former are better than immune indicators shows that the former are better than the latter, followed up 303 cases, the 1,3,5,10the latter, followed up 303 cases, the 1,3,5,10--year survival year survival rates were 99.01%, 77.31%, 53.40% and 47.37%.rates were 99.01%, 77.31%, 53.40% and 47.37%.

2.3 TCM Research on anti2.3 TCM Research on anti--metastasis and antimetastasis and anti--recurrencerecurrence

2.3.1. Known TCM ways to prevent recurrence and anti2.3.1. Known TCM ways to prevent recurrence and anti--metastasis metastasis mechanisme mechanisme

--Antimutagenic Antimutagenic

--Direct cytotoxicity Direct cytotoxicity

--Immunoenhancement Immunoenhancement

--Inhibit tumor cell proliferation, induction differentiation of cells tumor Inhibit tumor cell proliferation, induction differentiation of cells tumor

--Induced apoptosis of tumor cells Induced apoptosis of tumor cells

--Affecting telomerase activity Affecting telomerase activity

-- Inhibit tumor angiogenesisInhibit tumor angiogenesis

2.3.2 Anti2.3.2 Anti--recurrence and metastasis recurrence and metastasis of research results of research results

Data (1) Yang Guo Wang using Chinese Data (1) Yang Guo Wang using Chinese herbal compound, "Guben Xiaoliu Capsule" herbal compound, "Guben Xiaoliu Capsule" in research of Inhibition of mouse Lewis lung in research of Inhibition of mouse Lewis lung cancer growth and anticancer growth and anti--angiogenesis angiogenesis research found that: there is significant research found that: there is significant resistance effect to mouse Lewis lung resistance effect to mouse Lewis lung cancer, neovascularization generation cancer, neovascularization generation

2.3.2 TCM anti2.3.2 TCM anti--metastatis and recurrance metastatis and recurrance suppression research resultssuppression research results

Data (2) Xu Ling and friends, with "Yi Fei antiData (2) Xu Ling and friends, with "Yi Fei anti--tumor” tumor” compound ( astragalus, North Adenophora, winter days, compound ( astragalus, North Adenophora, winter days, Ligustrum lucidum, etc) in the treatment of 45 cases of lung Ligustrum lucidum, etc) in the treatment of 45 cases of lung cancer stage cancer stage •• , and TCM plus chemotherapy group 22 , and TCM plus chemotherapy group 22 cases and chemotherapy group 27 cases as control cases and chemotherapy group 27 cases as control group, group,

3 months later the metastatis rate is respectively 13 3 months later the metastatis rate is respectively 13 cases, 5 cases, and 17 cases. indicates that TCM, TCM cases, 5 cases, and 17 cases. indicates that TCM, TCM plus chemotherapy group effect in stabilising lesion, plus chemotherapy group effect in stabilising lesion, suppression of distant metastasis was superior to suppression of distant metastasis was superior to chemotherapy group (P <0.05 and 0.01), while increasing chemotherapy group (P <0.05 and 0.01), while increasing natural killer cell activity in patients, OKT3, OKT4 value.natural killer cell activity in patients, OKT3, OKT4 value.

2.3 TCM Research on anti2.3 TCM Research on anti--metastasis and metastasis and antianti--recurrencerecurrence

Data (3) In experimental studies, it is observed Data (3) In experimental studies, it is observed that fermentation of natural Cordyceps sinensis that fermentation of natural Cordyceps sinensis and water extract fermentated Cordyceps and water extract fermentated Cordyceps sinensis has significantly inhibited subcutaneous sinensis has significantly inhibited subcutaneous transplanted Lewis lung cancer local growth and transplanted Lewis lung cancer local growth and spontaneous lung metastasis. Probably caused by spontaneous lung metastasis. Probably caused by Chinese caterpillar fungus that regulates immune Chinese caterpillar fungus that regulates immune function; Rhizoma cnidi with the active ingredients function; Rhizoma cnidi with the active ingredients TMP significantly inhibited melanoma cells TMP significantly inhibited melanoma cells C57/BL6 in the mice spontaneous lung cancer C57/BL6 in the mice spontaneous lung cancer metastasis. metastasis.

2.3 TCM Research on anti2.3 TCM Research on anti--metastasis metastasis and antiand anti--recurrencerecurrence

Data (4) Lin Hongsheng reported,with the Data (4) Lin Hongsheng reported,with the Chinese herbal compound lung cancer Chinese herbal compound lung cancer inhibitor 2 , with high, medium and lowinhibitor 2 , with high, medium and low--dose dose respectively inhibited Lewis lung cancer respectively inhibited Lewis lung cancer metastasis rates as 39.7%, 54.6%, 64.1%, metastasis rates as 39.7%, 54.6%, 64.1%, as compared with the control group were as compared with the control group were significantly different (P <0.05 and 0.01).significantly different (P <0.05 and 0.01).

2.4. TCM Research of long term 2.4. TCM Research of long term extending survival rate resultsextending survival rate results

TCM goal to treat malignant tumors are TCM goal to treat malignant tumors are not limited by reducing tumor size, In recent not limited by reducing tumor size, In recent years, along with molecular targeted years, along with molecular targeted therapies in clinical application, the length of therapies in clinical application, the length of survival as the efficacy evaluation is more survival as the efficacy evaluation is more and more attentive. and more attentive.

2.4. TCM Research of long term 2.4. TCM Research of long term extending survival rate resultsextending survival rate results

§§ Data (Data (11) Guo) Guo--Rong Chen reported for nonRong Chen reported for non--small cell lung cancer, TCM plus small cell lung cancer, TCM plus chemotheraphy treatment group, 60 cases , chemotheraphy treatment group, 60 cases , and chemotherapy control group, 60 cases,and chemotherapy control group, 60 cases,§§ Results of the treatment group: CR + PR Results of the treatment group: CR + PR

58%, with a median survival period of 19 58%, with a median survival period of 19 months , while the control group was only 35 months , while the control group was only 35 %, and 10 months. %, and 10 months.

§§ Data (Data (22) Yu Guiqing observed 669 cases of ) Yu Guiqing observed 669 cases of advanced gastric cancer with "Jianpiyishenfang advanced gastric cancer with "Jianpiyishenfang powder" (radix Codonopsis pilosulae, powder" (radix Codonopsis pilosulae, Atractylodes, Ligustrum lucidum, etc) combined Atractylodes, Ligustrum lucidum, etc) combined with chemotherapy, 303 cases of longwith chemotherapy, 303 cases of long--term followterm follow--up , the 1,3 , 5,10up , the 1,3 , 5,10--year survival rate reached year survival rate reached 99.01%, 77.31%, 53.4%, 47.37%.99.01%, 77.31%, 53.4%, 47.37%.

§§ Data (Data (33) Zhou Jianhua with "Nourishing Yin and ) Zhou Jianhua with "Nourishing Yin and Yang Wei Fang" compound (radix adenophorae Yang Wei Fang" compound (radix adenophorae herba Dendrobium, rhizoma dioscorea herba Dendrobium, rhizoma dioscorea batatis,rhizoma curcumae, radix Ophiopogonosis, batatis,rhizoma curcumae, radix Ophiopogonosis, Polygonatum, etc) combined with radiotherapy in Polygonatum, etc) combined with radiotherapy in 85 patients with esophageal cancer patients . And 85 patients with esophageal cancer patients . And 50 cases of radiotheraphy as control, the results 50 cases of radiotheraphy as control, the results showed of treatment group 1,3,5showed of treatment group 1,3,5--year survival year survival rates were 74.12%, 30.16%, 21.05% , while the rates were 74.12%, 30.16%, 21.05% , while the control group 44%, 22.27%, 0%.control group 44%, 22.27%, 0%.

3. The strengths and limitations of 3. The strengths and limitations of Chinese medicine on cancer treatment Chinese medicine on cancer treatment §§ 3.1 The advantages of Chinese medicine to treat cancer 3.1 The advantages of Chinese medicine to treat cancer

A, emphasises on "the whole body concept", focusing on tumor A, emphasises on "the whole body concept", focusing on tumor with the patients body as part and the overall relationship, starting the with the patients body as part and the overall relationship, starting the antianti--cancer from the regulation of homeostatis environmentcancer from the regulation of homeostatis environment

B, Less toxicity effects, wide indications B, Less toxicity effects, wide indications

C, on the Western radiotherapy, chemotherapy, interventional C, on the Western radiotherapy, chemotherapy, interventional therapy has attenuated synergistic effect; therapy has attenuated synergistic effect;

D, has abundant methodes for antiD, has abundant methodes for anti--metastasis and recurrence metastasis and recurrence

E, can improve symptoms, improve quality of life and prolongE, can improve symptoms, improve quality of life and prolongsurvival; survival;

F, right precancerous lesions have some preventive effect.F, right precancerous lesions have some preventive effect.

3.2 The limitations of Chinese medicine to treat cancer3.2 The limitations of Chinese medicine to treat cancerA, weak effect of partial debridement A, weak effect of partial debridement

B, although according to specific diagnostic B, although according to specific diagnostic treatment is difficult to adjust the specific indicator, treatment is difficult to adjust the specific indicator, mainly rely on TCM theory and doctor’s experience mainly rely on TCM theory and doctor’s experience effects between different individuals is various; effects between different individuals is various;

CC formula are complicated, the determination of active formula are complicated, the determination of active ingredients is relatively difficult.ingredients is relatively difficult.

SummarySummary

TCM can assist the conventional TCM can assist the conventional treatment as treatment as complimentary means on complimentary means on oncology, oncology, in tumor prevention and in tumor prevention and treatment has very broad prospects, and treatment has very broad prospects, and we look forward to more Western medical we look forward to more Western medical experts and Chinese medicine experts to experts and Chinese medicine experts to join hands. to do more international join hands. to do more international cooperation, in order to effectively control cooperation, in order to effectively control the malignancy of human cancer.the malignancy of human cancer.

Thank you!Thank you!

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