Supported by the EC’s Horizon 2020 Programme and The Eve ... · Ethics • REC Approval, September 2014 • NIHR Adoption, October 2015 • UCL Joint Research Office, November 2015

Supported by the EC’s Horizon 2020 Programme and The Eve AppealCopyright © 2015 FORECEE Consortium - All rights reserved

The problem with cancer screening

RISK PREDICTION

Preventive measures

SURGERY, RADIOTHERAPY, CHEMOTHERAPY

Screening

Cancer onset

Symptoms

The challenge of cancer

Arau ́jo et al. (2013), European Journal of Preventive Cardiology

Age-s

tandard

ised m

ort

alit

y r

ate

s

European cancer trends 1980-2010

De

ath

s p

er

10

0 0

00

Women-specific cancers

47%

of all cancers in women are women-specific• Breast• Ovarian• Endometrial• Cervical

BRCA Gene Mutation

1:600 Population Risk

Triples prostate cancer risk

The FORECEE Vision

Collect hormone-sensitive cells from the cervix

Provide individualised prevention and health

promotion

Predict 5-10 year risk for breast, ovarian, endometrial,

and cervical cancer

Analyse cells forgenomic, epigenomic,

and metagenomic changes

The FORECEE Vision

Ethics

• REC Approval, September 2014

• NIHR Adoption, October 2015

• UCL Joint Research Office, November 2015

• Public Health England, August 2016

FORECEE Recruitment

Recruitment

• UCLH, December 2015

• BRCA PROTECT Research Clinic, December 2015

• European partners, January 2016

• Primary Care recruitment, February 2017

• Total of 21 recruitment centres, April 2017

FORECEE Partners

Charles University Prague

FORECEE Recruitment

FORECEE Recruitment

Identifiable data

Anonymised

Single recruitment meeting

• Consent

• iPad questionnaire

• Collection of biosamples

blood

buccal

cervical

FORECEE Recruitment

tissue,if for risk-reducing surgery

FORECEE Recruitment

FORECEE Recruitment

FORECEE Recruitment

How did you hear about the BRCA PROTECT Research Clinic?

Friend (40%)

Online, Google etc. (20%)

Link on social media via friend (20%)

Link on social media via charity (20%)

Please indicate your experience with regards to the booking website

Please indicate your experience with regards to the timeliness of the clinic

Please indicate your experience of having your blood sample taken

Please indicate your experience of having your cervical sample taken

Would you recommend us to your friends and family?

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Prevention is better than cure

Risk Prediction Screening Symptoms

PREVENTION SURGERY, RADIOTHERAPY, CHEMOTHERAPY

Cancer onset

20th Century

• Treatment of established diseases

21st Century

• Prediction• Prevention• Personalised• Participatory

P4 Medicine

Insights into sporadic cancers

Sporadic breast and ovarian cancers

PREVENT

PREDICT

UNDERSTAND

A collaborative partnership

THANK YOU

A collaborative partnership

brcaprotect.org