Supplementary webappendix This webappendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement to: de Araújo TVB, Rodrigues LC, de Alencar Ximenes RA, on behalf of investigators from the Microcephaly Epidemic Research Group, the Brazilian Ministry of Health, the Pan American Health Organization, Instituto de Medicina Integral Professor Fernando Figueira, and the State Health Department of Pernambuco. Association between Zika virus infection and microcephaly in Brazil, January to May, 2016: preliminary report of a case-control study. Lancet Infect Dis 2016; published online Sept 15. http://dx.doi.org/10.1016/S1473-3099(16)30318-8.
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Supplementary webappendix - The Lancet webappendix This webappendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement
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Supplementary webappendixThis webappendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors.
Supplement to: de Araújo TVB, Rodrigues LC, de Alencar Ximenes RA, on behalf of investigators from the Microcephaly Epidemic Research Group, the Brazilian Ministry of Health, the Pan American Health Organization, Instituto de Medicina Integral Professor Fernando Figueira, and the State Health Department of Pernambuco. Association between Zika virus infection and microcephaly in Brazil, January to May, 2016: preliminary report of a case-control study. Lancet Infect Dis 2016; published online Sept 15. http://dx.doi.org/10.1016/S1473-3099(16)30318-8.
48 Control M 33·5 Normal Yes 9 3,045 39·1 Normal 19 5 - Not
collected Neg - - - Neg Neg
49 Control M 34·0 Normal No - 3,850 39·5 Normal 21 7 1·1 Neg Neg - - - Neg Neg
50 Control M 33·0 Normal No - 2,630 37·4 Normal 16 10 1·1 Neg Neg - - - Neg Neg
51 Control M 36·0 Normal No - 3,515 38·2 Normal 42 17 0·8 Neg Neg - - - Neg Neg
52 Control F 41·0 Normal No - 3,565 38·1 Normal 22 7 0·8 Neg Neg - - - Neg Neg
53 Control M 36·0 Normal No - 3,170 37·1 Normal 25 12 1·0 Neg Neg - - - Neg Neg
54 Control M 33·5 Normal Yes 8 3,590 38·0 Normal 19 11 1·3 Neg Neg - - - Neg Neg
55 Control M 35·0 Normal No - 2,850 39·4 Normal 28 12 1·0 Neg Neg - - - Neg Neg
56 Control F 34·5 Normal No - 3,560 38·6 Normal 21 9 0·7 Neg Neg - - - Neg Neg
57 Control M 35·0 Normal No - 3,685 39·3 Normal 41 12 0·9 Neg Neg - - - Neg Neg
58 Control F 36·0 Normal No - 3,530 38·3 Normal 16 6 1·0 Neg Neg - - - Neg Neg
59 Control F 33·0 Normal No - 2,745 39·3 Normal 24 9 0·7 Neg Neg - - - Neg Neg
60 Control F 33·5 Normal No - 2,385 35·6 SGA 21 12 0·7 Neg Neg - - - Neg Neg
61 Control M 35·0 Normal No - 3,295 39·3 Normal 19 11 0·8 Neg Neg - - - Neg Neg
62 Control F 34·5 Normal No - 2,720 37·1 Normal 16 11 1·0 Neg Neg - - - Neg Neg
63 Control F 33·5 Normal Yes 7 2,760 38·1 SGA 21 10 1·1 Neg Neg - - - Neg Neg
64 Control M 32·0 Normal No - 2,165 34·2 Normal 23 0 0·8 Neg Neg - - - Neg Neg
65 Control M 36·0 Normal No - 3,845 40·0 Normal 33 12 - Not
collected Neg - - - Neg Neg
66 Control F 36·0 Normal No - 3,530 38·2 Normal 25 11 1·1 Neg Neg - - - Neg Neg
67 Control M 36·0 Normal No - 4,020 40·5 Normal 25 11 0·8 Neg Neg - - - Neg Neg
68 Control M 32·5 Normal Yes 1 2,610 38·0 Normal 38 0 1·0 Neg Neg - - - Neg Neg
69 Control F 34·0 Normal No - 2,890 39·5 Normal 40 7 0·8 Neg Neg - - - Neg Neg
70 Control M 35·0 Normal Yes 7 3,295 37·3 Normal 20 7 1·0 Neg Neg - - - Neg Neg
71 Control F 31·8 Normal Yes 4 2,380 38·3 Normal 26 12 0·8 Neg Neg - - - Neg Neg
72 Control M 34·0 Normal No - 3,013 37·3 Normal 27 12 0·9 Neg Neg - - - Neg Neg
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73 Control F 33·0 Normal Yes Don´t know
3,045 36·0 Normal 24 9 0·8 Neg Neg - - - Neg Neg
74 Control F 32·5 Normal No - 3,020 37·6 Normal 21 12 1·4 Neg Neg - - - Neg Neg
75 Control F 33·0 Normal Yes 6 2,970 41·4 Normal 34 5 2·1 Neg Neg - - - Neg Neg
76 Control F 35·0 Normal Yes 3 3,480 40·0 Normal 20 12 1·3 Neg Neg - - - Neg Neg
77 Control F 34·0 Normal No - 3,150 37·0 Normal 27 12 1·1 Neg Neg - - - Neg Neg
78 Control M 35·0 Normal No - 3,520 39·0 Normal 23 9 1·0 Neg Neg - - - Neg Neg
79 Control M 35·5 Normal No - 3,655 38·1 Normal 28 12 1·0 Neg Neg - - - Neg Neg
80 Control M 34·5 Normal No - 3,190 43·1 Normal 31 2 0·4 Neg Neg - - - Neg Neg
81 Control M 35·0 Normal Yes 8 3,615 39·0 Normal 18 9 1·6 Neg Neg - - - Neg Neg
82 Control M 33·0 Normal Yes 6 2,800 39·0 Normal 17 11 1·0 Neg Neg - - - Neg Neg
83 Control F 33·0 Normal Yes 6 2,840 40·0 Normal 33 10 - Not
collected Neg - - - Neg Neg
84 Control F 34·5 Normal No - 2,890 39·4 Normal 18 7 1·1 Neg Neg - - - Neg Neg
85 Control M 36·5 Normal No - 3,155 39·0 Normal 23 12 1·0 Neg Neg - - - Neg Neg
86 Control M 34·5 Normal No - 3,540 39·6 Normal 25 5 0·8 Neg Neg - - - Neg Neg
87 Control M 36·0 Normal No - 3,330 38·1 Normal 17 12 0·7 Neg Neg - - - Neg Neg
88 Control M 34·0 Normal No - 2,850 37·4 Normal 28 12 2·1 Neg Neg - - - Neg Neg
89 Control F 30·5 Normal Yes 7 2,360 35·6 SGA 32 13 0·8 Neg Neg - - - Neg Neg
90 Control F 37·0 Normal Yes 7 3,510 40·0 Normal 28 12 1·0 Neg Neg - - - Neg Neg
91 Control F 33·5 Normal No - 3,430 38·2 Normal 39 14 1·0 Neg Neg - - - Neg Neg
92 Control M 34·0 Normal No - 3,715 39·2 Normal 16 6 1·0 Neg Neg - - - Neg Neg
93 Control F 37·0 Normal No - 3,880 40·3 Normal 20 12 0·7 Neg Neg - - - Neg Neg
94 Control F 35·0 Normal No - 3,100 39·5 Normal 34 10 0·9 Neg Neg - - - Neg Neg
* Case 9 was stillbirth and case 10 was neonatal death, RT-PCR was tested in macerated tissues.
ELISA values are patient optical densities divided by negative control densities (OD); Values less than 2 were considered negative, 2–3 equivocal, and more than 3 positive;
CSF=cerebrospinal fluid.
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Annex Table 2: Maternal ZIKV and DENV serotype specific antibodies (IgG) by plaque reduction