Keun Soo Ahn, et al: Genetic features of intrahepatic cholangiocarcinoma according to FDG uptake Ann Surg Treat Res 2019;96(4):153-161 https://doi.org/10.4174/astr.2019.96.4.153 Supplementary Table 1. Detailed clinical information I D S e x A g e S U V m a x R e c u r r e n c e D i s e a s e f r e e p e r i o d ( m D e a t h O v e r a l l s u r v i v a l ( m o n t h C E A ( m g / d L C A 1 9 - 9 ( U / m D i f f e r e n c i a t i V a s c u l a r i n v T u m o r s i z e ( S t a g e 1T Male 54 8.65 No 112.6 No 112.6 1.14 12.9 Mod No 5 I 2T Male 49 5.47 Yes 3.9 Yes 14.3 1.15 128.5 NA No 16.5 I 4T Male 55 13.79 Yes 1.7 Yes 18.1 2.1 3049 Mod Yes 4.6 II 5T Male 61 6.16 Yes 9.6 Yes 24.3 12.8 26.08 Mod No 4.5 I 6T Male 65 6.1 Yes 57.3 No 99.0 1.84 169.71 Mod No 12 I 7T Male 53 11.89 Yes 3.3 Yes 18.9 1.89 119.43 Mod Yes 4 IVB 11T Male 79 7.73 No 17.3 No 17.3 1.9 40.19 Mod Yes 6 II 13T Male 63 8.5 Yes 9.2 Yes 38.2 1.6 NA Mod No 8.7 I 15T Male 60 4.46 Yes 21.8 Yes 25.6 3.17 831.04 Mod Yes 5 IVA 16T Male 67 7.46 No 65.2 Yes 68.2 2.14 18.85 Poor Yes 8 II 17T Male 69 12.12 Yes 6.9 Yes 28.3 NA 262.08 Mod Yes 5 II 18T Male 75 9.6 Yes 6.1 Yes 26.3 1.5 22.03 Poor Yes 4.5 IVA 19T Male 76 5.58 Yes 16.6 Yes 30.3 1.41 206.26 Mod No 4.3 I 20T Female 76 10.14 Yes 6.0 Yes 6.7 NA 10.1 Mod No 6.5 IVA 21T Male 75 1.82 No 41.7 No 41.7 NA NA Mod No 2.7 I 22T Female 67 2.79 No 54.1 No 54.1 0.5 22.1 Mod No 3.5 I 23T Male 73 11.1 Yes 40.0 No 46.6 4.25 8.3 Mod No 4 I 24T Female 63 8.41 No 49.7 No 49.7 2.74 12.1 Poor No 4.5 I 25T Male 58 12.5 Yes 17.3 Yes 35.5 1.13 4.21 Mod No 3.5 IVA 26T Male 51 11.79 Yes 25.7 Yes 29.4 1.6 1.2 Mod No 4.2 I 27T Female 74 8.79 Yes 26.7 No 23.1 12.5 5950.55 Poor No 12.5 III 29T Female 59 9.04 No 40.2 No 40.2 1.31 1.2 Mod No 10.5 I SUVmax, maximum standard uptake value.
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Supplementary Table 1. Detailed clinical informationdc f o · DNAJC7 DnaJ heat shock protein family (Hsp40) member C7(DNAJC7) 0.601 0.003 UQCC2 ubiquinol-cytochrome c reductase complex
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Keun Soo Ahn, et al: Genetic features of intrahepatic cholangiocarcinoma according to FDG uptake
Ann Surg Treat Res 2019;96(4):153-161https://doi.org/10.4174/astr.2019.96.4.153
19T Male 76 5.58 Yes 16.6 Yes 30.3 1.41 206.26 Mod No 4.3 I
20T Female 76 10.14 Yes 6.0 Yes 6.7 NA 10.1 Mod No 6.5 IVA
21T Male 75 1.82 No 41.7 No 41.7 NA NA Mod No 2.7 I
22T Female 67 2.79 No 54.1 No 54.1 0.5 22.1 Mod No 3.5 I
23T Male 73 11.1 Yes 40.0 No 46.6 4.25 8.3 Mod No 4 I
24T Female 63 8.41 No 49.7 No 49.7 2.74 12.1 Poor No 4.5 I
25T Male 58 12.5 Yes 17.3 Yes 35.5 1.13 4.21 Mod No 3.5 IVA26T Male 51 11.79 Yes 25.7 Yes 29.4 1.6 1.2 Mod No 4.2 I27T Female 74 8.79 Yes 26.7 No 23.1 12.5 5950.55 Poor No 12.5 III
29T Female 59 9.04 No 40.2 No 40.2 1.31 1.2 Mod No 10.5 I
SUVmax, maximum standard uptake value.
Keun Soo Ahn, et al: Genetic features of intrahepatic cholangiocarcinoma according to FDG uptake
Ann Surg Treat Res 2019;96(4):153-161https://doi.org/10.4174/astr.2019.96.4.153
Supplementary Table 2. Gene lists of positively correlated with maximum standard uptake valueSupplementary Table 2. Gene lists of positively correlated with SUVmax
Keun Soo Ahn, et al: Genetic features of intrahepatic cholangiocarcinoma according to FDG uptake
Ann Surg Treat Res 2019;96(4):153-161https://doi.org/10.4174/astr.2019.96.4.153
Supplementary Table 2. Continued
LHFPL5 lipoma HMGIC fusion partner-like 5(LHFPL5) 0.528 0.012KIAA1524 KIAA1524(KIAA1524) 0.528 0.012BRIX1 BRX1, biogenesis of ribosomes(BRIX1) 0.527 0.012GAPDH glyceraldehyde-3-phosphate dehydrogenase(GAPDH) 0.527 0.012THOC3 THO complex 3(THOC3) 0.526 0.012MRPL28 mitochondrial ribosomal protein L28(MRPL28) 0.525 0.012PLEK2 pleckstrin 2(PLEK2) 0.525 0.012COA3 cytochrome c oxidase assembly factor 3(COA3) 0.524 0.012CDC16 cell division cycle 16(CDC16) 0.523 0.012OGFOD3 2-oxoglutarate and iron dependent oxygenase domain containing 3(OGFOD3) 0.522 0.013SNRPB small nuclear ribonucleoprotein polypeptides B and B1(SNRPB) 0.522 0.013EDARADD EDAR associated death domain(EDARADD) 0.522 0.013RACGAP1 Rac GTPase activating protein 1(RACGAP1) 0.522 0.013FAM64A family with sequence similarity 64 member A(FAM64A) 0.521 0.013PRIM2 primase (DNA) subunit 2(PRIM2) 0.521 0.013CCNB1 cyclin B1(CCNB1) 0.519 0.013MFSD2B major facilitator superfamily domain containing 2B(MFSD2B) 0.519 0.013TRAIP TRAF interacting protein(TRAIP) 0.519 0.013KIF4A kinesin family member 4A(KIF4A) 0.519 0.013CDKN3 cyclin dependent kinase inhibitor 3(CDKN3) 0.518 0.013PPARD peroxisome proliferator activated receptor delta(PPARD) 0.518 0.014HSPB11 heat shock protein family B (small) member 11(HSPB11) 0.517 0.014TONSL tonsoku-like, DNA repair protein(TONSL) 0.515 0.014PRR11 proline rich 11(PRR11) 0.514 0.014MKI67 marker of proliferation Ki-67(MKI67) 0.513 0.015TPX2 TPX2, microtubule nucleation factor(TPX2) 0.513 0.015CDCA4 cell division cycle associated 4(CDCA4) 0.512 0.015NCAPG non-SMC condensin I complex subunit G(NCAPG) 0.512 0.015GINS2 GINS complex subunit 2(GINS2) 0.512 0.015CCDC167 coiled-coil domain containing 167(CCDC167) 0.511 0.015C12orf45 chromosome 12 open reading frame 45(C12orf45) 0.511 0.015SPAG5 sperm associated antigen 5(SPAG5) 0.511 0.015FAM207A family with sequence similarity 207 member A(FAM207A) 0.510 0.015MLX MLX, MAX dimerization protein(MLX) 0.510 0.015CNPY3 canopy FGF signaling regulator 3(CNPY3) 0.510 0.015SHCBP1 SHC binding and spindle associated 1(SHCBP1) 0.509 0.016EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1(EIF4EBP1) 0.508 0.016PDXK pyridoxal (pyridoxine, vitamin B6) kinase(PDXK) 0.507 0.016C1orf74 chromosome 1 open reading frame 74(C1orf74) 0.507 0.016TFB1M transcription factor B1, mitochondrial(TFB1M) 0.507 0.016ADA adenosine deaminase(ADA) 0.507 0.016ATP6V1G2-DDX39B ATP6V1G2-DDX39B readthrough (NMD candidate)(ATP6V1G2-DDX39B) 0.507 0.016LSM2 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated(LSM2) 0.506 0.016FAM104A family with sequence similarity 104 member A(FAM104A) 0.505 0.016MEA1 male-enhanced antigen 1(MEA1) 0.505 0.016APOL1 apolipoprotein L1(APOL1) 0.505 0.017MAPRE3 microtubule associated protein RP/EB family member 3(MAPRE3) 0.505 0.017SNF8 SNF8, ESCRT-II complex subunit(SNF8) 0.505 0.017NUDT1 nudix hydrolase 1(NUDT1) 0.504 0.017TOP2A topoisomerase (DNA) II alpha(TOP2A) 0.504 0.017U2AF1 U2 small nuclear RNA auxiliary factor 1(U2AF1) 0.503 0.017SAAL1 serum amyloid A like 1(SAAL1) 0.502 0.017TPI1 triosephosphate isomerase 1(TPI1) 0.502 0.017UHRF1 ubiquitin like with PHD and ring finger domains 1(UHRF1) 0.501 0.017AKIP1 A-kinase interacting protein 1(AKIP1) 0.501 0.018GTF2F2 general transcription factor IIF subunit 2(GTF2F2) 0.501 0.018
KIF20A kinesin family member 20A(KIF20A) 0.537 0.010KIF18B kinesin family member 18B(KIF18B) 0.537 0.010PTBP3 polypyrimidine tract binding protein 3(PTBP3) 0.537 0.010ASF1B anti-silencing function 1B histone chaperone(ASF1B) 0.535 0.010UBE2S ubiquitin conjugating enzyme E2 S(UBE2S) 0.534 0.010NDC80 NDC80, kinetochore complex component(NDC80) 0.534 0.010CMAS cytidine monophosphate N-acetylneuraminic acid synthetase(CMAS) 0.534 0.011CCT4 chaperonin containing TCP1 subunit 4(CCT4) 0.532 0.011NUFIP1 NUFIP1, FMR1 interacting protein 1(NUFIP1) 0.532 0.011PPIL1 peptidylprolyl isomerase like 1(PPIL1) 0.531 0.011PGAM1 phosphoglycerate mutase 1(PGAM1) 0.531 0.011HNRNPAB heterogeneous nuclear ribonucleoprotein A/B(HNRNPAB) 0.529 0.011
Gene symbol Gene name Pearson coefficient P
Keun Soo Ahn, et al: Genetic features of intrahepatic cholangiocarcinoma according to FDG uptake
Ann Surg Treat Res 2019;96(4):153-161https://doi.org/10.4174/astr.2019.96.4.153
Supplementary Table 3. Gene lists of negatively correlated with SUVmaxSupplementary Table 3. Gene lists of negatively correlated with SUVmax
Gene symbol Gene name Pearson coefficient PSLC27A2 solute carrier family 27 member 2(SLC27A2) -0.686 0.000OXTR oxytocin receptor(OXTR) -0.684 0.000TMEM86B transmembrane protein 86B(TMEM86B) -0.673 0.001HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1(HERPUD1) -0.666 0.001CXCL12 C-X-C motif chemokine ligand 12(CXCL12) -0.661 0.001PARD6B par-6 family cell polarity regulator beta(PARD6B) -0.659 0.001COLEC11 collectin subfamily member 11(COLEC11) -0.652 0.001PRR26 proline rich 26(PRR26) -0.636 0.001ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif 16(ADAMTS16) -0.632 0.002CYP2B6 cytochrome P450 family 2 subfamily B member 6(CYP2B6) -0.631 0.002TMEM60 transmembrane protein 60(TMEM60) -0.626 0.002SOGA2 Suppressor of glucose autophagy associated 2 -0.626 0.002GIMAP8 GTPase, IMAP family member 8(GIMAP8) -0.622 0.002TPPP3 tubulin polymerization promoting protein family member 3(TPPP3) -0.617 0.002CYYR1 cysteine and tyrosine rich 1(CYYR1) -0.617 0.002ART4 ADP-ribosyltransferase 4 (Dombrock blood group)(ART4) -0.615 0.002FAM200B family with sequence similarity 200 member B(FAM200B) -0.615 0.002NPR1 natriuretic peptide receptor 1(NPR1) -0.613 0.002FXYD6 FXYD domain containing ion transport regulator 6(FXYD6) -0.608 0.003ST7L suppression of tumorigenicity 7 like(ST7L) -0.601 0.003SCAND2P SCAN domain containing 2 pseudogene(SCAND2P) -0.599 0.003DTWD1 DTW domain containing 1(DTWD1) -0.598 0.003GUCD1 guanylyl cyclase domain containing 1(GUCD1) -0.598 0.003GIMAP7 GTPase, IMAP family member 7(GIMAP7) -0.595 0.003BCL2 BCL2, apoptosis regulator(BCL2) -0.595 0.004AKAP9 A-kinase anchoring protein 9(AKAP9) -0.590 0.004LDB2 LIM domain binding 2(LDB2) -0.590 0.004CLEC3B C-type lectin domain family 3 member B(CLEC3B) -0.590 0.004FZD4 frizzled class receptor 4(FZD4) -0.589 0.004SERINC4 serine incorporator 4(SERINC4) -0.588 0.004RERG RAS like estrogen regulated growth inhibitor(RERG) -0.588 0.004IGFBP7 insulin like growth factor binding protein 7(IGFBP7) -0.583 0.004DPYSL2 dihydropyrimidinase like 2(DPYSL2) -0.581 0.005PDGFD platelet derived growth factor D(PDGFD) -0.580 0.005EXOC3L2 exocyst complex component 3 like 2(EXOC3L2) -0.576 0.005ULK3 unc-51 like kinase 3(ULK3) -0.571 0.006COL14A1 collagen type XIV alpha 1 chain(COL14A1) -0.570 0.006ACMSD aminocarboxymuconate semialdehyde decarboxylase(ACMSD) -0.570 0.006RDH5 retinol dehydrogenase 5(RDH5) -0.569 0.006LPIN2 lipin 2(LPIN2) -0.568 0.006CTTNBP2 cortactin binding protein 2(CTTNBP2) -0.567 0.006SERPINA7 serpin family A member 7(SERPINA7) -0.566 0.006RAMP3 receptor activity modifying protein 3(RAMP3) -0.563 0.006MFAP4 microfibrillar associated protein 4(MFAP4) -0.561 0.007KCNH3 potassium voltage-gated channel subfamily H member 3(KCNH3) -0.561 0.007CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1(CSGALNACT1) -0.558 0.007CALCRL calcitonin receptor like receptor(CALCRL) -0.556 0.007SESN2 sestrin 2(SESN2) -0.555 0.007FGD4 FYVE, RhoGEF and PH domain containing 4(FGD4) -0.554 0.007CCDC3 coiled-coil domain containing 3(CCDC3) -0.553 0.008SDPR serum deprivation response(SDPR) -0.552 0.008ASPHD1 aspartate beta-hydroxylase domain containing 1(ASPHD1) -0.551 0.008SLC1A1 solute carrier family 1 member 1(SLC1A1) -0.550 0.008PANK1 pantothenate kinase 1(PANK1) -0.550 0.008CYP4V2 cytochrome P450 family 4 subfamily V member 2(CYP4V2) -0.546 0.009EMCN endomucin(EMCN) -0.545 0.009COLEC10 collectin subfamily member 10(COLEC10) -0.544 0.009BIVM basic, immunoglobulin-like variable motif containing(BIVM) -0.543 0.009MCCC1 methylcrotonoyl-CoA carboxylase 1(MCCC1) -0.543 0.009PLA2G6 phospholipase A2 group VI(PLA2G6) -0.543 0.009NGFR nerve growth factor receptor(NGFR) -0.541 0.009ALDH1B1 aldehyde dehydrogenase 1 family member B1(ALDH1B1) -0.541 0.009MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3(MAGI3) -0.540 0.009CNOT6L CCR4-NOT transcription complex subunit 6 like(CNOT6L) -0.540 0.010RCAN2 regulator of calcineurin 2(RCAN2) -0.540 0.010GIMAP6 GTPase, IMAP family member 6(GIMAP6) -0.539 0.010ITGA9 integrin subunit alpha 9(ITGA9) -0.538 0.010ANGPTL1 angiopoietin like 1(ANGPTL1) -0.538 0.010CLEC10A C-type lectin domain family 10 member A(CLEC10A) -0.536 0.010G6PC glucose-6-phosphatase catalytic subunit(G6PC) -0.536 0.010PEX12 peroxisomal biogenesis factor 12(PEX12) -0.535 0.010S1PR1 sphingosine-1-phosphate receptor 1(S1PR1) -0.535 0.010MZF1 myeloid zinc finger 1(MZF1) -0.535 0.010PDZD8 PDZ domain containing 8(PDZD8) -0.531 0.011MECP2 methyl-CpG binding protein 2(MECP2) -0.531 0.011
Keun Soo Ahn, et al: Genetic features of intrahepatic cholangiocarcinoma according to FDG uptake
Ann Surg Treat Res 2019;96(4):153-161https://doi.org/10.4174/astr.2019.96.4.153
C2orf74 chromosome 2 open reading frame 74(C2orf74) -0.519 0.013RRAGB Ras related GTP binding B(RRAGB) -0.519 0.013C11orf71 chromosome 11 open reading frame 71(C11orf71) -0.519 0.013ABCC3 ATP binding cassette subfamily C member 3(ABCC3) -0.518 0.014CD27 CD27 molecule(CD27) -0.518 0.014HGD homogentisate 1,2-dioxygenase(HGD) -0.518 0.014KDR kinase insert domain receptor(KDR) -0.517 0.014CD81 CD81 molecule(CD81) -0.516 0.014GSTA2 glutathione S-transferase alpha 2(GSTA2) -0.516 0.014ZMYM6 zinc finger MYM-type containing 6(ZMYM6) -0.516 0.014MMP24 matrix metallopeptidase 24(MMP24) -0.516 0.014ZBTB44 zinc finger and BTB domain containing 44(ZBTB44) -0.515 0.014GJB1 gap junction protein beta 1(GJB1) -0.514 0.014C14orf105 chromosome 14 open reading frame 105(C14orf105) -0.514 0.014IL6ST interleukin 6 signal transducer(IL6ST) -0.513 0.015SCMH1 sex comb on midleg homolog 1 (Drosophila)(SCMH1) -0.513 0.015THSD4 thrombospondin type 1 domain containing 4(THSD4) -0.511 0.015FRZB frizzled-related protein(FRZB) -0.511 0.015RPL9P25 ribosomal protein L9 pseudogene 25(RPL9P25) -0.509 0.016MYCT1 myc target 1(MYCT1) -0.509 0.016ARID4A AT-rich interaction domain 4A(ARID4A) -0.508 0.016FAXDC2 fatty acid hydroxylase domain containing 2(FAXDC2) -0.507 0.016LHFP lipoma HMGIC fusion partner(LHFP) -0.507 0.016CYP4A11 cytochrome P450 family 4 subfamily A member 11(CYP4A11) -0.506 0.016KIAA0430 KIAA0430(KIAA0430) -0.504 0.017LTB4R2 leukotriene B4 receptor 2(LTB4R2) -0.503 0.017CLEC14A C-type lectin domain family 14 member A(CLEC14A) -0.503 0.017INSR insulin receptor(INSR) -0.503 0.017SPG20 spastic paraplegia 20 (Troyer syndrome)(SPG20) -0.502 0.017GZMK granzyme K(GZMK) -0.502 0.017COCH cochlin(COCH) -0.501 0.018LAPTM4A lysosomal protein transmembrane 4 alpha(LAPTM4A) -0.500 0.018
SLC5A9 solute carrier family 5 member 9(SLC5A9) -0.530 0.011CRIM1 cysteine rich transmembrane BMP regulator 1(CRIM1) -0.530 0.011TGFBR3 transforming growth factor beta receptor 3(TGFBR3) -0.529 0.011WDR73 WD repeat domain 73(WDR73) -0.529 0.011MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1(MAGI1) -0.528 0.012SLC18A2 solute carrier family 18 member A2(SLC18A2) -0.527 0.012C7 complement C7(C7) -0.526 0.012AQP7 aquaporin 7(AQP7) -0.525 0.012ZNF75D zinc finger protein 75D(ZNF75D) -0.524 0.012SGSM2 small G protein signaling modulator 2(SGSM2) -0.522 0.013FCER1A Fc fragment of IgE receptor Ia(FCER1A) -0.521 0.013KRBOX4 KRAB box domain containing 4(KRBOX4) -0.520 0.013
Gene symbol Gene name Pearson coefficient P
Supplementary Table 3. Continued
Keun Soo Ahn, et al: Genetic features of intrahepatic cholangiocarcinoma according to FDG uptake
Ann Surg Treat Res 2019;96(4):153-161https://doi.org/10.4174/astr.2019.96.4.153
Supplementary Table 4. List of activated pathway in patients with high SUVmax (>9.0) by Gene Set Enrichment AnalysisSupplementary Table 4. List of activated pathway in patients with high SUVmax (>9.0) by Gene Set Enrichment Analysis