Supplementary Materials for Trastuzumab emtansine (T-DM1) renders HER2 + breast cancer highly susceptible to CTLA-4/PD-1 blockade Philipp Müller,* Matthias Kreuzaler, Tarik Khan, Daniela S. Thommen, Kea Martin, Katharina Glatz, Spasenija Savic, Nadia Harbeck, Ulrike Nitz, Oleg Gluz, Michael von Bergwelt-Baildon, Hans Kreipe, Sai Reddy, Matthias Christgen, Alfred Zippelius* *Corresponding author. E-mail: [email protected] (P.M.); [email protected] (A.Z.) Published 25 November 2015, Sci. Transl. Med. 7, 315ra188 (2015) DOI: 10.1126/scitranslmed.aac4925 The PDF file includes: Fig. S1. Effect of ansamitocin P3 and DM1 on the maturation of DCs. Fig. S2. CD8/CD4 ratios in human breast tumors before and after T-DM1 monotherapy. Fig. S3. H&E staining of treated Fo5 tumors. Fig. S4. Patterns of intratumoral immune cell subsets after T-DM1 therapy. Fig. S5. Tumor growth and tumor-infiltrating immune cell subsets in mice receiving trastuzumab instead of T-DM1. Fig. S6. Luminex-based cytokine and growth factor measurement in T-DM1– and α-CTLA-4/PD-1–treated tumors. Fig. S7. T cell function in mice receiving trastuzumab instead of T-DM1. Fig. S8. Helios expression, CD8/CD4 and CD8/Treg ratios, and splenic Tregs. Fig. S9. Helios expression and Tregs in mice receiving trastuzumab instead of T- DM1. www.sciencetranslationalmedicine.org/cgi/content/full/7/315/315ra188/DC1
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Supplementary Materials for · Supplementary Materials for Trastuzumab emtansine (T-DM1) renders HER2+ breast cancer highly susceptible to CTLA-4/PD-1 blockade Philipp Müller,* Matthias
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Supplementary Materials for
Trastuzumab emtansine (T-DM1) renders HER2+ breast cancer highly
susceptible to CTLA-4/PD-1 blockade
Philipp Müller,* Matthias Kreuzaler, Tarik Khan, Daniela S. Thommen, Kea Martin,
Katharina Glatz, Spasenija Savic, Nadia Harbeck, Ulrike Nitz, Oleg Gluz, Michael von
Bergwelt-Baildon, Hans Kreipe, Sai Reddy, Matthias Christgen, Alfred Zippelius*