Supplementary information of Publishable Summary: Proposal title: Single Cell Electroporation and DNA dynamics: from bulk to micro/nanofluidics Proposal Acronym: NanoEP First Reporting Period:01/04/2013-31/03/2015 Figure 1) Scientists from Delft, Ohio State and Duke University have found a safe and efficient way to deliver nanoparticles containing a wide range of biomolecules into living cells without going through the endocytosis route, by applying electrical pulses through a nanochannel. Pouyan E. Boukany, L. James Lee, Kam W. Leong and colleagues present a novel platform for in vitro nucleic acid delivery in regulating gene expression that holds great potential in advancing fundamental biological science and modifying cells for biomedical applications. This work has been recently published as the inside front cover story in Advanced Healthcare Materials, which is an international, interdisciplinary forum for peer-reviewed papers on materials science aimed at promoting human health.
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Supplementary information of Publishable Summary: Proposal title: Single Cell Electroporation and DNA dynamics: from bulk to micro/nanofluidics Proposal Acronym: NanoEP First Reporting Period:01/04/2013-31/03/2015
Figure 1) Scientists from Delft, Ohio State and Duke University have found a safe and efficient way to deliver nanoparticles containing a wide range of biomolecules into living cells without going through the endocytosis route, by applying electrical pulses through a nanochannel. Pouyan E. Boukany, L. James Lee, Kam W. Leong and colleagues present a novel platform for in vitro nucleic acid delivery in regulating gene expression that holds great potential in advancing fundamental biological science and modifying cells for biomedical applications. This work has been recently published as the inside front cover story in Advanced Healthcare Materials, which is an international, interdisciplinary forum for peer-reviewed papers on materials science aimed at promoting human health.
Figure 2) A team in chemical engineering has developed a new method to generate large arrays of micellar nanowires. On the front cover of Small journal recent work of MC fellow has been highlighted with an image illustrating a novel, simple, and affordable method for generating a large array of laterally ordered soft nanowires from worm-like micelles. These micellar nanowires can be successfully decorated with hydrophobic molecules that incorporate into the micelle core or with hydrophilic nanoparticles such as quantum dots entrapped in the corona. This platform should enable new opportunities in functional nano-scale devices, especially bio-chemical sensors.
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